J Nutr. 2015 Mar;145(3):541-6. doi: 10.3945/jn.114.204115. Epub 2014 Dec 31.
Low serum 25-hydroxyvitamin D concentrations are associated
with increased likelihood of having depressive symptoms among
Japanese workers.
Mizoue T1, Kochi T2, Akter S3, Eguchi M2, Kurotani K3, Tsuruoka H2, Kuwahara K4, Ito R2, Kabe I2,
Nanri A3.
Author information
Department of Epidemiology and Prevention, Center for Clinical Sciences, National
Center for Global Health and Medicine, Tokyo, Japan
[email protected].
Department of Health Administration, Furukawa Electric Corporation, Tokyo, Japan; and.
Department of Epidemiology and Prevention, Center for Clinical Sciences, National
Center for Global Health and Medicine, Tokyo, Japan.
Department of Epidemiology and Prevention, Center for Clinical Sciences, National
Center for Global Health and Medicine, Tokyo, Japan Teikyo University Graduate School
of Public Health, Tokyo, Japan.
Abstract
BACKGROUND:
Accumulating evidence suggests a protective role of vitamin D against mood disorders; however,
epidemiologic studies are scarce in working populations.
OBJECTIVE:
We investigated cross-sectionally the association of serum vitamin D status and depressive symptoms among
Japanese workers.
METHODS:
Participants were 1786 employees (9% women), aged 19-69 y, who received health check-ups and
participated in a nutrition and health survey. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were
measured with the use of a competitive protein binding assay. Depressive symptoms were assessed by using
the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression was used to estimate
ORs with adjustment for potential confounding variables including dietary factors.
RESULTS:
Overall, 92% of study participants had suboptimal vitamin D status [25(OH)D <30 g/L]. Depressive
symptoms were inversely associated with 25(OH)D. Compared with those with a 25(OH)D concentration of
<20 g/L, multivariable-adjusted ORs (95% CIs) for depressive symptoms (CES-D scale score 16) were
0.75 (0.59, 0.95) and 0.66 (0.41, 1.06) for those with a 25(OH)D concentration of 20-29 g/L and 30 g/L,
respectively (P-trend = 0.01). After further adjustment for leisure-time physical activity and shift work
(factors closely related to photo-initiated vitamin D production), the OR (95% CI) for the highest category of
25(OH)D was 0.70 (0.43, 1.14). The association between 25(OH)D and depressive symptoms appears to be
linear, according to restricted cubic spline regression.
CONCLUSION:
Results suggest that lower concentrations of circulating vitamin D are associated with increased likelihood
of having depressive symptoms among apparently healthy workers.
Hubungan Antara Kadar 25-hydroxyvitamin D yang rendah
kecenderungan Menderita Sindroma Depresi pada Pekerja Jepang
terhadap
Peningkatan
Abstract
Latar belakang
Penelitian sebelumnya menduga bahwa vitamin D berperan terhadap gangguan mood,
walaupun demikian masih sangat jarang dilakukan penelitian epidemiologi pada populasi
pekerja.
Tujuan:
Peneliti menggunakan metode cross-seksional untuk mengetahui hubungan antara status vitamin D serum
dan gejala depresi pada pekerja jepang.
Metode:
Sampel adalah 1786 pegawai (9% perempuan), berusia 19-69 tahun, yang mengikuti program pemeriksaan
kesehatan dan ikut serta dalam survey gizi dan kesehatan. Kadar 25-hydroxyvitamin D [25(OH)D] serum
diukur dengan menggunakan suatu competitive protein binding assay. Sementara Symdroma depresi
dievaluasi menggunakan Center for Epidemiologic Studies Depression (CES-D) scale. Regresi Logistik
digunakan untuk memperkirakan Ors untuk penyesuaian terhadap variable pengganggu termasuk factor
makanan.
Hasil Penelitian:
Secara keseluruhan, 92 % sampel penelitian memiliki status vitamin D yang kurang, [25(OH)D <30 g/L].
Syndroma Depresi Berbanding terbalik dengan kadar 25(OH)D. Setelah menyesuaikan variable penganggu
ORs (95% CIs), hasilnya didapatkan pekerja kadar 25(OH)D <20 g/L, memiliki kemungkinan 0,75 (0.59,
0.95) untuk memiliki symptom depresi (CES-D scale score 16), sementara pekerja dengan kadar 25(OH)D
20-29 g/L and 30 g/L hanya 0.66 (0.41, 1.06) untuk memiliki symptom depresi (CES-D scale score 16).
Bahkan setelah mengalami penyesuaian dengan factor waktu rekreasi dan jadwal shift pekerja (the OR (95%
CI) kategori ini memperoleh hasil 0.70 (0.43, 1.14)
Kesimpulan:
Hasil penelitian mendapati bahwa rendahnya kadar vitamin D berhubungan dengan meningkatnya resiko
terkena sindrom depresi pada pekerja yang sehat.
