Reference List

Benign Prostatic Hyperplasia (BPH)

DEVICES: CYBER TM, CYBER HO, FIBER DUST

Many publications provide evidences of Thulium and Holmium laser as an ideal solution for the treatment of BPH.
Thulium and Holmium can be used to carry out different techniques (enucleation, vaporization and resection), showing
significant flexibility in use, safety and reliability. Our Cyber TM, Cyber Ho and Fiber Dust devices are commonly and
effectively used worldwide to treat patients diagnosed with BPH. The following publications deal with the use of
Cyber TM and Cyber Ho lasers:

Rodríguez Socarrás ME, Fernandez Del Alamo J, Llanes Gonzalez L, enucleation of the prostate in management of benign prostatic
Gomez Rivas J, Carrion D, Reinoso Elbers J, Cuadros Rivera V, Juarez hyperplasia: A randomized controlled trial. Int J Urol. 2020 Dec 16. doi:
Del Dago P, Gomez Sancha F; En Bloc laser enucleation technique using 10.1111/iju.14462. Epub ahead of print. PMID: 33327043.
Holmium pulse modulation (Virtual Basket and Bubble Blast effects), for
the treatment of Benign Prostatic Enlargement (BPE). 36th Annual EAU Alnoomani MN, Abdallah HM, Mourad MS, Tawfick A, Yassin MM;
Congress (EAU21), AM21-4758. Comparison of holmium laser enucleation prostatectomy and open
transvesical prostatectomy in large prostate more than 80 g in Egyptian
Gómez-Sancha F; The constant search for the greater good: evolving men: a randomized controlled trial. Egypt J Surg 2020;39:1088-94.
from TURP to anatomic enucleation of the prostate is a safe bet. World
J Urol. 2021 Feb 24. doi: 10.1007/s00345-021-03637-1. Bozzini G, Berti L, Aydoğan TB, Maltagliati M, Roche JB, Bove P, Besana
U, Calori A, Pastore AL, Müller A, Micali S, Sighinolfi MC, Rocco B,
Sayed S, Elshorbagy A, Mahmoud MA, Mostafa D; Holmium laser Buizza C; A prospective multicenter randomized comparison between
enucleation of the prostate vs monopolar transurethral resection of the Holmium Laser Enucleation of the Prostate (HoLEP) and Thulium Laser
prostate in management of benign prostatic hyperplasia. Egypt J Surg Enucleation of the Prostate (ThuLEP). World J Urol. 2020 Sep 30. doi:
2021;40:121-30. 10.1007/s00345-020-03468-6.

Kaya E, Yılmaz S, Açıkgöz O, Aybal HC, Yılmaz M, Gazel E, Yalcın S, Saredi G, Pacchetti A, Dotta F, et al; Early anterior detachment of the
Suarez-Ibarrola R, Tunc L; Laser enucleation for prostates larger than adenoma: a novel approach for en bloc thulium laser enucleation of the
100 mL: Comparison of HoLEP and ThuLEP. Andrologia. 2021 May prostate. www.ceju.online/journal/2020/thulium-laser-enucleation-of-
24:e14125. the-prostate-en-bloc-enucleation-2075.php ; 25 September, 2020 doi:
10.5173/ceju.2020.0204.
Vaccaro C et al; Thulium vaporization of the prostate: Postoperative
bleeding risk in new vs. old generation anticoagulant therapy. 36th Gazel E,Yilmaz M, Aybal HC, Kaya E,Yalcin S, Yilmaz S, Acikgoz O, Tunc L;
Annual EAU Congress (EAU21) - P0082. The Experiences of Thulium laser enucleation of the prostate (ThuLEP).
Maltagliati M et al; Post-enucleation morcellation procedure: Lights and Endourol Bull 2020;12(2); 99-107 e-ISSN:2148-0532, accepted: June
shadows. 36th Annual EAU Congress (EAU21) - P0069. 2020.

Higazy A, Tawfeek AM, Abdalla HM, Shorbagy AA, Mousa W, Radwan AI; Minagawa, S. & Okada, Shinsuke & Morikawa, H.. (2018); HoLEP
Holmium laser enucleation of the prostate versus bipolar transurethral performed using Quanta Litho low power laser with anteroposterior en

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Reference List

bloc technique. European Urology Supplements. 17. e1982. 10.1016/ Socarras ME, Proietti S, Luciano R, Scarfo F, Saitta G, Gaboardi F, Giusti
S1569-9056(18)32384-4. G; Thulium:YAG vs Holmium:YAG laser effect on soft tissue: evidence
from an ex vivo experimental study. Poster presented at WCE 2019
Bozzini G, Berti L, Maltagliati M, Besana U, Calori A, Müller A, Sighinolfi (Abu Dhabi); MP26‐21.
MC, Micali S, Pastore AL, Ledezma R, Broggini P, Rocco B, Buizza C;
Ejaculation-sparing thulium laser enucleation of the prostate (ES- Castellani D, Pirola GM, Gasparri L, Pucci M, Rosa MD, Carcano G,
ThuLEP): outcomes on a large cohort. World J Urol. 2020;10.1007/ Saredi G, Dellabella M; Are outcomes of Thulium Laser Enucleation of
s00345-020-03442-2. the Prostate different in men aged 75 and over? A propensity score
analysis. Urology. 2019 Jun 25. pii: S0090-4295(19)30568-0.
Bozzini G, Maltagliati M, Besana U, Berti L, Calori A, Sighinolfi MC,
Micali S, Roche JB, Gozen A, Mueller A, Pushkar D, Liatsikos E, Boldini Maruccia S, Kinzikeeva E, Spiga P, Pastore A, Cacace G, Casellato S;
M, Buizza C, Rocco B; Holmium Laser Enucleation of the Prostate With Economic impact of the introduction of laser surgery in the treatment
Virtual Basket Mode: Faster and Better Control on Bleeding. of benign prostatic hyperplasia. AUA 2019; MP01-18.
BMC Urology (https://doi.org/10.21203/rs.3.rs-55897/v1).
Giordano S, Bozzini G, Coman I, Besana U, Turno Chisena SA, Buizza C;
Proietti S, Rodríguez-Socarrás ME, Eisner BH, Lucianò R, Basulto Martinez BBP Larger Than 150 Cc: Outcomes Reached With Thulep. The Journal
MJ, Yeow Y, Rapallo I, Saitta G, Scarfò F, Gaboardi F, Giusti G; Thulium:YAG of Urology 201(4S), May 2019 -MP45-03 (e638).
Versus Holmium:YAG Laser Effect on Upper Urinary Tract Soft Tissue:
Evidence from an Ex Vivo Experimental Study. J Endourol. 2020. Giordano S, Coman I, Besana U, Calori A, Buizza C, Bozzini G;
Ejaculation sparing thulium laser enucleation of the Prostate (es-
Nazzani S, Blezien O, Motta G, Molinari F, Signorini C, Ratti D, Acquati thulep): outcomes on a large cohort. The Journal of Urology, 201(4s),
P, Stubinski R, Picozzi S, Carmignani L; Energy Impact On Storage May 4, 2019 - MP27-07.
Symptoms After Thulium Enucleation Of Prostate: A Large Multi
Institutional Analysis. The Journal Of Urology, May 2020; Vol. 203 (4S), Bozzini G, Roche JB, Besana U, Romero Otero J, Gastaldi C, Calori A,
MP32-17 (e491). Buizza C; Thulium laser enucleation (ThuLEP) versus Holmium laser
enucleation of the prostate (HoLEP): A two institution trial to compare
Bozzini G, Berti L, Besana U, Calori A, Antonelli D, Malvestiti G, Sighinolfi intra and early postoperative outcomes. EAU Supplements, March
C, Rocco B, Buizza C; Prognostic factors predicting late bleeding after 2019, 18(1), e1913.
ThuLEP. 35th Annual EAU Congress- PT329.
Sarma D, Singh Y, Baruah SJ, Rajeev TP, Barua SK, Bagchi PK, Phukan
Bozzini G, Besana U, Calori A, Berti L, Maltagliati M, Sighinolfi MC, Micali M, Kashyap MP; Thulium laser vaporization versus vapoenucleation
S, Govorov A, Pushkar D, Liatsikos E, Gozen AS, Rocco B, Buizza C; (without Morcellation) technique for bph: do we have a winner? J
7U-Thulium Laser Enucleation of the Prostate (7U-ThuLEP): description Endolum Endourol Vol 2(1):e24-e36; February 15, 2019.
of the technique (with video). Urology Video Journal, Volume 7, 2020,
100036. Carmignani L, Clementi MC, Signorini C, Motta G, Nazzani S, Palmisano
F, De Lorenzi E, Catellani M, Mistretta A, Conti FA, Tringali V, MB Costa,
Sarma D, Singh Y, Baruah SJ, Rajeev TP, Barua SK, Bagchi PK, Phukan Vizziello D; Safety and feasibility of thullium laser transurethral resection
M, Kashyap MP; Thulium laser vaporization versus vapoenucleation of prostate for the treatment of benign prostatic enlargement in
(without Morcellation) technique for bph: do we have a winner? overweight patients. Asian Journal of Urology; 6(3) July 2019, Pp. 270-
J Endolum Endourol Vol 2(1):e24-e36; February 15, 2019. 274.

