Improving
Quality of Life
GELITA REVOLUTION: Péptidos
de Colágeno para Salud y
Nutrición
Collagen Peptide Business
Agenda
• GELITA Collagen Peptides Introducción
• Peptidos de Colágeno: Anãdiendo Valor a sus Productos
• Bioactividad de los Péptidos de Colágeno: Mecanismo de Acción
• Soluciones para Objetivos Específicos: Bioactive Collagen
Peptides
• Co-Branding
• Péptidos de Colágeno para Soluciones Diversas
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Our locations are part of our philosophy:
GELITA – Global Expertise in Collagen Protein
• 142 years old
• Leading expert in Collagen Protein
• 21 production sites worldwide – 8 producing Collagen Peptides
• First production 1980
• Complete range of collagen proteins for
• Texturizing
• Protein enrichment
• Physiological & nutritional functionality
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Company Structure
GELITA: The Number One in Collagen Clinical Research
Areas of Expertise
BUSINESS UNIT
Collagen Peptides • Life Science
• Product, Process, Application &
Health & Nutrition Concept Development
• Regulatory Issues & Patents
Global Product • Market & Consumer Research
Management Unit &
Accelerator of GELITA‘s • B2B & Consumer Solutions
Health & Nutrition
Business
Scientific Network
• CRI, Kiel DE
• SIT Hamburg, DE
• Australian Institute of Sport, AU
• Sport Science Uni. Freiburg, DE
• Sport Science Uni. Bochum, DE
• Tufts Medical Center, Boston, US
• Penn State University, PA, US
• LGC, Fordham, UK
• Pet Science LMU, Munich, DE
• ….
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
THE MOST DESIRED AND FAMED FUNCTIONAL INGREDIENT
Beyond stetic! With scientific evidences, collagen is an important ally to maintenance of beauty,
bone health, muscles and joints.
of women have interest
on new products
related to
health&wellness and
beauty
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
COLLAGEN IS “TOP OF MIND” AT INGREDIENT LISTS
DID YOU KNOW, WHY THIS PROTEIN IS SO IMPORTANT?
Collagen is a natural protein, Collagen reduction in our organism
presents in our body. It is considered results in a lose of muscle mass,
the basic structural protein, most decrease the bone density, increase
important to the connective tissue. joint fragility, also contributes to
increase dehydration and decrease of
skin elasticity.
During the aging process, from the
age of 30, our body starts to Therefore, to health maintenance,
decrease the collagen production, obtainment of collagen proteins in
being at 50 years old, the property quantities is essencial in
organism produce, in average, only our daily diet.
35% of this protein. .
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
Researches pointed out that 9 in 10 women
have interest in products containing collagen.
As much knowledge about the ingredient and
benefits better is the customer loyalty.
HOW GELITA ACTS TO PROMOTE THE KNOWLEDGE ABOUT YOUR EXCLUSIVE
SOLUTIONS IN COLLAGEN?
We know that Health&Wellness profissionals are the main
speakers of collagen to the market. For this reason, our
researches are worldwide, present in scientific congresses
and seminars of the segment.
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Collagen in Humans
Collagen dry mass & type in specific tissues
• Bones: ~ 90% of organic bone matrix; 25% of total mass
• Skin: ~ 75% collagen
• Joint cartilage ~ 70% collagen
• Ligaments ~ 70%
• Tendons ~ 85%
• Fascia tissue ~ 70%
• Muscle tissue ~ 6%
• Other tissues, e.g.:
• Gastrointestinal tract , teeth
• Eyes, ears, nose
• Blood vessel, lung
• Blood-brain barrier
With ~ 30% of the whole body protein content, collagen is the most abundant
protein in humans
Collagen Peptide Business
What are Collagen Peptides?
Collagen peptides are food ingredients derived by enzymatic hydrolysis of collagen.
• Clean label, natural
• Non GMO, GRAS, Kosher, Halal (beef)
• Superior sensorial profile
• Clearly water soluble
• High in pH and temperature resistance
• Highly bioavailable source of Amino Acids
• Stimulant of the body’s own collagen metabolism
Manifold Solution
to Excellent Functionality
Collagen Gelatine Collagen Peptides
9
Collagen Peptide Business
Not all Collagen Peptides are Equal
• There is a big variance in respect to mean molecular weight, molecular weight fractions and
terminal amino acids.
• Each marketed product is different, and there may be also a big variance between production
batches for one product.
