General Anesthesia

Osama Ali Ibraheim, MD

King Saud University
General anesthetics have been performed
since 1846 when Morton demonstrated the
first anesthetic (using ether) in Boston, USA.
Local anesthetics arrived later, the first being
scientifically described in1884.
General anesthesia is described as a reversible
state of unconsciousness with inability to respond
to a standardized surgical stimulus.
In modern anesthetic practice this involves the
triad of: unconsciousness, analgesia, muscle
relaxation.
 General Anesthesia

• Assessment
• Planning I: Monitors • Induction
• Planning II: Drugs • Maintenance
• Planning III: Fluids • Emergence
• Planning IV: Airway • Postoperative
Management
 Objectives of anesthesia

• Unconsciousness
• Amnesia
• Analgesia
• Oxygenation
• Ventilation
• Homeostasis
• Airway Management
• Reflex Management
• Muscle Relaxation
• Monitoring
 Role Of Anesthetists
• Preoperative evaluation and patient preparation
• Intraoperative management
- General anesthesia
Inhalation anesthesia
Total IV anesthesia
- Regional anesthesia & pain management
Spinal, epidural & caudal blocks
Peripheral never blocks
Pain management (acute and chronic pain)
• Postanesthesia care (PACU management)
• Anesthesia complication & management
• Case study
Preoperative anesthetic evaluation

Risks of Anesthesia
 Physical status classification
• Class I: A normal healthy patients
• Class II: A patient with mild systemic disease (no functional
limitation)
• Class III: A patient with severe systemic disease (some
• functional limitation)
• Class IV: A patient with severe systemic disease that is a
constant threat to life (functionality incapacitated)
• Class V: A moribund patient who is not expected to survive
without the operation
• Class VI: A brain-dead patient whose organs are being
removed for donor purposes
• Class E: Emergent procedure
 Anesthetic plan
Premed
Intraoperative Postoperative
management management
General Monitoring Pain control
PONV
Airway management Positioning Complications
Induction Fluid management postop ventilation
Maintenance Special techniques Hemodynanic monit
Muscle relaxation
 NPO status
• NPO, Nil Per Os, means nothing by mouth
• Solid food: 8 hrs before induction
• Liquid: 4 hrs before induction
• Clear water: 2 hrs before induction
• Pediatrics: stop breast milk feeding 4 hrs
before induction
 General Anesthesia
1. Monitor
2. Preoxygenation
3. Induction ( including RSI & cricoid pressure)
4. Muscle relaxants
5. Mask ventilation
6. Intubation & ETT position comfirmation
7. Maintenance
8. Emergence
 Airway exam
Mallampati
classification Class I:
uvula, faucial pillars,
soft palate visible

Class II:
faucial pillars, soft
pillars visible

Class III:
soft and hard palate
visible

Class IV:
hard palate visible
Sniffing position
Mask and airway tools
Mask ventilation and intubation
Oral and nasal
airway
Intubation
Intubation
Laryngeal view
Laryngeal view scoring system
Difficult airway
Fiberoptic scope intubation
Trachea view Carina view
Glidescope
Fast track LMA
LMA
 Induction agents
• Opioids – fentanyl
• Propofol, Thiopental and Etomidate
• Muscle relaxants:
Depolarizing
Nondepolarizing
 Induction
• IV induction

