Overview of Treatment For Inguinal and Femoral Hernia in Adults
Overview of Treatment For Inguinal and Femoral Hernia in Adults
Author:
David C Brooks, MD
Section Editor:
Michael Rosen, MD
Deputy Editor:
Wenliang Chen, MD, PhD
Contributor Disclosures
All topics are updated as new evidence becomes available and our peer review
process is complete.
Literature review current through: Aug 2020. | This topic last updated: May 05, 2020.
The clinical features and diagnosis of an inguinal or femoral hernia, the technical
details of performing an inguinal or femoral hernia repair, the complications of hernia
repair, and the treatment of recurrent hernias are discussed separately in other topics.
(See "Classification, clinical features, and diagnosis of inguinal and femoral hernias in
adults" and "Open surgical repair of inguinal and femoral hernia in adults" and
"Laparoscopic inguinal and femoral hernia repair in adults" and "Overview of
complications of inguinal and femoral hernia repair" and "Recurrent inguinal and
femoral hernia".)
INDICATIONS FOR SURGICAL REPAIRThere was a time when the mere presence
of a groin hernia was a sufficient indication for surgical repair. Contemporary
practice, however, triages patients to surgery versus watchful waiting according to the
severity of symptoms and the type of hernia (inguinal versus femoral).
Femoral hernia — For all patients with a newly diagnosed femoral hernia, we suggest
elective surgical repair, rather than watchful waiting, regardless of the patient's sex
and symptoms. Femoral hernias are associated with a high risk of complications, and
therefore early elective surgical repair is indicated.
Femoral hernias are associated with a higher risk of developing complications than
inguinal hernias. In one study, the rates of strangulation were 22 and 45 percent at 3
and 21 months, respectively, for femoral hernias, compared with 2.8 and 4.5 percent
for inguinal hernias [4].
Thus, early elective repair is advised for patients with a newly diagnosed femoral
hernia to avoid complications that may necessitate urgent surgery. Urgent surgery for
complicated hernias is more likely to involve bowel resection, which is associated
with a higher mortality rate. In one study, for example, bowel resection was required
in 23 percent of urgent compared with 0.6 percent of elective femoral hernia repairs,
and urgent femoral hernia repairs were associated with a 10-fold increase in mortality
[5].
For patients who have a long-standing (>3 months) femoral hernia that is
asymptomatic, surgery is preferred, but observation is a reasonable option.
The only nonsurgical therapy for groin hernia in men is a truss. A truss is a strap
similar to an athletic supporter with a metal or hard plastic plug positioned to lie over
the hernia defect. When applied appropriately, the hard disc or plug exerts pressure to
keep the hernia contents in the abdomen. Although the use of a truss may be helpful
in certain situations, we generally discourage their use because there is insufficient
evidence to prove their efficacy [6,7]. In addition, inappropriate use of a truss may
harm abdominal contents in a hernia sac or complicate subsequent surgical repair [8].
●Inability to perform daily activities due to pain or discomfort from the hernia
●Inability to manually reduce the hernia (ie, chronic incarceration)
Historically, inguinal hernias were repaired once detected, under the assumption that
complications from unrepaired hernias were common and could increase operative
morbidity. However, three randomized trials to date have compared watchful waiting
with surgical repair of inguinal hernias [10-12] and demonstrated that delaying
surgical repair in asymptomatic patients was safe, as acute complications rarely
occurred (1.8 emergency operations/1000 patient-years). However, for 38 percent of
patients at three years [12], and about 70 percent of patients at 7 to 10 years [13,14],
surgical repair was required eventually because symptoms (usually pain) gradually
increased over time. This information is particularly important when counselling
young patients. Surgical outcomes of delayed repairs were not compromised
compared with immediate surgery.
Patients with inguinal hernias managed with watchful waiting should be counseled
about modifiable risk factors, including smoking cessation, medical optimization (eg,
diabetes), and weight loss. They should be told that there is no evidence that physical
activity will result in a hernia incarceration or clinical worsening of an existing hernia
[9]. Thus, there is no compelling reason for such patients to curtail beneficial physical
activities (eg, cardiovascular or aerobic exercises) out of concern for exacerbating the
hernia. Patients who opt for watchful waiting should seek prompt surgical evaluation
if they experience new-onset pain or discomfort with certain physical activities, or if
their hernia becomes acutely incarcerated (for those whose hernias were reducible).
For patients who cannot tolerate general anesthesia, inguinal or femoral hernias can
be repaired under local anesthesia using one of the open techniques. For patients with
an active groin infection or systemic sepsis, mesh placement is contraindicated, but
groin hernias can be repaired using nonmesh techniques when necessary. (See
"Wound infection following repair of abdominal wall hernia".)
