Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect

Timing/Route Action Responsibilities
Generic Name Duodenal Ulcer Thiazole derivative, Short term Safe use during CNS: Dizziness, Monitor
Famotidine Adult: PO 40mg h.s structurally similar treatment of pregnancy Headache, improvement in
or 20mg b.i.d to histamine and active duodenal (Pregnancy confusion, GI distress.
PO maintenance pharmacologically ulcer. category B), by depression
therapy: 20mg h.s similar to Maintenance nursing mothers GI: Constipation,
Brand Name IV: 20mg q12h cimetidine. A therapy for diarrhea
Pepcid, Pepcid Child: PO/IV 0.5 potent competitive duodenal Cautious Use: Skin: Rash, acne,
AC mg/kg q8-12h (max inhibitor of patients on Renal pruritus, dry skin,
40mg/dl) histamine at reduced dosage Insufficiency flushing
histamine (h2) after healing of Hemat:
Classification GERD receptor site in an active ulcer. thrombocytopenia
Gastrointestinal Adult: PO 10mg gastric parietal cells. PO: Urogenital:
Agent; b.i.d Inhibits basal, Hypersecretory Increases in BUN
Antisecretory Child: PO 1mg/kg/d nocturnal, meal- conditions, and serum
Agent (H2 in 2 divided doses stimulated and including creatinine
receptor (max 40mg b.i.d) petagastrin- Zollinger-Ellison
antagonist) stimulated gastric syndrome.
secretion; also Unlabeled Uses:
inhibits pepsin Stress ulcer
secretion. Is 20- prophylaxis
160times more
potent than
ranitidine. Does not
affect gastric
emptying or
exocrine pancreatic
function.
Therapeutic Effect:
Reduces parietal
cell output of
hydrochloric acid;
 thus detrimental
effects of acid on
gastric mucosa are
diminished.

Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name GERD Binds to an enzyme Erosive Contraindicated CNS: headache. Do not confuse
Pantoprazole PO (Adults): Short- in the presence of esophagitis in: GI: CLOSTRIDIUM Protonix
term treatment of acidic gastric pH, associated with Hypersensitivity DIFFICILE- (pantoprazole)
erosive esophagitis preventing the final GERD. to rabeprazole or ASSOCIATED with Lotronex
associated with transport of Maintenance of related drugs DIARRHEA (alosetron) or
Brand Name GERD—40 mg once hydrogen ions into healing of (benzimidazoles); (CDAD), protam
Panto IV, daily for up to 8 wk; the gastric lumen. erosive OB: Should be abdominal pain, Monitor bowel
Pantoloc, Maintenance of Therapeutic esophagitis. used during diarrhea, function.
Protonix, healing of erosive Effects: Diminished Pathologic pregnancy only if eructation, Diarrhea,
Protonix IV, esophagitis—40 mg accumulation of gastric clearly needed flatulence. abdominal
Tecta once daily. acid in the gastric hypersecretory Lactation: Derm: cutaneous cramping, fever,
PO (Children 5 yr): lumen, with conditions. Discontinue lupus and bloody
15– 39 kg— 20 mg lessened acid Unlabeled Use: breast feeding erythematosus. stools should be
once daily for up to reflux. Healing of Adjunctive due to potential Endo: reported to
Classification 8 wk; 40 kg— 40 mg duodenal ulcers treatment of for serious hyperglycemia. health care
Therapeutic: once daily for up to and esophagitis. duodenal ulcers adverse reactions F and E: professional
antiulcer agents 8 wk. Decreased acid associated with in infants. hypomagnesemia promptly as a
Pharmacologic: IV (Adults): 40 mg secretion in Helicobacter Use Cautiously in (especially if sign of
proton-pump once daily for 7– 10 hypersecretory pylori Patients using treatment Clostridium
inhibitors days. Gastric conditions high-doses for 1 duration 3 mo). difficile-
Hypersecretory year (risk of hip, GU: acute associated
Conditions PO wrist, or spine interstitial diarrhea (CDAD).
(Adults): 40 mg fractures); nephritis. May begin up to
twice daily, up to Patients using Hemat: vitamin several wk
120 mg twice daily. therapy for 3 yr B12 deficiency. following
 IV (Adults): 80 mg q (risk of vitamin MS: bone cessation of
12 hr (up to 240 B12 deficiency; fracture. Misc: therapy
mg/day). Pedia: Safety not systemic lupus
Availability (generic established. erythematosis
available) Delayed-
release tablets: 20
mg, 40 mg. Cost:
Generic—All
strengths
$368.22/90.
Powder for
injection: 40
mg/vial. Delayed-
release oral
suspension: 40
mg/packet. Cost:
$7.60/1 pkt