• Collagen Peptides with similar specification sheets don’t have a similar physiological
functionality
Thermal/ Chemical
Hydrolysis
Enzymatic
Hydrolysis
Native Collagen – Gelatine HYDROLYSED COLLAGEN or
raw material Collagen Peptides
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Not all Collagen Peptides are Equal
Collagen Molecule broken into specific points, resulting
unique bioactive combinations of Collagen Peptides.
VERISOL
Enzyme 2
Thermal/ Chemical
Hydrolysis
Enzyme 3
Enzyme 1
FORTIGEL
Gelatine
Native Collagen – raw SPECIFIC COLLAGEN
BODYBALANCE
material PEPTIDES
Collagen Peptides with similar specification sheets
don’t have a similar physiological functionality (bioactivity)
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Not all Collagen Peptides are Bioactive Collagen
Peptides®!
• Stimulating effect on in-vitro collagen synthesis widely varies between different types
Collagen Peptides
• GELITA assures: Each clinical study is conducted with respective dedicated BCP and
dosages.
• Skin Fibroblasts VERISOL® 2,5g/day
• Joint Chondrocytes FORTIGEL® 10g/day
• Sarcopenia Body Composition BODYBALANCE® 15g/day
VERISOL
Fortigel
Collagen Peptides 2.1 kDa mean MW
Collagen peptides with mean MW of 3.0 -5.0 kDa
Collagen Peptides 2.9 kDa mean MW
x-fold of FORTIGEL® (=1)
1,2 1,2
x-fold of VERISOL® (=1)
1.0 1.0 1.0 1.0
1 1
0.7 0.4
RNA-expression
0,8 0,8
0.6 RNA-expression
0,6 0,6
0.4
0,4 0,4
0,2 0,2
0 0
Fortigel Ch1 Ch2 Ch3 Ch4 Collagen Type 1 Decorin Versican
In-vitro data, human chondrocytes In-vitro data, human dermal fibroblasts
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Mode of Action: Stimulation of Human Connective Tissue
Cells to Increase Anabolism
• Human Connective Tissue Cells as
Target
• Influence Anabolic-Catabolic Balance
to increased anabolism
Collagen Peptide Business
In-Vivo Stimulation via Bioactive Collagen Peptides®:
Mode of Action using the Example of Cartilage
Bioactive Collagen Peptide®
Cells (Misc.)
~ 25% Proteoglycans Cartilage Cell
(Chondrocyte) Stimulation
Production
~ 70% Collagen
Regeneration
Composition of Joint Cartilage
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Collagen Peptides Stimulate the Body’s Own Collagen
Metabolism
Bioactive Collagen Peptides® -
Science behind Branded Products
Beauty from Within
• Increasing elasticity
Body Toning and reducing wrinkles
• Increasing muscle mass
and decreasing fat mass
Joint Health
• Measurable recovery
of joint cartilage
Bone Health Connective Tissue
• Improving bone Improvement
stability and flexibility • Strengthening ligaments
and tendons
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
Thinking on that, GELITA has developed a portfolio of Bioactive Collagen Peptides, that can be easly applied in a range
of food and beverages products, without changes at the production process.
WHAT FUNCTIONALITY WOULD YOU LIKE TO ADD TO YOUR PRODUCT?
Population is getting old, and
Perfect for protein new opportunities are being
enrichment in food and lauching. BODYBALANCETM
Specifically optimazed
beverages. Versatile, is the newest collagen
for beauty from within
easy to handle. peptide from GELITA with
and supported by
Garantee of preference scientific studies regarding
scientific studies.
of food industry and prevention and action against
health&wellness. Sarcopenia.
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Collagen Peptides Stimulate the Body’s Own Collagen
Metabolism
Beauty from Within
• Increasing elasticity
Body Toning and reducing wrinkles
• Increasing muscle mass
and decreasing fat mass
Joint Health
• Measurable recovery
of joint cartilage
Bone Health Connective Tissue
• Improving bone Improvement
stability and flexibility • Strengthening ligaments
and tendons
Não é possív el
exibir esta
imagem no
momento.
Collagen Peptide Business
• Unique collagen specific to the skin
with scientific evidence of results
• German Technology, exclusive and
patented
• Unique combination of Collagen
Peptides® optimized for skin
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Não é possív el
exibir esta
imagem no
momento.
Collagen Peptide Business
• 5 Clinical Studies
• Elasticity – 2013
• Wrinkle Reduction – 2014
• Celullite – 2015
• Growth & Quality of Fingernails –
2016 (under publication)
• Wound Healing – 2017 (under
publication)
© 2016 GELITA AG. Any copies need to be authorized by GELITA
VERISOL®: How it Works
VERISOL® Summary
VERISOL® ST: Your Tool for High Degree of Fortification
Product range extension of
VERISOL®
• ST: SMART TECHNOLOGY
• New process, patent pending, which changes
the physical and process relevant features of
VERISOL® without changing the bioactivity!