Urgent hernia repair during pregnancy may be required if the patient develops severe
discomfort or one of the complications, such as acute incarceration, strangulation, or
bowel obstruction. In one study, such complications were rare and only accounted for
<5 percent of intestinal obstructions observed during pregnancy [20].
Thus, we perform an open hernia repair for patients who have had one or more
previous surgeries involving the preperitoneal space (eg, prostatectomy,
hysterectomy, cesarean section, or laparotomy via lower midline incision). Although
laparoscopic surgery is feasible in such patients (especially with the transabdominal
preperitoneal patch [TAPP] technique), it is technically challenging, requires a longer
operative time, and is associated with more complications than open surgery in such
patients [22,23].
Furthermore, in cases where bowel perforation has occurred due to bowel ischemia or
necrosis, the placement of mesh is contraindicated, thereby precluding a laparoscopic
repair. Open repair can be performed with or without mesh and therefore is the
preferred treatment for complicated hernias in which the risk of active infection or
contamination (from perforation) is high. (See 'Open techniques' below and "Wound
infection following repair of abdominal wall hernia".)
We also prefer to repair large scrotal hernias (>3 cm) with an open approach because
of the technical difficulty associated with managing and reducing a large hernia sac
laparoscopically [27].
Patients eligible for both open and laparoscopic repair — Patients who do not have a
history of prior preperitoneal surgery, ascites, or a complicated hernia are eligible for
both open and laparoscopic repairs of a groin hernia. The choice of the surgical
procedure then depends upon whether the hernia is primary or recurrent, unilateral or
bilateral, and femoral or inguinal.
Unilateral hernia
Open and laparoscopic approaches have been directly compared, most often in
inguinal hernia repairs. In general, laparoscopic repair has been associated with less
postoperative pain and quicker recovery but longer operative time and higher
recurrence rates [25,32-44]. Laparoscopic repair could also result in serious
complications (eg, massive pelvic bleeding) that would rarely occur during open
repairs.
●The largest trial randomly assigned 1983 men with inguinal hernias to receive open
or laparoscopic mesh repair at 1 of 14 United States Veterans Affairs Medical Centers
[45]. Patients treated laparoscopically had less pain on the day of surgery and at two
weeks and returned to work one day earlier. However, they suffered more
postoperative complications (39 versus 33.4 percent), life-threatening complications
(1.1 versus 0.1 percent), and hernia recurrences (10.1 versus 4.9 percent at two years).
In subgroup analysis, the difference in recurrence rate was significant for primary
(10.1 versus 4 percent), but not recurrent, hernias (10 versus 14 percent). This trial has
been criticized for higher than average rates of recurrences in both groups due to
surgeon inexperience, as well as for a patient population that is older (average age 58)
and less healthy (only 34 percent were American Society of Anesthesiologists class I)
than the average patient who needs inguinal hernia repair.
●A subsequent trial randomly assigned 389 patients with a primary unilateral inguinal
hernia to receive either open Lichtenstein repair under local anesthesia or
laparoscopic total extraperitoneal (TEP) repair under general anesthesia [46]. Fewer
patients in the laparoscopic group reported having persistent groin pain at one year
(21 versus 33 percent). However, this difference may not be clinically relevant, as
most patients reported mild pain (described as "can be easily ignored" on the
questionnaire); only a few patients in each group (2 percent in the laparoscopic versus
3 percent in open group) reported severe pain. In addition, fewer patients in the
laparoscopic group reported having groin pain that limited their ability to perform
physical exercise (3 versus 8 percent). The recurrence rates at one year were similarly
low in both groups (1 percent laparoscopic versus 2 percent open).
●Another trial (TEPLICH) randomly assigned 416 adults with primary inguinal
hernia to laparoscopic TEP repair versus Lichtenstein open repair [47]. At both one
and three years after surgery, patient satisfaction, groin pain, and recurrence rates
were similar between the two groups. Laparoscopic TEP repair had short-term
advantages of lower morbidity and faster recovery.
●Both hernias can be repaired through the same incisions, which improves cosmesis.
●A single large piece of mesh can be used with a laparoscopic TEP repair, reducing
costs and potentially the risk of direct hernia recurrence medially [52].
Patients with prior open repair — Many surgeons feel that recurrent hernias,
particularly those that recur after an anterior mesh repair, are best addressed via a
laparoscopic technique [34,38]. As with primary repairs, a laparoscopic repair of
recurrent hernias was also associated with faster recovery, less postoperative pain, and
fewer complications [38,56,59-61]. The NICE in the United Kingdom also advocates
laparoscopic repair for recurrent hernias [57].