Dosage/
Mechanism of Nursing
Name of Drug Frequency/ Indication Contraindication Adverse Effect
Action Responsibilities
Timing/Route
Generic Name Duodenal ulcer Inhibits  Short-term  Hypersensitivity CNS: GI complaints:
Ranitidine Adult: PO 150 mg histamine at  treatment of  Precautions: Headache,  assess patient
bid or 300 mg/day H2 receptor  site duodenal  Pregnancy B, sleeplessness,  with ulcers or
after pm meal or at in the gastric and gastric  breastfeeding, dizziness,  suspected ulcers:
bedtime, parietal cells, which ulcers and  child ,12 yr, confusion, epigastric or
Brand Name maintenance 150 inhibits gastric acid maintenance;  renal/hepatic agitation, abdominal pain,
Zantac mg at bedtime secretion management of disease depression; hematemesis,
Infant and child: PO Therapeutic GERD, Zollinger- hallucinations occult blood in
2-4 mg/kg bid, max outcome: Healing  Ellison (geriatric) stools, blood in
300 mg/day of duodenal ulcers syndrome, active CV: gastric aspirate
Classification Zollinger-Ellison or gastric ulcers; duodenal ulcers Tachycardia,  before,
Anticholinergics, syndrome Adult: PO prevention of with bradycardia,  throughout
antacids: 150 mg bid, may duodenal ulcers; Helicobacter premature  treatment •
decreased increase if needed decreased pylori in ventricular Monitor I&O
ranitidine Gastric ulcer Adult: symptoms of combination contractions ratio, BUN,
absorption PO 150 mg bid 3 6 gastroesophageal with EENT: Blurred  creatinine, CBC
Anticoagulants, wk, then 150 mg at reflux disease clarithromycin, vision,  with differential
sulfonylureas: bedtime (GERD), hypersecretory increased  monthly
increased Infant/child: PO 2-4 ZollingerEllison conditions, ocular 
absorption, mg/kg bid, max 300 syndrome, or stress ulcers, pressure
toxicity mg/ day GERD heartburn erosive GI:
Benzodiazepines, Adult: PO 150 mg esophagitis Constipation, 
calcium channel bid (maintenance), abdominal 
blockers: systemic pain, 
increased effect mastocytosis, diarrhea, 
of each product multiple nausea,
Cephalosporins: endocrine vomiting,
decreased effects adenoma hepatotoxicity
of cephalosporins syndrome, GU:
Iron salts: heartburn Impotence, 
decreased effects acute interstitial
of iron salts nephritis (rare)
INTEG:
Urticaria, 
rash, fever
RESP:
Pneumonia
SYST:
Anaphylaxis
(rare)

Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name PO (Adults): 1 g 4 Aluminum salt Short-term management Contraindicated CNS: dizziness, Assess patient
Sucralfate times daily, given 1 of sulfated of duodenal ulcers. in: drowsiness. routinely for
hr before meals and sucrose reacts Maintenance (preventive) Hypersensitivity. GI: abdominal pain
at bedtime; or 2 g with gastric therapy of duodenal Use Cautiously constipation, and frank or
Brand Name twice daily, on acid to form a ulcers. in: Renal failure diarrhea, dry occult blood in
Carafate, Iselpin waking and at thick paste, Unlabeled Use: (accumulation of mouth, gastric the stool.
bedtime. which Management of gastric aluminum can discomfort,
Prevention of selectively ulcer or gastroesophageal occur); Diabetes indigestion,
Ulcers adheres to the reflux. Prevention of (risk of nausea.
Classification PO (Adults): 1 g ulcer surface. gastric mucosal injury hyperglycemia Derm: pruritus,
Therapeutic: twice daily, given 1 Therapeutic caused by high-dose with rashes.
antiulcer agents hr before a meal. Effects: aspirin or other NSAIDs in suspension); Endo:
Pharmacologic: Gastroesophageal Protection of patients with rheumatoid Impaired hyperglycemia
GI protectants Reflux PO (Adults): ulcers, with arthritis or in high-stress swallowing (risk (with
1 g 4 times daily, subsequent situations (e.g., intensive of tablet suspension).
given 1 hr before healing care unit). Suspension: aspiration). Misc:
meals and at Mucositis/stomatitis/rectal ANAPHYLAXIS.
bedtime or oral ulcerations from
(unlabeled). various etiologies
PO (Children): 40–
80 mg/kg/day
divided q 6 hr, given
1 hr before meals
and at bedtime
(unlabeled).
Stomatitis
PO (Adults and
Children): 5– 10 mL
of suspension swish
and spit or swish
and swallow 4
times daily.
Proctitis Rect
(Adults): 2 g of
 suspension given as
an enema once or
twice daily.
Availability (generic
available) Tablets: 1
g. Cost: Generic—
$23.86/100. Oral
suspension: 1 g/10
mL. Cost:
$122.42/420 mL