Vartak KP, Raghuvanshi K; Outcome of thulium laser enucleation of Saredi G, Pirola GM, Ambrosini F, Barbieri S, Berti L, Pacchetti A,
prostate surgery in high-risk patients with benign prostatic hyperplasia. Iovino D, Ietto G, Libassi L, Carcano G; Feasibility of En Bloc Thulium
Urol Ann. 2019 Oct-Dec; 11(4): 358–362. Laser Enucleation of the Prostate in a Large Case Series. Are Results
Enhanced by Experience? PII: S2214-3882(19)30006-2.

2 QS - Surgery Reference List - Jul 2021

Reference List

Chang CH, Lin TP, Huang JY; Safety and effectiveness of high-power Carmignani L, Motta G, Signorini C, Vizziello D, Ratti D, Picozzi S;
thulium laser enucleation of the prostate in patients with glands larger Comparison of the urinary outcomes of ThuVAP in two groups of
than 80 mL. BMC Urol. 2019 Jan 21;19(1):8. patients with a prostate volume <80ml and >80ml (preliminary data).
WCE 2017 abstract, Vancouver 12-16 Sept.; MP30-7.
Pacchetti A, Pirola GM, Berti L, Palumbo M, Ietto G, Carcano G, Terrone
C, Saredi G; En Bloc Thulium Laser Enucleation of the Prostate: a step- Carmignani L, Vizziello D, Clementi MC, Conti A, De Lorenzis E, Acquati
by-step guide to improve enucleation time and efficiency for endoscopic P; Safety and Feasibility of Thulium laser transurethral resection of
enucleation of prostatic adenoma. Urology. 2019 Feb;124:307. prostate for benign prostatic enlargement surgery in overweight and
obese patients. WCE 2017 abstract, Vancouver 12-16 Sept.; MP30-6.
Carmignani L, Picozzi SC, Vizziello D, Finkelberg E, Ratti D, Stubinski R,
Acquati P, Manfredi M, Motta G, Clementi MC, Signorini C, Blezien O, Carmignani L, Signorini C, Clementi MC, Vizziello D, Motta G, Nazzani S,
Maruccia S; Thulium Laser Prostate Enucleation In Refractory Urinary Picozzi S, Stubinski R; Benign prostatic hyperplasia in octuagenarians: a
Retention: Operative And Functional Outcomes In A Large Cohort Of thulium laser vaporization experience. WCE 2017 abstract, Vancouver
Patients (Mid-Term Results). WCE 2018 (Paris); MP11-22. 12-16 Sept.; MP30-5.

Carmignani L, Picozzi SC, Vizziello D, Finkelberg E, Ratti D, Stubinski R, Carmignani L, Motta G, Signorini C, Vizziello D, Ratti D, Picozzi S,
Acquati P, Manfredi M, Motta G, Clementi MC, Signorini C, Blezien O, Marenghi C, Clementi MC, Nazzani S; Is preoperative urinary flow a
Nazzani S; Predictive factors of Acute urinary retention after thulium predictive value of postoperative acute urinary retention rate? WCE
prostate surgery for bladder outlet obstruction. WCE 2018 (Paris); 2017 abstract, Vancouver 12-16 Sept.; MP29-1.
UP3-28.
Carmignani L, Nazzani S, Motta G, Clementi MC, Signorini C, Acquati P,
Vizziello D, Clementi MC, Motta G, Signorini C, Nazzani S, Blezien O, Marenghi C, Vizziello D; Sexual outcomes of thulium laser ejaculation-
Ratti D, Finkelberg E, Acquati P, Carmignani L; Severe storage symptoms sparing surgery (TES) for benign prostatic hyperplasia. WCE 2017
improvement in men with LUTS treated with thulium laser enucleation abstract, Vancouver 12-16 Sept.; MP25-16.
and vaporization. WCE 2018 (Paris).
Carmignani L, Nazzani S, Motta G, Clementi MC, Signorini C, Acquati
Pirola GM, Saredi G, Duarte RC, Bernard L, Pacchetti A, Berti L, P, Marenghi C, Vizziello D; Postoperative complications in 400 patients
Martorana E, Carcano G, Badet L, Fassi-Fehri H; Holmium laser versus undergone endoscopic prostatic surgery with Thulium laser. WCE 2017
thulium laser enucleation of the prostate: a matched-pair analysis from abstract, Vancouver 12-16 Sept.; MP24-13.
two centers. Therapeutic Advances in Urology (2018), pp. 1-11.
Saredi G, Pacchetti A, Pirola GM, Berti L, Ambrosini F, Martorana E,
Castellani D, Saredi G, Pirola GM, Gasparri L, Pavia MP, Ambrosini F, Berti Marconi AM; En-Bloc Thulium Laser Enucleation of the Prostate:
L, Sembenini F, Dellabella M; Comparison between two different en bloc Surgical Technique and Advantages Compared with the Classical
Thulium laser enucleation of the prostate: does technique influence Technique. Urology. 2017 Oct;108:207-211.
complications and outcomes? Urology. 2018 Sep;119:121-126.
Palmero-Martí JL, Panach-Navarrete J, Valls-González L, Ganau-Ituren
Carmignani L, Motta G, Signorini C, Vizziello D, Ratti D, Picozzi S, A, Miralles-Aguado J, Benedicto-Redón A; Comparative study between
Marenghi C, Clementi MC, Nazzani S, Stubinski R; Can thulium thulium laser (Tm: YAG) 150W and greenlight laser (LBO:ND-YAG)
vaporization of the prostate be considered as safe and effective 120W for the treatment of benign prostatic hyperplasia: Short-term
as thulium vapoenucleation also for prostates larger than 80 ml? efficacy and security. Actas Urol Esp. 2017 Apr;41(3):188-193.
Preliminary results from a single institution. WCE 2017 abstract,
Vancouver 12-16 Sept.; MP30-10. Bozzini G, Seveso M, Melegari S, de Francesco O, Buffi NM, Guazzoni
G, Provenzano M, Mandressi A, Taverna G; Thulium laser enucleation
Carmignani L, Clementi MC, Nazzani S, Vizziello D, Finkelberg E, (ThuLEP) versus transurethral resection of the prostate in saline
Signorini C, Maruccia S, Motta G; Thulium laser vaporization: how many (TURis): A randomized prospective trial to compare intra and early
grams per minute? WCE 2017 abstract, Vancouver 12-16 Sept.; MP30-9. postoperative outcomes. Actas Urol Esp. 2017;41(5):309-315.

QS - Surgery Reference List - Jul 2021 3

Reference List

Carmignani L, Pastore A, Picozzi S, Vizziello D, Finkelberg E, Ratti D, Impact of Thuvep/Thuvap on sexual outcomes. The Journal of Urology
Schirinzi M, Saccà A, Pisano F, Maruccia S; Thulium laser prostate (2016), Volume 195 , Issue 4 , e576 - e577.
enucleation in refractory urinary retention: Operative and functional
outcomes in a large cohort of patients. Eur Urol Suppl 2017; 16(3);e516. Chang CH, Lin TP, Chang YH, Huang WJS, Lin ATL, Chen KK;
Vapoenucleation of the prostate using a high-power thulium laser: a
Bozzini G, Casellato S, Maruccia S, Saredi G, Parma P, Taverna G; one-year follow-up study. BMC Urology 2015, 15:40.
Thulium laser enucleation (ThuLEP) versus transurethral resection of the
prostate in saline (TURiS): a randomized prospective trial to compare Carmignani L, Bozzini G, Macchi A, Maruccia S, Picozzi S, Casellato S;
costs per procedure. April 2017 197(4), Supplement, e448. Sexual outcome of patients undergoing thulium laser enucleation of the
prostate for benign prostatic hyperplasia. Asian Journal of Andrology
Pearce SM, Pariser JJ, Malik RD, Famakinwa OJ, Chung DE; Outcomes 2015 Sep-Oct; 17(5):802-806.
following Thulium vapoenucleation of large prostates. Int Braz J Urol.
2016 Jul-Aug;42(4):757-65. Carmignani L, Macchi A, Ratti D, Finkelberg E, Casellato S, Bozzini G,
Maruccia S, Marenghi C, Picozzi S; Are Histological Findings of Thulium
Saredi G, Pacchetti A, Pirola GM, Martorana E, Berti L, Scroppo FI, Laser Vapo-Enucleation Versus Transurethral Resection of the Prostate
Marconi AM; Impact of Thulium Laser Enucleation of the Prostate on Comparable? Pathology & Oncology Research (September 2015), 21(4),
Erectile, Ejaculatory and Urinary Functions. Urol Int. 2016; 97(4):397-401. pp 1071-1075.

