Synthesis and reactions of carbenes
Diazomethane makes methyl esters from carboxylic acids
You remember, of course, that esters can be made from carboxylic acids and alcohols under acid catalysis, so you might expect them to use this type of method. On a small scale, its usually better to convert the acid to an acyl chloride before coupling with an alcohol, using pyridine (or DMAP + Et 3N) as a base; this type of reaction might have been a reasonable choice too.
But, in fact, they chose neither of these methods. Instead, they simply treated the carboxylic acid with a compound called diazomethane, CH2N2, and isolated the methyl ester.
Diazomethane, CH2N2, is a rather curious compound that has to be drawn as a dipole. There are several different ways of expressing its structure. Diazomethane methylates carboxylic acids because carboxylic acids readily protonate it, giving an extremely unstable diazonium cation. This compound is desperate to lose N 2, the worlds best leaving group, and so it does, with the N2 being substituted by the carboxylate anion. The carboxylate anion is in exactly the right position to carry out an SN2 reaction and that is what we have drawn.
Diazomethane methylation is a good way of making methyl esters from carboxylic acids on a small scale because yields are excellent and the only by-product is nitrogen. However, there is a drawback: diazomethane has a boiling point of 24 C, and it is a toxic and highly explosive gas. It therefore has to be used in solution, usually in ether; the solution must be dilute, because concentrated solutions of diazomethane are also explosive. It is usually produced by reaction of N-methyl-Nnitrosourea or N-methyl-N-nitrosotoluenesulfonamide with base, and distilled out of that reaction mixture as an azeotrope with ether, straight into a solution of the carboxylic acid. The mechanism of the reaction that forms diazomethane is shown below. The key step is basecatalysed elimination, though the curly arrows we have to draw to represent this are rather tortuous!
Diazomethane will also methylate phenols, because they too are acidic enough to protonate it. Ordinary alcohols, though, are not methylated because they are not strong enough acids to protonate diazomethane.
Photolysis of diazomethane produces a carbine
Alcohols can be methylated by diazomethane if the mixture is irradiated with light.
The mechanism is now totally different, because the light energy promotes loss of nitrogen (N 2) from the molecule without protonation. This means that what is left behind is a carbon atom carrying just two hydrogen atoms (CH2), and having only six electrons. Species like this are called carbenes.
How are carbenes formed?
Carbenes from diazo compounds
We showed you the formation of a carbene from diazomethane to illustrate how this reaction was different from the (ionic) methylation of carboxylic acids. But this is not a very practical way of generating carbenes, not least because of the explosive nature of diazoalkanes. However, diazocarbonyl compounds are a different matter.
They are much more stable, because the electron-withdrawing carbonyl group stabilizes the diazo dipole, and are very useful sources of carbenes carrying a carbonyl substituent. There are two main ways of making diazocarbonyl compounds: 1 by reacting an acyl chloride with diazomethane
2 by reacting the parent carbonyl compound with tosyl azide, TsN 3, in the presence of base.
The reaction of diazomethane with acyl chlorides starts as a simple acylation to give a diazonium compound. If there is an excess of diazomethane, a second molecule acts as a base to remove a rather acidic proton between the carbonyl and the diazonium groups to give the diazocarbonyl compound.
What happens to that second molecule of diazomethane? By collecting a proton it turns into the very reactive diazonium salt, which collects a chloride ion, and MeCl is given off as a gas. The second method uses tosyl azide, which is known as a diazo transfer reagentits just N2 attached to a good leaving group.
Diazocarbonyl compounds can be decomposed to carbenes by heat or light. The formation of very stable gaseous nitrogen compensates for the formation of the unstable carbene.
But it is much more common in modern chemistry to use a transition metal such as copper or rhodium, to promote formation of the carbene.
Carbenes formed in this way are, in fact, not true carbenes because it appears that they remain complexed with the metal used to form them. They are known as carbenoids.
Carbenes from tosylhydrazones
Many more carbenes can be made safely from diazoalkanes if the diazoalkane is just an intermediate in the reaction and not the starting material. Good starting materials for these reactions are tosylhydrazones, which produce transient diazo compounds by base-catalysed elimination of toluenesulfinate. The diazo compound is not normally isolated, and decomposes to the carbene on heating.
