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Hyperten Sion: Raas Dysfunction Chronic Inflammation

Chronic inflammation and genetic and lifestyle factors can precipitate hypertension by activating the sympathetic nervous system and renin-angiotensin-aldosterone system, increasing catecholamine production, vascular resistance, blood volume, and sodium and water retention. These changes lead to endothelial dysfunction, vascular remodeling, atherosclerosis, and increased peripheral vascular resistance, causing high blood pressure and restricting blood flow. Over time, this causes damage to vital organs like the heart, brain, kidneys, and eyes through mechanisms like ischemia, infarction, thrombosis, and atherosclerosis, potentially resulting in heart attack, stroke, kidney failure, vision loss, pain, or death.

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Nicoh Avila
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22 views3 pages

Hyperten Sion: Raas Dysfunction Chronic Inflammation

Chronic inflammation and genetic and lifestyle factors can precipitate hypertension by activating the sympathetic nervous system and renin-angiotensin-aldosterone system, increasing catecholamine production, vascular resistance, blood volume, and sodium and water retention. These changes lead to endothelial dysfunction, vascular remodeling, atherosclerosis, and increased peripheral vascular resistance, causing high blood pressure and restricting blood flow. Over time, this causes damage to vital organs like the heart, brain, kidneys, and eyes through mechanisms like ischemia, infarction, thrombosis, and atherosclerosis, potentially resulting in heart attack, stroke, kidney failure, vision loss, pain, or death.

Uploaded by

Nicoh Avila
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Predisposing Factors:

11
Genetics, Age,
Gender, Race

Chronic
Inflammation

Precipitating Factors:
Stress, Obesity,
Nutrients, Substance
abuse, DM, Kidney

Over-activity of
SNS

RAAS
Dysfunction

production of
catecholamine
Heart Rate
Vascular
Resistance

Renin

Peripheral
Vascular

Angiotensin
Sodium and
Water
Retention

Insulin
resistance
Glucose

Vascular changes
Blood
Volume

Hyperten
sion
Tissue Ischemia

End Organ
Dysfunction

Atherosclerosis

Peripheral Vascular
Resistance

Angiotensin II

Sodium and
Water
Retention

Hypertrophy of
myocardium
associated to
hypertension

Vascular
remodelling
Weak blood
vessels

Platelet
aggregation

Atherosclerosis

Endothelial
dysfunction

endomethel
in
(vasoconstrictor)

nitric oxcide

Smooth muscle
contraction

Tissue Ischemia
Anaerobic
metabolism
Lactic Acid fomation

Pain

Heart

Mayocardial
ischemia, MI
Chest pain

Kidney

Chronic
Urine
output
Kidney

Death

Stroke,
Transient
Head ache,
Brain
ischemic
dizziness,
attack,
fatigue, Acute
brainin
changes
infarction,
mentation,
Cerebral
sensorium
thrombosis,

Eyes
Blurring of
Retinal
vision,
double
Vascular
vision, and
sclerosis,
Loss
other
visual

Arterial vessels of lower


extremities

Claudication,
painful
Gangrene

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