Mass Spectrometry News and Applications
JEOL USA, Inc. December 2007
____________________________________________________________
In This Issue
Open Air Mass Spec Confirms Self-Assembled
Real Time Analysis of
Monolayers (SAMs)
Cuticular Hydrocarbons
DART Bibliography of
Published Papers
New Introduction to Mass
Spectrometry Published
New Midwest Sales Manager
Forensic Analysis on the
Cutting Edge
Self-Assembled Monolayers
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You are receiving this email
from JEOL USA and will Florida Institute of Technology photo (left to right) Dr. Kafui Kpegba
received future issues (Postdoctoral Researcher), Dr. Joel A. Olson, Dr. Nasri Nesnas, and
undergraduate student Tycho Spadaro on the DART.
unless you choose not to do
so. You can contact us at In a 2007 Analytical Chemistry paper, Florida Institute of Technology
[email protected]. researchers report their findings after using AccuTOF-DART open air mass
spectrometry to analyze self-assembled monolayers (SAMs). "A SAM consists
of a single layer of molecules chemically bonded to a surface; typically the
To be permanently removed
surface is gold and the SAM molecules are thiols. SAMs chemically modify
from this mailing list, please surfaces, which can be useful for applications such as sensor electrodes and
click unsubscribe at the photovoltaic cells," an article in FIT's 2007 Research News & Reports states.
bottom of this email. "In this work, a gold surface was treated with dodecanethiol and then
analyzed using DART mass spectrometry. The mass spectrum shows peaks
(with high resolution information) that confirm the identity of the molecules
To forward to a colleague, present at the surface. The remarkable nature of this technique stems from
please click the green box two factors - 1) The analysis is done on a single layer of molecules (roughly a
below. nanogram of material); 2) a pattern of monomers, dimers and trimers is
evidence that the material analyzed comes from the SAM."
New
Introduction to Mass
Spectrometry
"This book should be on the
bookshelf of every mass
spectrometrist."
Just published, the fourth edition of
Introduction to Mass Spectrometry is
"the first book in recent years to
facilitate an understanding of the
operating principles of
instrumentation and techniques
including those for emerging
technologies...."
Authors: J. Throck Watson and O.
David Sparkman
Work conducted in the labs of Nasri Nesnas and Joel A. Olson showed that
open air analysis using the AccuTOF-DART, a significantly less expensive
technique than Secondary Ion Mass Spectrometry (SIMS), "was unique in its
nature and displayed unambiguous characterization of the molecules present
at the gold surface."
The AccuTOF-DART will be used in organic chemistry classes and
Forensic Analysis on research at FIT, and may also be called upon for analysis to aid local law
the Cutting Edge enforcement.
A new book published by Wiley- "We're pleased that the DART ion source and the AccuTOF-DART
Interscience features a chapter on combination are being used for such a wide variety of applications, and
the revolutionary use of Direct being used in such novel techniques across the sciences.," says Dr.
Analysis in Real Time (DART) mass Robert (Chip) Cody, co-inventor of the DART ion source.
spectrometry for forensics. Samples
from the human body, including
To access the ACS website and a pdf file of the paper "Analysis of Self-
analysis of TATP on a fingertip,
Assembled Monolayers on Gold Surfaces Using Direct Analysis in Real
analysis of bodily fluids, drugs,
Time Mass Spectrometry," Kafui Kpegba, Tycho Spadaro, Robert B.
chemical warfare agents, arson Cody, Nasri Nesnas, and Joel A. Olson, click here.
accelerants, inks and adhesives are
included.
Real Time Analysis of
Chapter 7. Forensic Application Cuticular
of DART (Direct Analysis in Real
Time) Mass Spectrometry (James Hydrocarbons
A. Laramée, Robert B. Cody, J.
Michael Nilles, and H. Dupont Durst). The fruit fly's wings pulsated
rapidly, though she was stuck
fast in the grasp of a gentle
7.1 Introduction.
vacuum pick. Harvard Medical
School's Fruit Fly Fight Club
7.2 Experimental. researcher Joanne Yew carried
her to the mass spectrometer,
7.3 Drug and Pharmaceutical where her hydrocarbon profile
Analysis. was instantly analyzed. She returned her to a container that held
special food.