Patients with prior laparoscopic repair — An open repair is required for patients with
a recurrent hernia if they have had a previous laparoscopic hernia repair (usually with
mesh placement) or other surgeries involving the preperitoneal space (eg,
prostatectomy, hysterectomy, cesarean section, or laparotomy via lower midline
incision). In such patients, the preperitoneal space may be difficult to access. (See
'Patients with prior surgery involving the preperitoneal space' above.)
Special considerations
Cost effectiveness — Studies have generally found an overall cost benefit for open, as
opposed to laparoscopic, hernia repair [62-66]. Factors considered in such studies
included the cost of operating room time and equipment (especially single-use items),
length of hospital stay, and the cost of treating potential complications. Variations in
one or more of these factors (eg, by using reusable equipment) could make
laparoscopic surgery more cost-effective [62].
For women who have had a prior surgery involving the preperitoneal space (eg,
cesarean section or hysterectomy), an open anterior mesh repair is the best option. In
others, a laparoscopic approach is preferred because it allows identification and repair
of occult hernias (especially femoral hernias).
Obtain informed consent — The risks and benefits of hernia repair versus watchful
waiting, including potential complications of each approach, should be reviewed with
the patient. In particular, the surgeon should inform the patient of a potential risk of
chronic groin pain or discomfort after groin hernia repair. If surgical repair is elected,
the risks and benefits of an open versus laparoscopic approach should also be
discussed with the patient. (See 'Choosing a surgical approach' above.)
The role of prophylactic antibiotics given prior to inguinal or femoral hernia repair
remains controversial [80-85]. Uncomplicated hernia surgery is considered clean
surgery, for which prophylactic antibiotics are not indicated. Some surgeons,
however, prefer to administer antibiotics to patients undergoing hernioplasty (ie,
hernia repair with mesh) to prevent potential mesh infection [85,86]. Others omit
routine prophylactic antibiotics because the risk of SSI after groin hernia surgery is
low, and most SSIs that occur are superficial and can be easily treated with oral
antibiotics. (See "Overview of complications of inguinal and femoral hernia repair",
section on 'Superficial incisional surgical site infection'.)
A 2020 Cochrane review found that prophylactic antibiotics had little or no effect on
elective open groin hernia repair in preventing wound infections in low-infection-risk
settings but may be beneficial in preventing superficial wound infections in high-
infection-risk settings [86].
Prophylactic antibiotics should cover the usual skin flora, including aerobic gram-
positive organisms, aerobic streptococci, staphylococci, and enterococci (table 2)
[87]. To be effective, prophylactic antibiotics must be administered within one hour
before the time of incision [88,89]. (See "Antimicrobial prophylaxis for prevention of
surgical site infection in adults" and "Antimicrobial prophylaxis for prevention of
surgical site infection following gastrointestinal procedures in adults".)
Anesthesia for open repair — We prefer to perform open groin hernia repair with
local anesthesia, especially in patients with comorbidities (eg, advanced liver disease).
In a randomized trial of 616 patients undergoing open inguinal hernia repairs, the use
of local anesthesia resulted in less postoperative pain and nausea, a shorter recovery
room stay (3.1 versus 6.2 and 6.2 hours), and fewer unplanned overnight admissions
(3 versus 14 and 22 percent), compared with the use of regional and general
anesthesia, respectively [90]. Another randomized trial of open inguinal hernia repairs
also found that local anesthesia resulted in less postoperative pain, a shorter operating
time, and fewer overnight stays than spinal anesthesia [92].
The main disadvantage of local anesthesia is that it may not provide adequate
anesthesia during the repair of large hernias, particularly in patients who have a loss
of abdominal domain. In such patients, general anesthesia is preferred. General
anesthesia can also be used in open hernia repair by patient or surgeon preference.
●Totally extraperitoneal (TEP) repairs are most often performed under general
anesthesia but can also be performed under spinal or epidural anesthesia.
Mortality — The 30-day mortality rate for inguinal or femoral hernia repair is 0.1
percent after elective surgery and 2.8 to 3.1 percent after urgent surgery [67,93,94].
The mortality rate is higher when bowel resection is performed with hernia repair
[95]. Other risk factors associated with a higher mortality rate include:
●Older age – Older patients have higher mortality rates after emergency hernia
repair. In one study, the mortality rates were 1, 5, and 16 percent, respectively, for
patients who were in their seventies, eighties, and nineties [94].