Carbene formation by (lpa) elimination
Eliminations (eliminations in which both the proton and the leaving group are located
on the same atom) are also possiblein fact, the reaction weve just been talking about (elimination of toluenesulfinate from tosylhydrazones) is an elimination. Eliminations follow a mechanism akin to an E1cB eliminationa strong base removes an acidic proton adjacent to an electron withdrawing group to give a carbanion. Loss of a leaving group from the carbanion creates a carbene. One of the best known elimination reactions occurs when chloroform is treated with base. This is the most important way of making dichlorocarbene, :CCl 2, and other dihalocarbenes too, although it must be said that the widespread use of dichlorocarbene in chemistry is due mainly to the ease with which it can be made using this method!
Hydroxide and alkoxide anions are strong enough bases to promote elimination from chloroform, and from other trihalomethanes. Carbenes can be formed from dihaloalkanes by
deprotonation with stronger bases such as LDA, and even from primary alkyl chlorides using the extremely powerful bases phenylsodium or t-BuLi/t-BuOK (weaker bases just cause elimination).
When geminal dibromoalkanes are treated with BuLi, a halogenmetal exchange reaction produces a lithium carbenoid, with a metal atom and a halogen attached to the same carbon atom. Lithium carbenoids are stable at very low temperaturesthey can be observed by NMR, but they decompose to carbenes at about 100 C.
While lithium carbenoids have limited applicability in chemistry, an analogous zinc carbenoid, which can be formed by insertion of zinc into diiodomethane, is a reagent in one of the most widely used carbenoid reactions in chemistrythe SimmonsSmith reaction.
The essence of this type of carbenoid is that it should have a leaving group, such as a halogen, that can remove a pair of electrons and another, usually a metal, that can donate a pair of electrons. If the metal leaves first, a carbanion is created that can lose the halogen to make a carbene. They might also leave together. Both are eliminations.
The problem with many of these reactions is that they require strong baseseither the organometallic compound itself is basic or a base must be used to create the carbanion. Carbenes are so unstable that they must be formed in the presence of the compound they are intended to react with, and this can be a problem if that compound is base-sensitive. For dichlorocarbene, a way round the problem is to make the carbanion by losing CO 2 instead of a metal or a proton. Decarboxylation of sodium trichloroacetate is ideal as it happens at about 80 C in solution.
This is a good point to remind you of other double losses from molecules. Just as elimination gives a carbene while elimination gives an alkene, loss of nitrogen from a diazo compound gives a carbene but loss of nitrogen from an azo compound such as AIBN (azobisisobutyronitrile) gives two radicals
Carbenes can be divided into two types
The existence of the two spin states explains the different behaviour of triplet and singlet carbenes towards ESR spectroscopy; the orbital occupancy also explains the smaller bond angle in singlet carbenes, which have an electron-repelling lone pair in an sp2 orbital.
Most type of carbenes are more stable as triplets because the energy to be gained by bringing the electron in the p orbital down into the sp2 orbital is insufficient to overcome the repulsion that exists between two electrons in a single orbital. All carbenes have the potential to exist in either the singlet or the triplet state, so what we mean when we say that a carbene such as :CH2 is a triplet carbene is that the triplet state for this carbene is lower in energy than the singlet state, and vice versa for :CCl2. For most triplet carbenes the singlet spin state that would arise by pairing up the two electrons lies only about 40 kJ mol1 above the ground (triplet) state: in other words, 40 kJ mol1 is required to pair up the two electrons. When a carbene is actually formed in a chemical reaction, it may not be formed in its most stable state, as we shall see. Carbenes that have singlet ground states (such as :CCl2) all have electron-rich substituents carrying lone pairs adjacent to the carbene centre. These lone pairs can interact with the p orbital of the carbene to produce a new, lower-energy orbital which the two electrons occupy. This stabilization of the lone pair provides the incentive that the electron in the p orbital needs to pair up in the sp 2 orbital.
This molecular orbital formation moves electrons localized on oxygen into orbitals shared between carbon and oxygen. We can represent this in curly arrow terms as a delocalization of the lone pair electrons. As these arrows suggest, carbenes that have heavily electron-donating substituents are less electrophilic than other carbenes: indeed, diamino carbenes can be quite nucleophilic. The division of carbenes into two types explains their structure. It also helps to explain some of their reactions, especially those that have a stereochemical implication.