• Inhalation induction
 General Anesthesia
• Reversible loss of consciousness
• Analgesia
• Amnesia
• Some degree of muscle relaxation
 Intraoperative management
• Maintenance
Inhalation agents: N2O, Sevo, Deso, Iso
Total IV agents: Propofol
Opioids: Fentanyl, Morphine
Muscle relaxants
Balance anesthesia
 Intraoperative management
• Monitoring
• Position – supine, lateral, prone, sitting, Litho
• Fluid management
- Crystalloid vs colloid
- NPO fluid replacement: 1st 10kg weight-
4ml/kg/hr, 2nd 10kg weight-2ml/kg/hr and
1ml/kg/hr thereafter
- Intraoperative fluid replacement: minor
procedures 1-3ml/kg/hr, major procedures 4-
6ml/kg/hr, major abdominal procedures 7-10/kg/ml
 Intraoperative management
Emergence
• Turn off the agent (inhalation or IV agents)
• Reverse the muscle relaxants
• Return to spontaneous ventilation with
adequate ventilation and oxygenation
• Suction upper airway
• Wait for pts to wake up and follow command
• Hemodynamically stable
 Postoperative management
• Post-anesthesia care unit (PACU)
- Oxygen supplement
- Pain control
- Nausea and vomiting
- Hypertension and hypotension
- Agitation
• Surgical intensive care unit (SICU)
- Mechanical ventilation
- Hemodynamic monitoring
 General Anesthesia
Complications and Management

• Respiratory complication
- Aspiration – airway obstruction and pneumonia
- Bronchospasm
- Atelectasis
- Hypoventilation
• Cardiovascular complication
- Hypertension and hypotension
- Arrhythmia
- Myocardial ischemia and infarction
- Cardiac arrest
 General Anesthesia
Complication and Management

• Neurological complication
- Slow wake-up
- Stroke
• Malignant hyperthermia
 Case Report
Arterial oxygen desaturation
following PCNL

大林慈濟醫院麻醉科 陳炳碩
The Patient

• Patient : 73 y/o Female

BW 68 kg, BH 145 cm (BMI 32)

• Chief complaint :
Right flank pain (stabbing, frequent attacks)
General malaise and fatigue
The Patient
• Past history : Hypertension under regular control
Senile dementia (mild)

• Preoperative diagnosis : Right renal stone (3.2 cm)

• Operation planned : Right PCNL (percutaneous nephrolithotomy)

Pre-anesthetic Assessment
• EKG : Normal sinus rhythm
• CXR : Borderline cardiomegaly & tortuous aorta
• Lab data : Hb 10.5 / Hct 33.2
BUN 24 / Creatinine 1.1
GOT 14
PT, aPTT WNL
Preop
Anesthetic Technique
• General anesthesia with endotracheal intubation
• Standard monitoring apparatus for ETGA
• Induction : Fentanyl ug/kg
propofol 2mg/kg
Succinylcholine 80 mg
Atracurium 25 mg

• Endotracheal tube (ID 7.0-mm) @ 19cm

• Maintenance: Isoflurane 2~3% in O2 0.5 L/min
• Position: prone
• Blood loss : 300 mL → PRBC 2U
Intra-operative Events
• Stable hemodynamics
• Abnormal findings 30 minutes after surgery started
Increased airway pressure 35~40 mmHg
SpO2 dropped to 90~95%
• Bilateral breathing sounds were still audible then
• Management : Solu-cortef 100 mg IV stat
Aminophylline 250 mg IV drip
Bricanyl 5 mg inhalation
Intra-operative Events
• ABG data pH 7.2
PaO2 90.5
PaCO2 66.8
HCO3- 26.0
BE -2.4
Na+ 143.0
K+ 4.0
Ca2 + 1.1
Hb/Hct 11.4/36.1
Post-operative Course
• The patient’s condition was kept up until the end of surgery
• SpO2 90~92% after the patient was placed in the supine position
again with diminished breathing sound over right lower lung
• The patient was transferred to SICU for further care (*)
• Chest X-ray was followed in SICU
Immed.
Postop
Preop Immed. Postop
Postoperative Course
• Pigtail drainage in SICU

• Pleural effusion : bloody

RBC numerous
WBC 7800 (Seg 94%)
Gram stain (-)

• Impression : Right hydrothorax and hemothorax

s/p pigtail
Immed. Postop s/p pigtail
Postoperative Course
• Extubation and transfer to ordinary ward

• Pigtail removed