Cleanroom Specifications
U.S. Federal Standard 209E Cleanroom Standards*
Class 1 10 100 1,000 10,000 100,000 0.1 m 35 350 Maximum Particles / ft 0.2 m 0.3 m 0.5 m 7 3 1 75 30 10 750 300 100 1,000 10,000 100,000 5 m ISO Equivalent ISO 3 ISO 4 ISO 5 ISO 6 ISO 7 ISO 8
7 70 700
*US FED STD 209E was cancelled by the General Services Administration on November 29, 2001.
IEST ISO 14644-1 International Standard for Cleanrooms more information
Maximum Particles / m Class ISO 1 ISO 2 ISO 3 ISO 4 ISO 5 ISO 6 ISO 7 ISO 8 0.1 m 10 100 1,000 10,000 100,000 1,000,000 0.2 m 2 24 237 2,370 23,700 237,000 0.3 m 10 102 1,020 10,200 102,000 0.5 m 4 35 352 3,520 35,200 352,000 3,520,000 1 m 5 m U.S. Federal Standard 209E Equivalent
8 83 832 8,320 83,200 832,000
29 293 2,930 29,300
Class 1 Class 10 Class 100 Class 1000 Class 10,000 Class 100,000
Biosafety Levels
Biosafety levels define the levels of containment required for handling various types of biological hazards. In the United States, there are four levels of containment as specified by the Centers for Disease Control and Prevention (CDC). The table below is based on information provided by in CDC publications. Containment Level Description Biosafety Level 1 Basic level of protection, appropriate for agents that are not known to cause disease (BSL-1) in normal, healthy humans. Biosafety Level 2 Level of protection appropriate for handling moderate-risk agents that cause human (BSL-2) disease of varying severity by ingestion or through percutaneous or mucous membrane exposure. Biosafety Level 3 Level of protection appropriate for agents of indigenous of exotic origin with a know (BSL-3) potential for aerosol transmission that may cause serious and potentially lethal infections after inhalation. Biosafety Level 4 Highest level of protection, appropriate for exotic agents that pose a high individual (BSL-4) risk of life-threatening disease by infectious aerosols and for which no treatment is available.
Related Links
Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition Published by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Institutes of Health; Fifth Edition, Feb 2007
European Standard
Grade Grade A Grade B Grade C Grade D Air Changes per Hour 480-600 35-70 20 20
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