SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 1(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier

Trade name
ANTIFROGEN N
Material number: 107601
Chemical nature: Monoethylene glycol (1,2-ethane diol) with corrosion inhibitors

1.2. Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses of the substance or mixture
Industry sector : Functional Fluids
Type of use : Brine for refrigeration
Exposure scenarios: see annex

1.3. Details of the supplier of the safety data sheet

Identification of the company
Clariant Produkte (Deutschland) GmbH
65926 Frankfurt am Main
Telephone no. : +49 69 305 18000
Information about the substance/mix ture
BU Industrial & Consumer Specialties
Product Stewardship
e-mail: [email protected]

1.4. Emergency telephone number

00800-5121 5121 (24 h)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification (REGULATION (EC) No 1272/2008)
Acute toxicity, Category 4 H302: Harmful if swallowed.

Specific target organ toxicity - repeated H373: May cause damage to organs through
exposure, Category 2 prolonged or repeated exposure.

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms :

Signal word : Warning

Hazard statements : H302 Harmful if swallowed.

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ANTIFROGEN N Page 2(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

H373 May cause damage to organs through

prolonged or repeated exposure.

Precautionary statements : Prevention:

P260 Do not breathe dust/ fume/ gas/ mist/
vapours/ spray.
P264 Wash skin thoroughly after handling.
P280 Wear protective gloves/ protective clothing/
eye protection/ face protection.
Response:
P314 Get medical advice/ attention if you feel
unwell.
P337 + P313 If eye irritation persists: Get medical advice/
attention.
Disposal:
P501 Dispose of contents/ container to an
approved waste disposal plant.

2.3 Other hazards

After consideration of all available toxicity and ecotoxicity data it is concluded that the substance
does not fulfil the PBT or vPvB criteria.

No additional hazards are known except those derived from the labelling.

SECTION 3: Composition/information on ingredients

3.2 Mixtures
Hazardous components
Chemical name CAS-No. Classification Concentration
EC-No. (% w/w)
Registration number
Ethanediol 107-21-1 Acute Tox. 4; H302 >= 90 - <= 95
203-473-3 STOT RE 2; H373
01-2119456816-28 Acute Tox. 4; H302
01-2119456816-28- STOT RE 2; H373
0000
01-2119456816-28-
0003
01-2119456816-28-
XXXX
For explanation of abbreviations see section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice : Remove/Take off immediately all contaminated clothing.

If inhaled : Get medical attention if symptoms occur.

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 3(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

In case of skin contact : In case of contact, immediately flush skin with plenty of water.

In case of eye contact : In the case of contact with eyes, rinse immediately with plenty
of water and seek medical advice.

If swallowed : Get medical attention immediately.

4.2 Most important symptoms and effects, both acute and delayed
Symptoms : No symptoms known currently.

Risks : No hazards known at this time.

4.3 Indication of any immediate medical attention and special treatment needed
Treatment : Treat symptomatically.

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media : Water spray jet
Alcohol-resistant foam
Carbon dioxide (CO2)
Dry powder

5.2 Special hazards arising from the substance or mixture

Specific hazards during : In case of fires, hazardous combustion gases are formed:
firefighting Carbon monoxide (CO)
Nitrogen oxides (NOx)

5.3 Advice for firefighters

Special protective equipment : Self-contained breathing apparatus
for firefighters

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Personal precautions : Ensure adequate ventilation.
Wear suitable protective equipment.

6.2 Environmental precautions

Environmental precautions : Do not allow to enter drains or waterways

6.3 Methods and material for containment and cleaning up

Methods for cleaning up : Soak up with inert absorbent material (e.g. sand, silica gel,
acid binder, universal binder, sawdust).
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ANTIFROGEN N Page 4(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Can be landfilled or incinerated, when in compliance with local

regulations.

6.4 Reference to other sections

Information regarding Safe handling, see chapter 7., For personal protection see section 8., For
disposal considerations see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling : Handle and open container with care.
Provide adequate ventilation.

Advice on protection against : Observe the general rules of industrial fire protection
fire and explosion

Hygiene measures : Keep away from food and drink.

7.2 Conditions for safe storage, including any incompatibilities

Advice on common storage : Do not store with alkalies
Do not store with strong oxidizing agents

7.3 Specific end use(s)

Specific use(s) : No further recommendations.

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure Limits
Components CAS-No. Value type (Form Control parameters Basis
of exposure)
Ethanediol 107-21-1 TWA 20 ppm 2000/39/EC
52 mg/m3
Further information Identifies the possibility of significant uptake through the skin, Indicative
STEL 40 ppm 2000/39/EC
104 mg/m3
Further information Identifies the possibility of significant uptake through the skin, Indicative
Derived No Effect Level (DNEL) according to Regulation (EC) No. 1907/2006:
ethanediol : End Use: Workers
CAS-No.: 107-21-1 Exposure routes: Dermal
Potential health effects: Long-term systemic effects
Value: 106 mg/kg bw/day
DNEL
End Use: Workers
Exposure routes: Inhalation
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Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Potential health effects: Long-term local effects

Value: 35 mg/m3
DNEL
End Use: General population
Exposure routes: Dermal
Potential health effects: Long-term systemic effects
Value: 53 mg/kg bw/day
DNEL
End Use: General population
Exposure routes: Inhalation
Potential health effects: Long-term local effects
Value: 7 mg/m3
Predicted No Effect Concentration (PNEC) according to Regulation (EC) No. 1907/2006:
ethanediol : Fresh water
CAS-No.: 107-21-1 Value: 10 mg/l
salt water
Value: 1 mg/l
Water (intermittent release)
Value: 10 mg/l
Fresh water sediment
Value: 20,9 mg/kg dry weight (d.w.)
Soil
Value: 1,53 mg/kg dry weight (d.w.)
Sewage treatment plant
Value: 199,5 mg/l
8.2 Exposure controls
Personal protective equipment
Eye protection : Depending on the risk, wear sufficient eye protection (safety
glasses with side protection or goggles, and if necessary, face
shield.)

Hand protection
Break through time : 480 min
Glove thickness : 0,7 mm
Remarks : Long-term exposure Impervious butyl rubber gloves

Break through time : 30 min

Glove thickness : 0,4 mm
Remarks : For short-term exposure (splash protection): Nitrile rubber
gloves.

Remarks : These types of protective gloves are offered by various

manufacturers. Please note the manufacturers´ detailed
statements, especially about the minimum thickness and the
minimum breakthrough time. Consider also the particular
working conditions under which the gloves are being used.

Respiratory protection : Use respiratory protection in case of insufficient exhaust

ventilation or prolonged exposure
Full mask to standard DIN EN 136
Filter A (organic gases and vapours) to standard DIN EN 141
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 6(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

The use of filter apparatus presupposes that the environment

atmosphere contains at least 17% oxygen by volume, and
does not exceed the maximum gas concentration, usually
0.5% by volume. Relevant guidelines to be considered
include EN 136/141/143/371/372 as well as other national
regulations.

Protective measures : Do not inhale vapours

Avoid contact with skin and eyes.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

Appearance : Liquid

Particle size : Not applicable

Colour : yellow

Odour : slightly perceptible

Odour Threshold : not tested.

pH : approx. 8
Concentration: 100 g/l (20 °C)
Method: DIN 19268

Melting point : -32 °C

Method: DIN 51583

Boiling point : approx. 165 °C

(1.013 hPa)
Method: ASTM D 1120

166 °C
(1.013 hPa)
Method: ASTM D 1120

Flash point : 119 °C

Method: ASTM D6450 (closed cup)

Evaporation rate : not tested.

Upper explosion limit : not tested.

Lower explosion limit : 3 %(V)

Data relate to solvent
Combustion number : Not applicable
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ANTIFROGEN N Page 7(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : < 0,01 kPa (20 °C)

Method: Calculated by Syracuse.

Relative vapour density : not tested.

Density : 1,1138 g/cm3 (20 °C)

Method: DIN 51757

Bulk density : Not applicable

Solubility(ies)
Water solubility : completely miscible (20 °C)

Solubility in other solvents : not tested.

Solvent: fat

Partition coefficient: n- : Not applicable

octanol/water

Auto-ignition temperature : > 400 °C

Method: DIN 51794

Decomposition temperature : > 300 °C

Method: DSC
Measurement under nitrogen No decomposition up to 300 °C.

Viscosity
Viscosity, dynamic : 20,3 mPa.s (20 °C)

Viscosity, kinematic : 20,3 mm2/s (20 °C)

Method: DIN 51562

Explosive properties : Not explosive

Method: Expert judgement

Oxidizing properties : The substance or mixture is not classified as oxidizing.

Method: Expert judgement

9.2 Other information

Surface tension : 33,8 mN/m

Molecular weight : Not applicable

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 8(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

SECTION 10: Stability and reactivity

10.1 Reactivity
See section 10.3. "Possibility of hazardous reactions"
10.2 Chemical stability
Stable under normal conditions.
hygroscopic
10.3 Possibility of hazardous reactions
Hazardous reactions : Reactions with alkalies.
Reactions with oxidising agents.

Stable

10.4 Conditions to avoid

Conditions to avoid : None known.

10.5 Incompatible materials

Materials to avoid : not known

10.6 Hazardous decomposition products

When handled and stored appropriately, no dangerous decomposition products are known

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity
Product:
Acute oral toxicity : Acute toxicity estimate: 519,54 mg/kg
Method: Calculation method

Acute inhalation toxicity : LC50 (Rat, male and female): > 2,5 mg/l
Exposure time: 6 h
Remarks: Information refers to the main component.

Acute dermal toxicity : LD50 (Mouse, male and female): > 3.500 mg/kg
Remarks: Information refers to the main component.

Components:
Ethanediol:
Acute oral toxicity : LD50 (Rat, male and female): 22.000 mg/kg
Method: Other
GLP: no

Acute inhalation toxicity : LC50 (Rat, male and female): > 2,5 mg/l
Exposure time: 6 h
Method: Other
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 9(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

GLP: yes

Acute dermal toxicity : LD50 (Mouse, male and female): > 3.500 mg/kg
Method: Other
GLP: yes

Skin corrosion/irritation
Product:
Species: Rabbit
Result: No skin irritation
Remarks: Information refers to the main component.

Components:
Ethanediol:
Species: Rabbit
Exposure time: 20 h
Method: BASF test
Result: No skin irritation
GLP: no

Serious eye damage/eye irritation

Product:
Remarks: not tested.

Components:
Ethanediol:
Species: rabbit eye
Exposure time: 24 h
Method: BASF test
Result: non-irritant
GLP: no

Respiratory or skin sensitisation

Product:
Test Type: Guinea pig maximization test
Species: Guinea pig
Method: Magnusson/Kligman
Result: non-sensitizing
Remarks: Information refers to the main component.

Components:
Ethanediol:
Test Type: Maximisation Test
Exposure routes: Skin contact
Species: Guinea pig
Method: OECD Test Guideline 406
Result: Does not cause skin sensitisation.
GLP: yes
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ANTIFROGEN N Page 10(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Germ cell mutagenicity

Product:
Germ cell mutagenicity- : It is concluded that the product is not mutagenic based on
Assessment evaluation of several mutagenicity tests.

Information refers to the main component.

Components:
Ethanediol:
Genotoxicity in vitro : Test Type: Ames test
Species: Salmonella typhimurium
Concentration: 33 - 5000 µg/plate
Metabolic activation: with and without
Method: OECD Test Guideline 471
Result: negative
GLP: yes

: Test Type: Ames test

Species: Escherichia coli
Concentration: 33 - 5000 µg/plate
Metabolic activation: with and without
Method: OECD Test Guideline 471
Result: negative
GLP: yes

Genotoxicity in vivo : Test Type: Dominant lethal assay

Species: Rat (male and female)
Strain: Fischer F344
Application Route: oral (feed)
Exposure time: 3 generation
Dose: 40 - 200 - 1000 mg/kg
Method: Other
Result: negative
GLP: no

Germ cell mutagenicity- : It is concluded that the product is not mutagenic based on
Assessment evaluation of several mutagenicity tests.

Carcinogenicity
Product:
Carcinogenicity - : No evidence of carcinogenicity in animal studies.
Assessment

Information refers to the main component.

Components:
Ethanediol:
Carcinogenicity - : Not classifiable as a human carcinogen.
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Substance key: SXR024717 Revision Date: 02.02.2016
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Assessment

Reproductive toxicity
Product:
Reproductive toxicity - : No indications of toxic effects were observed in reproduction
Assessment studies in animals.

No reproductive toxicity to be expected.

Information refers to the main component.

Information refers to the main component.

Components:
Ethanediol:
Effects on fertility : Species: Rat
Sex: male and female
Dose: 40 - 200 - 1000
Frequency of Treatment: daily
Fischer F344
Application Route: oral (feed)
Test period: 3 generations
NOAEL: > 1.000 mg/kg,
F1: > 1.000 mg/kg,
F2: > 1.000 mg/kg,
Method: Other
GLP: no

Effects on foetal : Species: Rat

development Application Route: oral (gavage)
Exposure time: gestation day 6-15
Dose: 150 - 500 - 1000 - 2500 mg/kg
Group: yes
500 mg/kg
1.000 mg/kg
Number of exposures: daily
Method: Other
GLP: yes

Reproductive toxicity - : No reproductive toxicity to be expected.

Assessment No teratogenic effects to be expected.

STOT - single exposure

Product:
Remarks: not tested.

