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Pathophysiology of Diabetes

The document contains two diagrams showing the pathogenesis of the two main types of diabetes. Diagram I shows that type 1 diabetes results from genetic predisposition and an environmental insult triggering an autoimmune response that destroys the beta cells in the pancreas, preventing insulin release and leading to insulin-dependent diabetes. Diagram II shows that type 2 diabetes stems from hereditary and lifestyle factors like obesity that cause insulin resistance and increased insulin demand, exhausting and impairing the beta cells over time and resulting in non-insulin dependent diabetes.

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Cyrus De Asis
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20K views2 pages

Pathophysiology of Diabetes

The document contains two diagrams showing the pathogenesis of the two main types of diabetes. Diagram I shows that type 1 diabetes results from genetic predisposition and an environmental insult triggering an autoimmune response that destroys the beta cells in the pancreas, preventing insulin release and leading to insulin-dependent diabetes. Diagram II shows that type 2 diabetes stems from hereditary and lifestyle factors like obesity that cause insulin resistance and increased insulin demand, exhausting and impairing the beta cells over time and resulting in non-insulin dependent diabetes.

Uploaded by

Cyrus De Asis
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Diagrams:

Diagram I
Pathogenesis of Insulin Dependent DM (Type 1)
Genetic Predisposition (Susceptibility)

Environmental
insult

Autoimmunity
-Lymphocyte
infiltration
-Insulitis

- Viral infection
- Toxic chemical
agents

Immunologic Response
-

Islet cell antibodies


Cell- mediated immunity

cell destruction

Lack of insulin release

Insulin Dependent Diabetes Mellitus (IDDM)

Diagram II
Pathogenesis of Non- Insulin Dependent DM (Type 2)
Hereditary
Factors

Obesity

Delayed or insufficient insulin


secretion

Insulin resistance (Receptor


defect or other events)

Increased insulin demand

cell exhaustion and dysfunction

Impaired secretion
of insulin

Hyperglycemia

Non- Insulin Dependent DM (NIDDM)

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