Carmignani L, Pastore AL, Picozzi SCM, Finkelberg E, Ratti D, Vizziello Saredi G, Pirola G, Pacchetti A, Lovisolo JA, Borroni G, Sembenini,
D, Schirinzi ML, Saccà A, Pisano F, Maruccia S; Thulium Laser Prostate Marconi AM; Evaluation of the learning curve for thulium laser
Enucleation in Refractory Urinary Retention: Operative and Functional enucleation of the prostate with the aid of a simulator tool but
Outcomes in a Large Cohort of Patients. Urology. 2016 Jul;93:152-7. without tutoring: comparison of two surgeons with different levels of
endoscopic experience. BMC Urology 2015; 15:49.
Barbalat Y, Velez MC, Sayegh CI, Chung DE; Evidence of the efficacy
and safety of the thulium laser in the treatment of men with benign Casellato S, Picozzi S, Macchi A, Stubinski R, Marenghi C, Nazzari S,
prostatic obstruction. Ther Adv Urol. 2016 Jun; 8(3):181-91. Ratti D, Carmignani L; Terapia antiaggregante e tecnica endoscopica
laser al tullio per il trattamento dell’ipertrofia prostatica: Studio caso-
Carmignani L, Ratti D, Vizziello D, Marenghi C, Picozzi S, Finkelberg controllo in pazienti in terapia antiaggregante sottoposti a ThuVEP. 88°
E, Nazzani S, Stubinski R, Casellato S; Postoperative complications in Congresso Nazionale Società Italiana di Urologia, Ottobre 2015, P257.
400 patients undergone endoscopic prostatic surgery with Thullium
laser. The Journal of Urology (2016), April 2016 Volume 195, Issue 4, Carmignani L, Picozzi S, Bozzini G, Ratti D, Maruccia S, Macchi A,
Supplement, e571. Osmolorskiy B, Kamalov A; Transurethral thulium laser vapo-enucleation
versus transvesical open enucleation for prostate adenoma greater
Bozzini G, Taverna G, Seveso M, Bono P, De Franceco O, Buffi NM, than 80 g: a study of 78 patients. 25th World Congress on Videourology
Guazzoni GF, Provenzano M, Mandressi A; ThuLEP vs TURIS, a June 2015; PP-03.
randomized prospective trial to compare intra and early postoperative
outcomes. European Urology Supplements, March 2016; 15(3):e1086. Carmignani L, Bozzini G, Casellato S, Picozzi S, Finkelberg E, Marenghi
C, Osmolorskiy B, Kamalov A; Irritative symptoms after thulium laser
Ketan PV, Prashant HS; Thulium laser enucleation of the prostate is enucleation of the prostate (Thulep): our experience. 25th World
a safe and a highly effective modality for the treatment of benign Congress on Videourology June 2015; PP-05.
prostatic hyperplasia - Our experience of 236 patients. Urol Ann. 2016
Jan-Mar; 8(1): 76–80. Carmignani L, Macchi A, Ratti D, Finkelberg E, Casellato S, Maruccia
S, Marenghi C, Picozzi S; One day surgery in the treatment of
Carmignani L, Ratti D, Vizziello D, Marenghi C, Picozzi S, Finkelberg E, benign prostatic enlargement with thulium laser: A single institution
Nazzani S, Stubinski R, Casellato S; TES (Thullium ejaculation sparing): experience. Korean Journal of Urology 2015 May; 56(5):365–369.

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Reference List

Pariser JJ, Famakinwa OJ, Pearce SM, Chung DE; High-power thulium (white paper available at <http://www.radistribution.com/index.php/
laser vaporization of the prostate: short-term outcomes of safety and cybertm-publications>).
effectiveness. Journal of Endourology 2014 Nov; 28(11):1357-62.
Feneley MR. Institute of Urology and Nephrology, University College
Gianduzzo T; 180 Watt Thulium laser vaporization of the prostate for Hospital, London, UK; Cyber TM 150W Thulium:Yag: A unique laser
BPH - safety and efficacy in 100 cases with up to 1 year follow up. system for treatment of BPH. 2012 (white paper available at <http://
USANZ 2014, 67th annual scientific meeting, Brisbane; No. 085. www.drketanvartak.com/download/>).

Carmignani L, Bozzini G, Ratti D, Picozzi S, Casellato S, Macchi A, Picozzi S, Casellato S, Bozzini G, Stubinski R, Ratti D, Carmignani L;
Finkelberg E; Clinical course of patients receiving anti-platelets therapy Thulium Laser Enucleation of the Prostate in Patients on Anticoagulant
who underwent thulium laser enucleation of the prostate. Urology 2014 or Antiaggregant Therapy. Fukuoka 2012 - 32nm Congress of the SIU;
October; 84(4), supplement 1; MP-02.10. MP-13.14.

Vargas C, Garcia-Larrosa A, Capdevila S, Laborda A; Vaporization of Carmignani L, Lunelli L, Bozzini G, Picozzi S, Casellato S; Comparison
the Prostate with 150-W Thulium Laser: Complications with 6-Month between monopolar trans-urethral resection of prostate and thulium
Follow-Up. Journal of Endourology, Volume 28, Number 7, July 2014, laser enucleation of the prostate: a single institution experience.
Pp. 841–845. Fukuoka 2012 - 32nm Congress of the SIU; MP-06.08.

Mattioli S, Picinotti A, Burgio A; Thulium laser in patients with BPH on Saredi G, Pirola GM, Gianesini G, Marconi AM; ThuLep, primi risultati su
anticoagulant and antiplatelet drugs. European Urology Supplements 21 pazienti trattati. Urologia 2012; 79(Suppl. 19).
2014, 13;e135.
Benelli R, Fiorini A, Picinotti A, Burgio A, Mattioli S; Il laser tullio nel
Vargas C, Capdevila S, Laborda A, Garcia Larrosa A (Viladecans Hospital, trattamento della patologia prostatica. 2012 (white paper available at
Barcelona, Spain); Prostate vaporization. comparison of energy levels: http://www.legatumoriprato.it/wp-content/uploads/2012/06/lasertrullo.
Green laser 120W vs Thulium:YAG 150W,2013. (white paper available pdf).
at <http://www.radistribution.com/index.php/cybertm-publications>).

Sanchis L, Palmero JL, Garau C, Morán E, Miralles J, Benedicto A;

Vaporización de próstata con Láser Tulio: resultados tras 12 meses de
seguimiento. LXXVIII Congreso Nacional de Urología, Granada June
2013; P-99.

Carmignani L, Picozzi S, Macchi A, Casellato S, Bozzini G, Maruccia

S, Marenghi C; A prospective evaluation of 200 patients undergoing
ThuLEP at our institution. 8° Congresso Nazionale UrOP, Ravello (Italy);
May 2013.

Carmignani L, Marenghi C, Stefano P, Casellato S, Bozzini G; Thulium

laser enucleation of the prostate in a pulsed modality. 8° congresso
nazionale UrOP, Ravello (Italy); May 2013.

MR Feneley. Institute of Urology and Nephrology, University College

Hospital, London, UK; Cyber TM 150W 2010nm Thulium:YAG
continuous wave vaporesection for benign prostatic hyperplasia. 2012

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Reference List

Lithotripsy
DEVICES: CYBER HO, LITHO EVO, LITHO, FIBER DUST

The use of Holmium (Ho:YAG) laser in the treatment of stones is now widely accepted, with such technology repre-
senting a safe and reliable choice when used both percutaneously and endoscopically. During the latest years, TFL
technology emerged as a new alternative to Holmium laser, in particular for the treatment of stones.
Quanta System Ho:YAG and TFL laser devices are commonly and effectively used worldwide to perform lithotripsy
in patients. The following publications deal with the use of Cyber Ho, Litho EVO, Litho and Fiber Dust laser devices:

Basulto-Martínez M, Proietti S, Pavia MP, Rico L, Yeow Y, Flores-Tapia Disposable versus Reusable Ureteroscopes: A Prospective Multicenter
JP, Esqueda-Mendoza A, Gaboardi F, Giusti G; An in vitro analysis of Randomized Comparison. Res Rep Urol. 2021 Feb 10;13:63-71.
Holmium:YAG and Thulium fiber laser ablation rates. 36th Annual EAU
Congress (EAU21) - P0212. Ergani B, Ozbilen MH, Yalcın MY, Boyacıoglu H, Ilbey YO; The effect of
hydronephrosis grade on stone-free rate in retrograde intrarenal stone
Cebeci, Oguz & Özkan, Tayyar & Yalcin, Mustafa & Dillioglugil, Ozdal surgery with flexible ureterorenoscopy. Am J Clin Exp Urol. 2021 Apr
& Cevik, Ibrahim. (2021). Second-Look Flexible Ureterorenoscopy: 15;9(2):194-201.
A Technique Proposal to Achieve Real Stone Free Status. 10.22541/
au.161131535.53003454/v1. Doğan AB, Özkan KU, Güler AG. Proximal ureteral access for symp-
tomatic stone removal using ultrathin semirigid ureterorenoscope in
Okçelik S, Kurul NO, Kiziloz H, Temel MC, Yesildal C; Factors Affecting preschool-age children: Is it possible? Actas Urol Esp (Engl Ed). 2021
Success of Semi-rigid Ureterorenoscopy in Proximal Ureter Stone Tre- Jul-Aug;45(6):461-465.
atment. J Coll Physicians Surg Pak. 2021 Jan;31(1):65-69.
Erkoc M, Bozkurt M; Comparison of Mini-Percutaneous Nephrolitho-
Mahmood, S.N., Babarasul, M.H., Fakhralddin, S.S. et al. Retrograde tomy and Retrograde Intrarenal Surgery for Renal Pelvic Stones of
intrarenal surgery for the treatment of renal stones in patients with a 2-3 cm. J Laparoendosc Adv Surg Tech A. 2021 Jun;31(6):605-609.
solitary kidney: Does access sheath matter?. Afr J Urol 27, 35 (2021).
Osman Barut, Sefa Resim; Comparison of Semirigid and Flexible Urete-
Chandramohan V, Siddalingaswamy PM, Ramakrishna P, Soundarya G, roscopy Results in Isolated Kidney Pelvis Stones Smaller than Two Cen-
Manas B, Hemnath A; Retrograde intrarenal surgery for renal stones in timeters. Harran Üniversitesi Tıp Fakültesi Dergisi (Journal of Harran Uni-
children <5 years of age. Indian J Urol. 2021 Jan-Mar;37(1):48-53. versity Medical Faculty) 2021;18(1):45-49. DOI: 10.35440/hutfd.858497.