VERISOL® P HST:
• Bioactivity of VERISOL® P
• + customer process benefits
• + gelling/emulsifying/foaming
Benefit: High Degree of Fortification
• VERISOL density 25% 2,5 g in ~ 10 g
gummies
Collagen Peptide Business
Exemplary VERISOL® Beauty-From-Within Products
Beverages
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Exemplary VERISOL® Beauty-From-Within Products
Beverages
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Exemplary VERISOL® Beauty-From-Within Products
Beverages
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Exemplary VERISOL® Beauty-From-Within Products
Confectioneries
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Exemplary VERISOL® Beauty-From-Within Products
Dairy
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Bioactive Collagen Peptides® stimulate body functions
Beauty from Within
• Increasing elasticity
Body Toning and reducing wrinkles
• Increasing muscle mass
and decreasing fat mass
Joint Health
• Measurable recovery
of joint cartilage
Bone Health Connective Tissue
• Improving bone Improvement
stability and flexibility • Strengthening ligaments
and tendons
Collagen Peptide Business
Collagen: In Close Proximity to Muscle
~20% of total bone mass
85% in tendons
70% in ligaments
~ 6% of the weight of muscles
70% of cartilage tissue
no copyright on picture
Collagen Peptide Business
Sarcopenia
Sarcopenia:
Age related decline of muscle mass and reduction in functional muscular
performance
• 8% loss of muscle mass per decade – age 40-70
• 15% loss of muscle mass per decade after 70
• Loss of muscle mass is leading to decreased
mobility and higher risk of falls and frailty.
• Increase of body fat may also be a consequence
of muscle loss.
Cruz-Jentoft et al. ‘Sarcopenia: European consensus on definition and diagnosis’; Age and Ageing 2010; 39; 412-423
Benton MJ AJN; December 2011; Volume III; Issue 12; p. 38-44
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Sarcopenia Causes
Sarcopenia is associated with a deficiency situation
Physical activity Nutrition
• Lack of physical activity • Lack of proper nutrition
• Inadequate physical activity • Inadequate absorption and
utilization of nutrients
Aging
Aging combines both elements, due to changes in the body and in lifestyle
• Change in metabolic capabilities
• Cells in the human body become increasingly
insensitive to stimulation
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
BODYBALANCE® - Study Overview
Randomized Training Target Group Supplement
controlled trials
1 (2013) 3 -month resistance training elderly, untrained men 15 gram BODYBALANCE or placebo
3 x 60 minutes per week
middle-aged,
2 (2015)* guided training involving all
untrained men
15 gram BODYBALANCE or placebo,
larger muscle groups or 15 gram whey protein
individual adaptations of the
3 (2017)* training protocol young athletes 15 gram BODYBALANCE or placebo
Outcome measures DXA measurement (Gold standard)
• Changes in fat free mass (FFM)
• Changes in fat mass (FM)
• Changes in muscle power
Zdzieblik. et al. , (2015) Br J Nutr 114:1237-1245
Collagen Peptide Business
Effect of Resistance Exercise & BODYBALANCE™
Sarcopenia Study Body Toning Pilot Study
(Age > 65) (Age 35-65 years)
6
+4,2 x 1.5
4 x2
+2,9
+2,5
2 +1,2
[ kg ]
0
-0,4
-2 -1,5
x4
-4 -3,6
x 1.5
-6 -5,5
∆ Muscle ∆ Fat ∆ Muscle ∆ Fat
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Comparison to Whey – Decrease of fat mass
BODYBALANCE Whey Placebo
Delta Fat Mass (kg)
+20%
+52%
BODYBALANCE Whey Placebo
submitted for publication
Collagen Peptide Business
Conclusion – BODYBALANCE™ Supports Body Toning
• BODYBALANCE™ helps to slow age related muscle loss in combination with exercise.
• BODYBALANCE™ supports changes in body composition – increase of lean body mass and
decrease of body fat – in combination with exercise.
Muscle gain: double
your training effect
Fat loss: triple your
training effect
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Target Groups and Applications
Active people, who want to optimize body composition
• Active Nutrition
• Fitness Nutrition
People fighting age related muscle loss / sarcopenia
• Sports Nutrition
• Targeted Nutrition for
muscle maintenance
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Exemplary BODYBALANCETM
Collagen Peptide Business
Exemplary BODYBALANCETM
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
AND MORE.... Our press agency constantly contributes with
specialized media with our customers,
disseminating important information to the public
and consumers, that have doubts and difficults to
find out reliable products with collagen. For this
reason, we had developed an important action with
our customers, the...
