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Decreased Intraoral Secretions During Sedation-Analgesia With Propofol-Ketamine and Midazolam-Ketamine Combinations

This study investigated the effects of propofol-ketamine (PK) and midazolam-ketamine (MK) combinations on salivary flow and intraoral secretions in human volunteers undergoing sedation-analgesia. The study found that both PK and MK combinations significantly reduced mixed intraoral secretions by an average of 43% and 47% respectively compared to pre-sedation levels, and secretions had not returned to baseline levels 30 minutes after discontinuing the infusions. The combinations were effective at controlling intraoral secretions by reducing salivary flow during sedation-analgesia.

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27 views1 page

Decreased Intraoral Secretions During Sedation-Analgesia With Propofol-Ketamine and Midazolam-Ketamine Combinations

This study investigated the effects of propofol-ketamine (PK) and midazolam-ketamine (MK) combinations on salivary flow and intraoral secretions in human volunteers undergoing sedation-analgesia. The study found that both PK and MK combinations significantly reduced mixed intraoral secretions by an average of 43% and 47% respectively compared to pre-sedation levels, and secretions had not returned to baseline levels 30 minutes after discontinuing the infusions. The combinations were effective at controlling intraoral secretions by reducing salivary flow during sedation-analgesia.

Uploaded by

Rezza Hary
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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J Anesth. 2001;15(4):197-200.

Decreased intraoral secretions during sedation-analgesia with


propofol-ketamine and midazolam-ketamine combinations.
Morse Z, Sano K, Kanri T.

Author information

Abstract
PURPOSE:
To investigate salivary flow over time with a balanced sedation-analgesia technique
using a propofol-ketamine (PK) or a midazolam-ketamine (MK) combination in human
volunteers.
METHODS:
In the PK group, boluses of 1 mg.kg(-1) of propofol and 0.7 mg.kg(-1) of ketamine were
initially administered. This was followed by an infusion, given over a 1-h period, of
propofol (5 mg.kg(-1)) admixed with ketamine (0.7 mg.kg(-1)). In the MK group, 0.07
mg.kg(-1) of midazolam and 0.7 mg.kg(-1) of ketamine was followed by the infusion of a
midazolam (0.07 mg.kg(-1)) and ketamine (0.7 mg.kg(-1)) admixture, also given over a
period of 1 h. Salivary flow was measured prior to and at 10-min intervals during the
sedation-analgesia, as well as for 30 minutes after its termination.
RESULTS:
Mixed intraoral secretions were significantly reduced, by 43% and 47%, on average, in
the PK and MK groups, respectively, when compared with presedation levels, and had
not returned to baseline levels 30 min after discontinuation of the infusion.
CONCLUSION:
Sedation-analgesia with PK and MK combinations controls intraoral secretions by
reducing salivary flow.
PMID:
14569435
[PubMed]

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