Inoue T, Okada S, Hamamoto S, Fujisawa M. Retrograde intrarenal sur- Altun A, Bozkurt A, Erdogan A, Mertoglu C, Hirik E, Keskin E, Turan A; Com-
gery: Past, present, and future. Investig Clin Urol. 2021 Mar;62(2):121- parison Of Serum Kim-1 And Miox Levels In Patients That Underwent
135. Percutaneous Nephrolithotomy And Flexible Ureterorenoscopy. April
6, 2021; https://authorea.com/users/406027/articles/516848-compari-
Bozzini G, Filippi B, Alriyalat S, Calori A, Besana U, Mueller A, Pushkar D, son-of-serum-kim-1-and-miox-levels-in-patients-that-underwent-percu-
Romero-Otero J, Pastore A, Sighinolfi MC, Micali S, Buizza C, Rocco B; taneous-nephrolithotomy-and-flexible-ureterorenoscopy.

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Veneziano D, Ploumidis A, Van Cleynenbreugel BSEP, Gözen AS, Palou Guler Y, Erbin A; Comparison of extracorporeal shockwave lithotripsy
Redorta J, Sarica K, Liatsikos EN, Miano R, Ahmed K, Kamphuis G, Tokas and retrograde intrarenal surgery in the treatment of renal pelvic and
T, Somani BK; Development methodology of the novel Endoscopic Sto- proximal ureteral stones ≤2 cm in children. Indian J Urol. 2020 Oct-
ne Treatment step 2/A (EST s2/A) training/assessment curriculum and Dec;36(4):282-287. doi: 10.4103/iju.IJU_116_20. Epub 2020 Oct 1.
a roadmap on developing hands on training curriculums in future: An PMID: 33376264; PMCID: PMC7759164.
international collaborative work by EAU sections. J Endourol. 2021 May
18. doi: 10.1089/end.2021.0040. Trivedi P; Comparative evaluation of intracorporeal lithotripsy techni-
ques during ureteroscopy: a clinical experience. International Surgery
Ersoz C, Ilktac A, Dogan B, Kalkan S, Danacioglu YO, Silay MS; The opti- Journal, [S.l.], v. 7, n. 11, p. 3581-3585, oct. 2020. ISSN 2349-2902.
mal settings of holmium YAG laser in treatment of pediatric urolithiasis.
Lasers Med Sci. 2021 Jan 21. doi: 10.1007/s10103-021-03251-y. Aykac A, Baran O; Safety and efficacy of retrograde intrarenal sur-
gery in geriatric patients by age groups. Int Urol Nephrol. 2020
Erkoc M, Besiroglu H; Comparison of single-use flexible URS and re-u- Dec;52(12):2229-2236. doi: 10.1007/s11255-020-02564-1. Epub 2020
sable flexible URS: Effectiveness, reliability, cost-efficiency analysis. Jul 16. PMID: 32676812.
Medicine Science 2021| International MJ. 10(1):56; 10.5455/medscien-
ce.2020.07.139. Seckiner I, Yilmaz AE, Ozturk M; Fiberoptic or digital? Comparison of
the use of two different flexible ureteroscopes in kidney stone treat-
Kobayashi, M., Takazawa, R., Waseda, Y. et al.; How does pre-operati- ment. Endourol Bull 2020;12(2); 129-134 e-ISSN:2148-0532, Accepted:
ve antimicrobial treatment influence the intra-operative culture results July 2020.
and infectious complications in patients with positive baseline bladder
urine culture undergoing ureteroscopic lithotripsy?. Urolithiasis (2021). Waseda Y, Takazawa R, Kobayashi M, Yoshida S, Uchida Y, Kohno Y, Tsujii
https://doi.org/10.1007/s00240-020-01240-4. T; Successful outcomes of endoscopic lithotripsy in completely bedrid-
den patients with symptomatic urinary calculi. June 2020 Scientific Re-
Okada T, Taguchi K, Kato T, Sakamoto S, Ichikawa T, Yasui T; Efficacy of ports 10(1):8839 DOI: 10.1038/s41598-020-65807-2.
transurethral cystolithotripsy assisted by percutaneous evacuation and
the benefit of genetic analysis in a pediatric cystinuria patient with a Oztekin U, Caniklioglu M, Atac F, Kantekin CU, Gurel A, Isikay L; Com-
large bladder stone. Urology Case Reports, Volume 34, 2021, 101473, parison of Safety and Efficiency of General, Spinal and Epidural Ane-
ISSN 2214-4420, https://doi.org/10.1016/j.eucr.2020.101473. sthesia Methods Used for the Endoscopic Surgical Treatment of Ure-
teral Stones: Which One is Better To Access The Ureter and Reach The
Chandra Mohan Vaddi, Siddalinga Swamy Panchekante Matha, Rama- Stone? Urol J. 2020 May 16;17(3):237-242. doi: 10.22037/uj.v0i0.5638.
krishna Paidakula, Soundarya Ganesan, Manas Babu, Hemnath Anan- PMID: 32207134.
dan; Prospective Randomized Study of Fixed Laser Setting Verses
Variable Laser Settings for a Better Stone Free Rate. International Jour- Maltagliati M, Bozzini G, Besana U, Calori A, Rivolta L, Malvestiti G,
nal of Clinical Urology. Vol. 4, No. 2, 2020, pp. 68-72. doi: 10.11648/j. Pedaci G, Antonelli D, Sighinolfi C, Rocco B, Buizza C; Virtual Basket
ijcu.20200402.18. ureteroscopic holmium laser lithotripsy: Intraoperative and early posto-
perative outcomes. 35th Annual EAU Congress - Virtual (EAU20V) – 866.
Topaktaş R, Altin S, Aydin C, Akkoç A, Ürkmez A, Aydin ZB; Is spinal
anesthesia an alternative and feasible method for proximal ureteral sto- Waseda, Y., Takazawa, R., Kobayashi, M. et al. Successful outcomes of
ne treatment? Cent European J Urol. 2020;73(3):336-341. doi: 10.5173/ endoscopic lithotripsy in completely bedridden patients with sympto-
ceju.2020.0049. matic urinary calculi. Sci Rep 10, 8839 (2020).

Taguchi K, Hamamoto S, Kawase K, Hattori T, Okada T, Chaya R, Nagai Karagöz MA, Erihan IB, Doluoğlu ÖG, et al. Efficacy and safety of fURS
T, Kato T, Okada A, Yasui T; The First Case Report of Robot-Assisted in stones larger than 20 mm: is it still a threshold? Cent European J Urol.
Fluoroscopy-Guided Renal Access During Endoscopic Combined In- 2020; 73: 49-54.
trarenal Surgery. J Endourol Case Rep. 2020 Dec 29;6(4):310-314. doi:
10.1089/cren.2020.0125. PMID: 33457661; PMCID: PMC7803196.

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Zhang S, Qi R, Terry R, Whelan P, Preminger G et al.; Comparison of Yoshida S, Takazawa R, Uchida Y, Kohno Y, Waseda Y, Tsujii T; The signifi-
Stone Fragmentation Characteristics of the 9 Fr and 1.9 Fr Next-Gene- cance of intraoperative renal pelvic urine and stone cultures for patien-
ration Electrohydraulic Lithotripters and Current Lithotripsy Modalities. ts at a high risk of post-ureteroscopy systemic inflammatory response
J Urol Ren Dis 05: 1185 (2020). syndrome. Urolithiasis. 2019 Dec;47(6):533-540.

Bozzini G, Aydogan TB, Müller A, Sighinolfi MC, Besana U, Calori A, Bayar G, Kilinc MF, Yavuz A, Aydın M; Adjunction of Tamsulosin or Mi-
Lorenzo B, Govorov A, Pushkar D, Pini G, Pastore AL, Romero-Otero J, rabegron Before Semi-Rigid Ureterolithotripsy Improves Outcomes:
Rocco B, Buizza C; A comparison among PCNL, Miniperc and Ultramini- Prospective, Randomized Single-Blind Study. Int Urol Nephrol 51 (6),
perc for lower calyceal stones between 1 and 2 cm: a prospective, com- 931-936 Jun 2019.
parative, multicenter and randomised study. BMC Urol. 2020;20(1):67.
Kozyrakis DG, Kratiras ZK, Perikleous SK, Zarkadas AP, Chatzistamoy SE,
Pirani F, Makhani SS, Kim FY, et al. Prospective Randomized Trial Com- Karagiannis DK, Solinis IT; How Effective Is Retrograde Semirigid and
paring the Safety and Clarity of Water Versus Saline Irrigant in Uretero- Flexible Ureteroscopic Lithotripsy for the Treatment of Large Ureteral
scopy. Eur Urol Focus. 2020;S2405-4569(20)30066-3. Stones Equal of or Greater than 15 mm? Results from a Single Center.
Urol Int. 2019 Apr 18:1-7.
Socarrás M, González LL, Reinoso J, Gómez Rivas J, Cuadros V, Del Ala-
mo JF, Del Dago PJ, Gómez Sancha F; Pulse Modulation for Holmium Carmignani L, Clementi MC, Motta G, Nazzani S, Signorini C, Blezien
Laser: Vapor Tunnel–Virtual Basket–Bubble Blast. VideourologyVol. 34, O, Ratti D, Finkelberg E, Picozzi S, Manfredi M, Acquati P, Stubinski R,
No. 3. Vizziello D; RIRS in one day. WCE 2018 (Paris).