●Femoral hernia – Femoral hernia repairs are associated with higher mortality than
inguinal hernia repairs [5]. In one study, the 30-day standardized mortality ratios were
higher for femoral than inguinal hernia repairs in both men (6.81 and 1.29) and
women (7.16 versus 2.82) [95].
●Women – Women have higher mortality after groin hernia repair than men [5].
However, it is not clear if female sex is an independent risk factor, as women who
require groin hernia surgeries tend to be older, have more femoral hernias, and are
more likely to require emergency operations.
●Urgent/emergency surgery.
Here are the patient education articles that are relevant to this topic. We encourage
you to print or e-mail these topics to your patients. (You can also locate patient
education articles on a variety of subjects by searching on "patient info" and the
keyword(s) of interest.)
●Basics topics (see "Patient education: Inguinal and femoral (groin) hernias (The
Basics)")
●The definitive treatment of all hernias, regardless of origin or type, is surgical repair.
Inguinal/femoral hernia repair is one of the most commonly performed operations in
the world. (See 'Introduction' above.)
•For patients with newly diagnosed femoral hernia, we recommend elective repair,
rather than watchful waiting, regardless of symptoms (Grade 1B). In patients with
long-standing femoral hernias (>3 months), surgery is preferred, but observation is a
reasonable option. (See 'Femoral hernia' above.)
•Patients who have an inguinal hernia but minimal or no symptoms, who wish to
avoid surgery, can be managed with watchful waiting provided that they are
appropriately counseled to seek prompt medical attention should the hernia become
acutely incarcerated or more symptomatic. Although acute complications rarely
occurred (1.8 emergency operations/1000 patient-years), about 70 percent of patients
eventually required hernia repair at 7 to 10 years due to increasing symptoms (usually
pain). Trusses are associated with negative consequences and should not be used to
manage symptoms related to inguinal hernias. (See 'Asymptomatic hernia' above.)
●The surgical approach to groin hernia repair should be the one that the surgeon is
most comfortable with and most experienced in performing. For surgeons who are
equally facile with both open and laparoscopic repairs, the choice of a surgical
approach depends upon hernia and patient characteristics as follows (algorithm 1):
•We prefer an open approach for patients with prior surgery involving the
preperitoneal space (including laparoscopic groin hernia repair, prostatectomy,
hysterectomy, cesarean section, and laparotomy via lower midline incision),
complicated inguinal hernias (infected, incarcerated, strangulated, large scrotal),
ascites, or intolerance of general anesthesia. Laparoscopic repair is relatively
contraindicated in these patients. (See 'Patients precluded from laparoscopic repair'
above.)
•We prefer to repair a femoral hernia laparoscopically. (See 'Femoral hernia' above.)
•We prefer to repair a recurrent groin hernia with a laparoscopic approach if the initial
repair was open, but with an open approach if the initial repair was laparoscopic. (See
'Recurrent hernia' above.)
●For patients undergoing elective inguinal or femoral hernia repair requiring mesh
placement, we suggest using preoperative prophylactic antibiotics (Grade 2B). (See
'Antibiotics' above.)
●We prefer to perform open groin hernia repair under local anesthesia, especially in
patients with comorbidities (eg, advanced liver disease). Most laparoscopic repairs
require general anesthesia. (See 'Choice of anesthesia' above.)
REFERENCES
1. Rosenberg J, Bisgaard T, Kehlet H, et al. Danish Hernia Database
recommendations for the management of inguinal and femoral hernia in
adults. Dan Med Bull 2011; 58:C4243.
2. Bay-Nielsen M, Kehlet H, Strand L, et al. Quality assessment of 26,304
herniorrhaphies in Denmark: a prospective nationwide study. Lancet 2001;
358:1124.
3. Schumpelick V, Treutner KH, Arlt G. Inguinal hernia repair in adults. Lancet
1994; 344:375.
4. Gallegos NC, Dawson J, Jarvis M, Hobsley M. Risk of strangulation in groin
hernias. Br J Surg 1991; 78:1171.
5. Dahlstrand U, Wollert S, Nordin P, et al. Emergency femoral hernia repair: a
study based on a national register. Ann Surg 2009; 249:672.
6. McIntosh A, Hutchinson A, Roberts A, Withers H. Evidence-based
management of groin hernia in primary care--a systematic review. Fam Pract
2000; 17:442.
7. Cheek CM, Williams MH, Farndon JR. Trusses in the management of hernia
today. Br J Surg 1995; 82:1611.
8. Burns E, Whitley A. Trusses. BMJ 1990; 301:1319.
9. Montgomery J, Dimick JB, Telem DA. Management of Groin Hernias in
Adults-2018. JAMA 2018; 320:1029.
