FRCPath Part 1: Examination Preparation Guide: eBook

Preface      4

How to use this book      5

Examination papers:

Paper 1 Answers

7 - 33

34 - 49

Paper 2 Answers

50 - 76

77 - 92

Page(s)

PAPER 1

Part 1 EXAMINATION – Paper 1

(A) 2 + 2

(B) 2 + 3

(C) 5 + 5

(D) 3 + 4

(E) 4 + 3

showing suspicious atypia. Which of the following classifications is most appropriate for this description?

died and a post mortem was performed. During the autopsy part of the large intestine was found to be ischaemic. The most likely diagnosis is:

What is the likely diagnosis?

Using the clinical scenarios below choose the most likely diagnosis from the list of conditions given:

CD3 neg. CD5 neg. CD10 pos. CD20 pos. CD79a pos. CD23 neg. CD43 neg. c-myc pos.

CD 3 neg. CD5 pos. CD10 neg. CD23 pos. CD 43 pos. CD79a pos. cyclin D1 neg.

CD3 neg. CD5 neg. CD10 pos. CD20 pos. CD79a. pos. CD43 neg. CD23 neg.

CD3 neg. CD5 pos. CD20 pos. CD23 neg. CD79a pos. Cyclin D1 pos.

CD3 neg. CD5 pos. CD20 pos. CD79a pos. CD10 pos. CD43 neg. bcl-2 pos.

For each of the clinical scenarios below choose the best answer from the above list:

Using the clinical scenarios below choose the most likely diagnosis from the list of conditions given:

Pigmented substantia nigra, normal cerebellum, normal pons, normal hippocampus and basal ganglia, severe diffuse cortical atrophy.

Mild cortical atrophy, normal cerebellum, normal pons, normal hippocampus and basal ganglia, pale substantia nigra.

His brain shows a normal cortex, spongiform change in the cerebellum, normal hippocampus, basal ganglia and pons. The substantia nigra is pigmented.

Match the histological/cytological description to the most likely diagnosis chosen from the list of conditions given below:

obstructive cardiomyopathy

Choose the best answer from the list above that applies to the scenarios described below:

23

Match the following genes/gene products/genetic changes to the given disease states:

Relate the histological/cytological descriptions below to the most fitting pathologies above.

Thesmearcontainsclustersofcellsshowinglowgradedyskaryosis.

Thesmearshowsextensivebackgroundneutrophilsanddebriswithsparseelongateatypical orangeophyllicsquamous cells.

Cone biopsy reveals exophytic squamous lesions that show clear para-nuclearhalos, binucleate cells and cellular keratinisation. Focal low grade dyskaryosis ispresent.

Conebiopsyrevealsnon-invasiveglandsintheendocervixthatshowhyperchromasia,nuclearstratification,abnormalmitosesandanintestinal-typearchitecture.

A peritoneal biopsy contains glands with columnar epithelium, oval nuclei withsharp nuclear membranes and no nucleoli. An associated stroma and granular brownpigmentis noted.

Relate the clinical scenarios below to the most likely aetiological agent above:

For each of the descriptions below select the most appropriate answer A) – O) from the list