Bozzini G, Berti L, Besana U, Calori A, Maltagliati M, Roche JB, Gözen Vizziello D, Acquati P, Clementi MC, Motta G, Signorini C, Nazzani
AS, Breda A, Pini GA, Pastore AL, Micali S, Sighinolfi MC, Rocco B, Buiz- S, Blezien O, Carmignani L; Virtual Basket technology – Impact on
za C; “Vapor Tunnel”: Advantages of a New Setting Option for Urgent high frequency lithotripsy in a urological simulator. WCE 2018 (Paris);
Holmium Laser Lithotripsy with Cyber-Ho. Videourology 34(2). MP27-17.

Vaddi CM, Ramakrishna P, Swamy Pm S, Ganesan S, Anandan H; Bilate- Carmignani L, Clementi MC, Motta G, Nazzani S, Signorini C, Blezien
ral simultaneous RIRS for calculus anuria in a 4 months male baby. Urol O, Ratti D, Finkelberg E, Picozzi S, Manfredi M, Acquati P, Stubinski R,
Case Rep. 2019 Dec 20;29:101085. Vizziello D; RIRS in one day. WCE 2018 (Paris).

Erkoc M, Agalarov S; RIRS (Retrograde Intrarenal Surgery) is safe and Bozzini G, Verze P, Arcaniolo D, Dal Piaz O, Buffi NM, Guazzoni G, Pro-
effective in aging male patients: A single surgeon experience. Annals of venzano M, Osmolorskij B, Sanguedolce F, Montanari E, Macchione N,
Medical Research 2019;26(11):2545-8. Pummer K, Mirone V, De Sio M, Taverna G; A prospective randomi-
zed comparison among SWL, PCNL and RIRS for lower calyceal sto-
Erdoğan A, Keskin E, Altun A; Percutaneous nephrolithotomy versus nes less than 2 cm: a multicenter experience: A better understanding
flexible ureteroscopy in terms of cost-effectiveness in patients with 10- on the treatment options for lower pole stones. World J Urol. 2017
30 mm renal stones. Urologia. 2019 Sep 23:391560319876805. Dec;35(12):1967-1975.

Kızılaya F, Kalemci S, Turna B, Şimşir A, Nazlıa O; Ho:YAG Laser versus Kucukdurmaz F, Efe E, Sahinkanat T, Amasyalı AS, Resim S; Uretero-
Pneumatic Lithotripsy for Management of Pediatric Ureteral Stones: scopy With Holmium:Yag Laser Lithotripsy for Ureteral Stones in Pre-
a Prospective - Comparative Analysis with Adults. Journal of Pediatric school Children: Analysis of the Factors Affecting the Complications
Urology, November 2019 and Success. Urology. 2018 Jan;111:162-167.

Topaktas R, Aydin C, Altin S, Akkoc A, Aydın ZB, Urkmez A; The Efficacy Çimen HI, Halis F, Sağlam HS, Gökçe A; Flouroscopy-free technique is
of Ultra-thin Semi-rigid Ureteroscopy with Holmium Laser Lithotripsy safe and feasible in retrograde intrarenal surgery for renal stones. Turk
in Pediatric Ureteral Stones: A Single-center Experience. Cureus 2019 J Urol. 2017 Sep;43(3):309-312.
Aug 27;11(8):e5496.

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Reference List

Vartak KP, Salvi PH; Laparoscopic-assisted mini percutaneous Halinski A, Halinski A; Flexible Ureterorenoscopy as a New Possibility of
nephrolithotomy for treatment of large calculi in pelvic ectopic kidney. Treating Nephrolithiasis in Children – Preliminary Reports. International
Urol Ann. 2017 Apr-Jun;9(2):174-176. Journal of Medical and Health Sciences Vol:2, No:9, 2015.

Maruccia S, Sanguedolce F, Casellato S, Dal Piaz, Montanari E, Pummer Palmero JL, Castelló A, Miralles J, Nuño de La Rosa I, Garau C, Pastor
K, Verze P, Mirone V, Taverna G, Romero Otero J, Bozzini G; A comparison JC; Results of retrograde intrarenal surgery in the treatment of renal
among PCNL, miniperc and ultraminiperc for lower calyceal stones stones greater than 2 cm. Actas Urol Esp. 2014 May;38(4):257-62.
between 1 and 2 cm: A multicenter experience. Eur Urol Suppl 2017;
16(3);e961. Palmero JL, Miralles J, Garau C, Nuño de la Rosa I, Amoros A, Benedicto
A; Retrograde intrarenal surgery (RIRS) in the treatment of calyceal
Bozzini G, Verze P, Dal Piaz O, Seveso M, Mandressi A, Buffi N, diverticulum with lithiasis. Arch Esp Urol. 2014 May;67(4):331-6.
Guazzoni G, Provenzano M, Osmolorskij B, Sanguedolce F, Montanari
E, Macchione N, Mirone V, Taverna G; A prospective randomized Azili MN, Ozcan F, Tiryaki T; Retrograde intrarenal surgery for the
comparison among SWL, PCNL and RIRS for lower calyceal stones less treatment of renal stones in children: Factors influencing stone
than 2 cm: a multicenter experience. European Urology Supplements, clearance and complications. Journal of Pediatric Surgery, Volume 49,
15(3);e689. Issue 7, July 2014, Pages 1161-1165.

Palmero JL, Durán-Rivera AJ, Miralles J, Pastor JC, Benedicto A; Kirac M, Tepeler A, Guneri C, Kalkan S, Kardas S, Armagan A, Biri H;
Comparative study for the efficacy and safety of percutaneous Reduced radiation fluoroscopy protocol during retrograde intrarenal
nefhrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) surgery for the treatment of kidney stones. Urol J. 2014 Jul 8;11(3):1589-
for the treatment of 2-3,5 cm kidney stones. Arch Esp Urol. 2016 94.
Mar;69(2):67-72.
Tiryaki T, Azili MN, Özmert S; Ureteroscopy for treatment of ureteral
Bagcioglu M, Demir A, Sulhan H, Karadag MA, Uslu M, Tekdogan stones in children: factors influencing the outcome. Urology. 2013
UY; Comparison of flexible ureteroscopy and micropercutaneous May;81(5):1047-51.
nephrolithotomy in terms of cost-effectiveness: analysis of 111
procedures. Urolithiasis. 2016 Aug;44(4):339-44. Armagan A,Tepeler A, Silay MS, Ersoz C, Akcay M, Akman T, Erdem
MR, Onol SY; Micropercutaneous Nephrolithotomy in the Treatment of
Istanbulluoǧlu MO, Alptekin H, Işık H, Buldu I; Ureteroscopy and Laser Moderate-Size Renal Calculi. J Endourol. 2013, Feb; 27(2):177-81.
Lithotripsy for Treatment of Ureteral Stones in Pregnants: Single Center
Experience. Dicle Medical Journal 2016; 43 (1): 122-125. Humanski P. Specjalista Hospital, Kutno, Poland; Holmium:YAG laser:
an obviously necessary piece of equipment for an outpatient urological
Karatag T, Buldu I, Kaynar M, Taskapu H, Tekinarslan E, Istanbulluoglu surgery. 2012 (white paper available at <http://www.radistribution.com/
MO; Treatment of Symptomatic Lower Pole Stones of a Kidney with index.php/litho-publications>).
Partial Nephrectomy Using Micropercutaneous Nephrolithotomy
Technique. Case Reports in Urology, Volume 2015 (2015), Article ID Mattioli S. Clinica Columbus, Milan, Italy; Versatile applications of
456714. Holmium:Yag 30W laser in endourology. (white paper available at
<http://www.radistribution.com/index.php/litho-publications>).
Azili MN, Ozturk F, Inozu M, Çayci FS, Acar B, Ozmert S, Tiryaki T;
Management of stone disease in infants. Urolithiasis (2015) 43:513–519. Palmero JL, Amoros A, Ramírez M, Pastor JC, Benedicto A; Surgical
therapy of lithiasis in horseshoe kidney. Actas Urol Esp. 2012;36(7):439
Tanik S, Zengin K, Albayrak S, Atar M, Imamoglu MA, Bakirtas H, Gurdal – 443.
M; The Effectiveness of Flexible Ureterorenoscopy for Opaque and
Non-opaque Renal Stone. Urology journal (2015), 12(1):2005-9.

