Helaina's effera™ trial shows no immune response to human lactoferrin

Uncover the benefits of using vitreous humor in post-mortem toxicology with the Thermo Scientific Tox Explorer method. Sheffield Teaching Hospitals NHS Foundation Trust's latest study highlights the method's robustness and sensitivity, even with low-volume samples. Dive into the details in our blog! http://spr.ly/6048ALsxy #ForensicToxicology #HRAM #ToxExplorer #ForensicScience #LCMS

Computational approaches require usable, machine accessible data. But what is a data point or a model output without context? As we move towards more cross-disciplinary work in the environmental health sciences space, increased development of supporting standards and terminology is critical to support smarter use and reuse. Listen in and see what we are doing to support this effort.

Update from ICT 2025: During the International Union of Toxicology (IUTOX) Congress in Beijing, SenzaGen presented the GARD® platform, demonstrating how the integration of genomics and machine learning enables high predictive accuracy, broad applicability across chemical domains, and quantitative potency assessment — contributing to the advancement of NAMs for in vitro skin sensitization assessment. Senzagen Group: SenzaGen, VitroScreen and ToxHub Srl

New DoSChem “International Exchange Programme” awardee: Judith Gufler (Department of Food Chemistry and Toxicology, Doris Marko) will conduct her project "Exasperation of genotoxicity through co-exposure of deoxynivalenol with anticancer drugs (SN38 and etoposide) in vitro” in the group of Prof. Ariane Vettorazzi at the at the Department of Pharmacology and Toxicology, Universidad de Navarra, School of Pharmacy and Nutrition, Pamplona, Spain. https://lnkd.in/d3-sUNxb

Small structures. Big insights. The micronucleus may be one of the smallest components within a cell — yet it holds powerful clues about a compound’s potential to damage our genetic material. In our latest article, we explore the fascinating science behind micronucleus formation and its critical role in genotoxicity testing. Understanding how and why micronuclei appear isn’t just a technical detail — it’s a cornerstone of predictive toxicology, helping us assess chemical safety long before exposure occurs. 🔗 Dive into the mechanisms, implications, and applications of the micronucleus assay in modern toxicology: 👉 https://lnkd.in/eKPZcgrJ #Genotoxicity #MicronucleusAssay #InVitroToxicology #PredictiveScience #GenEvolutioN

🎙️ Have you listened to Episode 10 of #ImagineMoreCreateSolutions yet? In this episode, Dr. L. Andrew Lee and Dr. Thomas Rosano dive into the evolving landscape of clinical and forensic toxicology. ☠️ As we get ready for #SOFT2025 next week, now’s the perfect time to tune in, and then stop by our poster presentation to continue the conversation in person! 📊 Poster#013 | "Hydrolysis of Drug Glucuronides by β-Glucuronidase is Contingent on Both pH and N- or O-Glucuronide Linkage", presented by IMCS Regional Technical Sales Manager Anusha Chaparala on October 29th from 12:00 - 2:00 PM

We’re pleased to share our latest paper in Regulatory Toxicology and Pharmacology, produced in collaboration with Labcorp. This study evaluates several defined approaches (DAs) for predicting human skin sensitisation potential using chemicals previously untested in New Approach Methodologies (NAMs). The findings contribute valuable insight into the performance and applicability of these non-animal methods and support ongoing efforts to advance regulatory acceptance of NAMs. 🔗 Read the full paper (free access until 19 December): https://buff.ly/WtirTWz #CollaboratorSpotlight - Darren Kidd

Marketed in a variety of colorful and misleading packaging, highly potent and dangerous semi-synthetic opioid NPS derived from Kratom have flooded the consumer herbal supplement market. Our team is proud to announce the completion of our work to introduce a new Certified Reference Material of Mitragynine Pseudoindoxyl enabling accurate quantification.

🚨 Cayman Chemical has just introduced a new Certified Reference Material of Mitragynine Pseudoindoxyl (Item: 44084), related to 7-hydroxy mitragynine (aka 7-OH). There are reported increases of overdoses related to 7-OH. This CRM is relevant and another tool to assist scientists with their testing and research into this class of opioids. Learn more about the Mitragynine pseudoindoxyl CRM here: https://lnkd.in/gqjdDFxV #ISO17034 #CRM #CertifiedReferenceMaterial #Kratom #Mitragynine #7OH #CaymanChemical #HMRP

🚨 🚨 🚨 NEW #IATDMCT Guideline is out, on when (and how) to convert (capillary) blood concentrations to plasma concentrations! Following the publication in 2019 of the "Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring" (https://lnkd.in/e9bEqBpt), there's now a new guideline on what to do with the results: "To Convert or Not to Convert? Official International Association of Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Considerations and Recommendations for Converting Capillary Blood Microsampling Concentrations to Plasma Concentrations" (https://lnkd.in/e3MuYiUG). Credits to almost-Dr. Laura Boffel for lifting the heavy weight of this one! 👏 👏 👏 International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) 👇