The structure of carbenes depends on how they are made
In real life, a carbene will be formed in a chemical reaction and may well be formed as the less stable of the alternatives. If a reaction occurs by an ionic mechanism on a molecule with all electrons paired (as most molecules are!) then it must be formed as a singlet. Follow the elimination mechanism, for example.
The starting material, a normal molecule of chloroform CHCl3, has all paired electrons. The CH bond breaks and the two paired electrons from it form the lone pair of the carbanion. The carbanion also has all paired electrons. The two paired electrons of one of the CCl bonds leaves the carbanion and the carbene is formed. It has two paired electrons in each of the two remaining CCl bonds and the lone pair, also paired. It is formed as a singlet. As it happens, the singlet version of CCl2 is also the more stable. If the carbene were instead CH2 and if it reacted rapidly, it might not have a chance to change into the more stable triplet state. And carbenes are very reactive. In explaining their reactions in the next section we shall need to consider:
How do carbenes react?
Carbenes are desperate to find another pair of electrons with which to complete their valence shell of electrons. In this respect they are like carbocations. Like carbocations, they are electrophilic but, unlike carbocations, they are uncharged. This has consequences for the type of nucleophiles carbenes choose to react with. Carbocations attack nucleophiles with high charge densitythose carrying a negative or partial negative charge (think of the type of nucleophiles that will take part in SN1 or FriedelCrafts reactions). Carbenes, on the other hand, attack compounds wed normally never consider as nucleophileseven simple alkanesby taking electrons from their HOMO. Of course, a carbocation will usually react with the HOMO of a molecule, but it will be much more selective about which HOMOs will dousually these have to be lone pairs or electron-rich alkenes. For carbenes, any HOMO will doa lone pair, a C=C double bond (electron-rich or -poor), or even a CH bond.
Carbenes react with alkenes to give cyclopropanes
The mechanism of this type of reaction depends on whether the carbene is a singlet or a triplet, and the outcome of the reaction can provide our first chemical test of the conclusions we came to in the previous section. Singlet carbenes, like this one here (remember that electron-rich substituents stabilize the singlet spin state), can add to alkenes in an entirely concerted manner: the curly arrows for the process can be written to show this.
Because the process is concerted, we expect that the geometry of the alkene should be preserved in the productthe reaction ought to be stereospecific. The two examples below show that this is indeed the case. It is more impressive that the Z-alkene gives the cis cyclopropane as this is less stable than the trans cyclopropane and would change if it could.
The alkene insertion reaction is stereospecific only for singlet carbenes. For triplet carbenes, the reaction is nonstereospecific. Though carbenes formed thermally from diazoalkenes must initially be
singlets, photochemistry is one way to provide the energy needed for their transformation to the more stable triplet.
The mechanism of this nonspecific reaction must be different. In fact, a concerted reaction is impossible for triplet carbenes because of the spins of the electrons involved. After the carbene adds to the alkene in a radical reaction, the diradical (triplet) intermediate must wait until one of the spins inverts so that the second CC bond can be formed with paired electrons. This intermediate also lives long enough for CC bond rotation and loss of stereochemistry.
A cyclopropane has three bondsin other words, six electrons, all spin-paired (three up, three down). One of these was the bond in the starting material; the other two electron pairs come from the bond and from the carbene. The electrons in the bond must have been paired, and thus they can form one of the new bonds. A singlet carbene (whose electrons are also paired) can then provide the second electron pair.
But a triplet carbene cannot, because its electrons are not paired. The second bond can only form once one of the two electrons has flipped its spin. Spin-flipping, which can only occur through collision with another molecule (of solvent, say), is relatively slow on the time-scale of molecular rotations and, by the time the electrons are in a fit state to pair up, the stereochemistry of the starting material has been scrambled by free rotation in the intermediate.
Carbenes substituted with electron-withdrawing carbonyl groups, are even more powerful electrophiles than carbenes like :CCl2, and will even add to the double bonds of benzene. The product is not stable, but immediately undergoes electrocyclic ring opening.
Dichlorocarbene :CCl2 will not add to benzene, but does attack the electron-rich aromatic ring of phenol: the product is not a cyclopropane, but an aldehyde.
The ReimerTiemann reaction used to be an important way of making ortho-substituted phenols, but the yields are often poor, and modern industry is wary of using large quantities of chlorinated solvents. On a small, laboratory scale it has largely been superseded by ortholithiation and by modern methods outside the scope of this book. The mechanism probably goes something like this.