QS - Surgery Reference List - Jul 2021 9

Reference List

Other Urology Surgery

DEVICES: CYBER TM, CYBER HO, LITHO, LITHO EVO

Many publications report the use of lasers, including Thulium and Holmium, in the treatment of urinary tumors (inclu-
ding bladder and UUT tumors), and other soft tissue procedures in urology, as alternative to the standard techniques.
The use of Quanta System Cyber TM, Litho and Cyber Ho devices is reported and described in the following works:

Aydogan TB, Binbay M; Alternative Management of a Pediatric G; Thulium:YAG Versus Holmium:YAG Laser Effect on Upper Urinary
Case of Hemorrhagic Cystitis due to BK Virus: Use of Thulium Laser Tract Soft Tissue: Evidence from an Ex Vivo Experimental Study.
Coagulation. European Urology Open Science Volume 27, May 2021, J Endourol. 2020.
Pages 73-76.
Bozzini G, Gastaldi C, Besana U, Calori A, Casellato S, Parma P, Pastore
Waseda Y, Takazawa R, Kobayashi M, Tsujii T. Chronic Unilateral A, Macchi A, Breda A, Gozen A, Skolarikos A, Herrmann T, Scoffone C,
Hematuria: Compound Papillae Are Likely to Bleed. J Endourol. 2021 Eissa A, Sighinolfi MC, Rocco B, Buizza C, Liatsikos E; Thulium-laser Re-
Jan 25. doi: 10.1089/end.2020.0783. Epub ahead of print. PMID: trograde Intra Renal Ablation (T-RIRA) of upper urinary tract transitional
33327863. cell carcinoma: an ESUT study. Minerva Urol Nefrol. 2020 Jan 30. doi:
10.23736/S0393-2249.20.03689-9.
Maltagliati et al; Laparoscopic partial nephrectomy with Thulium Laser
enucleation of the tumour: Perioperative and functional outcomes. Karabulut I, Yılmaz AH, Keskin E, Erdoğan A; Two methods in bladder
36th Annual EAU Congress (EAU21) - P0585. neck stenosis treatment efficiency: Holmium YAG laser and cold blade
incision. Ann Clin Anal Med 2020;11(Suppl 2): S123-126.
Prem, Kumar & Kumar, Pankaj & Rehman, Zia & Janoria, Somesh.
(2020); Open Partial Nephrectomy With Zero Ischemia Technique Socarras ME, Proietti S, Luciano R, Scarfo F, Saitta G, Gaboardi F, Giusti
Using Thulium Laser: Our Experience of 4 Cases. The Korean G; Thulium:YAG vs Holmium:YAG laser effect on soft tissue: eviden-
Journal of Urological Oncology 18(2):155-160; DOI: 10.22465/ ce from an ex vivo experimental study. Poster presented at WCE 2019
kjuo.2020.18.2.155. (Abu Dhabi); MP26‐21.

Hsieh YC, Huang SK, Su CC, Wang JC, Feng IJ, Chiu AW, Liu CL; Signorini C, Motta G, Vizziello D, Clementi MC, Nazzani S, Nazzani S,
Conservative management of upper tract urothelial carcinoma Blezien O, Stubinski R, Acquati P, Picozzi S, Finkelberg E, Ratti D, Man-
with endoscopic thulium laser ablation: A retrospective study with fredi M, Carmignani L; Thulium Laser Coagulation of Residual Ureteral
subgroup analyses. Urological Science 2020, 31(6), pp. 258-266. Endometriosis. Videourology. 2019, DOI: 10.1089/vid.2018.0047.

Shakir OM, Kareem D; Al Shawi AF, Ibrahim WK; Treatment of Retained Caione P, Gerocarni Nappo S, Collura G, Matarazzo E, Bada M, Del Prete
DJ(neglected DJ) in AL-Anbar Government, A Postconfict Study. L, Innocenzi M, Mele E and Capozza N; Minimally Invasive Laser Treat-
Medico-legal Update, July-September 2020, Vol.20, No. 3. ment of Ureterocele. Front. Pediatr. 7:106 (2019).

Proietti S, Rodríguez-Socarrás ME, Eisner BH, Lucianò R, Basulto Signorini C, Motta G, Vizziello D, Clementi MC, Nazzani S, Nazzani S,
Martinez MJ, Yeow Y, Rapallo I, Saitta G, Scarfò F, Gaboardi F, Giusti Blezien O, Stubinski R, Acquati P, Picozzi S, Finkelberg E, Ratti D, Man-

10 QS - Surgery Reference List - Jul 2021

Reference List

fredi M, Carmignani L; Thulium laser coagulaton of residual ureteral en- surgery. 2012 (white paper available at <http://www.radistribution.com/
dometriosis. The Journal of Urology 201(4S) May 2019; V01-12. index.php/litho-publications>).

Garg S, Gupta VG, Singh A, Garg R; Thulium:YAG Laser Partial Ne- Mattioli S. Clinica Columbus, Milan, Italy; Versatile applications of
phrectomy: A Successful Approach for Small Renal Masses”. EC Clinical Holmium:Yag 30W laser in endourology. (white paper available at
and Medical Case Reports 2.3 (2019): 94-97. <http://www.radistribution.com/index.php/litho-publications>).

Garg S, Gupta VG, Singh A, Garg R; Synchronous Primary Malignancy

Of Urinary Bladder And Kidney: A Rare Case Report. Acta Scientific
Cancer Biology 3(11) 2019.

Bozzini G, Maruccia S, Pastore A, Buffi N, Guazzoni G, Parma P, Saredi

G, Casellato S, Montanari E; Thulium laser en-bloc resection of blad-
der tumor (THUEB-BT): TIGER (Thulium Italian Group Established on
Research) study to compare laser and electrical en-bloc transurethral
resection of bladder tumor. Eur Urol Suppl 2018; 17(2);e1611.

Musi G, Mistretta FA, Marenghi C, Russo A, Catellani M, Nazzani S, Conti

A, Luzzago S, Ferro M, Matei DV, Carmignani L, de Cobelli O; Thulium
Laser Treatment of Upper Urinary Tract Carcinoma: A Multi-Institution-
al Analysis of Surgical and Oncological Outcomes. J Endourol. 2018
Mar;32(3):257-263.

Maruccia S, Saredi G, Parma P, Casellato S, Bozzini G; Thulium laser

treatment of upper urinary tract transitional cell carcinoma. Eur Urol
Suppl 2017; 16(3);e1802.

Ghaddar Y, Ghaddar J; Étude comparative des traitements des tumeurs

vésicales superficielles: (laser Thulium) versus (RTU monopolaire).
Progrès en Urologie. 2016 Nov;26(13):720-721.

Mattioli S, Picinotti A, Burgio A; Single laser incision for treatment of

congenital bladder neck sclerosis: new technique. Urologia. 2016 Nov
18;83(4):204-206.

Ghaddar Y, Ghaddar J; Étude comparative de l’efficacité du traitement

du cancer localise de la prostate: (Laser Thulium + Ablatherm) versus
(RTUP + Ablatherm). Progrès en Urologie. 2016 Nov; 26(13):706–707.

Bialek W et al; Thulium laser TURBT - initial experience. 43rd National

Congress of the Polish Urological Association, September 5-7, 2013
Jachranka, Poland.

Humanski P. Specjalista Hospital, Kutno, Poland; Holmium:YAG laser:

an obviously necessary piece of equipment for an outpatient urological

QS - Surgery Reference List - Jul 2021 11

Reference List

Thoracic Surgery
DEVICES: CYBER TM, OPERA EVO

Many publications report the use of lasers in thoracic surgery, including Thulium laser.
The use of Quanta System Cyber TM device is reported and described in the following publications:

Zhang J, Zhang Z, Liu D, Shao W, Feng H; A randomized trial of who is Droghetti A, Vannucci J, Bufalari A, Bellezza G, De Monte V, Marulli G,
better at treating the incomplete pulmonary fissure between stapler Bottoli MC, Giovanardi M, Daddi N, De Angelis V, Moriconi F, Puma F;
and thulium laser. Minerva Surg 2021 Apr 08. Pleurodesis with Thulium Cyber Laser versus talc poudrage: a compara-
tive experimental study. Lasers Med Sci. 2016 Sep;31(7):1407-13.
Lococo F, Iaffaldano A, Zanfrini E, Pogliani L, Tabacco D, Sassorossi
C, Mazzarella C, Margaritora S; Thulium cyber laser-assisted uniportal Marulli G, Droghetti A, Di Chiara F, Calabrese F, Rebusso A, Perissinotto
thoracoscopic resection of a pulmonary metastasis from colorectal E, Muriana G, Rea F; A prospective randomized trial comparing stapler
cancer. Minerva Chir. 2020 Dec;75(6):475-477. doi: 10.23736/S0026- and laser techniques for interlobar fissure completion during pulmonary
4733.20.08416-3. lobectomy. Lasers Med Sci. 2013 Feb; 28(2):505-11.

Liu L, Zhang Y, Zhi X et al; Comparison of Thulium Laser and Mechanical Scanagatta P, Furia S, Leo F, Duranti L, Tavecchio L, Polimeno E, Acerbis
Staplers During Pulmonary Wedge Resections Under Thoracoscopy. F, Pelosi G, Pastorino U; Feasibility and safeness of laser pulmonary
Chin J Min Inv Surg, December 2019, Vol.19, No. 12; p.1062. anatomic resection in patients with incomplete fissures. Results of a
randomized, phase II, controlled trial. 48° STS Annual Meeting, Fort
Zhang X, Sun C, Yang M, Liu L; Safety analysis of thulium laser in Lauderdale, Florida, January 2012; P97.
thoracoscopic pulmonary wedge resection. Chinese Journal of Clinical
Thoracic and Cardiovascular Surgery, Oct. 2019, Vol. 26, No.10. Scanagatta P, Pelosi G, Leo F, Furia S, Duranti L, Fabbri A, Manfrini A,
Villa A, Vergani B, Pastorino U; Pulmonary resections: cytostructural
Wang R, Qian K, Tan X et al; Treatment of Pulmonary Air Leakage During effects of different-wavelength lasers versus electrocautery. Tumori,
2-μm Thulium Laser Lung Resection. Chin J Min Inv Surg December 98:90-93, 2012.
2018, 18(12), p.1129.