Using our ingredient trademarks in your end products, our customers help
consumers to identify reliable products, quality products with exclusive
functionality of GELITA collagen peptides.
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Co-Branding
Country: Brazil
Company: Linea Sucralose
Product: Shake
Presentation: Powder
Target Market: Brazil
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Co-Branding
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Co-Branding
Country: Brazil
Company: Verde Campo e Boa
Forma
Product: Greek with Collagen
Presentation: liquid 90g
Target Market: Brazil
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Co-Branding
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Adding value to your products - GELITA® Collagen Proteins: Trends
DO YOU KNOW THE MOST DESIRED PRODUCTS WITH COLLAGEN WANTED BY
CONSUMERS?
FOOD & BEVERAGES
Gelatines, Yoghurts, Cereal bars, Jams, Cereals
Whole breads & pastas, Teas, Juices, Confectioneries, Powder desserts.
SUPPLEMENTS
Capsules, Tablets, Magistral Pharmacies Products.
Protein Bars, Meal Replacer Products, Sport Supplements, Sachets.
COLLAGEN - ALL THE BEST!!!
Natural Ingredient - Clean Label – Non Alergenic – High Digestibility
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
PROTEIN ENRICHMENT WITH
COLLAGEN PROTEINS
Collagen Peptide Business
PEPTIPLUS®
PEPTIPLUS®: Standard Collagen Peptide, applied in a ruge range of
products: edible, protein supplements, ceral/protein bars, meal replacers,
etc.
• High Protein Concentration;
• Clear Solution;
pH 3
• Cold Soluble;
• Binding Agent;
• Foam Formation.
pH 4
pH 5
pH 6
1 2 3 4 5 6
© 2016 GELITA AG. Any copies need to be authorized by GELITA 1:CP; 2:WPI; 3:Batata; 4:Tremoço; 5:Soja; 6:Ervilha
Collagen Peptide Business
Range of Products: PEPTIPLUS®
Instant dissolution, more neutral flavor
immediately after 5 seconds after 1 minute *
Concentration: 10 %; Temperature: 25 °C
Agglomerated powder Fine powder
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Protein Enrichment: Collagen Peptides
• Protein Supplements
• Great perfomance when combined with other sources of protein as Whey Protein
(WPC or WPI)
• Zero allergenic aspects (no lactose, no fat, no gluten)
Collagen Peptide Business
Protein Enrichment: Collagen Peptides
• Meal Replacers
• Normally used with other source of proteins (casein & WPC),
• Promotes satiety
• Promotes foam formation during preparation
Collagen Peptide Business
Protein Enrichment: Collagen Peptides
• Protein Enrichment
Mocotó Jelly
Protein Beverages
Governmental Programs
Collagen Peptide Business
Protein Enrichment: Collagen Peptides
• Protein source
• Read to Drink Beverages containing Collagen Peptides as ingredient.
Enriquecimento proteico com proteínas de colágeno
Protein Enrichment: Collagen Peptides
• Protein source
• Powder beverages
Collagen Peptide Business
Protein Enrichment: Collagen Peptides
• Protein Source
• Other presentations:
• Gummies
• Tablets
• Spredables (nuts, cream cheese).
Collagen Peptide Business
Technological Ingredient: Collagen Peptides
Binding Agent
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Technological Ingredient: Collagen Peptides
Texture Improvement
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Technological Ingredient: Collagen Peptides
Fat Replacer
© 2016 GELITA AG. Any copies need to be authorized by GELITA
Collagen Peptide Business
Ana Cláudia De Nadai
Welcome to South America Account Manager
[email protected] How can we help you? GELITA do Brasil Ltda
Germany Sweden USA Brazil South Africa China
Eberbach Stidsvig Sioux City, IA Cotia São Paulo West Krugersdorp Shanghai
Phone: +49 62 71 84-01 Phone: +46 4 35 265 - 00 Phone: +1 712 943 5516 Phone: +55 11 4612-8111 Phone: +27 11 662 5300 Phone: +86 21 6335 3099
UK France Mexico Australia New Zealand
Holmes Chapel Aix-en-Provence Lerma Beaudesert Christchurch www.GELITA.com
Phone: +44 14 77 53 69 00 Phone: +33 4 42 63 28 40 Phone: +52 7 28 285 0101 Phone: +61 (7) 55 41 - 35 44 Phone: +64 33 84 30 93
[email protected] © 2016 GELITA AG. Any copies need to be authorized by GELITA
