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Elisabeth Johanne Rook: Curriculum Vitae

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141 views2 pages

Elisabeth Johanne Rook: Curriculum Vitae

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Abdullah The
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Curriculum Vitae

PERSONAL INFORMATION Elisabeth Johanne Rook


WORK EXPERIENCE

January 2019- Present COMP member


Medicine Evaluation Board (Netherlands)
member Committee for Orphan Medicinal Products, EMA

February 2004- Present Senior Clinical Assessor


Medicine Evaluation Board (Netherlands)
Senior Clinical Assessor in the field of :
Rheumatology- Immunology,
Addiction
Anaesthesiology
PK (including Modeling and Simulation)

EDUCATION AND TRAINING

February 2000-February 2004 PhD


Utrecht University/Slotervaart Hospital Amsterdam (Netherlands)
PhD project/clincial investigator Pk_PD diacetylmorphine in heroin addected patients

September 1984-May 1991 MD


Utrecht University (Netherlands)
MD

August 1998-September 1999 post-academic education


EMGO Institute VU Amsterdam (Netherlands)
epidemiology

ADDITIONAL INFORMATION

Expertise Rheumatology
Clinical Pharmacology (Modeling and Simulation)

Addiction (substance dependence and abuse)

Publications D. Da Silva, E.Rook, N. Semis-Costa, J. Mueller-Berghaus , R. Vesely, EUROPEAN MEDICINES


AGENCY'S GUIDELINE ON THE CLINICAL INVESTIGATION OF MEDICINAL PRODUCTS FOR
THE TREATMENT OF RHEUMATOID ARTHRITIS
http://dx.doi.org/10.1136/annrheumdis-2018-eular.6853
Yvette Weesie, Liset van Dijk, Liesbeth Rook, Lieke Sandberg- Smits, Bert Leufkens, Robert
Verheij, Karin Hek Trends in opioid prescribing in Dutch general practice Poster EUROPEAN DRUG
UTILISATION RESEARCH GROUP CONFERENCE 2017
E. Rook The Development of A New European Regulatory Guideline on The Clinical Investigation of
Medicinal Products for The Treatment of Gout
http://dx.doi.org/10.1136/annrheumdis-2016-eular.6124
Rook E, REVISION OF EUROPEAN MEDICINE AGENCYS (EMA) GUIDELINE ON CLINICAL
INVESTIGATION OF MEDICINAL PRODUCTS OTHER THAN NSAIDS FOR TREATMENT OF

19/12/2020 European Medicine Agency Page 1/2


RHEUMATOID ARTHRITIS, http://dx.doi.org/10.1136/annrheumdis-2016-eular.5721
A Staab, E Rook, M Maliepaard, L Aarons and C Benson,
Modeling and Simulation in Clinical Pharmacology and
Dose Finding
Pharmacometrics & Systems Pharmacology (2013) 2, e29
Rook EJ, Varenicline (Champix®) geregistreerd, Gebu 2007(mei);41:56-7
Rook EJ, Huitema AD, van den Brink W, van Ree JM, Beijnen JH. Pharmacokinetics and
pharmacokinetic variability of heroin and its metabolites: review of the literature. Curr Clin
Pharmacol. 2006 Jan;1(1):109-18. Review. PubMed PMID: 18666382.
Rook EJ, Huitema AD, van den Brink W, Hillebrand MJ, van Ree JM, Beijnen JH. Screening for illicit
heroin use in patients in a heroin-assisted treatment program. J Anal Toxicol. 2006
Jul-Aug;30(6):390-4. PubMed PMID: 16872571.
Rook EJ, van Zanten AP, Van den Brink W, van Ree JM, Beijnen JH. Mast cell mediator tryptase
levels after inhalation or intravenous administration of high doses pharmaceutically prepared heroin.
Drug Alcohol Depend. 2006 Dec 1;85(3):185-90. Epub 2006 Jun 12. PubMed PMID: 16765536.
Rook EJ, Huitema AD, van den Brink W, van Ree JM, Beijnen JH. Population pharmacokinetics of
heroin and its major metabolites. Clin Pharmacokinet. 2006;45(4):401-17. PubMed PMID:
16584286.
Rook EJ, van Ree JM, van den Brink W, Hillebrand MJ, Huitema AD, Hendriks VM, Beijnen JH.
Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by
intravenous or by inhalation route in opioid-dependent patients. Basic Clin Pharmacol Toxicol. 2006
Jan; 98(1):86-96. PubMed PMID: 16433897.
Rook EJ, Hillebrand MJ, Rosing H, van Ree JM, Beijnen JH. The quantitative analysis of heroin,
methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their
metabolites in human plasma by high-performance liquid chromatography coupled with tandem
mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):213-21.
PubMed PMID: 16103023.

Projects CBG-MEB workgroup opioids

Memberships EMA: member RIWP (Rheumatology Immunology Working Party)


Member Nederlandse Vereniging voor Reumatologie

Other Relevant Information

19/12/2020 European Medicine Agency Page 2/2

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