Components:
Ethanediol:
Assessment: The substance or mixture is not classified as specific target organ toxicant, single
exposure.
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ANTIFROGEN N Page 12(204)

Substance key: SXR024717 Revision Date: 02.02.2016
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STOT - repeated exposure

Product:
Remarks: not tested.

Components:
Ethanediol:
Target Organs: Kidney
Assessment: May cause damage to organs through prolonged or repeated exposure.

Repeated dose toxicity

Product:
Species: Rat, male and female
NOAEL: 200 mg/kg
Application Route: oral (gavage)
Method: OECD Test Guideline 407

Species: Rat, male

NOAEL: 150 mg/kg
Application Route: oral (feed)
Method: OECD Test Guideline 408

Species: Dog, male

NOAEL: 2,22 mg/kg
Application Route: Dermal
Method: OECD Test Guideline 410
Remarks: Information refers to the main component.

Components:
Ethanediol:
Species: Rat, male
NOAEL: 150 mg/kg
Application Route: oral (feed)
Exposure time: 16 w
Number of exposures: daily
Dose: 50 - 150 - 500 - 1000 mg/kg
Group: yes
Method: OECD Test Guideline 408
GLP: yes

Species: Dog, male

NOAEL: ca. 2.200 mg/kg
Application Route: Skin contact
Exposure time: 4 w
Number of exposures: daily
Dose: 0,5 - 2 - 8 ml/kg
Group: yes
Method: OECD Test Guideline 410
GLP: yes
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Substance key: SXR024717 Revision Date: 02.02.2016
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Aspiration toxicity
Product:
no data available

Components:
Ethanediol:
No aspiration toxicity classification

Further information
Product:
Remarks: Kidney injury may occur.

Remarks: Poisoning affects the central nervous system

Remarks: The classification was made by the conventional (calculation) method of the CLP
Regulation (EC) No 1272/2008.

SECTION 12: Ecological information

12.1 Toxicity
Product:
Toxicity to fish : LC0 (Leuciscus idus (Golden orfe)): 1.000 mg/l

LL50 (Danio rerio (zebra fish)): > 100 mg/l

Exposure time: 96 h
Test Type: static test
Method: OECD Test Guideline 203
GLP: yes
Remarks: By analogy with a product of similar composition

Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): > 100 mg/l
aquatic invertebrates Exposure time: 48 h
Method: OECD Test Guideline 202
Remarks: Information refers to the main component.

Toxicity to algae : EC50 (Selenastrum capricornutum (green algae)): 6.500 -

13.000 mg/l
Exposure time: 96 h
Remarks: Information refers to the main component.

Toxicity to bacteria : EC20 (activated sludge): > 1.995 mg/l

Exposure time: 30 min
Method: ISO 8192
Remarks: Information refers to the main component.

Components:
Ethanediol:
Toxicity to fish : LC50 (Pimephales promelas (fathead minnow)): 72.860 mg/l
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Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposure time: 96 h
Test Type: static test
Analytical monitoring: yes
Method: EPA
GLP: no
Remarks: The details of the toxic effect relate to the nominal
concentration.

Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): > 100 mg/l
aquatic invertebrates Exposure time: 48 h
Test Type: static test
Analytical monitoring: yes
Method: OECD Test Guideline 202
GLP: yes

Toxicity to algae : EC50 (Chlamydomonas angulosa. Green algae): 3.536 mg/l

Exposure time: 96 h
Analytical monitoring: no
Method: Estimated (Ecosar)
GLP: no

Toxicity to bacteria : EC20 (activated sludge, domestic): > 1.995 mg/l

End point: Bacteria toxicity (respiration inhibition)
Exposure time: 0,5 h
Analytical monitoring: no
Method: ISO 8192
GLP: no
Remarks: By analogy with a product of similar composition

Toxicity to fish (Chronic : Chronic Toxicity Value: 2.629 mg/l

toxicity) Exposure time: 30 d
End point: Other
Species: Fish
Method: Other
GLP: no
Remarks: The details of the toxic effect relate to the nominal
concentration.

Toxicity to daphnia and other : NOEC: 8.590 mg/l

aquatic invertebrates Exposure time: 7 d
(Chronic toxicity) End point: Reproduction rate
Species: Ceriodaphnia spec.
Test Type: semi-static test
Analytical monitoring: yes
Method: Other
GLP: No information available.
Remarks: The details of the toxic effect relate to the nominal
concentration.

Toxicity to soil dwelling :

organisms Remarks: The study is not necessary from a scientific
perspective.

Plant toxicity : Remarks: The study is not necessary from a scientific

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Substance key: SXR024717 Revision Date: 02.02.2016
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perspective.

Sediment toxicity : Remarks: The study is not necessary from a scientific

perspective.

Toxicity to terrestrial : Remarks: The study is not necessary from a scientific

organisms perspective.

12.2 Persistence and degradability

Product:
Biodegradability : Biodegradation: 90 - 100 %
Exposure time: 10 d
Method: OECD Test Guideline 301A
Remarks: Readily biodegradable, according to appropriate
OECD test.
Information refers to the main component.

Components:
Ethanediol:
Biodegradability : Test Type: aerobic
Inoculum: activated sludge
Concentration: 53 mg/l
Result: Readily biodegradable
Biodegradation: 90 - 100 %
Related to: DOC decrease
Exposure time: 10 d
Method: OECD Test Guideline 301A
GLP: yes

12.3 Bioaccumulative potential

Product:
Bioaccumulation : Remarks: not tested.

Components:
Ethanediol:
Bioaccumulation : Remarks: Due to the low logPow bioaccumulation is not
expected

12.4 Mobility in soil

Product:
Distribution among : Remarks: not tested.
environmental compartments

Components:
Ethanediol:
Distribution among : Adsorption/Soil
environmental compartments Medium:water - soil
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log Koc: 0
Method: other (calculated)

12.5 Results of PBT and vPvB assessment

Product:
Assessment : After consideration of all available toxicity and ecotoxicity data
it is concluded that the substance does not fulfil the PBT or
vPvB criteria.
.
Remarks: Information refers to the main component.

Components:
Ethanediol:
Assessment : This substance is not considered to be persistent,
bioaccumulating and toxic (PBT)..

12.6 Other adverse effects

Product:
Additional ecological : Remarks: If handled correctly it causes no disturbance in
information treatment plants.
The classification was made by the conventional (calculation)
method of the CLP Regulation (EC) No 1272/2008.

Components:
Ethanediol:
Environmental fate and : not available
pathways

Additional ecological : Remarks: Do not allow to enter ground water, waterways or

information waste water.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product : Dispose of in accordance with local regulations.

Contaminated packaging : Uncontaminated packaging may be reused

Packaging that cannot be cleaned should be disposed of as
product waste

SECTION 14: Transport information

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ANTIFROGEN N Page 17(204)

Substance key: SXR024717 Revision Date: 02.02.2016
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Section 14.1. to 14.5.

ADR not restricted

ADN not restricted
RID not restricted
IATA not restricted
IMDG not restricted

14.6. Special precautions for user

See sections 6 to 8 of this Safety Data Sheet.

14.7. Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code (International
Bulk Chemicals Code)
No transport as bulk according IBC - Code.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or
mixture
Volatile organic compounds : Directive 1999/13/EC on the limitation of emissions of volatile
organic compounds
Remarks: According to the composition the product contains
no VOC component as defined by Directive 1999/13/EC.

Directive 2004/42/EC
Remarks: According to the composition, the product contains
no VOC components as defined by Directive 2004/42/EC.

Other regulations : Apart from the data/regulations specified in this chapter, no

further information is available concerning safety, health and
environmental protection.

15.2 Chemical safety assessment

Chemical Safety Assessments (CSAs) are available for one or more of the component
substances contained in this product.

SECTION 16: Other information

Full text of H-Statements

H302 : Harmful if swallowed.
H373 : May cause damage to organs through prolonged or repeated
exposure.
Full text of other abbreviations
Acute Tox. : Acute toxicity
STOT RE : Specific target organ toxicity - repeated exposure
Further information
Other information : Observe national and local legal requirements
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ANTIFROGEN N Page 18(204)

Substance key: SXR024717 Revision Date: 02.02.2016
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This information corresponds to the present state of our knowledge and is intended as a general
description of our products and their possible applications. Clariant makes no warranties, express
or implied, as to the information's accuracy, adequacy, sufficiency or freedom from defect and
assumes no liability in connection with any use of this information. Any user of this product is
responsible for determining the suitability of Clariant's products for its particular application.
Nothing included in this information waives any of Clariant's General Terms and Conditions of
Sale, which control unless it agrees otherwise in writing. Any existing intellectual/indust rial
property rights must be observed. Due to possible changes in our products and applicable
national and international regulations and laws, the status of our products could change. Material
Safety Data Sheets providing safety precautions, that should be observed when handling or
storing Clariant products, are available upon request and are provided in compliance with
applicable law. You should obtain and review the applicable Material Safety Data Sheet
information before handling any of these products. For additional information, please contact
Clariant.

REG_EU / EN
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Substance key: SXR024717 Revision Date: 02.02.2016
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Exposure Scenario(s)

Number Title
ES 1 Industrial use; Use as an intermediate
PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a, PROC8b, PROC9, PROC15 -
ERC6a
Ethane-1,2-diol
ES 2 Industrial use; Industrial use of processing aids in processes and
products, not becoming part of articles
PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a, PROC8b, PROC9, PROC13,
PROC14, PROC15 - ERC4
Ethane-1,2-diol
ES 3 Industrial use; Distribution of substance
PROC1, PROC2, PROC3, PROC4, PROC8a, PROC8b, PROC9, PROC15 - ERC1,
ERC2, ERC3, ERC4, ERC5, ERC6a, ERC6b, ERC6c, ERC6d, ERC7
Ethane-1,2-diol
ES 4 Industrial use; Formulation [mixing] of preparations and/or re-packaging
PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a, PROC8b, PROC9, PROC14,
PROC15 - ERC2
Ethane-1,2-diol
ES 5 Industrial use; Use in polymer production
PROC1, PROC2, PROC3, PROC4, PROC5, PROC6, PROC8a, PROC8b, PROC9,
PROC15 - ERC6c
Ethane-1,2-diol
ES 6 Industrial use; Paints, pastels, pigment powders, Coatings
PROC1, PROC2, PROC3, PROC4, PROC5, PROC7, PROC8a, PROC8b, PROC10,
PROC13, PROC15 - ERC4
Ethane-1,2-diol
ES 7 Professional use; Paints, pastels, pigment powders, Coatings,
Adhesives, sealants, Foaming, Use in polymer processing
PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a, PROC8b, PROC9, PROC10,
PROC11, PROC13, PROC14, PROC15, PROC19 - ERC8a, ERC8c, ERC8d, ERC8f
Ethane-1,2-diol
ES 8 Consumer use; Coatings and paints, thinners, paint removers, Surface
treatment
PC9a, PC15, PC18, PC31, PC24, PC34 - ERC8a, ERC8c, ERC8d, ERC8f
Ethane-1,2-diol
ES 9 Industrial use; Use in cleaning agents
PROC1, PROC2, PROC3, PROC4, PROC7, PROC8a, PROC8b, PROC10, PROC13 -
ERC4
Ethane-1,2-diol
ES 10 Professional use; Use in cleaning agents
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 20(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

PROC1, PROC2, PROC3, PROC4, PROC8a, PROC8b, PROC10, PROC11, PROC13

- ERC8a, ERC8d
Ethane-1,2-diol
ES 11 Consumer use; Use in cleaning agents
PC35 - ERC8a, ERC8d
Ethane-1,2-diol
ES 12 Industrial use; Use in lubricants
PROC1, PROC2, PROC3, PROC4, PROC5, PROC7, PROC8a, PROC8b, PROC9,
PROC10, PROC13, PROC17, PROC18 - ERC4, ERC7
Ethane-1,2-diol
ES 13 Industrial use; Metal working fluids
PROC1, PROC2, PROC3, PROC4, PROC5, PROC7, PROC8a, PROC8b, PROC9,
PROC10, PROC13, PROC17 - ERC4
Ethane-1,2-diol
ES 14 Professional use; Metal working fluids
PROC1, PROC2, PROC3, PROC5, PROC8a, PROC8b, PROC9, PROC10, PROC11,
PROC13, PROC17 - ERC8a, ERC8d
Ethane-1,2-diol
ES 15 Professional use; Use in agrochemicals
PROC1, PROC2, PROC4, PROC8a, PROC8b, PROC9, PROC11, PROC13 - ERC8a,
ERC8d
Ethane-1,2-diol
ES 16 Industrial use; Use in functional fluids
PROC1, PROC2, PROC3, PROC4, PROC8a, PROC8b, PROC9 - ERC7
Ethane-1,2-diol
ES 17 Professional use; Use in functional fluids
PROC1, PROC2, PROC3, PROC4, PROC8a, PROC9, PROC20 - ERC9a, ERC9b
Ethane-1,2-diol
ES 18 Consumer use; Heat transfer fluids, Hydraulic fluids
PC16, PC17 - ERC9a, ERC9b
Ethane-1,2-diol
ES 19 Professional use; Anti-freeze and de-icing products
PROC1, PROC2, PROC8a, PROC8b, PROC11 - ERC8d
Ethane-1,2-diol
ES 20 Consumer use; Anti-freeze and de-icing products
PC4 - ERC8d
Ethane-1,2-diol
ES 21 Industrial use, Professional use; Laboratory use
PROC15 - ERC8a
Ethane-1,2-diol
ES 22 Industrial use; Use in water treatment agents
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 21(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

