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Connective Tissue DZ

ANA low positive positive if suspicion for connective tissue disease is low, consider drug induced, chronic autoimmune disease, chronic hepatitis c virus negative No disease, in remission, or being treated ORDER Connective Tissue Diseases Profile Peripheral pattern Homogenous pattern Speckled pattern Nucleolar pattern Centromere pattern Cytoplasmic pattern CREST No specificity Antibody Key ANA Anti-Nuclear Antibodies (ANA), IgG Screen with Reflex to IFA

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283 views1 page

Connective Tissue DZ

ANA low positive positive if suspicion for connective tissue disease is low, consider drug induced, chronic autoimmune disease, chronic hepatitis c virus negative No disease, in remission, or being treated ORDER Connective Tissue Diseases Profile Peripheral pattern Homogenous pattern Speckled pattern Nucleolar pattern Centromere pattern Cytoplasmic pattern CREST No specificity Antibody Key ANA Anti-Nuclear Antibodies (ANA), IgG Screen with Reflex to IFA

Uploaded by

Andre Garcia
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Connective Tissue Disease Testing

Click here for topics associated with this algorithm

INDICATIONS FOR TESTING


Patient with systemic symptoms
Arthritis, arthralgias, skin rashes, anemia, renal dysfunction, pleuritis, pericarditis

ORDER If suspicion for connective tissue disease is low, consider drug


positive
ANA induced, chronic autoimmune disease, chronic hepatitis C virus

low
negative
positive
ORDER
Connective
No No Tissue
disease; disease, in Diseases
however, remission, Profile
if strong or being
suspicion treated
still exists,
repeat
ANA
Peripheral Homogenous Speckled Centromere Cytoplasmic
Nucleolar pattern
pattern pattern pattern pattern pattern

SLE SLE SSc, SLE, PM


CREST
DIL PM, PM/SSc DM
SLE
SjS

SM + SSA + SSB + RNP + Scl-70 + No specificity*

SLE SLE SLE SLE SSc


SjS SjS MCTD
RA
SSc
UCTD

Antibody Key Disease legend


ANA Anti-Nuclear Antibodies (ANA), IgG Screen CREST CREST syndrome (calcinosis, Raynaud phenomenon,
with Reflex to IFA Titer esophageal dysmotility, sclerodactyly and telangiectasia)
DIL Drug-induced lupus erythematosus
The following sit on Connective Tissue Diseases Profile test EBV Epstein-Barr virus
panel MCTD Mixed connective tissue disease
RA Rheumatoid arthritis
RNP RNP (U1) (Ribonucleic Protein) (ENA) PM Polymyositis
Antibody, IgG DM Dermatomyositis
Scl-70 Scleroderma (Scl-70) (ENA) Antibody, IgG SLE Systemic lupus erythematosus
SM Smith (ENA) Antibody, IgG SSc Scleroderma (systemic scleroderma)
SSA SSA (Ro) (ENA) Antibody, IgG
SSB SSB (La) (ENA) Antibody, IgG UCTD Undifferentiated connective tissue disease
SjS Sjögren syndrome
PM/SSc Polymyositis/systemic scleroderma overlap

* Unidentified specificities or markers of low prevalence in CTD that are not routinely offered
Note: Overlap may occur among the antibodies and syndromes

Note: Associations between ANA IFA pattern and disorders such as autoimmune hepatitis
(AIH) and primary biliary cirrhosis (PBC) are not indicated

© 2006-2011 ARUP Laboratories. All Rights Reserved. Revised 2/22/2011 www.arupconsult.com

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