University of St.
La Salle
College of Nursing
DRUG STUDY
Name of Student: _Artillo, Aljean Altheo L._________________________________ Section and Group: __BSN3-B_______
Name of CI: __Estella Isabel M. Villa, RN, MN________________________________ Area of Exposure: BCMHCC
Dosage/
Name of Drug Frequency/ Mechanism of Action Indication Contraindication Adverse Effect Nursing Responsibilities
Timing/Route
Generic Name: 15ml per tab OD AM Angiotensin II [formed COZAAR is indicated for Cozaar is Cozaar may cause May cause hypotension,
losartan potassium from angiotensin I in a the treatment of contraindicated: serious side effects tacycardia, angiodema,
reaction catalyzed by hypertension in adults including: and hyerkalemia
angiotensin converting and pediatric patients 6 In patient who May increase digoxin
enzyme (ACE, kininase II)] years of age and older, are Lightheadedness levels
is a potent to lower blood pressure. hypersensitive to Pain or burning Assess blood pressure
Brand Name: vasoconstrictor, the Lowering blood pressure any component when you and heart rate
Cozaar primary vasoactive lowers the risk of fatal of this product. urinate, Assess fluid levels
hormone of the renin- and nonfatal For Nausea, Monitor daily weights
angiotensin system, and cardiovascular (CV) coadministration Weakness, with CHF
an important component events, primarily strokes with aliskiren in Tingly feeling Monitor renal and liver
in the pathophysiology of and myocardial patients with Chest pain Instruct patient on how
Classification: hypertension. It also infarction. These diabetes. Irregular to take blood pressure.
Angiotensin II stimulates aldosterone benefits have been seen heartbeats
receptor blockers secretion by the adrenal in controlled trials of Loss of
cortex. Losartan and its antihypertensive drugs movements
principal active metabolite from a wide variety of Little or no
block the vasoconstrictor pharmacologic classes urination
and aldosterone-secreting including losartan. Rapid weight
effects of angiotensin II by gain, and
selectively blocking the Swelling in your
binding of angiotensin II hands, feet or
to the AT1 receptor found ankles
in many tissues, (e.g.,
vascular smooth muscle,
adrenal gland). There is
also an AT2 receptor
found in many tissues but
it is not known to be
associated with
cardiovascular
homeostasis. Neither
losartan nor its principal
active metabolite exhibits
any partial agonist activity
at the AT1 receptor, and
both have much greater
affinity (about 1000-fold)
for the AT1 receptor than
for the AT2 receptor. In
vitro binding studies
indicate that losartan is a
reversible, competitive
inhibitor of the AT1
receptor. The active
metabolite is 10 to 40
times more potent by
weight than losartan and
appears to be a reversible,
non-competitive inhibitor
of the AT1 receptor.