PROC1, PROC2, PROC3, PROC4, PROC8a, PROC8b, PROC13 - ERC3, ERC4

Ethane-1,2-diol
ES 23 Consumer use; Adhesives, sealants
PC1 - ERC8c, ERC8f
Ethane-1,2-diol
ES 24 Industrial use; Manufacture of substance, Adhesives, sealants, Foaming,
Coatings, Use in polymer production
PROC1, PROC2, PROC3, PROC4, PROC5, PROC7, PROC8a, PROC8b, PROC9,
PROC10, PROC13, PROC14, PROC15 - ERC2, ERC3, ERC5, ERC6c
Ethane-1,2-diol
ES 25 Consumer use; Insulation foams
PC32 - ERC8c, ERC8f
Ethane-1,2-diol

1. ES 1: Industrial use; Use as an intermediate

1.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use resulting in manufacture of another ERC6a
substance (use of intermediates))
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS7: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS8: Industrial use (Use as laboratory reagent) PROC15

1.2. ES 1 Conditions of use affecting exposure

1.2.1 ES 1 - CS 1: Control of environmental exposure: Industrial use (Industrial use
resulting in manufacture of another substance (use of intermediates)) (ERC6a)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 22(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

1.2.2 ES 1 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.3 ES 1 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 23(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.4 ES 1 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 24(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.5 ES 1 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.6 ES 1 - CS 6: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 25(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.7 ES 1 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.2.8 ES 1 - CS 8: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 26(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

1.3. ES 1 Exposure estimation and reference to its source

1.3.2 ES 1 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

1.3.3 ES 1 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 27(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

1.3.4 ES 1 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

1.3.5 ES 1 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

1.3.6 ES 1 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 28(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

1.3.7 ES 1 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

1.3.8 ES 1 - CS 8: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 29(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

1.4. ES 1 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

2. ES 2: Industrial use; Industrial use of processing aids in

processes and products, not becoming part of articles
2.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of processing aids in processes and ERC4
products, not becoming part of articles)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS7: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS8: Industrial use (Treatment of articles by dipping and pouring) PROC13
CS9: Industrial use (Production of preparations or articles by tabletting, PROC14
compression, extrusion, pelettisation)
CS10: Industrial use (Use as laboratory reagent) PROC15

2.2. ES 2 Conditions of use affecting exposure

2.2.1 ES 2 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of processing aids in processes and products, not becoming part of articles) (ERC4)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 30(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in :
Mixture/Article As no environmental hazard was identified no environmental-
related exposure assessment and risk characterization was
performed., The use is assessed to be safe.

2.2.2 ES 2 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.3 ES 2 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 31(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.4 ES 2 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 32(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.5 ES 2 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.6 ES 2 - CS 6: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 33(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.7 ES 2 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.8 ES 2 - CS 8: Control of worker exposure: Industrial use (Treatment of articles

by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 34(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.9 ES 2 - CS 9: Control of worker exposure: Industrial use (Production of

preparations or articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.2.10 ES 2 - CS 10: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 35(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

2.3. ES 2 Exposure estimation and reference to its source

2.3.2 ES 2 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

2.3.3 ES 2 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 36(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

2.3.4 ES 2 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

2.3.5 ES 2 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

2.3.6 ES 2 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 37(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

2.3.7 ES 2 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

2.3.8 ES 2 - CS 8: Worker exposure: Industrial use (Treatment of articles by dipping

and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 38(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

all exposure routes)

2.3.9 ES 2 - CS 9: Worker exposure: Industrial use (Production of preparations or

articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 3,43 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

2.3.10 ES 2 - CS 10: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

2.4. ES 2 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

3. ES 3: Industrial use; Distribution of substance

3.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Manufacture of substances, Formulation of preparations, ERC1, ERC2, ERC3,
Formulation in materials, Industrial use of processing aids in processes ERC4, ERC5,
and products, not becoming part of articles, Industrial use resulting in ERC6a, ERC6b,
inclusion into or onto a matrix, Industrial use resulting in manufacture of ERC6c, ERC6d,
another substance (use of intermediates), Industrial use of reactive ERC7
processing aids, Industrial use of monomers for manufacture of
thermoplastics, Industrial use of process regulators for polymerisation
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 39(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

processes in production of resins, rubbers, polymers, Industrial use of

substances in closed systems)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS6: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS7: Industrial use (Use as laboratory reagent) PROC15

3.2. ES 3 Conditions of use affecting exposure

3.2.1 ES 3 - CS 1: Control of environmental exposure: Industrial use (Manufacture of
substances, Formulation of preparations, Formulation in materials, Industrial use of
processing aids in processes and products, not becoming part of articles, Industrial
use resulting in inclusion into or onto a matrix, Industrial use resulting in manufacture
of another substance (use of intermediates), Industrial use of reactive processing
aids, Industrial use of monomers for manufacture of thermoplastics, Industrial use of
process regulators for polymerisation processes in production of resins, rubbers,
polymers, Industrial use of substances in closed systems) (ERC1, ERC2, ERC3, ERC4,
ERC5, ERC6a, ERC6b, ERC6c, ERC6d, ERC7)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

3.2.2 ES 3 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 40(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.2.3 ES 3 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.2.4 ES 3 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 41(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.2.5 ES 3 - CS 5: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 42(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.2.6 ES 3 - CS 6: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.2.7 ES 3 - CS 7: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 43(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

3.3. ES 3 Exposure estimation and reference to its source

3.3.2 ES 3 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

3.3.3 ES 3 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
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ANTIFROGEN N Page 44(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

- local and systemic version)

Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

3.3.4 ES 3 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

3.3.5 ES 3 - CS 5: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

3.3.6 ES 3 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 45(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

3.3.7 ES 3 - CS 7: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

3.4. ES 3 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

4. ES 4: Industrial use; Formulation [mixing] of

preparations and/or re-packaging
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 46(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

4.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Formulation of preparations) ERC2
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS7: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS8: Industrial use (Production of preparations or articles by tabletting, PROC14
compression, extrusion, pelettisation)
CS9: Industrial use (Use as laboratory reagent) PROC15

4.2. ES 4 Conditions of use affecting exposure

4.2.1 ES 4 - CS 1: Control of environmental exposure: Industrial use (Formulation of
preparations) (ERC2)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

4.2.2 ES 4 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 47(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.3 ES 4 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.4 ES 4 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 48(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.5 ES 4 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 49(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.6 ES 4 - CS 6: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.7 ES 4 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 50(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.8 ES 4 - CS 8: Control of worker exposure: Industrial use (Production of

preparations or articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.2.9 ES 4 - CS 9: Control of worker exposure: Industrial use (Use as laboratory

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 51(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

4.3. ES 4 Exposure estimation and reference to its source

4.3.2 ES 4 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

4.3.3 ES 4 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 52(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

4.3.4 ES 4 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

4.3.5 ES 4 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

4.3.6 ES 4 - CS 6: Worker exposure: Industrial use (Transfer of substance or

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 53(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

preparation (charging/discharging) from/to vessels/large containers at non dedicated

facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

4.3.7 ES 4 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

4.3.8 ES 4 - CS 8: Worker exposure: Industrial use (Production of preparations or

articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 3,43 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 54(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

4.3.9 ES 4 - CS 9: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

4.4. ES 4 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

5. ES 5: Industrial use; Use in polymer production

5.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of monomers for manufacture of ERC6c
thermoplastics)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Calendering operations) PROC6
CS7: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS8: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS9: Industrial use (Use as laboratory reagent) PROC15
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 55(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

5.2. ES 5 Conditions of use affecting exposure

5.2.1 ES 5 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of monomers for manufacture of thermoplastics) (ERC6c)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

5.2.2 ES 5 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.3 ES 5 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 56(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.4 ES 5 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 57(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.5 ES 5 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.6 ES 5 - CS 6: Control of worker exposure: Industrial use (Calendering

operations) (PROC6)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 58(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposure duration : <= 480 min

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.7 ES 5 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 59(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

5.2.8 ES 5 - CS 8: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.2.9 ES 5 - CS 9: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 60(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

5.3. ES 5 Exposure estimation and reference to its source

5.3.2 ES 5 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

5.3.3 ES 5 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

5.3.4 ES 5 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 61(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

5.3.5 ES 5 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

5.3.6 ES 5 - CS 6: Worker exposure: Industrial use (Calendering operations) (PROC6)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

5.3.7 ES 5 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 62(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

5.3.8 ES 5 - CS 8: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

5.3.9 ES 5 - CS 9: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

5.4. ES 5 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 63(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

6. ES 6: Industrial use; Paints, pastels, pigment powders,

Coatings
6.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of processing aids in processes and ERC4
products, not becoming part of articles)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Spraying in industrial settings and applications) PROC7
CS7: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS8: Industrial use (Transfer of substance or preparation PROC8b
(charging/discharging) from/to vessels/large containers at dedicat ed
facilities)
CS9: Industrial use (Roller application or brushing) PROC10
CS10: Industrial use (Treatment of articles by dipping and pouring) PROC13
CS11: Industrial use (Use as laboratory reagent) PROC15

6.2. ES 6 Conditions of use affecting exposure

6.2.1 ES 6 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of processing aids in processes and products, not becoming part of articles) (ERC4)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 64(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

6.2.2 ES 6 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.3 ES 6 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 65(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.4 ES 6 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.5 ES 6 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 66(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.6 ES 6 - CS 6: Control of worker exposure: Industrial use (Spraying in industrial

settings and applications) (PROC7)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,6 L/min

Frequency and duration of use

Exposure duration : 360 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : > 1000 m3

Risk management measures

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 50 %
Note : Ensure that the direction of airflow is clearly away from the
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 67(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

worker.

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.7 ES 6 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 68(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.8 ES 6 - CS 8: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Transfer of substance or preparation (charging/discharging)
from/to vessels/large containers at dedicated facilities
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.9 ES 6 - CS 9: Control of worker exposure: Industrial use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 69(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.2.10 ES 6 - CS 10: Control of worker exposure: Industrial use (Treatment of articles

by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 70(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

6.2.11 ES 6 - CS 11: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

6.3. ES 6 Exposure estimation and reference to its source

6.3.2 ES 6 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

6.3.3 ES 6 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 71(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

6.3.4 ES 6 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

6.3.5 ES 6 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 72(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

6.3.6 ES 6 - CS 6: Worker exposure: Industrial use (Spraying in industrial settings

and applications) (PROC7)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 9,79 mg/m³ (Stoffenmanager v4.0) 0,28
- local and systemic
Worker - dermal, long-term - 54,6 mg/kg bw/day (RISKOFDERM v2.1) 0,52
systemic
Human health (combined for Not applicable 0,80
all exposure routes)

6.3.7 ES 6 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

6.3.8 ES 6 - CS 8: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,43
all exposure routes)

6.3.9 ES 6 - CS 9: Worker exposure: Industrial use (Roller application or brushing)

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 73(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human health (combined for ECETOC TRA v2.0 worker; modified version 0,77
all exposure routes)

6.3.10 ES 6 - CS 10: Worker exposure: Industrial use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

6.3.11 ES 6 - CS 11: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

6.4. ES 6 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

7. ES 7: Professional use; Paints, pastels, pigment

powders, Coatings, Adhesives, sealants, Foaming, Use in
polymer processing
7.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8c,
systems, Wide dispersive indoor use resulting in inclusion into or onto a ERC8d, ERC8f
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 74(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

matrix, Wide dispersive outdoor use of processing aids in open systems,

Wide dispersive outdoor use resulting in inclusion into or onto a matrix)
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2,
in closed, continuous process with occasional controlled exposure, Use PROC3
in closed batch process (synthesis or formulation))
CS3: Professional use (Use in batch and other process (synthesis) where PROC4, PROC5
opportunity for exposure arises, Mixing or blending in batch processes
for formulation of preparations and articles (multistage and/or significant
contact))
CS4: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS5: Professional use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS6: Professional use (Roller application or brushing) PROC10
CS7: Professional use (Spraying outside industrial settings and/or PROC11
applications)
CS8: Professional use (Treatment of articles by dipping and pouring, PROC13, PROC14
Production of preparations or articles by tabletting, compression,
extrusion, pelettisation)
CS9: Professional use (Use as laboratory reagent) PROC15
CS10: Professional use (Hand-mixing with intimate contact and only PPE PROC19
available)

7.2. ES 7 Conditions of use affecting exposure

7.2.1 ES 7 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive indoor use of processing aids in open systems, Wide dispersive indoor use
resulting in inclusion into or onto a matrix, Wide dispersive outdoor use of processing
aids in open systems, Wide dispersive outdoor use resulting in inclusion into or onto
a matrix) (ERC8a, ERC8c, ERC8d, ERC8f)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

7.2.2 ES 7 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 75(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

occasional controlled exposure, Use in closed batch process (synthesis or

formulation)) (PROC1, PROC2, PROC3)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Technical conditions and : Use in closed batch process (synthesis or formulation)

measures With occasional controlled exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.3 ES 7 - CS 3: Control of worker exposure: Professional use (Use in batch and

other process (synthesis) where opportunity for exposure arises, Mixing or blending
in batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC4, PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

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ANTIFROGEN N Page 76(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposure duration : <= 480 min

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.4 ES 7 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.5 ES 7 - CS 5: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
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ANTIFROGEN N Page 77(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

dedicated facilities, Transfer of substance or preparation into small containers

(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.6 ES 7 - CS 6: Control of worker exposure: Professional use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 78(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Effectiveness (of a measure) : 90 %

Exposure routes : Inhalation exposure

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.7 ES 7 - CS 7: Control of worker exposure: Professional use (Spraying outside

industrial settings and/or applications) (PROC11)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,05 L/min

Frequency and duration of use

Exposure duration : 150 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : <= 1000 m3

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Personal protective measures : Wear a respirator conforming to EN140 with type A filter or
better.
Effectiveness (of a measure) : 40 %

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure
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ANTIFROGEN N Page 79(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that the direction of airflow is clearly away from the
prevent /limit releases, dispersion worker.
and exposure
Note : Not applicable

Organisational measures to : Provide enhanced general ventilation by mechanical means.