Zhang et al; Clinical application of thulium laser in thoracoscopic

resection of pulmonary nodules. Chin J Thorac Cardiovasc Surg, June
2017, 33(6), p.360.

Zhang Y, Wang R, Qian K, Su L, Liu L, Hu M, Li Y, Zhao X, Hua L, Zhi

X; Clinical applications of Thulium laser in thoracoscopic resection of
pulmonary nodules. Chin J Thorac Cardiovasc Surg, June 2017, Vol.33,
No.06.

12 QS - Surgery Reference List - Jul 2021

Reference List

Gastroenterology
DEVICES: OPERA EVO, CYBER TM, LITHO, CYBER HO

The use of lasers in the GI field has been recently explored, showing interesting features with respect to alternative
and more established methods.
The use of Quanta System Opera EVO, Cyber TM, Litho and Cyber Ho devices is reported and described in the
following publications:

Goenka MK, Shah BB, Rodge GA, Rai VK, Afzalpurkar S, Agarwal R, Dioscoridi L, Forti E, Pugliese F, Cintolo M, Italia A, Mutignani M; Thulium
Goenka U; Efficacy and safety of cholangioscopy guided laser lithotripsy laser coagulation: a new effective endotherapy to treat gastrointestinal
for difficult bile duct stones - A prospective study from a tertiary care angiodysplasia. Letter to the Editor published on Gastrointestinal
centre in Eastern India. Arab J Gastroenterol. 2021 Jun;22(2):111-114. Endoscopy 2019 Volume 90(2), pp.319-320.
doi: 10.1016/j.ajg.2021.05.012.
Dioscoridi L, Pugliese F, Forti E, Cintolo M, Italia A, Tringali A,
Dioscoridi L, Pugliese F, Bertoglio CL et al; Thulium laser to endoscopically Bonato G, Giannetti A, Pontecorvi V, Mutignani M; Gastrointestinal
manage a rectal erosion and intraluminal mesh migration after ventral angiodysplasias' endotherapy: a single-center comparison between
rectopexy. BMJ Case Reports CP 2021;14:e235807. argon-plasma coagulation and thulium-laser coagulation. Digestive and
Liver Disease 2019, 51(2), e155–e156; P.02.19.
Han S, Shah RJ; Cholangiopancreatoscopy-guided Soft Tissue Laser
Dissection And Ablation For Refractory Strictures And Neoplasia. Tontini GE, Marinoni B, Pastorelli L, Rimondi A, Neumann H, Spina L,
Gastrointestinal Endoscopy 91(6s), 2020 ; Su1422. Vecchi M; In Vivo Endoscopic Hemostasis On Small Bowel Oozing
Lesions: First Experience In The Emergency Setting with the Thulium/
Mutignani M, Dioscoridi L, Italia A, Forti E, Pugliese F, Cintolo M, Bonato Erbium Laser System. Endoscopy 2018; 50(04): S181-S182 (ESGE Days
G, Giannetti A, Massad M; Thulium laser to manage a difficult biliary 2018 ePosters).
lithiasis: a first case report. Endoscopy. 2019 Aug 9.
Siboni S, Aiolfi A, Ceriani C, Tontini GE, Bonavina L; Cricopharyngeal
Tontini GE, Dioscoridi L, Rimondi A, Cantù P, Cavallaro F, Elli L, Pastorelli myotomy with thulium laser through flexible endoscopy: proof-of-
L, Pugliese F, Mutignani M, Vecchi M; Safety and efficacy of the Thulium concept study. Endoscopy International Open 2018; 06: E470–E473.
& Erbium Laser System on bleeding vascular lesions of the GI tract:
a real life multi centre study. ESGE Days 2019, April 4-6, Prague Mittal C, Shah RJ; Pancreatoscopy-guided laser dissection and ablation
(Endoscopy 2019; 51(04): S64). for treatment of benign and neoplastic pancreatic disorders: an initial
report (with videos). Gastrointest Endosc. 2019 Feb;89(2):384-389.
Tontini GE, Rimondi A, Neumann H, Annunziata ML, Cavallaro F,
Lagoussis P, Spina L, Vavassori S, Pastorelli L, Vecchi M; Safety and Tontini GE, Rimondi A, Neumann H, Annunziata ML, Cavallaro F,
Efficacy of the new Thulium / Erbium laser system in patients with Lagoussis P, Spina L, Vavassori S, Pastorelli L, Vecchi M; Safety and
gastrointestinal bleeding from vascular lesions. Poster presented at Efficacy of the new Thulium/Erbium laser system in patients with
UEG Week 2019. gastrointestinal bleeding from vascular lesions. UEG Week Wien Oct.
2018; P0558.

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Tontini GE, Neumann H, Rimondi A, Vavassori S, Bruni B, Cattignoli Tontini GE, Neumann H, Carmignani L, Bruni B, Pastorelli L, Cavallaro
G, Zhou PH, Pastorelli L, Vecchi M; Ex vivo experimental study on the F, Fagnani F, Clemente C, Bottani M, Vecchi M; Safety and efficacy of a
Thulium laser system: new horizons for interventional endoscopy (with new therapeutic laser system for hemostatic treatments in luminal GI
videos). Endosc Int Open. 2017 Jun;5(6):E410-E415. endoscopy – first results in an established animal model. UEG Week
2015; Topic 11.1, UEG15-ABS-2916.
Tontini GE, Soriani P, Neumann H, Spina L, Fagnani F, Carmignani L,
Pastorelli L, Vecchi M, Cavallaro F, Rimondi A, Bruni B, Clemente C, Neumann H, Tontini GE, Carmignani L, Bruni B, Soriani P, Cavallaro
Lagoussis P; Thulium laser in interventional endoscopy: animal and F, Fagnani F, Clemente C, Bottani M, Vecchi M; Evaluation of a new
human studies. Endoscopy. 2017 Apr; 49 (4): 365-370. therapeutic laser system for endoscopic submucosal dissection in
established animal model. UEG Week 2015; Topic 11.1, UEG15-
Tontini GE, Neumann H, Carmignani L, Bruni B, Soriani P, Pastorelli ABS-3058.
L, Fagnani F, Clemente C, Bottani M, Vecchi M; Per-oral endoscopic
myotomy (poem) with a new therapeutic laser system: first study in an Tontini GE, Neumann H, Carmignani L, Bruni B, Soriani P, Pastorelli
ex vivo animal model. FISMAD Feb. 2016 (Naples), issue: February 24 L, Fagnani F, Clemente C, Bottani M, Vecchi M; First study on a new
2016 - V.01.2. therapeutic laser system for per-oral endoscopic myotomy in an ex vivo
animal model. UEG Week 2015; Topic 11.1, UEG15-ABS-3323.
Tontini GE, Soriani P, Neumann H, Spina L, Annunziata ML, Vavassori S,
Fagnani F, Carmignani L, Pastorelli L, Vecchi M; Haemostatic treatment
with a new therapeutic laser system – first in vivo experience. FISMAD
Feb. 2016 (Naples), issue: February 24 2016 - V.01.8.

Tontini GE, Soriani P, Neumann H, Spina L, Annunziata ML, Vavassori S,

Fagnani F, Carmignani L, Pastorelli L, Vecchi M; A new therapeutic laser
system for endoscopic ablation of esophageal lesions – first results
in an established animal model. FISMAD Feb. 2016 (Naples), issue:
February 24 2016 P.14.16

Tontini GE, Soriani P, Neumann H, Spina L, Annunziata ML, Vavassori S,

Fagnani F, Carmignani L, Pastorelli L, Vecchi M; First In Vivo Experience
of Haemostatic Treatment With a New Therapeutic Laser System (With
Video). GIE Journal (May 2016); Volume 83, Issue 5, Supplement, Page
AB638.

Tontini GE, Soriani P, Neumann H, Fagnani F, Zhou PH, Carmignani L,

Pastorelli L, Vecchi M; Safety and efficacy of a new therapeutic laser
system for endoscopic ablation of Esophageal lesions – first results in an
established animal model. UEG Week 2015; Topic 11.1, UEG15-LB-5732.

Tontini GE, Soriani P, Neumann H, Fagnani F, Zhou PH, Carmignani L,

Pastorelli L, Vecchi M; Haemostatic treatment with a new therapeutic
laser system – first in vivo experience (with video). UEG Week 2015;
Topic 11.1, UEG15-LB-5707.

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Reference List

Other Studies
DEVICES: DIODE SERIES, OPERA EVO, LITHO

Diode lasers represent versatile and multidisciplinary tools aimed at ablation, incision and coagulation of different
soft tissues. Their use is widely reported in literature and commonly accepted for many treatments.
Quanta System Diode lasers (including 532, 980 and 1470 nm wavelengths), Opera EVO (1.9μm and 1.5μm) and Litho
devices have been largely distributed worldwide for different medical specialties.
The following publications deal with the use of Quanta System Diode Series, Opera EVO and Litho devices:

Shim HK, Kim MR; Potassium-Titanyl-Phosphate (KTP) Laser Kassab AN, Ahmed MR, Saber M, Mekawy S; Comparative intraindividual
Photocoagulation Combined with Resection Using an Ultrasonic Scalpel ablative tissue effects of diode laser 980 nm versus radiofrequency
for Pharyngolaryngeal Hemangioma via a Transoral Approach: Case in tonsillar hypertrophy management. Acta Otorhinolaryngol Ital.
Report and Literature Review. Am J Case Rep. 2021 Mar 23;22:e931042. 2019;39(3):150-155.