10. Fitzgibbons RJ Jr, Giobbie-Hurder A, Gibbs JO, et al. Watchful waiting vs
repair of inguinal hernia in minimally symptomatic men: a randomized clinical
trial. JAMA 2006; 295:285.
11. O'Dwyer PJ, Norrie J, Alani A, et al. Observation or operation for patients
with an asymptomatic inguinal hernia: a randomized clinical trial. Ann Surg
2006; 244:167.
12. de Goede B, Wijsmuller AR, van Ramshorst GH, et al. Watchful Waiting
Versus Surgery of Mildly Symptomatic or Asymptomatic Inguinal Hernia in
Men Aged 50 Years and Older: A Randomized Controlled Trial. Ann Surg
2018; 267:42.
13. Fitzgibbons RJ Jr, Ramanan B, Arya S, et al. Long-term results of a
randomized controlled trial of a nonoperative strategy (watchful waiting) for
men with minimally symptomatic inguinal hernias. Ann Surg 2013; 258:508.
14. Chung L, Norrie J, O'Dwyer PJ. Long-term follow-up of patients with a
painless inguinal hernia from a randomized clinical trial. Br J Surg 2011;
98:596.
15. Hurst RD, Butler BN, Soybel DI, Wright HK. Management of groin hernias in
patients with ascites. Ann Surg 1992; 216:696.
16. Hur YH, Kim JC, Kim DY, et al. Inguinal hernia repair in patients with liver
cirrhosis accompanied by ascites. J Korean Surg Soc 2011; 80:420.
17. Ochsenbein-Kölble N, Demartines N, Ochsenbein-Imhof N, Zimmermann R.
Cesarean section and simultaneous hernia repair. Arch Surg 2004; 139:893.
18. Buch KE, Tabrizian P, Divino CM. Management of hernias in pregnancy. J
Am Coll Surg 2008; 207:539.
19. Gabriele R, Conte M, Izzo L, Basso L. Cesarean section and hernia repair:
simultaneous approach. J Obstet Gynaecol Res 2010; 36:944.
20. Mayer IE, Hussain H. Abdominal pain during pregnancy. Gastroenterol Clin
North Am 1998; 27:1.
21. Prassas D, Rolfs TM, Knoefel WT, Krieg A. Meta-analysis of totally
extraperitoneal inguinal hernia repair in patients with previous lower
abdominal surgery. Br J Surg 2019; 106:817.
22. Wauschkuhn CA, Schwarz J, Bittner R. Laparoscopic transperitoneal inguinal
hernia repair (TAPP) after radical prostatectomy: is it safe? Results of
prospectively collected data of more than 200 cases. Surg Endosc 2009;
23:973.
23. Dulucq JL, Wintringer P, Mahajna A. Totally extraperitoneal (TEP) hernia
repair after radical prostatectomy or previous lower abdominal surgery: is it
safe? A prospective study. Surg Endosc 2006; 20:473.
24. Deeba S, Purkayastha S, Paraskevas P, et al. Laparoscopic approach to
incarcerated and strangulated inguinal hernias. JSLS 2009; 13:327.
25. McCormack K, Scott NW, Go PM, et al. Laparoscopic techniques versus open
techniques for inguinal hernia repair. Cochrane Database Syst Rev 2003;
:CD001785.
26. Kald A, Anderberg B, Carlsson P, et al. Surgical outcome and cost-
minimisation-analyses of laparoscopic and open hernia repair: a randomised
prospective trial with one year follow up. Eur J Surg 1997; 163:505.
27. Matthews RD, Anthony T, Kim LT, et al. Factors associated with
postoperative complications and hernia recurrence for patients undergoing
inguinal hernia repair: a report from the VA Cooperative Hernia Study Group.
Am J Surg 2007; 194:611.
28. Simons MP, Aufenacker T, Bay-Nielsen M, et al. European Hernia Society
guidelines on the treatment of inguinal hernia in adult patients. Hernia 2009;
13:343.
29. Society for Surgery of the Alimentary Tract. SSAT patient care guidelines.
Surgical repair of groin hernias. J Gastrointest Surg 2007; 11:1228.
30. Brooks DC. Laparoscopic herniorrhaphy: where are we now? Surg Endosc
1999; 13:321.
31. Köckerling F, Bittner R, Kofler M, et al. Lichtenstein Versus Total
Extraperitoneal Patch Plasty Versus Transabdominal Patch Plasty Technique
for Primary Unilateral Inguinal Hernia Repair: A Registry-based, Propensity
Score-matched Comparison of 57,906 Patients. Ann Surg 2019; 269:351.