Dosage/ Nursing
Mechanism of Adverse
Name of Drug Frequency/ Indication Contraindication Responsibiliti
Action Effect
Timing/Route es
Generic Name Tablets: 500 mg Essential for PO, IV: Contraindicated in: CNS: High Alert:
Calcium Carbonate (200 mg Ca)OTC, nervous, Treatment and Hypercalcemia; Renal syncope (IV Errors with IV
600 mg (240 mg muscular, and prevention of calculi; Ventricular only), calcium
Ca)OTC, 650 mg skeletal systems. hypocalcemia. fibrillation; tingling. CV: gluconate and
Brand Name (260 mg Ca)OTC, Maintain cell PO: Adjunct in Concurrent use of CARDIAC chloride have
Alka-Mints, Amitone, 667 mg (266.8 mg membrane and the prevention of calcium supplements ARREST (IV occurred
Apo-Cal, BioCal, Ca)OTC, 1 g (400 capillary postmenopausal (calcium acetate). only), secondary to
Calcarb, Calci-Chew, mg Ca)OTC, 1.25 permeability. Act osteoporosis. Use Cautiously in: arrhythmias, confusion
Calciday, Calcilac, Calci- g (500 mg as an activator in IV: Emergency Patients receiving bradycardia. over which
Mix, Calcite, Calglycine, Ca)OTC, 1.5 g the transmission treatment of digitalis glycosides; F and E: salt is
Cal-Plus, Calsan, (600 mg Ca)OTC. of nerve impulses hyperkalemia and Severe respiratory hypercalcemi ordered.
Caltrate, Chooz, Chewable tablets: and contraction hypermagnesemi insufficiency; Renal a. GI: Clarify
Dicarbosil, Equilet, 350 mg (300 mg of cardiac, a and adjunct in disease; Cardiac constipation, incomplete
Gencalc, Liqui-Cal, Ca)OTC, 420 mg skeletal, and cardiac arrest or disease; OB: diarrhea orders.
Liquid Cal-600, Maalox (168 mg Ca)OTC, smooth muscle. calcium channel Hypercalcemia (oral solution Confusion has
Antacid Caplets, 450 mg OTC, 500 Essential for bone blocking agent mayqrisk of maternal only), occurred with
Mallamint, Mylanta mg (200 mg formation and toxicity (calcium and fetal nausea, milligram
Lozenges, Nephro-Calci, Ca)OTC, 750 mg blood chloride, calcium complications;Lactati vomiting. doses of
Nu-Cal, Os-Cal, Oysco, (300 mg Ca)OTC, coagulation. gluconate). on: Breast feeding GU: calculi, calcium
Oyst-Cal, Oystercal, 1 g (400 mg Binds to dietary Calcium not expected to harm hypercalciuri chloride and
Rolaids Calcium Rich, Ca)OTC, 1.25 g phosphate to carbonate: May infant provided that a. Local: calcium
Surpass, Surpass Extra (500 mg Ca)OTC. form an insoluble be used as an serum calcium levels phlebitis (IV gluconate,
Strength, Titralac, Gum tablets: 300 calcium antacid. Calcium monitored. only). which are not
Tums, Tums E-X mg OTC, 450 mg phosphate acetate: Control equal.
OTC, 500 mg (200 complex, which is of Chloride and
mg Ca)OTC. excreted in the hyperphosphate gluconate
Capsules: 1.25 g feces, resulting in mia in end-stage forms are
(500 mg Ca)OTC. decreased serum renal disease routinely
Classification Lozenges: 600 mg phosphorus available on
Therapeutic: mineral (240 mg Ca)OTC. concentrations most hospital
and electrolyte Oral suspension: (calcium acetate). crash carts;
replacements/suppleme 1.25 g (500 mg Therapeutic specify form
nts Pharmacologic: Ca)/5 mLOTC. Effects: of calcium
antacids Powder: 6.5 g Replacement of desired.
(2400 mg calcium in Doses should
Ca)/packetO deficiency states. be expressed
Control of in mEq.
hyperphosphate Do not
mia in end-stage confuse Os-
renal disease Cal (calcium
without carbonate)
promoting with Asacol
aluminum (mesalamine).
absorption
(calcium acetate)
 Dosage/Frequency/ Mechanism of Nursing
Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name PO (Adults): Binds to an PO, IV: GERD/erosive Contraindicated CNS: headache. High Alert: Do
Esomeprazole Healing of erosive enzyme on gastric esophagitis (IV in: Derm: cutaneous not confuse
esophagitis—20 mg parietal cells in therapy should only Hypersensitivity lupus Nexium with
or 40 mg once daily the presence of be used if PO therapy to esomeprazole erythematosus. Nexavar
Brand Name for 4– 8 wk; acidic gastric pH, is not or related drugs GI: CLOSTRIDIUM (sorafenib).
Nexium Maintenance of preventing the possible/appropriate). (benzimidazoles); DIFFICILE- Antacids may
healing of erosive final transport of IV: Reduction in risk Hypersensitivity. ASSOCIATED be used while
Classification esophagitis—20 mg hydrogen ions of rebleeding DIARRHEA taking
Therapeutic: once daily; into the gastric following therapeutic Use Cautiously in (CDAD), esomeprazole.
antiulcer Symptomatic GERD lumen. endoscopy for acute Severe hepatic abdominal pain, PO: Administer
agents —20 mg once daily bleeding gastric or impairment; constipation, at least 1 hr
Pharmacologic: for 4 wk (additional Therapeutic duodenal ulcers. Patients using diarrhea, dry before meals.
proton-pump 4 wk may be Effects: PO: Hypersecretory high doses for 1 mouth, Swallow tablets
inhibitors considered for Diminished conditions, including year (risk of hip, flatulence, and capsules
nonresponders); accumulation of Zollinger-Ellison wrist, or spine nausea. whole.
Heartburn—20 mg acid in the gastric syndrome. fractures); F and E: Delayed-release
once daily for 2 wk. lumen with PO: With amoxicillin Patients using hypomagnesemia capsules: For
PO (Children 12– 17 lessened and clarithromycin to therapy for 3 yr (especially if patients with
yr):Short-term gastroesophageal eradicate (q risk of vitamin treatment difficulty
treatment of GERD reflux. Healing of Helicobacter pylori in B12 deficiency. duration 3 mo). swallowing,
—20– 40 mg once duodenal ulcers. duodenal ulcer GU: acute place 1 tbsp of
daily for up to 8 wk. Decreased disease or history of OB, Lactation: interstitial applesauce in
PO (Children 1– 11 incidence of duodenal ulcer Use only if the nephritis. an empty bowl.
yr):Short-term gastric ulcer disease. potential benefit Hemat: vitamin Open capsule
treatment of GERD during continuous PO: Decrease risk of outweighs the B12 deficiency. and carefully
—10 mg once daily NSAID therapy gastric ulcer during potential risk MS: bone empty the
for up to 8 wk; continuous NSAID fracture. pellets inside
Healing for erosive therapy. Misc: systemic onto
esophagitis—20 kg: OTC: Heartburn lupus applesauce. Mix
10 mg once daily occurring twice/wk. erythematosus. pellets with
for 8 wk; 20 kg: 10– applesauce and
20 mg once daily swallow
for 8 wk. immediately.
PO (Infants and Applesauce
Children 1 mo– 1 should not be
yr): 7.5– 12 kg—10 hot and should
mg once daily for be soft enough
up to 6 wk; 5– 7.5 to swallow
kg—5 mg once daily without
for up to 6 wk; 3– 5 chewing. Do not
kg—2.5 mg once store
daily for up to 6 wk. applesauce
IV (Adults): 20 or mixture for
40 mg once daily. IV future use. Tap
(Children 1– 17 yr): water, orange
55 kg—10 mg once juice, apple
daily; 55 kg—20 mg juice, and
once daily. IV yogurt have
(Children 1 mo– 1 also been used.
yr): 0.5 mg/kg once Do not crush or
daily. chew pellets.
For patients
with an NG
tube, delayed-
release capsules
can be opened
and intact
granules
emptied into a
60-mL syringe
and mixed with
50 mL of water.
Replace plunger
and shake
syringe
vigorously for
15 sec. Hold
syringe with tip
up and check
for granules in
tip. Attach
syringe to NG
tube and
administer
solution. After
administering,
flush syringe
with additional
water. Do not
administer if
granules have
dissolved or
disintegrated.

