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Atherosclerosis

Atherosclerosis is a disease affecting blood vessels that is classified into six types according to the American Heart Association. It involves the buildup of plaque on the inner walls of arteries from endothelial injury and inflammation. This progresses over time from intimal lesions and is influenced by both modifiable and non-modifiable risk factors such as lipids, smooth muscle cells, infections, and genetic predispositions.

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37 views22 pages

Atherosclerosis

Atherosclerosis is a disease affecting blood vessels that is classified into six types according to the American Heart Association. It involves the buildup of plaque on the inner walls of arteries from endothelial injury and inflammation. This progresses over time from intimal lesions and is influenced by both modifiable and non-modifiable risk factors such as lipids, smooth muscle cells, infections, and genetic predispositions.

Uploaded by

saket
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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BLOOD VESSELS

ATHEROSCLEROSIS

Endothelial cells

Neointima

Arteriosclerosis
Atherosclerosis
Monckebergs medial calcific sclerosis
Arteriosclerosis

Atherosclerosis
Intimal lesions

Six types of atherosclerotic lesions


American heart association classification

Risk factors
Non modifiable
Modifiable

Pathogenesis of atherosclerosis
Response to injury hypothesis
Ch. Inflammatory response of arterial wall
initiated by injury to endothelium

Progression

Role of endothelial injury


Role of inflammation
Role of lipids
Role of smooth muscle cells
Other factors
-Oligoclonality of lesions
-Infections

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