PREDISPOSING FACTORS ETIOLOGICAL AGENT CONSEQUENCES
• Related to Underlying Diseases • MRSA
• Clostridium difficile
• Serious illness/death
• Related to Invasive Procedures
• Related to Acute diseases such as Trauma , Skin Lacerations • Enterobacteria • Prolonged hospital stay
• Treatment Related NI • Pseudomas • Additional antibiotic therapy
• Legionella • Can become source of infection
SOURCE • MSSA
• Endogenous : self infection
PREVENTION
(patients’ normal flora)
NOSOCOMIAL INFECTION / • Proper cleaning and sterilization
• Exogenous : outside patients’ body
HOSPITAL ACQUIRED INFECTION/ • Proper management of surgical site
(cross infection and hospital
• Good hygiene (Environment, Staff, Personal)
environment) HEALTHCARE ASSOCIATED INFECTION
• Proper waste disposal
• UTI • Skin Infection
MODE OF TRANSMISSION
• Bacteremia • GIT Infection MANAGEMENT
• Direct contact : patient to patient,
• RTI • CNS Infection • Antibiotic Treatment – Vancomycin
staff to patient
• Bloodstream • SSI • Supportive Treatment – Antiviral & Antifungal Therapy
• Indirect contact : inanimate object,
Infection • Removal/ Change of Device
contaminated medical devices
• Proper managemet of wound
(catheters),
• Airborne : dust/ droplet PATHOGENESIS OF BSI
• Oral route : contaminated food • Microbes migrate from skin along the
catheter LAB INVESTIGATION
• Some secrete biofilm layer that gives • FBC-neutrophil and TWBC ↑ (inflammation)
CRBSI • CRP- a acute phase protein that is high due to inflammation
protection against antimicrobial agents
• Catalase test - +ve (Staphylococcus)
CLABSI SYMPTOMS/ PHYSICAL FINDINGS • Coagulase test- +ve
• Fever : 39°C • Blood culture- beta-haemolysis (S.Aureus)
• CVL site at right cubital fossa - • DNAse test- +ve (can hydrolyse DNA
swollen, inflammed, warm and • Antibiotic Susceptibility Test
tender • Resistant to: penicillin, cloxacillin, erythromycin, ciprofloxacin
• PR : 110beats/minute (tachycardia) • Susceptible to: fusidic acid, rifampicin, vancomycin,
• RR : 24 breaths/minute (tachypnoe) teicoplanin