32. Koning GG, Wetterslev J, van Laarhoven CJ, Keus F. The totally
extraperitoneal method versus Lichtenstein's technique for inguinal hernia
repair: a systematic review with meta-analyses and trial sequential analyses of
randomized clinical trials. PLoS One 2013; 8:e52599.
33. Yang J, Tong da N, Yao J, Chen W. Laparoscopic or Lichtenstein repair for
recurrent inguinal hernia: a meta-analysis of randomized controlled trials.
ANZ J Surg 2013; 83:312.
34. Dedemadi G, Sgourakis G, Radtke A, et al. Laparoscopic versus open mesh
repair for recurrent inguinal hernia: a meta-analysis of outcomes. Am J Surg
2010; 200:291.
35. Schmedt CG, Sauerland S, Bittner R. Comparison of endoscopic procedures
vs Lichtenstein and other open mesh techniques for inguinal hernia repair: a
meta-analysis of randomized controlled trials. Surg Endosc 2005; 19:188.
36. Bittner R, Sauerland S, Schmedt CG. Comparison of endoscopic techniques vs
Shouldice and other open nonmesh techniques for inguinal hernia repair: a
meta-analysis of randomized controlled trials. Surg Endosc 2005; 19:605.
37. Memon MA, Cooper NJ, Memon B, et al. Meta-analysis of randomized
clinical trials comparing open and laparoscopic inguinal hernia repair. Br J
Surg 2003; 90:1479.
38. Karthikesalingam A, Markar SR, Holt PJ, Praseedom RK. Meta-analysis of
randomized controlled trials comparing laparoscopic with open mesh repair of
recurrent inguinal hernia. Br J Surg 2010; 97:4.
39. Voyles CR, Hamilton BJ, Johnson WD, Kano N. Meta-analysis of
laparoscopic inguinal hernia trials favors open hernia repair with preperitoneal
mesh prosthesis. Am J Surg 2002; 184:6.
40. Grant AM, EU Hernia Trialists Collaboration. Laparoscopic versus open groin
hernia repair: meta-analysis of randomised trials based on individual patient
data. Hernia 2002; 6:2.
41. EU Hernia Trialists Collaboration. Laparoscopic compared with open methods
of groin hernia repair: systematic review of randomized controlled trials. Br J
Surg 2000; 87:860.
42. Hernandez-Rosa J, Lo CC, Choi JJ, et al. Laparoscopic versus open inguinal
hernia repair in octogenarians. Hernia 2011; 15:655.
43. Sajid MS, Bokhari SA, Mallick AS, et al. Laparoscopic versus open repair of
incisional/ventral hernia: a meta-analysis. Am J Surg 2009; 197:64.
44. Laparoscopic versus open repair of groin hernia: a randomised comparison.
The MRC Laparoscopic Groin Hernia Trial Group. Lancet 1999; 354:185.
45. Neumayer L, Giobbie-Hurder A, Jonasson O, et al. Open mesh versus
laparoscopic mesh repair of inguinal hernia. N Engl J Med 2004; 350:1819.
46. Westin L, Wollert S, Ljungdahl M, et al. Less Pain 1 Year After Total Extra-
peritoneal Repair Compared With Lichtenstein Using Local Anesthesia: Data
From a Randomized Controlled Clinical Trial. Ann Surg 2016; 263:240.
47. Gutlic N, Gutlic A, Petersson U, et al. Randomized clinical trial comparing
total extraperitoneal with Lichtenstein inguinal hernia repair (TEPLICH trial).
Br J Surg 2019; 106:845.
48. Lundström KJ, Holmberg H, Montgomery A, Nordin P. Patient-reported rates
of chronic pain and recurrence after groin hernia repair. Br J Surg 2018;
105:106.
49. Patterson TJ, Beck J, Currie PJ, et al. Meta-analysis of patient-reported
outcomes after laparoscopic versus open inguinal hernia repair. Br J Surg
2019; 106:824.
50. Bisgaard T, Bay-Nielsen M, Kehlet H. Re-recurrence after operation for
recurrent inguinal hernia. A nationwide 8-year follow-up study on the role of
type of repair. Ann Surg 2008; 247:707.
51. Waltz P, Luciano J, Peitzman A, Zuckerbraun BS. Femoral Hernias in Patients
Undergoing Total Extraperitoneal Laparoscopic Hernia Repair: Including
Routine Evaluation of the Femoral Canal in Approaches to Inguinal Hernia
Repair. JAMA Surg 2016; 151:292.
52. Ohana G, Powsner E, Melki Y, et al. Simultaneous repair of bilateral inguinal
hernias: a prospective, randomized study of single versus double mesh
laparoscopic totally extraperitoneal repair. Surg Laparosc Endosc Percutan
Tech 2006; 16:12.
53. O'Rourke A, Zell JA, Varkey-Zell TT, et al. Laparoscopic diagnosis and repair
of asymptomatic bilateral inguinal hernias. Am J Surg 2002; 183:15.
54. Sarli L, Iusco DR, Sansebastiano G, Costi R. Simultaneous repair of bilateral
inguinal hernias: a prospective, randomized study of open, tension-free versus
laparoscopic approach. Surg Laparosc Endosc Percutan Tech 2001; 11:262.
55. Krähenbühl L, Schäfer M, Schilling M, et al. Simultaneous repair of bilateral
groin hernias: open or laparoscopic approach? Surg Laparosc Endosc 1998;
8:313.
56. Mahon D, Decadt B, Rhodes M. Prospective randomized trial of laparoscopic
(transabdominal preperitoneal) vs open (mesh) repair for bilateral and
recurrent inguinal hernia. Surg Endosc 2003; 17:1386.
57. National Institute for Health and Clinical Excellence (NICE). Laparoscopic
surgery for inguinal hernia repair. NICE; 2004.
https://www.nice.org.uk/guidance/ta83 (Accessed on May 03, 2016).
58. Amid PK, Shulman AG, Lichtenstein IL. Simultaneous repair of bilateral
inguinal hernias under local anesthesia. Ann Surg 1996; 223:249.
59. Dedemadi G, Sgourakis G, Karaliotas C, et al. Comparison of laparoscopic
and open tension-free repair of recurrent inguinal hernias: a prospective
randomized study. Surg Endosc 2006; 20:1099.
60. Eklund A, Rudberg C, Leijonmarck CE, et al. Recurrent inguinal hernia:
randomized multicenter trial comparing laparoscopic and Lichtenstein repair.
Surg Endosc 2007; 21:634.
61. Kouhia ST, Huttunen R, Silvasti SO, et al. Lichtenstein hernioplasty versus
totally extraperitoneal laparoscopic hernioplasty in treatment of recurrent
inguinal hernia--a prospective randomized trial. Ann Surg 2009; 249:384.
62. Medical Research Council Laparoscopic Groin Hernia Trial Group.. Cost-
utility analysis of open versus laparoscopic groin hernia repair: results from a
multicentre randomized clinical trial. Br J Surg 2001; 88:653.
63. Payne JH Jr, Grininger LM, Izawa MT, et al. Laparoscopic or open inguinal
herniorrhaphy? A randomized prospective trial. Arch Surg 1994; 129:973.
64. Hynes DM, Stroupe KT, Luo P, et al. Cost effectiveness of laparoscopic
versus open mesh hernia operation: results of a Department of Veterans
Affairs randomized clinical trial. J Am Coll Surg 2006; 203:447.
65. Anadol ZA, Ersoy E, Taneri F, Tekin E. Outcome and cost comparison of
laparoscopic transabdominal preperitoneal hernia repair versus Open
Lichtenstein technique. J Laparoendosc Adv Surg Tech A 2004; 14:159.
66. Stylopoulos N, Gazelle GS, Rattner DW. A cost--utility analysis of treatment
options for inguinal hernia in 1,513,008 adult patients. Surg Endosc 2003;
17:180.
67. Koch A, Edwards A, Haapaniemi S, et al. Prospective evaluation of 6895
groin hernia repairs in women. Br J Surg 2005; 92:1553.
68. Nilsson E, Kald A, Anderberg B, et al. Hernia surgery in a defined population:
a prospective three year audit. Eur J Surg 1997; 163:823.
69. Bay-Nielsen M, Kehlet H. Inguinal herniorrhaphy in women. Hernia 2006;
10:30.
70. EU Hernia Trialists Collaboration. Repair of groin hernia with synthetic mesh:
meta-analysis of randomized controlled trials. Ann Surg 2002; 235:322.
71. Scott NW, McCormack K, Graham P, et al. Open mesh versus non-mesh for
repair of femoral and inguinal hernia. Cochrane Database Syst Rev 2002;
:CD002197.
72. EU Hernia Trialists Collaboration. Mesh compared with non-mesh methods of
open groin hernia repair: systematic review of randomized controlled trials. Br
J Surg 2000; 87:854.
