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Cefoxitin Drug Study Overview

Cefoxitin is an antibiotic used for prophylaxis of surgical infections by inhibiting bacterial cell wall synthesis. It works by binding to penicillin-binding proteins and inhibiting the final step of peptidoglycan synthesis in bacterial cell walls. Common side effects include hypersensitivity reactions and elevated renal enzymes. It should not be used in patients with a hypersensitivity to cefoxitin or other cephalosporins. Nursing considerations include monitoring for signs of anaphylaxis, renal function, and administering the medication correctly.

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Arthur Christopher Corpuz
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313 views1 page

Cefoxitin Drug Study Overview

Cefoxitin is an antibiotic used for prophylaxis of surgical infections by inhibiting bacterial cell wall synthesis. It works by binding to penicillin-binding proteins and inhibiting the final step of peptidoglycan synthesis in bacterial cell walls. Common side effects include hypersensitivity reactions and elevated renal enzymes. It should not be used in patients with a hypersensitivity to cefoxitin or other cephalosporins. Nursing considerations include monitoring for signs of anaphylaxis, renal function, and administering the medication correctly.

Uploaded by

Arthur Christopher Corpuz
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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REPUBLIC of the PHILIPPINES

City of Makati
COLLEGE OF ALLIED HEALTH STUDIES
J. P. Rizal Extension, West Rembo, Makati City 1215
Telephone No. : (+632) – 881 – 1571
_____________________________________________________________________________________
DRUG STUDY
Drug Name Mechanism of Action Indication Side Effects/Adverse Effect Contraindication Nursing Consideration
Generic Name: Cefoxitin inhibits bacterial cell wall Prophylaxis of surgical Hypersensitivity reactions (e.g. Hypersensitivity to cefoxitin - Assess the 12 Rights in Giving Medication
Cefoxitin synthesis by binding to 1 or more of infections maculopapular or and other cephalosporins.
Brand Name: the penicillin-binding proteins erythematous rash, exfoliative - Monitor renal function periodically when used in combination
Cefovex (PBPs) which in turn inhibit the final dermatitis, pruritus, urticaria, w/ other nephrotoxic drugs; prothrombin time. Observe for signs
Dosage transpeptidation step of eosinophilia, fever, and symptoms of anaphylaxis during 1st dose.
Intravenous peptidoglycan synthesis in bacterial angioedema); elevated serum - Special precautions to patients w/ history of penicillin allergy,
Prophylaxis of surgical cell walls, thus inhibiting cell wall creatinine and/or BUN GI disease (particularly colitis) and seizure disorder. Renal
infections biosynthesis and arresting cell wall concentrations, anaemia; impairment. Pregnancy and lactation. encephalopathy.
Adult:  2 g 30-60 min prior assembly resulting in bacterial cell transient increase in serum Pregnancy and lactation
to surgery, then 6 hrly for death. AST (SGOT), ALT (SGPT), - Evaluate therapeutic response.
not more than 24 hr. For LDH and alkaline phosphatase
caesarean section: 2 g as levels; jaundice;
a single dose as soon as thrombophlebitis. Rarely,
the umbilical cord is oliguria, renal toxicity,
clamped; a further 2 g Reference: neutropenia, transient
dose 4 hr and 8 hr after MIMS 151st Edition 2017 leucopenia, granulocytopenia,
the initial dose may be DRUG REFERENCE: thrombocytopenia, bone
given if necessary. https://www.mims.com/ marrow depression; GI effects
(e.g. nausea, vomiting,
diarrhoea).

Potentially Fatal: Anaphylaxis,
pseudomembranous colitis.

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