PDB 8zj4 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

[Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond., Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.]

[Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.]

Biochemical function:

not assigned

Biological process:

not assigned

Cellular component:

not assigned

Structure analysis Details

Assembly composition:

hetero trimer (preferred)

Assembly name:

Serine protease 1 and Enteropeptidase catalytic light chain (preferred)

PDBe Complex ID:

PDB-CPX-272386 (preferred)

Entry contents:

3 distinct polypeptide molecules

Macromolecules (10 distinct):

Enteropeptidase catalytic light chain Chain: D

Molecule details ›

Chain: D
Length: 235 amino acids
Theoretical weight: 26.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P98073 (Residues: 785-1019; Coverage: 23%)

Gene names: ENTK, PRSS7, TMPRSS15
Sequence domains: Trypsin

Serine protease 1 Chain: C

Molecule details ›

Chain: C
Length: 232 amino acids
Theoretical weight: 25.04 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P07477 (Residues: 16-247; Coverage: 100%)

Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin

Enteropeptidase non-catalytic heavy chain Chain: A

Molecule details ›

Chain: A
Length: 603 amino acids
Theoretical weight: 66.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: