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Exp 6TO-STUDY-THE-ACTION-OF-STRYCHNINE-ON-FROG

The document describes an experiment to study the effects of strychnine on a frog. Strychnine is injected subcutaneously into a frog and causes muscular convulsions and hyperreflexia as it inhibits the inhibitory neurotransmitter glycine in the spinal cord.

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Subodh Shah
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144 views1 page

Exp 6TO-STUDY-THE-ACTION-OF-STRYCHNINE-ON-FROG

The document describes an experiment to study the effects of strychnine on a frog. Strychnine is injected subcutaneously into a frog and causes muscular convulsions and hyperreflexia as it inhibits the inhibitory neurotransmitter glycine in the spinal cord.

Uploaded by

Subodh Shah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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PHARMACOLOGY AND TOXICOLOGY PRACTICAL

EXPERIMENT NO.: 10 DATE:

AIM: TO STUDY THE ACTION OF STRYCHNINE ON FROG


REQUIREMENTS:
 Frog
 Syringe and needles

I
Glass jar

ED
DRUGS:
 Strychnine (4 mg/mL)
PRINCIPLE: IV
 Strychnine is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide,
TR
particularly for killing small vertebrates such as birds and rodents. Strychnine, when

I
&
inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which

ED
results in muscular convulsions and eventually death through asphyxia.
D

IV
PROCEDURE:
Frog is weighed and strychnine (4 mg/mL) is injected subcutaneously into frog (i.e in
IK

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lymph sinuses).
IT

 After few minutes, convulsion will be observed in frog.


 If you tape the table, the frog will jump very high. This is hyperreflexia.
N.
NA

DISCUSSION:
 The above observations suggest that inhibits the inhibitory neurotransmitter glycine
in the spinal cord and produces these effects.
A
.

 Drug like pentylenetetrazole, picrotoxin etc. also produce similar effects. However
AM
DR

hyperreflexia may not be observed.


 These drugs inhibit activity of GABA in brain.
UP
.
DR

TEACHER’S SIGNATURE

https://www.drnaitiktrivedi.com/ 38

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