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Organisational measures to : Ensure that the task is not carried out by more than one
prevent /limit releases, dispersion worker simultaneously.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.8 ES 7 - CS 8: Control of worker exposure: Professional use (Treatment of

articles by dipping and pouring, Production of preparations or articles by tabletting,
compression, extrusion, pelettisation) (PROC13, PROC14)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 80(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Outdoor / Indoor : Indoor

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %
Note : Treatment of articles by dipping and pouring

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.9 ES 7 - CS 9: Control of worker exposure: Professional use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.2.10 ES 7 - CS 10: Control of worker exposure: Professional use (Hand-mixing with

intimate contact and only PPE available) (PROC19)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 81(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency and duration of use

Exposure duration : < 15 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands and main part of the arms
Exposed skin surface assumed : 1980 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

7.3. ES 7 Exposure estimation and reference to its source

7.3.2 ES 7 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure, Use in closed batch process (synthesis or formulation)) (PROC1, PROC2,
PROC3)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 82(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

systemic version, Use in closed batch process (synthesis or

formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)

7.3.3 ES 7 - CS 3: Worker exposure: Professional use (Use in batch and other

process (synthesis) where opportunity for exposure arises, Mixing or blending in
batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC4, PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,80
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Mixing or blending in batch processes for
formulation of preparations and articles (multistage
and/or significant contact))
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,01
systemic modified version, Mixing or blending in batch processes
for formulation of preparations and articles (multistage
and/or significant contact))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Mixing or 0,75
all exposure routes) blending in batch processes for formulation of
preparations and articles (multistage and/or significant
contact)

7.3.4 ES 7 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

7.3.5 ES 7 - CS 5: Worker exposure: Professional use (Transfer of substance or

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 83(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

preparation (charging/discharging) from/to vessels/large containers at dedicated

facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

7.3.6 ES 7 - CS 6: Worker exposure: Professional use (Roller application or brushing)

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

7.3.7 ES 7 - CS 7: Worker exposure: Professional use (Spraying outside industrial

settings and/or applications) (PROC11)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 14,05 mg/m³ (Stoffenmanager v4.0) 0,40
- local and systemic
Worker - dermal, long-term - 53,75 mg/kg bw/day (RISKOFDERM v2.1) 0,51
systemic
Human health (combined for Not applicable 0,91
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 84(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

all exposure routes)

7.3.8 ES 7 - CS 8: Worker exposure: Professional use (Treatment of articles by

dipping and pouring, Production of preparations or articles by tabletting,
compression, extrusion, pelettisation) (PROC13, PROC14)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Treatment of articles by dipping and pouring)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Treatment of articles by dipping and pouring)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Treatment 0,75
all exposure routes) of articles by dipping and pouring
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Production of preparations or articles by
tabletting, compression, extrusion, pelettisation)
Worker - dermal, long-term - 3,43 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version, Production of preparations or articles by
tabletting, compression, extrusion, pelettisation)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Production 0,77
all exposure routes) of preparations or articles by tabletting, compression,
extrusion, pelettisation

7.3.9 ES 7 - CS 9: Worker exposure: Professional use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

7.3.10 ES 7 - CS 10: Worker exposure: Professional use (Hand-mixing with intimate

contact and only PPE available) (PROC19)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 6,47 mg/m³ (ECETOC TRA v2.0 worker; modified 0,18
- local and systemic version)
Worker - dermal, long-term - 14,14 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,31
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 85(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

7.4. ES 7 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

8. ES 8: Consumer use; Coatings and paints, thinners,

paint removers, Surface treatment
8.1. Titles of Contributing scenarios (CS)

Coatings and paints, thinners, paint removers (PC9a)

Non-metal surface treatment products (PC15)
Ink and toners (PC18)
Polishes and wax blends (PC31)
Lubricants, greases, release products (PC24)
Textile dyes, finishing and impregnating products: including bleaches and other processing aids
(PC34)
Environment
CS1: Consumer use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8c,
systems, Wide dispersive indoor use resulting in inclusion into or onto a ERC8d, ERC8f
matrix, Wide dispersive outdoor use of processing aids in open systems,
Wide dispersive outdoor use resulting in inclusion into or onto a matrix)
Consumer
CS2: Consumer use (Coatings and paints, thinners, paint removers, Non- PC9a, PC15
metal surface treatment products)
CS3: Consumer use (Coatings and paints, thinners, paint removers, Non- PC9a, PC15
metal surface treatment products)
CS4: Consumer use (Ink and toners) PC18
CS5: Consumer use (Ink and toners) PC18
CS6: Consumer use (Polishes and wax blends) PC31

8.2. ES 8 Conditions of use affecting exposure

8.2.1 ES 8 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive indoor use of processing aids in open systems, Wide dispersive indoor use
resulting in inclusion into or onto a matrix, Wide dispersive outdoor use of processing
aids in open systems, Wide dispersive outdoor use resulting in inclusion into or onto
a matrix) (ERC8a, ERC8c, ERC8d, ERC8f)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 86(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

The use is assessed to be safe.

8.2.2 ES 8 - CS 2: Control of consumer exposure: Consumer use (Coatings and

paints, thinners, paint removers, Non-metal surface treatment products) (PC9a, PC15)

Remarks : Waterborne wall paint

Rolling, Brushing
No spraying

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Molecular weight : 45 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 1,25 kg/day

Frequency and duration of use

Application duration : 120 min
Frequency of use : 1 days per year
Remarks : Type of activity or process, light work
Exposure duration : 132 min

Human factors not influenced by risk management

Dermal exposure : Hands and forearms
Exposed skin surface assumed : 1900 cm²
Dermal exposure : 0,00003 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 20 m3
Temperature : 25 °C
Ventilation rate per hour : 0,6

Mass transfer rate : 0,331 m/min

Release area : 10 m2

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

8.2.3 ES 8 - CS 3: Control of consumer exposure: Consumer use (Coatings and

paints, thinners, paint removers, Non-metal surface treatment products) (PC9a, PC15)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 87(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Remarks : Spraying

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,0198 kg/min

Frequency and duration of use

Application duration : 15 min
Frequency of use : 2 days per year
Remarks : Type of activity or process, light work
Exposure duration : 15 min

Human factors not influenced by risk management

Dermal exposure : Hands and forearms
Exposed skin surface assumed : 1900 cm²
Dermal exposure : 0,0001 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 34 m3
Temperature : 25 °C
Ventilation rate per hour : 1,5

Room height : 2,25 m

Weight percent : 30 %
Remarks : Non-Volatile
Density : 1,5 g/cm3
Remarks : Non-Volatile
Airborne fraction : 100 %
Remarks : Non-Volatile
Non-respirable uptake fraction : 1
Inhalation cut-off diameter : 0,015 mm

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : Ensure spraying away from persons.

8.2.4 ES 8 - CS 4: Control of consumer exposure: Consumer use (Ink and toners)

(PC18)

Remarks : Refilling

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 88(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Molecular weight : 22 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amount per use : 0,05 kg

Frequency and duration of use

Application duration : 0,3 min
Frequency of use : 104 days per year
Remarks : Type of activity or process, light work
Exposure duration : 0,75 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Temperature : 25 °C
Ventilation rate per hour : 0,5

Mass transfer rate : 0,331 m/min

Release area : 20 cm²

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

8.2.5 ES 8 - CS 5: Control of consumer exposure: Consumer use (Ink and toners)

(PC18)

Remarks : Printing process

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
: 0,016 kg/day

Frequency and duration of use

Exposure duration : 600 min
Frequency of use : 365 days per year
Remarks : Type of activity or process, light work

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 25 m3
Temperature : 25 °C
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 89(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Ventilation rate per hour : 0,6

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

8.2.6 ES 8 - CS 6: Control of consumer exposure: Consumer use (Polishes and wax

blends) (PC31)

Remarks : No spraying

Product characteristics
Concentration of the Substance in : <= 2,5 %
Mixture/Article

Molecular weight : 272 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
: 0,55 kg/day

Frequency and duration of use

Application duration : 900 min
Frequency of use : 1 days per year
Release duration : 120 min
Exposure duration : 240 min

Human factors not influenced by risk management

Dermal exposure : Hand, or, Palm of both hands
Exposed skin surface assumed : 430 cm²
Dermal exposure : 0,00003 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 58 m3
Temperature : 25 °C
Ventilation rate per hour : 0,5

Mass transfer rate : 4740 m/min

Release area : 22 m2

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

8.3. ES 8 Exposure estimation and reference to its source

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 90(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

8.3.2 ES 8 - CS 2: Consumer exposure: Consumer use (Coatings and paints,

thinners, paint removers, Non-metal surface treatment products) (PC9a, PC15)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,72 mg/m³ (ConsExpo v4.1) 0,10
term - local and systemic
Consumer - dermal, long-term 2,77 mg/kg bw/day (ConsExpo v4.1) 0,05
- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,15
all exposure routes)

8.3.3 ES 8 - CS 3: Consumer exposure: Consumer use (Coatings and paints,

thinners, paint removers, Non-metal surface treatment products) (PC9a, PC15)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,26 mg/m³ (ConsExpo v4.1) 0,04
term - local and systemic
Consumer - dermal, long-term 1,15 mg/kg bw/day (ConsExpo v4.1) 0,02
- systemic
Consumer - oral, long-term - 0,13 mg/kg bw/day (ConsExpo v4.1, Risk management
systemic measures are based on qualitative risk characterisation.)
Human health (combined for ConsExpo v4.1 0,06
all exposure routes)

8.3.4 ES 8 - CS 4: Consumer exposure: Consumer use (Ink and toners) (PC18)

Route of exposure and type Exposure estimate RCR

of effects
Consumer - dermal, long-term 0,008 mg/kg bw/day (ConsExpo v4.1) 0,0002
- systemic

8.3.5 ES 8 - CS 5: Consumer exposure: Consumer use (Ink and toners) (PC18)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 1,29 mg/m³ (ConsExpo v4.1) 0,18
term - local and systemic

8.3.6 ES 8 - CS 6: Consumer exposure: Consumer use (Polishes and wax blends)

(PC31)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 91(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 3,93 mg/m³ (ConsExpo v4.1) 0,56
term - local and systemic
Consumer - dermal, long-term 2,12 mg/kg bw/day (ConsExpo v4.1) 0,04
- systemic
Human health (combined for ConsExpo v4.1 0,60
all exposure routes)

8.4. ES 8 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

9. ES 9: Industrial use; Use in cleaning agents

9.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of processing aids in processes and ERC4
products, not becoming part of articles)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Spraying in industrial settings and applications) PROC7
CS6: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS7: Industrial use (Transfer of substance or preparation PROC8b
(charging/discharging) from/to vessels/large containers at dedicated
facilities)
CS8: Industrial use (Roller application or brushing) PROC10
CS9: Industrial use (Treatment of articles by dipping and pouring) PROC13

9.2. ES 9 Conditions of use affecting exposure

9.2.1 ES 9 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of processing aids in processes and products, not becoming part of articles) (ERC4)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 92(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

Concentration of the Substance in : <= 100 %

Mixture/Article

9.2.2 ES 9 - CS 2: Control of worker exposure: Industrial use (Use in closed process,

no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.3 ES 9 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 93(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.4 ES 9 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 94(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.5 ES 9 - CS 5: Control of worker exposure: Industrial use (Spraying in industrial

settings and applications) (PROC7)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,6 L/min

Frequency and duration of use

Exposure duration : 360 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : > 1000 m3

Risk management measures

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 50 %
Note : Ensure that the direction of airflow is clearly away from the
worker.

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Regular cleaning of work area

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 95(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

prevent /limit releases, dispersion

and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.6 ES 9 - CS 6: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at non
dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.7 ES 9 - CS 7: Control of worker exposure: Industrial use (Transfer of substance

or preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 96(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Transfer of substance or preparation (charging/discharging)
from/to vessels/large containers at dedicated facilities
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.8 ES 9 - CS 8: Control of worker exposure: Industrial use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 97(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.2.9 ES 9 - CS 9: Control of worker exposure: Industrial use (Treatment of articles

by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

9.3. ES 9 Exposure estimation and reference to its source

9.3.2 ES 9 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 98(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

9.3.3 ES 9 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

9.3.4 ES 9 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

9.3.5 ES 9 - CS 5: Worker exposure: Industrial use (Spraying in industrial settings

and applications) (PROC7)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 9,79 mg/m³ (Stoffenmanager v4.0) 0,28
- local and systemic
Worker - dermal, long-term - 54,6 mg/kg bw/day (RISKOFDERM v2.1) 0,52
systemic
Human health (combined for Not applicable 0,80
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 99(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

9.3.6 ES 9 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

9.3.7 ES 9 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,43
all exposure routes)

9.3.8 ES 9 - CS 8: Worker exposure: Industrial use (Roller application or brushing)

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,77
all exposure routes)

9.3.9 ES 9 - CS 9: Worker exposure: Industrial use (Treatment of articles by dipping

and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 100(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

9.4. ES 9 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

10. ES 10: Professional use; Use in cleaning agents

10.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8d
systems, Wide dispersive outdoor use of processing aids in open
systems)
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2,
in closed, continuous process with occasional controlled exposure, Use PROC3
in closed batch process (synthesis or formulation))
CS3: Professional use (Use in batch and other process (synthesis) where PROC4
opportunity for exposure arises)
CS4: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS5: Professional use (Transfer of substance or preparation PROC8b
(charging/discharging) from/to vessels/large containers at dedicated
facilities)
CS6: Professional use (Roller application or brushing) PROC10
CS7: Professional use (Spraying outside industrial settings and/or PROC11
applications)
CS8: Professional use (Treatment of articles by dipping and pouring) PROC13

10.2. ES 10 Conditions of use affecting exposure

10.2.1 ES 10 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive indoor use of processing aids in open systems, Wide dispersive outdoor
use of processing aids in open systems) (ERC8a, ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 101(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

The use is assessed to be safe.