Caution patient
to notify health
care
professional if
fever and
diarrhea occur,
especially if
stool contains
blood, pus, or
mucus. Advise
patient not to
treat diarrhea
without
consulting
health care
 professional

Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name Tablets for Maintain acid-base PO, IV: Contraindicated CNS: confusion, Monitor pulse,
Potassium effervescent oral balance, Treatment/prevention in: Hyperkalemia; restlessness, BP, and ECG
Bicarbonate solution: 12 mEq, isotonicity, and of potassium Severe renal weakness. periodically
25 mEq. electrophysiologic depletion. impairment; CV: during IV
Tablets for balance of the cell. IV: Arrhythmias due Untreated ARRHYTHMIAS, therapy
Brand Name effervescent oral Activator in many to digoxin toxicity Addison’s ECG changes. Toxicity and
Gaviscon solution: 10 mEq, enzymatic disease; Severe GI: abdominal Overdose:
Advance 20 mEq, 25 mEq, 50 reactions; essential tissue trauma; pain, diarrhea, Symptoms of
mEq to the transmission Hyperkalemic flatulence, toxicity are
of nerve impulses; familial periodic nausea, those of
contraction of paralysis; Some vomiting; hyperkalemia
Classification cardiac, skeletal, products may tablets, (slow, irregular
for peptic and smooth contain tartrazine capsules only, heartbeat;
ulcer and muscle; gastric (FDC yellow dye GI ulceration, fatigue; muscle
gastro- secretion; renal #5) or alcohol; stenotic lesions. weakness;
oesophageal function; tissue avoid using in Local: irritation paresthesia;
reflux disease. synthesis; and patients with at IV site. confusion;
carbohydrate known Neuro: dyspnea;
metabolism. hypersensitivity paralysis, peaked T waves;
Therapeutic or intolerance; paresthesia depressed ST
Effects: Potassium segments;
Replacement. acetate injection prolonged QT
Prevention of contains segments;
deficiency. aluminum, which widened QRS
may become complexes; loss
toxic with of P waves; and
prolonged use to cardiac
high risk groups arrhythmias
 (renal
impairment,
premature
neonates).
Use Cautiously in
Cardiac disease;
Renal
impairment;
Diabetes mellitus
(liquids may
contain sugar);
Hypomagnesemia
(may make
correction of
hypokalemia
more difficult); GI
hypomotility
including
dysphagia or
esophageal
compression
from left atrial
enlargement
(tablets,
capsules);
Patients receiving
potassium-
sparing drugs

Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name PO (Adults): 1.9– Binds Lowering of Contraindicated in: GI: constipation. Antacids cause
Aluminum 4.8 g (30– 40 mL of phosphate in phosphate Severe abdominal F and E: premature
Hydroxide regular suspension the GI tract. levels in pain of unknown hypophosphatemia dissolution and
or 15– 20 mL of Neutralizes patients with cause. absorption of
concentrated gastric acid chronic Use Cautiously in: enteric-coated
Brand Name suspension) 3– 4 and inactivates renal failure. Hypercalcemia; tablets and may
Maalox times daily. PO pepsin. Adjunctive Hypophosphatemia; interfere with
(Children): 50– 150 Therapeutic therapy in the OB: Generally absorption of
mg/kg/24 hr in 4– 6 Effects: treatment of considered safe; other oral
divided doses; Lowering of peptic, chronic high-dose medications.
Classification titrate to normal serum duodenal, and therapy should be Separate
Therapeutic: serum phosphate phosphate gastric ulcers. avoided. administration of
antiulcer agents, levels. Antacid PO levels. Healing Hyperacidity, aluminum
hypophosphatemics (Adults): 500– 1500 of ulcers and indigestion, hydroxide and oral
Pharmacologic: mg (5– 30 mL) 3– 6 decreased reflux medications by at
antacids, phosphate times daily pain esophagitis least 1– 2 hr.
binders associated Tablets must be
with ulcers or chewed
gastric thoroughly before
hyperacidity. swallowing to
Constipation prevent their
limits use entering small
alone in the intestine in
treatment of undissolved form.
ulcer disease. Follow with a glass
Frequently of water.
found in Shake liquid
combination preparations well
with before pouring.
magnesium- Follow
containing administration
compounds with water to
ensure passage
into stomach.
 Liquid dosage
forms are
considered more
effective than
tablets

