Making a Model of DNA Instructions
1) Colour the individual structures on the worksheet as follows: adenine = red guanine = blue phosphate = brown 2) Cut out each structure. 3) Using the small symbols (squares, circles and stars) on the structures as guides, line up the bases, phosphates and sugars. 4) Glue the appropriate pairs together to form nucleotides. 5) Construct the right side of your DNA molecule by putting together in sequence a cytosine, thymine, guanine and adenine nucleotide. 6) Complete the left side of the DNA ladder by adding complementary nucleotides or nucleotides that fit. Your finished model should resemble a ladder. 7) To show replication of your model, separate the left side from the right side on your desk, leaving a space of about 15 to 20 cm. 8) Using the remaining nucleotides, add to the left side of the model to build a new DNA molecule. Do the same with the separated right side. 9) Tape or glue the nucleotides together to form two complete identical DNA ladders or molecules. 10) Answer the following questions. thymine = green cytosine = yellow deoxyribose = purple
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Making a Model of DNA Questions
a) When constructing the DNA molecule, what did you notice about the orientation of the two strands?
b) Define replication.
c) What DNA strand would bond opposite S----P----S----P----S----P----S----P----S----P----S T G G A C C
d) How does DNA of yellow perch differ from human DNA?
e) Would yellow perch DNA be closer to walleye DNA or deer DNA? Why?
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MANITOBA FISHERIES @ http://www.gov.mb.ca/conservation/fish/
Making a Model of DNA Example
Sugar Phosphate Backbone
MANITOBA FISHERIES @ http://www.gov.mb.ca/conservation/fish/
Base Pairs A
Sugar Phosphate Backbone
T S
P
S
P
G S
C S
P
T S
A S
P
A S
T S
P
C
Base Pair
G S
P
S
P
G S
Nucleotide
C S
P
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Making a Model of DNA Cut out sheet
Guanine Adenine Cytosine Thymine
Guanine
Adenine
Cytosine
Thymine
Guanine
Adenine
Cytosine
Thymine
Guanine
Adenine
Cytosine
Thymine
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
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Making a Model of DNA Cut out sheet
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
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Making a Model of DNA Cut out sheet
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Deoxyribose
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
Phosphate
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Making a Model of DNA Answer key
1) Colour the individual structures on the worksheet as follows: adenine = red guanine = blue phosphate = brown 2) Cut out each structure. 3) Using the small symbols (squares, circles and stars) on the structures as guides, line up the bases, phosphates and sugars. 4) Glue the appropriate pairs together to form nucleotides.
Phosphate Brown
thymine = green cytosine = yellow deoxyribose = purple
Adenine Nucleotide
Phosphate Brown
Guanine Nucleotide
Deoxyribose Purple
Adenine Red
Deoxyribose Purple
Guanine Blue
Phosphate Brown
Thymine Nucleotide
Phosphate Brown
Cytosine Nucleotide
Green
5) Construct the right side of your DNA molecule by putting together in sequence a cytosine, thymine, guanine and adenine nucleotide.See next page. 6) Complete the left side of the DNA ladder by adding complementary nucleotides or nucleotides that fit. Your finished model should resemble a ladder. See next page. 7) To show replication of your model, separate the left side from the right side on your desk, leaving a space of about 15 to 20 cm. 8) Using the remaining nucleotides, add to the left side of the model to build a new DNA molecule. Do the same with the separated right side. 9) Tape or glue the nucleotides together to form two complete identical DNA ladders or molecules. 10) Answer the following questions.
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Cytosine
Yellow
Thymine
Deoxyribose Purple
Deoxyribose Purple
Making a Model of DNA Answer key
5) Construct the right side of your DNA model by putting together in sequence a cytosine, thymine, guanine and adenine nucleotide.
Phosphate
Deoxyribose
Phosphate Phosphate
Phosphate Phosphate
Phosphate Phosphate
Phosphate
6) Complete the left side of the DNA ladder by adding complementary nucleotides or nucleotides that fit. Your finished model should resemble a ladder.
Deoxyribose
Deoxyribose Adenine Thymine
Deoxyribose
Deoxyribose Guanine Cytosine
Deoxyribose
Deoxyribose
Adenine
Thymine
Deoxyribose
Guanine
Cytosine
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Making a Model of DNA Answer key
QUESTIONS:
a) When constructing the DNA molecule, what did you notice about the orientation of the two strands? One of the strands is inverted.
b) Define replication. Replication is the process by which genetic material, a single-celled organism or a virus reproduces or makes a copy of itself. c) What DNA strand would bond opposite S----P----S----P----S----P----S----P----S----P----S T A G C G C A T C G C G
d) How does DNA of yellow perch differ from human DNA? DNA of yellow perch would be different from human DNA since it would have different chromosomes and different nucleotide pairings.
e) Would yellow perch DNA be closer to walleye DNA or deer DNA? Why? Yellow perch DNA would be closer to walleye DNA because they are both species of fish. Their genetic make-up would be very similar since they are more closely related to each other than to deer.
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