7.3.1 Confiscated Samples.
Experiments held at JEOL USA made it possible to use a new technique
for analyzing hydrocarbons and other surface molecules from awake
7.3.2 Endogenous Drugs. behaving animals. In this research, fruit fly behavior and pheromones
are being studied for neurobiological purposes. The cuticular
7.3.3 Drug Residues on Surfaces. hydrocarbons were analyzed using the AccuTOF-DART (Direct Analysis in
Real Time) mass spectrometer.
7.4 Samples from the Human Body.
A new paper submitted for
7.4.1 Fingerprints. publication demonstrates
applications for profiling
7.4.2 Bodily Fluids. individual Drosophila
melanogaster and monitoring
changes in hydrocarbon
7.5 Condom Lubricants. expression.
7.6 Dyes.
7.6.1 Self-Defense Sprays.
7.6.2 Currency-Pack Dye.
7.7 Explosives.
7.8 Arson Accelerants.
7.9 Chemical Warfare Agents.
7.10 Elevated-Temperature DART for
Material Identification.
7.11 Glues.
7.12 Plastics.
7.13 Fibers.
7.14 Identification of Inks.
"Forensic Analysis on the Cutting
Edge - New Methods for Trace
Evidence Analysis" - is available now
from Wiley or other booksellers.
Visit JEOL at
AAFS
American Academy of Forensic
Science Annual Meeting
February 20-22 ASMS Fall Workshop 2007
Washington, D.C.
Booth 605/607 The Art of Open Air Ionization on Surfaces
Chemical Heritage Foundation Philadelphia, PA
PITTCON November 8 - 9, 2007
March 3-6
New Orleans, LA DART Presentations
Booth 4121
"The Development of a Searchable Library for Direct Analysis Real
________________
Time (DART) Accurate Mass Spectra Data" - Lisa Schumacher, FBI
Laboratories
Quick Links "DESI and DART for Counterfeit Drug Fingerprinting" - Facundo M.
Fernandez, Georgia Institute of Technology
Our Website "The Art of DART" R. Cody - JEOL USA
Mass Spec Products
Back Issues of Mass Media
New Midwest Sales Manager
Joins JEOL
We welcome a new sales representative to the
JEOL USA family. Anthony (Tony) Borre of
Waukegan, Illinois, is now the JEOL mass
CONTACT JEOL spectrometry liaison for the Midwest states.
If you would like to speak directly Tony's background includes 8 years of organic
with us, please call synthesis/proprietary formulations/high
978-536-2310 pressure reactions (IR, TLC, and GC) and 24
years of analytical chemistry. He spent four of
East Coast
those years employing HPLC, electrochemistry, and AA methods
National Sales Mgr.
development in support of hospital products, and another four years in
Bob DiPasquale
[email protected]
HPLC methods development (UV,RI, and EC) in support of new drug
discovery and pharmacology projects. His experience also includes 14
Midwest
years of LC/MS/MS high throughput methods development in support of
Tony Borre drug metabolism projects, and high efficiency sample preparation
[email protected] by ultracentrifugation, SPE, and robotic methods.
Southwest: Tony's alma mater is the University of Wisconsin-Parkside. He and his
Dave Vargas wife of 31 years, Sheila, have a daughter who is a chemical engineer,
[email protected] and a son who is a police officer. They now share their home with a
Boston Terrier and a cat.
West:
Tim Hawkins
[email protected] Published Papers on DART Direct Analysis in Real
Service: Time
Bill Miller
[email protected] In the three years since DART, the open air ion source that revolutionized
Visit mass spectrometry, has been in production, numerous presentations and
papers have been given by our customers, as well as ourselves.
a REALab
Below is the most recent bibliography of peer-reviewed journal or book
publications:
General
Cody, Robert B., Laramée, James A., and Durst, H. Dupont. Versatile New
Ion Source for the Analysis of Materials in Open Air under Ambient
Conditions. Anal. Chem, 2005, 77(8) pp 2297 - 2302; (Accelerated Article)
DOI: 10.1021/ac050162j.
Cody, R. B., Laramée, J. A., Nilles, J.M., Durst, H. D. Direct Analysis in Real
Time (DARTtm) Mass Spectrometry. JEOL News; 2005.
