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(Sumber: NHL-BFM 90 Protokol) : Anaplastic Large-Cell Lymphoma Protocol

This document outlines a treatment protocol for anaplastic large-cell lymphoma based on the NHL-BFM 90 protocol. It describes 3 branches (K1-K3) of different chemotherapy courses (A, B, etc.) based on the stage of disease. Course A includes drugs like dexamethasone, ifosfamide, methotrexate, cytarabine, and etoposide. Course B includes cyclophosphamide, methotrexate, doxorubicin and others. The treatment schedules, which differ for each course and branch, aim to administer chemotherapy in cycles over several weeks to treat the lymphoma.

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Fandi Argiansya
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147 views6 pages

(Sumber: NHL-BFM 90 Protokol) : Anaplastic Large-Cell Lymphoma Protocol

This document outlines a treatment protocol for anaplastic large-cell lymphoma based on the NHL-BFM 90 protocol. It describes 3 branches (K1-K3) of different chemotherapy courses (A, B, etc.) based on the stage of disease. Course A includes drugs like dexamethasone, ifosfamide, methotrexate, cytarabine, and etoposide. Course B includes cyclophosphamide, methotrexate, doxorubicin and others. The treatment schedules, which differ for each course and branch, aim to administer chemotherapy in cycles over several weeks to treat the lymphoma.

Uploaded by

Fandi Argiansya
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL

(Sumber: NHL-BFM 90 protokol)

Branch Stage Therapy course


K1 I,II-
A B A
resected v

K2 II-not A B A B A B
resected, III v

K3 IV or multiple AA BB CC AA BB CC
bone involvement v

Prephase V
Dexametason
10 mg/m2 po/IV

CPA  
200 mg/m2 IV 1 h infus

Hari 1 2 3 4
ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL
(Sumber: NHL-BFM 90 protokol)

Course A

Dexametason
10 mg/m2 po/IV

Ifosfamide
800 mg/m2 IV 1 h infus     

Metotrexat 500 mg/m2 IV* 


(24 h infus)

MTX + Ara-C + Predn IT** 


12 mg 30 mg 10 mg
Keterangan :
Ara-C    
150 mg/m2 IV 1 h infus *10% dosis diberikan dalam 30 menit pertama,
90% sisanya diberikan dalam 23,5 jam. Folinic
Etoposide   acid diberikan 12 mg/m2 pada 48 jam dan 54 jam.
100 mg/ m2 IV 1 h infus
**Diberikan 12 jam setelah dimulai pemberian
Hari 1 2 3 4 5 MTX IV
ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL
(Sumber: NHL-BFM 90 protokol)

Course B

Dexametason
10 mg/m2 po/IV

Cyclophosphamide
200 mg/m2 IV     

Metotrexat 500 mg/m2 IV 


(24 h infus)

MTX + Ara-C + Predn IT 


12 mg 30 mg 10 mg

Doxorubicin  
25 mg/m2 IV 1 h infus

Hari 1 2 3 4 5
ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL
(Sumber: NHL-BFM 90 protokol)

Course BB

Dexametason
10 mg/m2 po/IV

Cyclophosphamide
200 mg/m2 IV     

Metotrexat 5000 mg/m2 IV 


(24 h infus)

MTX + Ara-C + Predn IT  


6 mg 15 mg 10 mg

Vincristin 
1,5 mg/m2 IV

Doxorubicin  
25 mg/ m2 IV 1 h infus

Hari 1 2 3 4 5
ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL
(Sumber: NHL-BFM 90 protokol)

Course AA
Dexametason
10 mg/m2 po/IV

Ifosfamide
800 mg/m2 IV 1 h infus     

Metotrexat 5000 mg/m2 IV 


(24 h infus)

MTX + Ara-C + Predn IT  


6 mg 15 mg 5 mg

Vincristin 
1,5 mg/m2

Ara-C    
150 mg/m2 IV 1 h infus
Etoposide  
100 mg/ m2 IV 1 h infus

Hari 1 2 3 4 5
ANAPLASTIC LARGE-CELL LYMPHOMA PROTOCOL
(Sumber: NHL-BFM 90 protokol)

Course CC

Dexametason
20 mg/m2 po/IV

Vindesine
3 mg/m2 IV(max 5 mg) 

Cytarabine 2000 mg/m2 IV    


(24 h infus)

MTX + Ara-C + Predn IT 


12 mg 30 mg 10 mg

Hari 1 2 3 4 5

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