10.2.2 ES 10 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
occasional controlled exposure, Use in closed batch process (synthesis or
formulation)) (PROC1, PROC2, PROC3)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Technical conditions and : Use in closed batch process (synthesis or formulation)

measures With occasional controlled exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.3 ES 10 - CS 3: Control of worker exposure: Professional use (Use in batch and

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 102(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

other process (synthesis) where opportunity for exposure arises) (PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.4 ES 10 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 103(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Effectiveness (of a measure) : 80 %

Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.5 ES 10 - CS 5: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities) (PROC8b)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.6 ES 10 - CS 6: Control of worker exposure: Professional use (Roller application

or brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 104(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Exposure routes : Inhalation exposure

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.7 ES 10 - CS 7: Control of worker exposure: Professional use (Spraying outside

industrial settings and/or applications) (PROC11)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,05 L/min

Frequency and duration of use

Exposure duration : 150 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : <= 1000 m3

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 105(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Effectiveness (of a measure) : 80 %

Personal protective measures : Wear a respirator conforming to EN140 with type A filter or
better.
Effectiveness (of a measure) : 40 %

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that the direction of airflow is clearly away from the
prevent /limit releases, dispersion worker.
and exposure
Note : Not applicable

Organisational measures to : Provide enhanced general ventilation by mechanical means.

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Organisational measures to : Ensure that the task is not carried out by more than one
prevent /limit releases, dispersion worker simultaneously.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.2.8 ES 10 - CS 8: Control of worker exposure: Professional use (Treatment of

articles by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Concentration of the Substance in : <= 100 %

Mixture/Article

Physical Form (at time of use) : Low volatile liquid

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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 106(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

10.3. ES 10 Exposure estimation and reference to its source

10.3.2 ES 10 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure, Use in closed batch process (synthesis or formulation)) (PROC1, PROC2,
PROC3)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 107(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)

10.3.3 ES 10 - CS 3: Worker exposure: Professional use (Use in batch and other

process (synthesis) where opportunity for exposure arises) (PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,80
all exposure routes)

10.3.4 ES 10 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

10.3.5 ES 10 - CS 5: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation (charging/discharging) from/to
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 108(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

vessels/large containers at dedicated facilities

10.3.6 ES 10 - CS 6: Worker exposure: Professional use (Roller application or

brushing) (PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

10.3.7 ES 10 - CS 7: Worker exposure: Professional use (Spraying outside industrial

settings and/or applications) (PROC11)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 14,05 mg/m³ (Stoffenmanager v4.0) 0,40
- local and systemic
Worker - dermal, long-term - 53,75 mg/kg bw/day (RISKOFDERM v2.1) 0,51
systemic
Human health (combined for Not applicable 0,91
all exposure routes)

10.3.8 ES 10 - CS 8: Worker exposure: Professional use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Treatment of articles by dipping and pouring)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Treatment of articles by dipping and pouring)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Treatment 0,75
all exposure routes) of articles by dipping and pouring

10.4. ES 10 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 109(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

11. ES 11: Consumer use; Use in cleaning agents

11.1. Titles of Contributing scenarios (CS)

Washing and cleaning products (including solvent based products) (PC35)

Environment
CS1: Consumer use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8d
systems, Wide dispersive outdoor use of processing aids in open
systems)
Consumer
CS2: Consumer use (Washing and cleaning products (including solvent PC35
based products))
CS3: Consumer use (Washing and cleaning products (including solvent PC35
based products))
CS4: Consumer use (Washing and cleaning products (including solvent PC35
based products))
CS5: Consumer use (Washing and cleaning products (including solvent PC35
based products))
CS6: Consumer use (Washing and cleaning products (including solvent PC35
based products))
CS7: Consumer use (Washing and cleaning products (including solvent PC35
based products))

11.2. ES 11 Conditions of use affecting exposure

11.2.1 ES 11 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive indoor use of processing aids in open systems, Wide dispersive outdoor
use of processing aids in open systems) (ERC8a, ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

11.2.2 ES 11 - CS 2: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : No spraying
Default database: cleaning and washing/all purpose
cleaner/liquid/mixing and loading
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 110(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 20 %
Mixture/Article

Molecular weight : 22 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,5 kg/day

Frequency and duration of use

Application duration : 0,3 min
Frequency of use : 104 days per year
Remarks : Type of activity or process, light work
Exposure duration : 0,75 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Temperature : 25 °C
Ventilation rate per hour : 0,5

Mass transfer rate : 4740 m/min

Release area : 20 cm²

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

11.2.3 ES 11 - CS 3: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : No spraying
Application

Product characteristics
Concentration of the Substance in : <= 4 %
Mixture/Article

Molecular weight : 18 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,4 kg/day

Frequency and duration of use

Application duration : 20 min
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 111(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency of use : 104 days per year

Remarks : Type of activity or process, light work
Exposure duration : 240 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 58 m3
Temperature : 25 °C
Ventilation rate per hour : 0,5

Mass transfer rate : 4740 m/min

Release area : 10 m2

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

11.2.4 ES 11 - CS 4: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : Spray cleaners

Spraying

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,0468 kg/min

Frequency and duration of use

Spray duration : 0,41 min
Frequency of use : 365 days per year
Exposure duration : 60 min
Release duration : 2,6 s

Human factors not influenced by risk management

Dermal exposure : Hands and forearms
Exposed skin surface assumed : 1900 cm²
Dermal exposure : 0,000046 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 15 m3
Temperature : 25 °C
Ventilation rate per hour : 2,5
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 112(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Room height : 2,5 m

Weight percent : 5%
Remarks : Non-Volatile
Density : 1,8 g/cm3
Remarks : Non-Volatile
Airborne fraction : 20 %
Remarks : Non-Volatile
Non-respirable uptake fraction : 1
Inhalation cut-off diameter : 0,015 mm

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : Ensure spraying away from persons.

11.2.5 ES 11 - CS 5: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : Spray cleaners

Cleaning work

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Molecular weight : 22 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,0162 kg/day

Frequency and duration of use

Application duration : 10 min
Frequency of use : 365 days per year
Remarks : Type of activity or process, light work
Exposure duration : 60 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 15 m3
Temperature : 25 °C
Ventilation rate per hour : 2,5

Mass transfer rate : 4740 m/min

Release area : 17100 cm²

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 113(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Consumer Measures : No specific measures identified.

11.2.6 ES 11 - CS 6: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : Floor cleaning (liquids)

Mixing operations (open systems)
Loading of application equipment

Product characteristics
Concentration of the Substance in : <= 2,5 %
Mixture/Article

Molecular weight : 22 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,5 kg/day

Frequency and duration of use

Application duration : 0,3 min
Frequency of use : 104 days per year
Remarks : Type of activity or process, light work
Exposure duration : 0,75 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Temperature : 25 °C
Ventilation rate per hour : 1,0

Mass transfer rate : 4740 m/min

Release area : 20 cm²

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

11.2.7 ES 11 - CS 7: Control of consumer exposure: Consumer use (Washing and

cleaning products (including solvent based products)) (PC35)

Remarks : Floor cleaning (liquids)

Application

Product characteristics
Concentration of the Substance in : <= 2,5 %
Mixture/Article

Molecular weight : 18 g/mol

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 114(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,88 kg/day

Frequency and duration of use

Application duration : 30 min
Frequency of use : 104 days per year
Remarks : Type of activity or process, light work
Exposure duration : 240 min

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 58 m3
Temperature : 25 °C
Ventilation rate per hour : 0,5

Mass transfer rate : 4740 m/min

Release area : 22 m2

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

11.3. ES 11 Exposure estimation and reference to its source

11.3.2 ES 11 - CS 2: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,01 mg/m³ (ConsExpo v4.1) 0,001
term - local and systemic
Consumer - dermal, long-term 0,03 mg/kg bw/day (ConsExpo v4.1) 0,0006
- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,002
all exposure routes)

11.3.3 ES 11 - CS 3: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 115(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,61 mg/m³ (ConsExpo v4.1) 0,09
term - local and systemic
Consumer - dermal, long-term 11,70 mg/kg bw/day (ConsExpo v4.1) 0,22
- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,31
all exposure routes)

11.3.4 ES 11 - CS 4: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,000011 mg/m³ (ConsExpo v4.1)
term - local and systemic
Consumer - dermal, long-term 0,01 mg/kg bw/day (ConsExpo v4.1) 0,0002
- systemic
Consumer - oral, long-term - 0,0006 mg/kg bw/day (ConsExpo v4.1)
systemic
Human health (combined for ConsExpo v4.1 0,0002
all exposure routes)

11.3.5 ES 11 - CS 5: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,11 mg/m³ (ConsExpo v4.1) 0,02
term - local and systemic
Consumer - dermal, long-term 0,12 mg/kg bw/day (ConsExpo v4.1) 0,002
- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,02
all exposure routes)

11.3.6 ES 11 - CS 6: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,01 mg/m³ (ConsExpo v4.1) 0,001
term - local and systemic
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 116(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Consumer - dermal, long-term 0,04 mg/kg bw/day (ConsExpo v4.1) 0,0008

- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,002
all exposure routes)

11.3.7 ES 11 - CS 7: Consumer exposure: Consumer use (Washing and cleaning

products (including solvent based products)) (PC35)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,38 mg/m³ (ConsExpo v4.1) 0,05
term - local and systemic
Consumer - dermal, long-term 7,31 mg/kg bw/day (ConsExpo v4.1) 0,14
- systemic
Consumer - oral, long-term - ConsExpo v4.1, Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,19
all exposure routes)

11.4. ES 11 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

12. ES 12: Industrial use; Use in lubricants

12.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of processing aids in processes and ERC4, ERC7
products, not becoming part of articles, Industrial use of substances in
closed systems)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Spraying in industrial settings and applications) PROC7
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 117(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

CS7: Industrial use (Transfer of substance or preparation PROC8a

(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS8: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS9: Industrial use (Roller application or brushing) PROC10
CS10: Industrial use (Treatment of articles by dipping and pouring) PROC13
CS11: Industrial use (Lubrication at high energy conditions and in partly open PROC17, PROC18
process, Greasing at high energy conditions)

12.2. ES 12 Conditions of use affecting exposure

12.2.1 ES 12 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of processing aids in processes and products, not becoming part of articles, Industrial
use of substances in closed systems) (ERC4, ERC7)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

12.2.2 ES 12 - CS 2: Control of worker exposure: Industrial use (Use in closed

process, no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 118(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.3 ES 12 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.4 ES 12 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 119(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposed skin surface assumed : 240 cm²

Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.5 ES 12 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 120(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

12.2.6 ES 12 - CS 6: Control of worker exposure: Industrial use (Spraying in

industrial settings and applications) (PROC7)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,6 L/min

Frequency and duration of use

Exposure duration : 360 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : > 1000 m3

Risk management measures

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 50 %
Note : Ensure that the direction of airflow is clearly away from the
worker.

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 121(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.7 ES 12 - CS 7: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.8 ES 12 - CS 8: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 122(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.9 ES 12 - CS 9: Control of worker exposure: Industrial use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.10 ES 12 - CS 10: Control of worker exposure: Industrial use (Treatment of

articles by dipping and pouring) (PROC13)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 123(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.2.11 ES 12 - CS 11: Control of worker exposure: Industrial use (Lubrication at high

energy conditions and in partly open process, Greasing at high energy conditions)
(PROC17, PROC18)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 124(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Technical conditions and : Local exhaust ventilation

measures
Effectiveness (of a measure) : 90 %

Exposure routes : Dermal exposure

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %
Note : Lubrication at high energy conditions and in partly open
process

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

12.3. ES 12 Exposure estimation and reference to its source

12.3.2 ES 12 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

12.3.3 ES 12 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

12.3.4 ES 12 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 125(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

12.3.5 ES 12 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

12.3.6 ES 12 - CS 6: Worker exposure: Industrial use (Spraying in industrial settings

and applications) (PROC7)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 9,79 mg/m³ (Stoffenmanager v4.0) 0,28
- local and systemic
Worker - dermal, long-term - 54,6 mg/kg bw/day (RISKOFDERM v2.1) 0,52
systemic
Human health (combined for Not applicable 0,80
all exposure routes)

12.3.7 ES 12 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 126(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

12.3.8 ES 12 - CS 8: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

12.3.9 ES 12 - CS 9: Worker exposure: Industrial use (Roller application or brushing)

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,77
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 127(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

12.3.10 ES 12 - CS 10: Worker exposure: Industrial use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

12.3.11 ES 12 - CS 11: Worker exposure: Industrial use (Lubrication at high energy

conditions and in partly open process, Greasing at high energy conditions) (PROC17,
PROC18)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version, Lubrication at high energy conditions and in
partly open process)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version, Lubrication at high energy conditions and in
partly open process)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Lubrication 0,10
all exposure routes) at high energy conditions and in partly open process
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version, Greasing at high energy conditions)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version, Greasing at high energy conditions)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Greasing at 0,20
all exposure routes) high energy conditions

12.4. ES 12 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

13. ES 13: Industrial use; Metal working fluids

13.1. Titles of Contributing scenarios (CS)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 128(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Environment
CS1: Industrial use (Industrial use of processing aids in processes and ERC4
products, not becoming part of articles)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Spraying in industrial settings and applications) PROC7
CS7: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS8: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS9: Industrial use (Roller application or brushing) PROC10
CS10: Industrial use (Treatment of articles by dipping and pouring) PROC13
CS11: Industrial use (Lubrication at high energy conditions and in partly open PROC17
process)

13.2. ES 13 Conditions of use affecting exposure

13.2.1 ES 13 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of processing aids in processes and products, not becoming part of articles) (ERC4)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

13.2.2 ES 13 - CS 2: Control of worker exposure: Industrial use (Use in closed

process, no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 129(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.3 ES 13 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.4 ES 13 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 130(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.5 ES 13 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 131(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.6 ES 13 - CS 6: Control of worker exposure: Industrial use (Spraying in

industrial settings and applications) (PROC7)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,6 L/min

Frequency and duration of use

Exposure duration : 360 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : > 1000 m3

Risk management measures

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 50 %
Note : Ensure that the direction of airflow is clearly away from the
worker.