Werner M, Meyer-Lindenberg A, Felten S et al; Cystoscopic-guided Im NR, Kim B, Kim J, Baek SK; Treating Oral Leukoplakia with a 532-nm
laser ablation for treatment of ectopic ureteroceles in 2 female dogs. Pulsed Diode Laser. Medical Lasers; Engineering, Basic Research, and
Tierarztl Prax Ausg K Kleintiere Heimtiere DOI: 10.1055/a-1428-7266. Clinical Application 2019; 8(1): 39-42.
Park YM, Lim JY, Kang MS, Choi HS; Treatment Outcomes of Angiolytic
Filauro M, Vallin A, Fragale M, Sampieri C, Guastini L, Mora F, Peretti Laser-Assisted Glottoplasty in Patients With Sulcus Vocalis. Ann Otol
G; Office-based procedures in laryngology. Acta Otorhinolaryngol Ital Rhinol Laryngol. 2019 May;128(5):377-383.
2020;40:1-5.
Tamburro R, Brunetti B, Muscatello V, Mantovani C, De Lorenzi D; Short-
Carobbio ALC, Missale F, Fragale M, Mora F, Guastini L, Parrinello term surgical outcomes and histomorphological evaluation of thermal
G, Canevari FRM, Peretti G, Mattos LS; Transoral laser microsurgery: injury following palatoplasty performed with diode laser or air plasma
feasibility of a new exoscopic HD-3D system coupled with free beam device in dogs with brachycephalic airway obstructive syndrome. The
or fiber laser. Lasers Med Sci. 2021 Jan 3. doi: 10.1007/s10103-020- Veterinary Journal 253, November 2019, 105391.
03221-w.
Ban MJ, Park JH, Ban WW, Kim JW, Park KN, Lee SW; Efficacy of fibre-
Son S, Lee SG, Ahn Y, Kim WK, Jeong TS; Outcomes of epiduroscopic optic laryngeal potassium titanyl phosphate laser surgery under local
laser ablation in patients with lumbar disc herniation. Medicine anaesthesia for the treatment of vocal polyps: A prospective study of
(Baltimore). 2020 Dec 18;99(51):e23337. 65 patients. Clin Otolaryngol. 2018 Dec;43(6):1617-1621.

Ozdemir S; Outcomes of Pneumatic Lithotripsy Versus Holmium De Lorenzi D, Bertoncello D, Mantovani C, Bottero E; Nasopharyngeal
Laser-Assisted Lithotripsy With Sialendoscopy in Management of sialoceles in 11 brachycephalic dogs. Vet Surg. 2018 Apr;47(3):431-438.
Submandibular Sialolithiasis. J Craniofac Surg. 2020 Oct;31(7):1974-
1977.

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Reference List

Nejm CS Jr, Timi JR, de Araújo WB Jr, Caron FC; Endovenous laser undergoing laser thermal ablation with a 1470-nm bare fiber laser with
ablation of the great saphenous vein. Varying energy may not affect low linear endovenous energy density. J. Vasc. Bras.14 (4); Porto Alegre
outcome. Phlebology 2017 Feb;32(1):1318. Oct./Dec. 2015.

Nermin MY, Ali MS Samah SM; Impact of welding the dental enamel Akay F, Ilhan A, Yolcu Ü, Gundogan FC, Yildirim Y, Toyran S; Diode laser-
walls of the fissure system using semiconductor laser: In-Vitro study. assisted transcanalicular dacryocystorhinostomy: the effect of age on
Dentistry 2017, 7:8. the results. Arq Bras Oftalmol. 2015 May-Jun;78(3):164-7.

Rizzi M, Migliario M, Rocchetti V, Tonello S, Renò F; Near-infrared Markevičius N, Sudikas S, Gutauskas J, Gečas G; Recurrences after
laser increases MDPC-23 odontoblast-like cells proliferation by treatment of varicose veins with endovascular laser. Medicinos Teorija ir
activating redox sensitive pathways. J Photochem Photobiol B. 2016 Praktika 2015 - T.21 (Nr.1), 8–10 p; doi:10.15591/mtp.2015.001.
Nov;164:283-288.
Malskat WS, Stokbroekx MA, van der Geld CW, Nijsten TE, van den
Fornaini C, Merigo E, Sozzi M, Rocca JP, Poli F, Selleri S, Cucinotta Bos RR; Temperature profiles of 980- and 1,470-nm endovenous laser
A; Four different diode lasers comparison on soft tissues surgery: a ablation, endovenous radiofrequency ablation and endovenous steam
preliminary ex vivo study. Laser Ther. 2016 Jun 29;25(2):105-114. ablation. Lasers Med Sci. 2014 Mar;29(2):423-9.

De Lorenzi D, Mantovani C, Tripaldi F, Ferasin H; Redundant arytenoid Luo DX, Jin XJ, Li GT, Sun HT, Li YY, Qi Y; The use of targeted
mucosa: clinical presentation, treatment and outcome in three cats. J percutaneous laser disc decompression under the guidance of
Small Anim Pract. 2016 Jan;57(1):40-3. puncture-radiating pain leads to better short-term responses in lumbar
disc herniation. Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3048-55.
Saleh HM, Ibrahim DR, Michael MI, Kamal AM, El-Kharbotly AM, Bahgat
MM; Immunologic changes after diode laser inferior turbinoplasty in Nardini G, Bielli M, S Nicoli, Corlazzoli D, Selleri P, Leopardi S, Di
allergic rhinitis. Egypt J Otolaryngol 2016;32:141-6. Girolamo N; Litotripsia endoscopica laser nei cheloni: due casi.
Veterinaria, Anno 28, n. 6, Dicembre 2014.
Aydin A, Raison N, Khan MS, Dasgupta P, Ahmed K; Simulation-based
training and assessment in urological surgery. Nature Reviews Urology Abud B, Karaarslan K, Turhan S, Karaman Y; Is the temperature
13, 503–519 (2016). of tumescent anesthesia applied in the endvenous laser ablation
important? Comparison of different temperatures for tumescent
Fornaini C, Merigo E, Sozzi M, Selleri S, Vescovi P, Cucinotta A; 810nm, anesthesia applied during endovenous ablation of incompetent
980nm, 1470nm and 1950nm diode laser comparison: a preliminary “ex great saphenous vein with a 1470 nm diode laser. Vascular. 2014
vivo” study on oral soft tissues. Proceedings Volume 9306, Lasers in Dec;22(6):421-6.
Dentistry XXI; 930606 (2015).
Marqa MF, Mordon S, Hernández-Osma E, Trelles M, Betrouni
Di Girolamo N, Selleri P; Clinical Applications of Cystoscopy in N; Numerical simulation of endovenous laser treatment of the
Chelonians. Vet Clin North Am Exot Anim Pract. 2015 Sep;18(3):507-26. incompetent great saphenous vein with external air cooling. Lasers in
Medical Science, May 2013, 28(3), pp 833–844.
Sayed IS, Saafan A, Abdel-Gawad FK, Harhash TA, Abdel-Rahman
MA; Effect of low-level laser therapy on gene expression of vascular Osma EH, Mordon SR, Marqa MF, Vokurka J, Trelles MA; A comparative
endothelial growth factor and interleukin-1 ß in scalpel-induced and study of the efficacy of endovenous laser treatment of the incompetent
laser-induced oral wounds in rats. J Dent Lasers 2015;9:23-30. great saphenous under general anesthesia with external air cooling
with and without tumescent anesthesia. Dermatol Surg. 2013
WJB Araujo, JRR Timi, Júnior CSN, Caron FC; Evaluation of great Feb;39(2):255-62.
saphenous vein occlusion rate and clinical outcome in patients

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Reference List

Kassab AN, El Kharbotly A; Management of ear lobule keloids using

980-nm diode laser. Eur Arch Otorhinolaryngol. 2012 Feb;269(2):419-23.

Kassab AN, Rifaat M, Madian Y; Comparative study of management

of inferior turbinate hypertrophy using turbinoplasty assisted
by microdebrider or 980 nm diode laser. J Laryngol Otol. 2012
Dec;126(12):1231-7.

Vuylsteke ME, Thomis S, Mahieu P, Mordon S, Fourneau I; Endovenous

laser ablation of the great saphenous vein using a bare fibre versus a
tulip fibre: a randomised clinical trial. Eur J Vasc Endovasc Surg 44 (6),
587-592. 2012 Oct 16.

Hesham A, Fathi A, Attia M, Safwat S, Hesham A; Laser and topical

mitomycin C for management of nasal synechia after FESS: a preliminary
report. Eur Arch Otorhinolaryngol (2011) 268:1289–1292.

Amabile G, Rotondi M, Pirali B, Dionisio R, Agozzino L, Lanza M,

Buonanno L, Di Filippo B, Fonte R, Chiovato L; Interstitial laser
photocoagulation for benign thyroid nodules: time to treat large
nodules. Lasers Surg Med. 2011 Sep;43(8):797-803.

Elhayes KA; Low intensity laser versus synthetic bone graft to increase
bone density after enucleation of large cystic lesions of jaws. Journal of
American Science, 2011;7(6).

Radwan DA, Mohammed NH, Zaky AA; Effectiveness of low power laser
therapy and betamethasone in minimizing postoperative edema and
trismus after third molar surgery: a clinical trial. Journal of American
Science, 2010;6(12).

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