PYSCHIATRIC ILLNESS in
HYPOTHYROIDISM
-By Dr. SHRUTHI.M.K
PLAN OF PRESENTATION
Historic notes
Normal
Hypothyroidism
Psychiatric symptoms
Lab investigations
Treatment
Historic notes
Hypothalamo-Pitutary-Thyroid
Axis
HYPOTHYROIDISM
Decrease in Throid hormone or its action leads to
hypothyroidism.
It can beprimary - 95% of cases
central (cause in
Hypothalamus/Pitutary)
Primary hypothroidism can be due to
loss/atrophy of throid gland
compensatory gland hypertrophy
secondary to defective hormone biosynthesis.
Though most of the cases are Idiopathic,
some are Iatrogenicsurgical/radioiodine treatment of
hyperthyroidism
excess of anti-thyroid drugs
various drugs (ex-Lithium)
Others causes include Iodine deficieny, autoimmune disorders
The disorder can occur at any age though the risk
increases with age. It is 10 times more common
with women than men.
Generally onset is insidious (excepti in
chemical/surgical ablation of gland).
In children, it may be associated with irreverisble
physical and mental retardation. In adults, physical
and mental changes are almost always correctable
with hormone replacement therapy.