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Dig Ox in

This document summarizes information about the medication digoxin, including its uses for congestive heart failure, atrial fibrillation and flutter, and paroxysmal atrial tachycardia. It provides dosage guidelines for both adults and pediatric patients by age, noting adjustments for renal impairment. Potential side effects include heart block, low potassium levels, nausea, headache, and visual disturbances. Cautions are also given regarding drug interactions and monitoring of serum electrolytes and digoxin levels.

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Connie Mueller Novak
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37 views3 pages

Dig Ox in

This document summarizes information about the medication digoxin, including its uses for congestive heart failure, atrial fibrillation and flutter, and paroxysmal atrial tachycardia. It provides dosage guidelines for both adults and pediatric patients by age, noting adjustments for renal impairment. Potential side effects include heart block, low potassium levels, nausea, headache, and visual disturbances. Cautions are also given regarding drug interactions and monitoring of serum electrolytes and digoxin levels.

Uploaded by

Connie Mueller Novak
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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Digoxin (Lanoxin, Lanoxicaps, Digitek)

Action: Positive inotrope; AV node refractory period Uses: CHF, AF & flutter, & PAT Dosage and Routes: Adults: PO digitalization: 0.50.75 mg PO, then 0.25 mg PO q68h to total 11.5 mg. IV or IM digitalization: 0.250.5 mg IM or IV, then 0.25 mg q46h to total 0.1250.5 mg/d PO, IM, or IV (average daily dose 0.1250.25 mg). Peds: Preterm Infants: Digitalization: 30 mcg/kg PO or 25 mcg/kg IV; give 1/2 of dose initial, then 1/4 of dose at 812-h intervals for 2 doses. Maint: 57.5 mcg/kg/24 h PO

or 46 mcg/kg/24 h IV q12h. Term Infants: Digitalization: 2535 mcg/kg PO or 20 30 mcg/kg IV; give 1/2 the initial dose, then 1/3 of dose at 812 h. Maint: 610 mcg/kg/24 h PO or 58 mcg/kg/24 h q12h. 1 mo2 y: Digitalization: 3560 mcg/kg PO or 3050 mcg/kg IV; give 1/2 the initial dose, then 1/3 dose at 812-h intervals for 2 doses. Maint: 1015 mcg/kg/24 h PO or 7.515 mcg/kg/24 h IV q12h. 210 y: Digitalization: 3040 mcg/kg PO or 25 mcg/kg IV; give 1/2 initial dose, then 1/3 of the dose at 812-h intervals for 2 doses. Maint: 810 mcg/kg/24 h PO or 68 mcg/kg/24 h IV q12h. 710 y: Same as for adults; in renal impair DISP: Caps 0.05, 0.1, 0.2 mg; tabs 0.125, 0.25, 0.5 mg; elixir 0.05 mg/mL; Inj 0.1, 0.25 mg/mL Caution: Pregnancy Category C, w/ K+, Mg2+, renal failure CI: AV block; idiopathic hypertrophic subaortic stenosis; constrictive pericarditis SE: Can cause heart block; K+ potentiates tox; N/V, HA, fatigue, visual disturbances (yellow-green halos around lights), cardiac arrhythmias

Interactions: Effects W/ alprazolam, amiodarone, azole antifungals, BBs, carvedilol, cyclosporine, corticosteroids, diltiazem, diuretics, erythromycin, NSAIDs, quinidine, spironolac-tone, tetracyclines, verapamil, goldenseal, hawthorn, licorice, quinine, Siberian ginseng; effects W/ charcoal, cholestyramine, cisapride, neomycin, rifampin, sucralfate, thyroid hormones, psyllium, St. Johns wort Labs: Monitor serum electrolytes. Monitor for therapeutic blood levels. NIPE: Different bioavailability in various brands; IM Inj painful, has erratic absorption & should not be used. NOTES: Levels: Trough: Just before next dose; Therapeutic: 0.82.0 ng/mL; Toxic >2 ng/mL; 1/2-life: 36 h

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