University of Santo Tomas
FACULTY OF PHARMACY
DEPARTMENT OF MEDICAL TECHNOLOGY
SEMINAR 2
Diagnostic Research
Article/Paper Title:
P (population)
A (assessment)
C (comparison)
O (outcome/s)
Draw the consort diagram for this study:
1
Critical appraisal skills program YES NO Comments
questions
1
Was there a clear question
for the study to address?
Was there a comparison
with an appropriate
reference standard
3
Did all patients get the
diagnostic test and the
reference standard?
Could the results of the test
of interest have been
influenced by the results of
the reference standard?
(blinding)
5
Is the disease status of the
tested population clearly
described?
HINTS:
Presenting symptoms
Disease stage or severity
Co-morbidity
Differential diagnoses
2
Critical appraisal skills program YES NO Comments
questions
Were the methods for
performing the test
described in sufficient
detail?
HINTS:
Was a protocol followed
7
What are the results?
HINTS: consider
Are the sensitivity and
specificityand/or likelihood
ratios presented?
Are the results presented
in such a way that we can
work them out?
8
How sure are we about
these results?
HINTS: consider
Could they have occurred
by chance?
Are there confidence limits
What are they?
9
Can the results be applied
to your patients/the
population of interest?
HINT: Do you think your
patients/population are so
different from those in the
study that the results cannot
be applied? Such as age, sex,
ethnicity.
10
3
Critical appraisal skills program YES NO Comments
questions
Can the test be applied to
your patient or population
of interest?
HINT:
Think of resources and
opportunity costs
Level and availability of
expertise required to interpret
the tests
Current practice and
availability of services
11.
Were all outcomes
important to the individual
or population considered?
HINT:
Will the knowledge of the test
result improve patient
wellbeing?
Will the knowledge of the test
result
12. What would be the
impact of using this test on
your patients/population?
Student Name: ____________________________________________ Date: ____________________