Laramée, J. A., Cody, R. B., Chemi-ionization and Direct Analysis in Real
Time (DARTtm) Mass Spectrometry. In Encyclopedia of Mass
Spectrometry, Michael L. Gross, editor. Elsevier, in press.
Tutorials and Forensics
Applications Notes
Jones, Roger W., Cody, Robert B., McClelland, John F. Differentiating
Writing Inks Using Direct Analysis in Real Time Mass Spectrometry.
Bookmark www.jeolusa.com for
Journal of Forensic Science, July 2006, Vol. 51, No. 4, pages 915-918.
complete access to useful mass
spec Tutorials and applications
notes. Laramée, J. A., Cody, R. B., Nilles, J.M., Durst, H. D. Forensic Application
of DART (Direct Analysis in Real Time) Mass Spectrometry in Forensic
Analysis on the Cutting Edge, Robert D. Blackledge, editor, John Wiley and
The tutorials have been updated and
Sons, Inc, 2007. ISBN: 0471716448.
include useful reference tables for
day-to-day DART operation.
Coates, Cristina M. et al. The persistence of common accelerants
We continually add to our measured by direct analysis in real time (DART) time-of-flight mass
applications notes. spectrometry. J. Forensic Sci., submitted for publication.
Pharmaceuticals
Fernández, Facundo M. et al.Characterization of Solid Counterfeit Drug
Samples by Desorption Electrospray Ionization and Direct-analysis-in-
real-time Coupled to Time-of-flight Mass Spectrometry. ChemMedChem
July, 10, 2006, v. 1 no. 7, 702-705.
Published Online: 8 May 2006
DOI: 10.1002/cmdc.200600041
Diffendal, Jason, et al. Direct Analysis in Real Time for Reaction
Monitoring in Drug Discovery. Anal. Chem., 2007. 79 (13), 5064-5070.
Biological
Pierce,Carrie Y. et al. Ambient generation of fatty acid methyl ester
ions from bacterial whole cells by direct analysis in real time (DART)
mass spectrometry. Chem. Commun., 2007. DOI: 10.1039/b613200f.
Food, Flavors and Fragrances
To Download the Third Edition of
Applications Notes for the JEOL
AccuTOF-DART, visit our Haefliger, Olivier P. and Jeckelmann, Nicolas. Direct mass spectrometric
webpages or click on the analysis of flavors and fragrances in real applications using DART.
notebook image. Rapid Commun. Mass Spectrom. 2007, 21: 1361-1366.
Vail, T., Jones, P.R., Sparkman, O.D. Rapid and unambiguous
identification of melamine in contaminated pet food based on mass
spectrometry with four degrees of confirmation. J. Anal. Toxicol.,
2007, 31 (6):304-12.
Synthesis
Morlock, Gertrud and Ueda, Yoshihisa. New coupling of planar
chromatography with direct analysis in real time mass spectrometry.
Journal of chromatography A, 1143, 2007, 243-251.
Kpegba, K., et al. Analysis of Self-Assembled Monolayers on Gold
Surfaces Using Direct Analysis in Real Time Mass Spectrometry. Anal.
Chem., 79, 14, 5479-5483, 2007. 10.1021/1c062276g.
Taking Mass Spec Into the Open
Open-air ionization methods were featured in the October 8th issue of C&E
News.
The article, Taking Mass Spec Into The Open, describes methods that are
either commercially available or currently in development.
Since DART is one of the few widely used open-air ionization techniques
available in the market, our users were quoted heavily as they shared their
experiences with DART.
Some excerpts:
"Ambient ionization methods are helping Facundo Fernandez identify
counterfeit pharmaceuticals. Fernandez, an assistant professor of chemistry at
Georgia Institute of Technology, collaborates with scientists at the Centers for
Disease Control & Prevention and the Wellcome Trust to investigate
antimalarial medications collected in Southeast Asia."
"Jeanette Adams gets excited talking about all the things she can do with
mass spectrometry at the Library of Congress. A scientist in its Preservation
Research & Testing Division, Adams uses mass spectrometry to look for early
signs of degradation in documents, photographs, and microfilm from the
library's collections. In most cases she does so without even taking a sample,
thanks to an ionization method called DART (direct analysis in real time)."
For access to the full article, click here:
http://pubs.acs.org/cen/coverstory/85/8541cover.html