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 132(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.7 ES 13 - CS 7: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 133(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.8 ES 13 - CS 8: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.9 ES 13 - CS 9: Control of worker exposure: Industrial use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 134(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.10 ES 13 - CS 10: Control of worker exposure: Industrial use (Treatment of

articles by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.2.11 ES 13 - CS 11: Control of worker exposure: Industrial use (Lubrication at high

energy conditions and in partly open process) (PROC17)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

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ANTIFROGEN N Page 135(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Exposure duration : <= 480 min

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %

Exposure routes : Dermal exposure

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

13.3. ES 13 Exposure estimation and reference to its source

13.3.2 ES 13 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

13.3.3 ES 13 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 136(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

13.3.4 ES 13 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

13.3.5 ES 13 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

13.3.6 ES 13 - CS 6: Worker exposure: Industrial use (Spraying in industrial settings

and applications) (PROC7)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 9,79 mg/m³ (Stoffenmanager v4.0) 0,28
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according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 137(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

- local and systemic

Worker - dermal, long-term - 54,6 mg/kg bw/day (RISKOFDERM v2.1) 0,52
systemic
Human health (combined for Not applicable 0,80
all exposure routes)

13.3.7 ES 13 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

13.3.8 ES 13 - CS 8: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

13.3.9 ES 13 - CS 9: Worker exposure: Industrial use (Roller application or brushing)

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 138(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,77
all exposure routes)

13.3.10 ES 13 - CS 10: Worker exposure: Industrial use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

13.3.11 ES 13 - CS 11: Worker exposure: Industrial use (Lubrication at high energy

conditions and in partly open process) (PROC17)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version, Lubrication at high energy conditions and in
partly open process)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version, Lubrication at high energy conditions and in
partly open process)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Lubrication 0,10
all exposure routes) at high energy conditions and in partly open process

13.4. ES 13 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

14. ES 14: Professional use; Metal working fluids

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 139(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

14.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8d
systems, Wide dispersive outdoor use of processing aids in open
systems)
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2,
in closed, continuous process with occasional controlled exposure, Use PROC3
in closed batch process (synthesis or formulation))
CS3: Professional use (Mixing or blending in batch processes for formulation PROC5
of preparations and articles (multistage and/or significant contact))
CS4: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS5: Professional use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS6: Professional use (Roller application or brushing) PROC10
CS7: Professional use (Spraying outside industrial settings and/or PROC11
applications)
CS8: Professional use (Treatment of articles by dipping and pouring) PROC13
CS9: Professional use (Lubrication at high energy conditions and in partly PROC17
open process)

14.2. ES 14 Conditions of use affecting exposure

14.2.1 ES 14 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive indoor use of processing aids in open systems, Wide dispersive outdoor
use of processing aids in open systems) (ERC8a, ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

14.2.2 ES 14 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
occasional controlled exposure, Use in closed batch process (synthesis or
formulation)) (PROC1, PROC2, PROC3)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 140(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Technical conditions and : Use in closed batch process (synthesis or formulation)

measures With occasional controlled exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.3 ES 14 - CS 3: Control of worker exposure: Professional use (Mixing or

blending in batch processes for formulation of preparations and articles (multistage
and/or significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 141(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Dermal exposure : Palm of both hands

Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.4 ES 14 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.5 ES 14 - CS 5: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 142(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Concentration of the Substance in : <= 100 %

Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.6 ES 14 - CS 6: Control of worker exposure: Professional use (Roller application

or brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Exposure routes : Inhalation exposure

Technical conditions and : Local exhaust ventilation
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 143(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.7 ES 14 - CS 7: Control of worker exposure: Professional use (Spraying outside

industrial settings and/or applications) (PROC11)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,05 L/min

Frequency and duration of use

Exposure duration : 150 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : <= 1000 m3

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Personal protective measures : Wear a respirator conforming to EN140 with type A filter or
better.
Effectiveness (of a measure) : 40 %

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 144(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Organisational measures to : Ensure that the direction of airflow is clearly away from the
prevent /limit releases, dispersion worker.
and exposure
Note : Not applicable

Organisational measures to : Provide enhanced general ventilation by mechanical means.

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Organisational measures to : Ensure that the task is not carried out by more than one
prevent /limit releases, dispersion worker simultaneously.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.8 ES 14 - CS 8: Control of worker exposure: Professional use (Treatment of

articles by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 145(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.2.9 ES 14 - CS 9: Control of worker exposure: Professional use (Lubrication at

high energy conditions and in partly open process) (PROC17)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %

Exposure routes : Dermal exposure

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

14.3. ES 14 Exposure estimation and reference to its source

14.3.2 ES 14 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure, Use in closed batch process (synthesis or formulation)) (PROC1, PROC2,
PROC3)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 146(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)

14.3.3 ES 14 - CS 3: Worker exposure: Professional use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Mixing or blending in batch processes for
formulation of preparations and articles (multistage
and/or significant contact))
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,01
systemic modified version, Mixing or blending in batch processes
for formulation of preparations and articles (multistage
and/or significant contact))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Mixing or 0,75
all exposure routes) blending in batch processes for formulation of
preparations and articles (multistage and/or significant
contact)

14.3.4 ES 14 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 147(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

14.3.5 ES 14 - CS 5: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

14.3.6 ES 14 - CS 6: Worker exposure: Professional use (Roller application or

brushing) (PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 148(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

14.3.7 ES 14 - CS 7: Worker exposure: Professional use (Spraying outside industrial

settings and/or applications) (PROC11)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 14,05 mg/m³ (Stoffenmanager v4.0) 0,40
- local and systemic
Worker - dermal, long-term - 53,75 mg/kg bw/day (RISKOFDERM v2.1) 0,51
systemic
Human health (combined for Not applicable 0,91
all exposure routes)

14.3.8 ES 14 - CS 8: Worker exposure: Professional use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

14.3.9 ES 14 - CS 9: Worker exposure: Professional use (Lubrication at high energy

conditions and in partly open process) (PROC17)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

14.4. ES 14 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

15. ES 15: Professional use; Use in agrochemicals

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 149(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

15.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive indoor use of processing aids in open ERC8a, ERC8d
systems, Wide dispersive outdoor use of processing aids in open
systems)
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2
in closed, continuous process with occasional controlled exposure)
CS3: Professional use (Use in batch and other process (synthesis) where PROC4
opportunity for exposure arises)
CS4: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS5: Professional use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS6: Professional use (Spraying outside industrial settings and/or PROC11
applications)
CS7: Professional use (Treatment of articles by dipping and pouring) PROC13

15.2. ES 15 Conditions of use affecting exposure

15.2.1 ES 15 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive indoor use of processing aids in open systems, Wide dispersive outdoor
use of processing aids in open systems) (ERC8a, ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

15.2.2 ES 15 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
occasional controlled exposure) (PROC1, PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 150(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.2.3 ES 15 - CS 3: Control of worker exposure: Professional use (Use in batch and

other process (synthesis) where opportunity for exposure arises) (PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 151(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.2.4 ES 15 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.2.5 ES 15 - CS 5: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 152(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.2.6 ES 15 - CS 6: Control of worker exposure: Professional use (Spraying outside

industrial settings and/or applications) (PROC11)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,05 L/min

Frequency and duration of use

Exposure duration : 150 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : <= 1000 m3

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Personal protective measures : Wear a respirator conforming to EN140 with type A filter or
better.
Effectiveness (of a measure) : 40 %
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 153(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that the direction of airflow is clearly away from the
prevent /limit releases, dispersion worker.
and exposure
Note : Not applicable

Organisational measures to : Provide enhanced general ventilation by mechanical means.

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Organisational measures to : Ensure that the task is not carried out by more than one
prevent /limit releases, dispersion worker simultaneously.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.2.7 ES 15 - CS 7: Control of worker exposure: Professional use (Treatment of

articles by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 154(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

15.3. ES 15 Exposure estimation and reference to its source

15.3.2 ES 15 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure) (PROC1, PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure

15.3.3 ES 15 - CS 3: Worker exposure: Professional use (Use in batch and other

process (synthesis) where opportunity for exposure arises) (PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 155(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human health (combined for ECETOC TRA v2.0 worker; modified version 0,80
all exposure routes)

15.3.4 ES 15 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

15.3.5 ES 15 - CS 5: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

15.3.6 ES 15 - CS 6: Worker exposure: Professional use (Spraying outside industrial

settings and/or applications) (PROC11)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 156(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 14,05 mg/m³ (Stoffenmanager v4.0) 0,40
- local and systemic
Worker - dermal, long-term - 53,75 mg/kg bw/day (RISKOFDERM v2.1) 0,51
systemic
Human health (combined for Not applicable 0,91
all exposure routes)

15.3.7 ES 15 - CS 7: Worker exposure: Professional use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

15.4. ES 15 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

16. ES 16: Industrial use; Use in functional fluids

16.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Industrial use of substances in closed systems) ERC7
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS6: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 157(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

facilities, Transfer of substance or preparation into small containers

(dedicated filling line, including weighing))

16.2. ES 16 Conditions of use affecting exposure

16.2.1 ES 16 - CS 1: Control of environmental exposure: Industrial use (Industrial use
of substances in closed systems) (ERC7)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

16.2.2 ES 16 - CS 2: Control of worker exposure: Industrial use (Use in closed

process, no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

16.2.3 ES 16 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 158(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

16.2.4 ES 16 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 159(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

16.2.5 ES 16 - CS 5: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

16.2.6 ES 16 - CS 6: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 160(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Concentration of the Substance in : <= 100 %

Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa
Physical Form (at time of use) : Low volatile liquid
Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year
Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

16.3. ES 16 Exposure estimation and reference to its source

16.3.2 ES 16 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 161(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

16.3.3 ES 16 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

16.3.4 ES 16 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

16.3.5 ES 16 - CS 5: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 162(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

16.3.6 ES 16 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

16.4. ES 16 Guidance to Downstream User to evaluate whether he

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 163(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

works inside the boundaries set by the Exposure Scenario

ECHA guidance for downstream users
Section 2

17. ES 17: Professional use; Use in functional fluids

17.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive indoor use of substances in closed ERC9a, ERC9b
systems, Wide dispersive outdoor use of substances in closed systems )
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2,
in closed, continuous process with occasional controlled exposure, Use PROC3
in closed batch process (synthesis or formulation))
CS3: Professional use (Use in batch and other process (synthesis) where PROC4
opportunity for exposure arises)
CS4: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS5: Professional use (Transfer of substance or preparation into small PROC9
containers (dedicated filling line, including weighing))
CS6: Professional use (Heat and pressure transfer fluids in dispersive use but PROC20
closed systems)

17.2. ES 17 Conditions of use affecting exposure

17.2.1 ES 17 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive indoor use of substances in closed systems, Wide dispersive outdoor use
of substances in closed systems) (ERC9a, ERC9b)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

17.2.2 ES 17 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 164(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

occasional controlled exposure, Use in closed batch process (synthesis or

formulation)) (PROC1, PROC2, PROC3)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Technical conditions and : Use in closed batch process (synthesis or formulation)

measures With occasional controlled exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

17.2.3 ES 17 - CS 3: Control of worker exposure: Professional use (Use in batch and

other process (synthesis) where opportunity for exposure arises) (PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 165(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

17.2.4 ES 17 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

17.2.5 ES 17 - CS 5: Control of worker exposure: Professional use (Transfer of

substance or preparation into small containers (dedicated filling line, including
weighing)) (PROC9)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 166(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

17.2.6 ES 17 - CS 6: Control of worker exposure: Professional use (Heat and

pressure transfer fluids in dispersive use but closed systems) (PROC20)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 167(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

17.3. ES 17 Exposure estimation and reference to its source

17.3.2 ES 17 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure, Use in closed batch process (synthesis or formulation)) (PROC1, PROC2,
PROC3)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)

17.3.3 ES 17 - CS 3: Worker exposure: Professional use (Use in batch and other

process (synthesis) where opportunity for exposure arises) (PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,80
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 168(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

17.3.4 ES 17 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

17.3.5 ES 17 - CS 5: Worker exposure: Professional use (Transfer of substance or

preparation into small containers (dedicated filling line, including weighing)) (PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