73. Eklund AS, Montgomery AK, Rasmussen IC, et al. Low recurrence rate after
laparoscopic (TEP) and open (Lichtenstein) inguinal hernia repair: a
randomized, multicenter trial with 5-year follow-up. Ann Surg 2009; 249:33.
74. Zhao G, Gao P, Ma B, et al. Open mesh techniques for inguinal hernia repair:
a meta-analysis of randomized controlled trials. Ann Surg 2009; 250:35.
75. Amato B, Moja L, Panico S, et al. Shouldice technique versus other open
techniques for inguinal hernia repair. Cochrane Database Syst Rev 2009;
:CD001543.
76. Glassow F. The Shouldice Hospital technique. Int Surg 1986; 71:148.
77. Rutkow IM, Robbins AW. "Tension-free" inguinal herniorrhaphy: a
preliminary report on the "mesh plug" technique. Surgery 1993; 114:3.
78. Kugel RD. Minimally invasive, nonlaparoscopic, preperitoneal, and sutureless,
inguinal herniorrhaphy. Am J Surg 1999; 178:298.
79. Bittner R, Arregui ME, Bisgaard T, et al. Guidelines for laparoscopic (TAPP)
and endoscopic (TEP) treatment of inguinal hernia [International Endohernia
Society (IEHS)]. Surg Endosc 2011; 25:2773.
80. Mazaki T, Mado K, Masuda H, Shiono M. Antibiotic prophylaxis for the
prevention of surgical site infection after tension-free hernia repair: a Bayesian
and frequentist meta-analysis. J Am Coll Surg 2013; 217:788.
81. Sanabria A, Domínguez LC, Valdivieso E, Gómez G. Prophylactic antibiotics
for mesh inguinal hernioplasty: A meta-analysis. Ann Surg 2007; 245:392.
82. Li JF, Lai DD, Zhang XD, et al. Meta-analysis of the effectiveness of
prophylactic antibiotics in the prevention of postoperative complications after
tension-free hernioplasty. Can J Surg 2012; 55:27.
83. Aufenacker TJ, Koelemay MJ, Gouma DJ, Simons MP. Systematic review and
meta-analysis of the effectiveness of antibiotic prophylaxis in prevention of
wound infection after mesh repair of abdominal wall hernia. Br J Surg 2006;
93:5.
84. Moon V, Chaudry GA, Choy C, Ferzli GS. Mesh infection in the era of
laparoscopy. J Laparoendosc Adv Surg Tech A 2004; 14:349.
85. Yin Y, Song T, Liao B, et al. Antibiotic prophylaxis in patients undergoing
open mesh repair of inguinal hernia: a meta-analysis. Am Surg 2012; 78:359.
86. Orelio CC, van Hessen C, Sanchez-Manuel FJ, et al. Antibiotic prophylaxis
for prevention of postoperative wound infection in adults undergoing open
elective inguinal or femoral hernia repair. Cochrane Database Syst Rev 2020;
4:CD003769.
87. Sanchez VM, Abi-Haidar YE, Itani KM. Mesh infection in ventral incisional
hernia repair: incidence, contributing factors, and treatment. Surg Infect
(Larchmt) 2011; 12:205.
88. Fry DE. Surgical site infections and the surgical care improvement project
(SCIP): evolution of national quality measures. Surg Infect (Larchmt) 2008;
9:579.
89. Bratzler DW, Houck PM, Surgical Infection Prevention Guidelines Writers
Workgroup, et al. Antimicrobial prophylaxis for surgery: an advisory
statement from the National Surgical Infection Prevention Project. Clin Infect
Dis 2004; 38:1706.
90. Nordin P, Zetterström H, Gunnarsson U, Nilsson E. Local, regional, or general
anaesthesia in groin hernia repair: multicentre randomised trial. Lancet 2003;
362:853.
91. Young DV. Comparison of local, spinal, and general anesthesia for inguinal
herniorrhaphy. Am J Surg 1987; 153:560.
92. van Veen RN, Mahabier C, Dawson I, et al. Spinal or local anesthesia in
lichtenstein hernia repair: a randomized controlled trial. Ann Surg 2008;
247:428.
93. Abi-Haidar Y, Sanchez V, Itani KM. Risk factors and outcomes of acute
versus elective groin hernia surgery. J Am Coll Surg 2011; 213:363.
94. Arenal JJ, Rodríguez-Vielba P, Gallo E, Tinoco C. Hernias of the abdominal
wall in patients over the age of 70 years. Eur J Surg 2002; 168:460.
95. Nilsson H, Stylianidis G, Haapamäki M, et al. Mortality after groin hernia
surgery. Ann Surg 2007; 245:656.