Dosage/Frequency/ Mechanism of Nursing

Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name N/A Increases  Constipation,  Hypersensitivity, CNS: Muscle  Assess
Magnesium Salts osmotic  bowel  abdominal pain, weakness,  magnesium
pressure,  preparation  nausea/vomiting, flushing, toxicity: thirst,
draws fluid  before  obstruction, acute sweating,  confusion,
into colon,  surgery or  surgical abdomen, confusion, sedation, decrease in
Brand Name neutralizes HCl exam,  rectal bleeding, depressed reflexes, reflexes
Kremil S Therapeutic electrolyte,  heart block, flaccid paralysis,
outcome: anticonvulsant, myocardial hypothermia
Magnesium  in preeclampsia, damage CV: Hypotension, 
levels  WNL, eclampsia Precautions: heart block, 
Classification absence of (magnesium Pregnancy circulatory collapse,
Electrolyte; constipation sulfate) Category: A, B vasodilatation
anticonvulsant, (magnesium GI: Nausea,
laxative, saline; sulfate), renal vomiting, anorexia,
antacid disease/cardiac cramps, diarrhea
disease HEMA: Prolonged 
bleeding time
META:
Electrolyte, 
fluid imbalances
RESP: Respiratory
depression/paralysis
 Dosage/Frequency/ Mechanism of Nursing
Name of Drug Indication Contraindication Adverse Effect
Timing/Route Action Responsibilities
Generic Name PO (Adults): Binds to an GERD/ Contraindicated CNS: dizziness, Monitor bowel
Omeprazole GERD/erosive enzyme on gastric maintenance of in: drowsiness, function.
esophagitis and parietal cells in the healing in erosive Hypersensitivity fatigue, Diarrhea,
maintenance of presence of acidic esophagitis. to omeprazole or headache, abdominal
Brand Name healing of erosive gastric pH, Duodenal ulcers related drugs weakness. cramping, fever,
Prilosec esophagitis—20 mg preventing the (with or without (benzimidazoles); CV: chest pain. and bloody
once daily. final transport of anti-infectives for Concurrent use GI: CLOSTRIDIUM stools should be
Duodenal ulcers hydrogen ions into Helicobacter of rilpivirine. DIFFICILE- reported to
associated with H. the gastric lumen. pylori). Short-term Use Cautiously in ASSOCIATED health care
Classification pylori—40 mg once Therapeutic treatment of active Hepatic DIARRHEA professional
Therapeutic: daily in the morning Effects: benign gastric impairment (CDAD), promptly as a
antiulcer agents with clarithromycin Diminished ulcer. Pathologic (doses may be abdominal pain, sign of
Pharmacologic: for 2 wk, then 20 accumulation of hypersecretory necessary); acid Clostridium
proton-pump mg once daily for 2 acid in the gastric conditions, Patients using regurgitation, difficile-
inhibitors wk or 20 mg twice lumen with including Zollinger- high-doses for 1 constipation, associated
daily with lessened Ellison syndrome. year (risk of hip, diarrhea, diarrhea (CDAD).
clarithromycin 500 gastroesophageal Reduction of risk of wrist, or spine flatulence, May begin up to
mg twice daily and reflux. Healing of GI bleeding in fractures); nausea, vomiting. several wk
amoxicillin 1000 mg duodenal ulcers. critically ill Patients using F and E: following
twice daily for 10 patients. therapy for 3 yr hypomagnesemia cessation of
days (if ulcer is OTC: Heartburn (risk of vitamin (especially if therapy.
present at occurring twice/w B12 deficiency; treatment Do not confuse
beginning of OB, Lactation: duration 3 mo). Prilosec
therapy, continue Use only if GU: acute (omeprazole)
omeprazole 20 mg potential benefit interstitial with Prozac
daily for 18 more outweighs nephritis. (fluoxetine) or
days); has also been potential risk; Derm: cutaneous Pristiq
used with Pedia: Children 1 lupus (desvenlafaxine).
clarithromycin and mo (safety and erythematosus, Do not confuse
metronidazole. effectiveness not itching, rash. omeprazole with
Gastric ulcer—40 established) Hemat: vitamin fomepizole.
mg once daily for B12 deficiency.
4– 6 wk. Reduction MS: bone
of the risk of GI fracture.
bleeding in critically Misc: allergic
ill patients—40 mg reactions,
initially, then systemic lupus
another 40 mg 6– 8 erythematosis
hr later, followed by
40 mg once daily
for up to 14 days.
Gastric
hypersecretory
conditions—60 mg
once daily initially;
may be increased
up to 120 mg 3
times daily (doses
80 mg/day should
be given in divided
doses); OTC—20 mg
once daily for up to
14 days. PO
(Children 1–16 yr
and 20 kg):
GERD/erosive
esophagitis—20 mg
once daily for 4– 8
wk. PO (Children 1–
16 yr and 10–19
kg): GERD/erosive
esophagitis—10 mg
once daily for 4– 8
wk. PO (Children 1–
16 yr and 5–9 kg):
 GERD/erosive
esophagitis—5 mg
once daily for 4– 8
wk. PO (Children 1
mo– 1 yr and 10
kg): Erosive
esophagitis—10 mg
once daily for up to
6 wk. PO (Children
1 mo– 1 yr and 5–9
kg): Erosive
esophagitis—5 mg
once daily for up to
6 wk. PO (Children
1 mo– 1 yr and 3–4
kg): Erosive
esophagitis—2.5
mg once daily for
up to 6

References:

Wilson, B. A., Shields, K. M., Shannon, M. T., & Stang, C. L. (2007). Prentice Hall Nurse's Drug Guide. Prentice Hall.

Vallerand, A. H., & Sanoski, C. A. (2021). Davis's drug guide for Nurses. F.A. Davis Company.

Skidmore-Roth, L. (2013). Mosby's Drug Guide for Nursing Students, with 2014 update. Elsevier Health Sciences.