17.3.6 ES 17 - CS 6: Worker exposure: Professional use (Heat and pressure transfer

fluids in dispersive use but closed systems) (PROC20)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,71 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,02
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,39
all exposure routes)

17.4. ES 17 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 169(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

18. ES 18: Consumer use; Heat transfer fluids, Hydraulic

fluids
18.1. Titles of Contributing scenarios (CS)

Heat transfer fluids (PC16)

Hydraulic fluids (PC17)
Environment
CS1: Consumer use (Wide dispersive indoor use of substances in closed ERC9a, ERC9b
systems, Wide dispersive outdoor use of substances in closed systems )
Consumer
CS2: Consumer use (Heat transfer fluids, Hydraulic fluids) PC16, PC17

18.2. ES 18 Conditions of use affecting exposure

18.2.1 ES 18 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive indoor use of substances in closed systems, Wide dispersive outdoor use
of substances in closed systems) (ERC9a, ERC9b)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

18.2.2 ES 18 - CS 2: Control of consumer exposure: Consumer use (Heat transfer

fluids, Hydraulic fluids) (PC16, PC17)

Remarks : Transfer of substance or preparation (charging/discharging)

from/to vessels/large containers at non dedicated facilities

Product characteristics
Concentration of the Substance in : <= 30 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : < 15 min
Remarks : Type of activity or process, light work
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 170(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Temperature : 25 °C

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

18.3. ES 18 Exposure estimation and reference to its source

18.3.2 ES 18 - CS 2: Consumer exposure: Consumer use (Heat transfer fluids,

Hydraulic fluids) (PC16, PC17)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 1,93 mg/m³ (ECETOC TRA v2.0 worker; modified 0,28
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
non dedicated facilities)
Worker - dermal, long-term - 4,11 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,08
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
non dedicated facilities)
Oral exposure Not applicable
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,36
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at non dedicated facilities

18.4. ES 18 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

19. ES 19: Professional use; Anti-freeze and de-icing

products
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 171(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

19.1. Titles of Contributing scenarios (CS)

Environment
CS1: Professional use (Wide dispersive outdoor use of processing aids in ERC8d
open systems)
Workers
CS2: Professional use (Use in closed process, no likelihood of exposure, Use PROC1, PROC2
in closed, continuous process with occasional controlled exposure)
CS3: Professional use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS4: Professional use (Transfer of substance or preparation PROC8b
(charging/discharging) from/to vessels/large containers at dedicated
facilities)
CS5: Professional use (Spraying outside industrial settings and/or PROC11
applications)

19.2. ES 19 Conditions of use affecting exposure

19.2.1 ES 19 - CS 1: Control of environmental exposure: Professional use (Wide
dispersive outdoor use of processing aids in open systems) (ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

19.2.2 ES 19 - CS 2: Control of worker exposure: Professional use (Use in closed

process, no likelihood of exposure, Use in closed, continuous process with
occasional controlled exposure) (PROC1, PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 172(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed process, no likelihood of exposure, Use in
closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in closed, continuous process with occasional controlled
exposure

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Technical conditions and : Use in closed, continuous process with occasional controlled
measures exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

19.2.3 ES 19 - CS 3: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 80 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 173(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Effectiveness (of a measure) : 80 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

19.2.4 ES 19 - CS 4: Control of worker exposure: Professional use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities) (PROC8b)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

19.2.5 ES 19 - CS 5: Control of worker exposure: Professional use (Spraying outside

industrial settings and/or applications) (PROC11)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,05 L/min

Frequency and duration of use

Exposure duration : 150 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 174(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : <= 1000 m3

Risk management measures

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Personal protective measures : Wear a respirator conforming to EN140 with type A filter or
better.
Effectiveness (of a measure) : 40 %

Organisational measures to : Ensure that direction of application is only horizontal or

prevent /limit releases, dispersion downward.
and exposure

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that the direction of airflow is clearly away from the
prevent /limit releases, dispersion worker.
and exposure
Note : Not applicable

Organisational measures to : Provide enhanced general ventilation by mechanical means.

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Organisational measures to : Ensure that the task is not carried out by more than one
prevent /limit releases, dispersion worker simultaneously.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 175(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

19.3. ES 19 Exposure estimation and reference to its source

19.3.2 ES 19 - CS 2: Worker exposure: Professional use (Use in closed process, no

likelihood of exposure, Use in closed, continuous process with occasional controlled
exposure) (PROC1, PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version, Use in closed process, no likelihood of exposure)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed process, no likelihood of exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,004
all exposure routes) closed process, no likelihood of exposure
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in closed, continuous process with
occasional controlled exposure)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version, Use in closed, continuous process with
occasional controlled exposure)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,38
all exposure routes) closed, continuous process with occasional controlled
exposure

19.3.3 ES 19 - CS 3: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,50
all exposure routes)

19.3.4 ES 19 - CS 4: Worker exposure: Professional use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,88 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 176(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

- local and systemic version, Transfer of substance or preparation

(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,80
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities

19.3.5 ES 19 - CS 5: Worker exposure: Professional use (Spraying outside industrial

settings and/or applications) (PROC11)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 14,05 mg/m³ (Stoffenmanager v4.0) 0,40
- local and systemic
Worker - dermal, long-term - 53,75 mg/kg bw/day (RISKOFDERM v2.1) 0,51
systemic
Human health (combined for Not applicable 0,91
all exposure routes)

19.4. ES 19 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario

20. ES 20: Consumer use; Anti-freeze and de-icing

products
20.1. Titles of Contributing scenarios (CS)

Anti-freeze and de-icing products (PC4)

Environment
CS1: Consumer use (Wide dispersive outdoor use of processing aids in open ERC8d
systems)
Consumer
CS2: Consumer use (Anti-freeze and de-icing products) PC4
CS3: Consumer use (Anti-freeze and de-icing products) PC4
CS4: Consumer use (Anti-freeze and de-icing products) PC4

20.2. ES 20 Conditions of use affecting exposure

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 177(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

20.2.1 ES 20 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive outdoor use of processing aids in open systems) (ERC8d)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

20.2.2 ES 20 - CS 2: Control of consumer exposure: Consumer use (Anti-freeze and

de-icing products) (PC4)

Remarks : De-icing of vehicles and similar equipment by spraying

Spraying

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,0468 kg/min

Frequency and duration of use

Spray duration : 0,7 min
Frequency of use : 365 days per year
Exposure duration : 240 min

Human factors not influenced by risk management

Dermal exposure : Hands and forearms
Exposed skin surface assumed : 1900 cm²
Dermal exposure : 0,000046 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 58 m3
Temperature : 25 °C
Ventilation rate per hour : 0,5

Room height : 2,5 m

Weight percent : 100 %
Remarks : Non-Volatile
Density : 1,8 g/cm3
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 178(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Remarks : Non-Volatile
Airborne fraction : 100 %
Remarks : Non-Volatile
Non-respirable uptake fraction : 1
Inhalation cut-off diameter : 0,015 mm

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : Ensure spraying away from persons.

20.2.3 ES 20 - CS 3: Control of consumer exposure: Consumer use (Anti-freeze and

de-icing products) (PC4)

Remarks : De-icing of vehicles and similar equipment by spraying

Cleaning work

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,00029 kg/day

Frequency and duration of use

Frequency of use : 365 days per year
Remarks : Type of activity or process, light work

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 215 cm²

Other given operational conditions affecting consumers exposure

Temperature : 25 °C

20.2.4 ES 20 - CS 4: Control of consumer exposure: Consumer use (Anti-freeze and

de-icing products) (PC4)

Product characteristics
Concentration of the Substance in : <= 30 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : < 15 min
Remarks : Type of activity or process, light work

Human factors not influenced by risk management

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 179(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Dermal exposure : Both hands

Exposed skin surface assumed : 960 cm²

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Temperature : 25 °C

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

20.3. ES 20 Exposure estimation and reference to its source

20.3.2 ES 20 - CS 2: Consumer exposure: Consumer use (Anti-freeze and de-icing

products) (PC4)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,0006 mg/m³ (ConsExpo v4.1) 0,0001
term - local and systemic
Consumer - dermal, long-term 0,50 mg/kg bw/day (ConsExpo v4.1) 0,009
- systemic
Consumer - oral, long-term - 0,005 mg/kg bw/day (ConsExpo v4.1)
systemic
Human health (combined for ConsExpo v4.1 0,009
all exposure routes)

20.3.3 ES 20 - CS 3: Consumer exposure: Consumer use (Anti-freeze and de-icing

products) (PC4)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- Not applicable
term - local and systemic
Consumer - dermal, long-term 4,46 mg/kg bw/day (ConsExpo v4.1) 0,08
- systemic
Consumer - oral, long-term - Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,08
all exposure routes)

20.3.4 ES 20 - CS 4: Consumer exposure: Consumer use (Anti-freeze and de-icing

products) (PC4)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 180(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 1,93 mg/m³ (ECETOC TRA v2.0 worker; modified 0,28
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
non dedicated facilities)
Worker - dermal, long-term - 4,11 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,08
systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
non dedicated facilities)
Oral exposure Not applicable
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,36
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at non dedicated facilities

20.4. ES 20 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario

21. ES 21: Industrial use, Professional use; Laboratory use

21.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use, Professional use (Wide dispersive indoor use of ERC8a
processing aids in open systems)
Workers
CS2: Industrial use, Professional use (Use as laboratory reagent) PROC15

21.2. ES 21 Conditions of use affecting exposure

21.2.1 ES 21 - CS 1: Control of environmental exposure: Industrial use, Professional
use (Wide dispersive indoor use of processing aids in open systems) (ERC8a)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 181(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

21.2.2 ES 21 - CS 2: Control of worker exposure: Industrial use, Professional use

(Use as laboratory reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

21.3. ES 21 Exposure estimation and reference to its source

21.3.2 ES 21 - CS 2: Worker exposure: Industrial use, Professional use (Use as

laboratory reagent) (PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

21.4. ES 21 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 182(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

ECHA guidance for downstream users

Section 2

22. ES 22: Industrial use; Use in water treatment agents

22.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Formulation in materials, Industrial use of processing ERC3, ERC4
aids in processes and products, not becoming part of articles )
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS6: Industrial use (Transfer of substance or preparation PROC8b
(charging/discharging) from/to vessels/large containers at dedicated
facilities)
CS7: Industrial use (Treatment of articles by dipping and pouring) PROC13

22.2. ES 22 Conditions of use affecting exposure

22.2.1 ES 22 - CS 1: Control of environmental exposure: Industrial use (Formulation
in materials, Industrial use of processing aids in processes and products, not
becoming part of articles) (ERC3, ERC4)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

22.2.2 ES 22 - CS 2: Control of worker exposure: Industrial use (Use in closed

process, no likelihood of exposure) (PROC1)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 183(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

22.2.3 ES 22 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 184(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

22.2.4 ES 22 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

22.2.5 ES 22 - CS 5: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 185(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

22.2.6 ES 22 - CS 6: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
dedicated facilities) (PROC8b)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Transfer of substance or preparation (charging/discharging)
from/to vessels/large containers at dedicated facilities
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 186(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

22.2.7 ES 22 - CS 7: Control of worker exposure: Industrial use (Treatment of articles

by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

22.3. ES 22 Exposure estimation and reference to its source

22.3.2 ES 22 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

22.3.3 ES 22 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 187(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

22.3.4 ES 22 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

22.3.5 ES 22 - CS 5: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 188(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

22.3.6 ES 22 - CS 6: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities) (PROC8b)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,43
all exposure routes)

22.3.7 ES 22 - CS 7: Worker exposure: Industrial use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

22.4. ES 22 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

23. ES 23: Consumer use; Adhesives, sealants

23.1. Titles of Contributing scenarios (CS)

Adhesives, sealants (PC1)

Environment
CS1: Consumer use (Wide dispersive indoor use resulting in inclusion into or ERC8c, ERC8f
onto a matrix, Wide dispersive outdoor use resulting in inclusion into or
onto a matrix)
Consumer
CS2: Consumer use (Adhesives, sealants) PC1
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 189(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

23.2. ES 23 Conditions of use affecting exposure

23.2.1 ES 23 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive indoor use resulting in inclusion into or onto a matrix, Wide dispersive
outdoor use resulting in inclusion into or onto a matrix) (ERC8c, ERC8f)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

23.2.2 ES 23 - CS 2: Control of consumer exposure: Consumer use (Adhesives,

sealants) (PC1)

Remarks : Worst case assumption

Mixing operations (open systems)
Loading of application equipment

Product characteristics
Concentration of the Substance in : <= 0,075 %
Mixture/Article

Molecular weight : 3.000 g/mol

Physical Form (at time of use) : Liquid
Vapour pressure : 0,123 hPa

Amount used
Amounts used : 9 kg/day

Frequency and duration of use

Application duration : 75 min
Frequency of use : 0,25 days per year
Exposure duration : 75 min

Human factors not influenced by risk management

Exposed skin surface assumed : 110 cm²
Dermal exposure : 0,00003 kg/min

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 58 m3
Temperature : 25 °C
Ventilation rate per hour : 0,5
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 190(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Mass transfer rate : 4740 m/min

Release area : 4 m2

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

23.3. ES 23 Exposure estimation and reference to its source

23.3.2 ES 23 - CS 2: Consumer exposure: Consumer use (Adhesives, sealants) (PC1)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 4,1 mg/m³ (ConsExpo v4.1) 0,59
term - local and systemic
Consumer - dermal, long-term 0,26 mg/kg bw/day (ConsExpo v4.1) 0,005
- systemic
Consumer - oral, long-term - Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,60
all exposure routes)

23.4. ES 23 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario

24. ES 24: Industrial use; Manufacture of substance,

Adhesives, sealants, Foaming, Coatings, Use in polymer
production
24.1. Titles of Contributing scenarios (CS)

Environment
CS1: Industrial use (Formulation of preparations, Formulation in materials, ERC2, ERC3, ERC5,
Industrial use resulting in inclusion into or onto a matrix, Industrial use of ERC6c
monomers for manufacture of thermoplastics)
Workers
CS2: Industrial use (Use in closed process, no likelihood of exposure) PROC1
CS3: Industrial use (Use in closed, continuous process with occasional PROC2
controlled exposure)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 191(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

CS4: Industrial use (Use in closed batch process (synthesis or formulation), PROC3, PROC4
Use in batch and other process (synthesis) where opportunity for
exposure arises)
CS5: Industrial use (Mixing or blending in batch processes for formulation of PROC5
preparations and articles (multistage and/or significant contact))
CS6: Industrial use (Spraying in industrial settings and applications) PROC7
CS7: Industrial use (Transfer of substance or preparation PROC8a
(charging/discharging) from/to vessels/large containers at non dedicated
facilities)
CS8: Industrial use (Transfer of substance or preparation PROC8b, PROC9
(charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing))
CS9: Industrial use (Roller application or brushing) PROC10
CS10: Industrial use (Treatment of articles by dipping and pouring) PROC13
CS11: Industrial use (Production of preparations or articles by tabletting, PROC14
compression, extrusion, pelettisation)
CS12: Industrial use (Use as laboratory reagent) PROC15

24.2. ES 24 Conditions of use affecting exposure

24.2.1 ES 24 - CS 1: Control of environmental exposure: Industrial use (Formulation
of preparations, Formulation in materials, Industrial use resulting in inclusion into or
onto a matrix, Industrial use of monomers for manufacture of thermoplastics) (ERC2,
ERC3, ERC5, ERC6c)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
The use is assessed to be safe.

24.2.2 ES 24 - CS 2: Control of worker exposure: Industrial use (Use in closed

process, no likelihood of exposure) (PROC1)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 192(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed process, no likelihood of exposure
measures Sample via a closed loop or other system to avoid exposure.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.3 ES 24 - CS 3: Control of worker exposure: Industrial use (Use in closed,

continuous process with occasional controlled exposure) (PROC2)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use in closed, continuous process with occasional controlled
exposure
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.4 ES 24 - CS 4: Control of worker exposure: Industrial use (Use in closed batch

process (synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 193(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of one hand
Exposed skin surface assumed : 240 cm²
Remarks : Use in closed batch process (synthesis or formulation)
Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
Remarks : Use in batch and other process (synthesis) where opportunity
for exposure arises

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Technical conditions and : Use in closed batch process (synthesis or formulation)
measures

Note : Use in batch and other process (synthesis) where opportunity

for exposure arises
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.5 ES 24 - CS 5: Control of worker exposure: Industrial use (Mixing or blending in

batch processes for formulation of preparations and articles (multistage and/or
significant contact)) (PROC5)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 194(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with specific activity training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.6 ES 24 - CS 6: Control of worker exposure: Industrial use (Spraying in

industrial settings and applications) (PROC7)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Amounts used : 0,6 L/min

Frequency and duration of use

Exposure duration : 360 min
Frequency of use : <= 5 days per week

Human factors not influenced by risk management

Dermal exposure : Whole body

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor
Room size : > 1000 m3

Risk management measures

Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 50 %
Note : Ensure that the direction of airflow is clearly away from the
worker.

Personal protective measures : Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Personal protective measures : Wear suitable working clothes.

Wear suitable coveralls to prevent exposure to the skin.
Effectiveness (of a measure) : 80 %

Organisational measures to : Ensure that the distance from worker to task is greater than 1
prevent /limit releases, dispersion m.
and exposure

Organisational measures to : Ensure that direction of application is only horizontal or

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 195(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

prevent /limit releases, dispersion downward.

and exposure

Organisational measures to : Regular cleaning of work area

prevent /limit releases, dispersion
and exposure

Organisational measures to : Regular cleaning of equipment

prevent /limit releases, dispersion
and exposure

Organisational measures to : Ensure regular inspection, cleaning and maintenance of

prevent /limit releases, dispersion equipment and machines.
and exposure

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.7 ES 24 - CS 7: Control of worker exposure: Industrial use (Transfer of

substance or preparation (charging/discharging) from/to vessels/large containers at
non dedicated facilities) (PROC8a)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Inhalation exposure
Technical conditions and : Local exhaust ventilation
measures
Effectiveness (of a measure) : 90 %
Personal protective measures : If technical exhaust or ventilation measures are not possible
or insufficient, respiratory protection must be worn.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.8 ES 24 - CS 8: Control of worker exposure: Industrial use (Transfer of

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 196(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

substance or preparation (charging/discharging) from/to vessels/large containers at

dedicated facilities, Transfer of substance or preparation into small containers
(dedicated filling line, including weighing)) (PROC8b, PROC9)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.9 ES 24 - CS 9: Control of worker exposure: Industrial use (Roller application or

brushing) (PROC10)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Both hands
Exposed skin surface assumed : 960 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 197(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

combination with ‘basic’ employee training.

Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.10 ES 24 - CS 10: Control of worker exposure: Industrial use (Treatment of

articles by dipping and pouring) (PROC13)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Exposure routes : Dermal exposure
Personal protective measures : Wear chemically resistant gloves (tested to EN374) in
combination with ‘basic’ employee training.
Effectiveness (of a measure) : 90 %

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.11 ES 24 - CS 11: Control of worker exposure: Industrial use (Production of

preparations or articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 480 cm²
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 198(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.2.12 ES 24 - CS 12: Control of worker exposure: Industrial use (Use as laboratory

reagent) (PROC15)

Product characteristics
Concentration of the Substance in : <= 100 %
Mixture/Article

Physical Form (at time of use) : Low volatile liquid

Vapour pressure : 0,123 hPa

Amount used
Storage : < 1 kg, < 1 l

Frequency and duration of use

Exposure duration : <= 480 min
Frequency of use : <= 240 days per year

Human factors not influenced by risk management

Dermal exposure : Palm of both hands
Exposed skin surface assumed : 240 cm²

Other operational conditions affecting workers exposure

Outdoor / Indoor : Indoor

Risk management measures

Note : Use as laboratory reagent
No specific measures identified.

Additional good practice advice beyond the REACH Chemical Safety Assessment
Additional good practice advice : Wear solely goggles.

24.3. ES 24 Exposure estimation and reference to its source

24.3.2 ES 24 - CS 2: Worker exposure: Industrial use (Use in closed process, no

likelihood of exposure) (PROC1)

Route of exposure and type Exposure estimate RCR

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 199(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

of effects
Worker - inhalative, long-term 0,03 mg/m³ (ECETOC TRA v2.0 worker; modified 0,0007
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,004
all exposure routes)

24.3.3 ES 24 - CS 3: Worker exposure: Industrial use (Use in closed, continuous

process with occasional controlled exposure) (PROC2)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,08
all exposure routes)

24.3.4 ES 24 - CS 4: Worker exposure: Industrial use (Use in closed batch process

(synthesis or formulation), Use in batch and other process (synthesis) where
opportunity for exposure arises) (PROC3, PROC4)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 7,76 mg/m³ (ECETOC TRA v2.0 worker; modified 0,22
- local and systemic version, Use in closed batch process (synthesis or
formulation))
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version, Use in closed batch process (synthesis or
formulation))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,23
all exposure routes) closed batch process (synthesis or formulation)
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Use in batch and other process (synthesis)
where opportunity for exposure arises)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Use in 0,43
all exposure routes) batch and other process (synthesis) where opportunity for
exposure arises

24.3.5 ES 24 - CS 5: Worker exposure: Industrial use (Mixing or blending in batch

processes for formulation of preparations and articles (multistage and/or significant
contact)) (PROC5)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 200(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,38
all exposure routes)

24.3.6 ES 24 - CS 6: Worker exposure: Industrial use (Spraying in industrial settings

and applications) (PROC7)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 9,79 mg/m³ (Stoffenmanager v4.0) 0,28
- local and systemic
Worker - dermal, long-term - 54,6 mg/kg bw/day (RISKOFDERM v2.1) 0,52
systemic
Human health (combined for Not applicable 0,80
all exposure routes)

24.3.7 ES 24 - CS 7: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at non dedicated
facilities) (PROC8a)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 2,59 mg/m³ (ECETOC TRA v2.0 worker; modified 0,07
- local and systemic version)
Worker - dermal, long-term - 13,71 mg/kg bw/day (ECETOC TRA v2.0 worker; 0,13
systemic modified version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,20
all exposure routes)

24.3.8 ES 24 - CS 8: Worker exposure: Industrial use (Transfer of substance or

preparation (charging/discharging) from/to vessels/large containers at dedicated
facilities, Transfer of substance or preparation into small containers (dedicated filling
line, including weighing)) (PROC8b, PROC9)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
dedicated facilities)
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 201(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

(charging/discharging) from/to vessels/large containers at

dedicated facilities)
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Worker - dermal, long-term - 6,86 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,06
systemic version, Transfer of substance or preparation into small
containers (dedicated filling line, including weighing))
Human health (combined for ECETOC TRA v2.0 worker; modified version, Transfer of 0,43
all exposure routes) substance or preparation into small containers (dedicated
filling line, including weighing)

24.3.9 ES 24 - CS 9: Worker exposure: Industrial use (Roller application or brushing)

(PROC10)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 2,74 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,77
all exposure routes)

24.3.10 ES 24 - CS 10: Worker exposure: Industrial use (Treatment of articles by

dipping and pouring) (PROC13)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 25,87 mg/m³ (ECETOC TRA v2.0 worker; modified 0,74
- local and systemic version)
Worker - dermal, long-term - 1,37 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,01
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,75
all exposure routes)

24.3.11 ES 24 - CS 11: Worker exposure: Industrial use (Production of preparations

or articles by tabletting, compression, extrusion, pelettisation) (PROC14)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 3,43 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,03
systemic version)
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 202(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

Human health (combined for ECETOC TRA v2.0 worker; modified version 0,40
all exposure routes)

24.3.12 ES 24 - CS 12: Worker exposure: Industrial use (Use as laboratory reagent)

(PROC15)

Route of exposure and type Exposure estimate RCR

of effects
Worker - inhalative, long-term 12,94 mg/m³ (ECETOC TRA v2.0 worker; modified 0,37
- local and systemic version)
Worker - dermal, long-term - 0,34 mg/kg bw/day (ECETOC TRA v2.0 worker; modified 0,003
systemic version)
Human health (combined for ECETOC TRA v2.0 worker; modified version 0,37
all exposure routes)

24.4. ES 24 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2

25. ES 25: Consumer use; Insulation foams

25.1. Titles of Contributing scenarios (CS)

Polymer preparations and compounds (PC32)

Environment
CS1: Consumer use (Wide dispersive indoor use resulting in inclusion into or ERC8c, ERC8f
onto a matrix, Wide dispersive outdoor use resulting in inclusion into or
onto a matrix)
Consumer
CS2: Consumer use (Polymer preparations and compounds) PC32

25.2. ES 25 Conditions of use affecting exposure

25.2.1 ES 25 - CS 1: Control of environmental exposure: Consumer use (Wide

dispersive indoor use resulting in inclusion into or onto a matrix, Wide dispersive
outdoor use resulting in inclusion into or onto a matrix) (ERC8c, ERC8f)

Remarks : As no environmental hazard was identified no environmental-

related exposure assessment and risk characterization was
performed.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 203(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

The use is assessed to be safe.

25.2.2 ES 25 - CS 2: Control of consumer exposure: Consumer use (Polymer

preparations and compounds) (PC32)

Product characteristics
Concentration of the Substance in : <= 5 %
Mixture/Article

Physical Form (at time of use) : Liquid

Vapour pressure : 0,123 hPa

Amount used
Amount per use : 0,825 kg

Frequency and duration of use

Exposure duration : 30 min
Frequency of use : 0,2 days per year

Human factors not influenced by risk management

Exposed skin surface assumed : 1900 cm²
Breathing volume : 1,5 m3/day

Other given operational conditions affecting consumers exposure

Outdoor / Indoor : Indoor
Room size : 57,5 m3
Temperature : 25 °C

Conditions and measures related to protection of consumer (e.g. behavioural advice,

personal protection and hygiene)
Consumer Measures : No specific measures identified.

25.3. ES 25 Exposure estimation and reference to its source

25.3.2 ES 25 - CS 2: Consumer exposure: Consumer use (Polymer preparations and

compounds) (PC32)

Route of exposure and type Exposure estimate RCR

of effects
Consumer- inhalative, long- 0,06 mg/m³ (ConsExpo v4.1) 0,009
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

ANTIFROGEN N Page 204(204)

Substance key: SXR024717 Revision Date: 02.02.2016
Version : 5 - 2 / EU Date of printing : 10.04.2017

term - local and systemic

Consumer - dermal, long-term 0,007 mg/kg bw/day (ConsExpo v4.1) 0,0008
- systemic
Consumer - oral, long-term - Not applicable
systemic
Human health (combined for ConsExpo v4.1 0,01
all exposure routes)

25.4. ES 25 Guidance to Downstream User to evaluate whether he

works inside the boundaries set by the Exposure Scenario
ECHA guidance for downstream users
Section 2