Aplicaciones Diagnosticas Del Ultrasonido en Pediatria
Aplicaciones Diagnosticas Del Ultrasonido en Pediatria
P o i n t - o f - C a re U l t r a s o u n d i n
Pediatric Emergency Medicine
a,b, a,b
Margaret Lin-Martore, MD *, Aaron E. Kornblith, MD
KEYWORDS
Pediatrics Emergency medicine Point-of-care ultrasound Diagnostic
KEY POINTS
Point-of-care ultrasound is an essential part of pediatric emergency training and practice.
Point-of-care ultrasound can decrease lengths of stay, decrease radiation exposure, and
improve patient satisfaction.
There are a variety of different diagnostic applications for point-of-care ultrasound in pe-
diatric emergency medicine, which have varying levels of evidence.
Understanding the evidence and techniques for point-of-care ultrasound applications,
can assist providers in using point-of-care ultrasound in their clinical practice.
INTRODUCTION
a
Department of Emergency Medicine, University of California, San Francisco, 550 16th Street,
Box 0632, San Francisco, CA 94143, USA; b Department of Pediatrics, University of California,
San Francisco, 550 16th Street, Box 0632, San Francisco, CA 94143, USA
* Corresponding author. Department of Emergency Medicine, University of California, San
Francisco, 550 16th Street, Box 0632, San Francisco, CA 94143.
E-mail address: [email protected]
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510 Lin-Martore & Kornblith
Assessment with Sonography in Trauma, cardiac, inferior vena cava (IVC), bladder,
renal, gallbladder and biliary, pelvic obstetrics, pelvic gynecology, and pediatric
abdomen—intussusception, appendicitis, and pyloric stenosis, pulmonary, ocular,
and testicular. A companion review on the procedural applications of POCUS in
PEM discusses further applications focusing on procedural applications.
Fig. 1. Pediatric FAST with anechoic fluid collection located between the hepatorenal junc-
tion of the right upper quadrant view.
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Diagnostic Applications of Pediatric Emergency POCUS 511
Fig. 2. Pediatric FAST with mirror image artifact at the interface of the liver and the dia-
phragm. This finding suggests the patient does not have hemothorax.
spaces. In younger children, traumatic pneumothorax is a rare finding, but the provider
could evaluate the thorax for pulmonary contusion as represented by asymmetric or
focal B-lines on pulmonary evaluation.
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512 Lin-Martore & Kornblith
Fig. 3. Cardiac POCUS with a parasternal long axis view shown with pericardial and pleural
effusions. The anechoic free fluid tracking between the descending thoracic aorta (red dot)
and myocardium is pericardial effusion. In contrast, the anechoic free fluid tracking deflect-
ing laterally to the descending thoracic aorta is pleural effusion.
IVC/aorta ratio of less than 0.8 has been suggested for assessment of pediatric dehy-
dration; however, the accuracy of this cutoff as well as of POCUS IVC/aorta ratio for
assessment of pediatric dehydration is still under debate21–25 FOCUS performed
dynamically and in real-time may alter therapeutics intervention; for example, if the
IVC remains collapsible during initial emergency resuscitation, the provider may
choose to give intravenous volume over starting a vasopressor agent.
Bladder
One of the first PEM POCUS applications studied and commonly used in the pediatric
emergency department is measuring the bladder’s size before catheterization in chil-
dren. A bladder index (defined as a product of the anteroposterior and the transverse
diameters) of 2.4 cm2 or greater predicts success for urinary catheterization in children
less than 2 years of age. Furthermore, using POCUS to measure bladder volume helps
to avoid repeat catheterization and increases caregiver satisfaction.26–28 A POCUS for
bladder volume also decreases time to radiology-performed transabdominal pelvic
ultrasound.29
Typically, a low-frequency probe (curvilinear or phased array) is fanned while posi-
tioned over the pelvis to examine the bladder in both transverse and sagittal views
(Figs. 4 and 5). Measurements can be taken of the bladder in different dimensions
to calculate an estimated bladder volume.
Renal
POCUS in adult patients has been shown to have modest diagnostic accuracy for the
diagnosis of nephrolithiasis.30 However, the use of POCUS for pediatric renal pathol-
ogy such as obstructive uropathy remains an area of debate. Studies have shown that
radiology-performed ultrasound is not as accurate as a CT scan for diagnosing pedi-
atric urolithiasis.31,32 However, there are noted benefits of ultrasound over a CT scan,
including the lack of ionizing radiation. Thus, there is practice-dependent variation in
imaging for renal pathology.
There are case reports of POCUS being used in pediatric and adolescent patients to
identify urolithiasis and avoid CT radiation.33–35 Still, more research is required to
assess the accuracy of POCUS for this use in children and adolescents.
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Diagnostic Applications of Pediatric Emergency POCUS 513
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514 Lin-Martore & Kornblith
cholelithiasis were high: 89.8% (95% confidence interval [CI], 86.4%–92.5%) and
88.0% (95% CI, 83.7%–91.4%), respectively.39 There are case reports of POCUS im-
aging being used to diagnose cholelithiasis in pediatric patients as young as neo-
nates.40,41 However, data on its diagnostic accuracy in the pediatric population are
lacking.
A low-frequency probe is used to perform various approaches to image the gall-
bladder, including the subcostal sweep (where the probe is moved along the right
costal margin from medial to lateral), the lateral approach (where the probe is placed
laterally on the upper right abdomen similar to a FAST approach, but then tilted ante-
riorly to view the gallbladder), or the X minus 7 approach (where the probe is placed
either 7 cm to the right of the xiphoid process or at the midclavicular line in smaller
patients)41,42 to visualize the gallbladder. The gallbladder can then be assessed for
hyperechoic stones with shadowing and biliary sludge (Figs. 8 and 9). The anterior
wall thickness and common bile duct can also be measured. Standard measure-
ments are typically derived from adult measurements (3 mm for gallbladder wall
for adults and 4 mm common bile duct for adults <40 years old) as standard mea-
surements for gallbladder/biliary POCUS for pediatric and neonatal patients are un-
clear. Secondary signs of inflammation or infection include pericholecystic fluid and
Murphy’s sign.
Fig. 7. POCUS image of kidney without hydronephrosis (contralateral kidney in same pa-
tient as Fig. 6) for comparison.
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Diagnostic Applications of Pediatric Emergency POCUS 515
Fig. 8. POCUS image of gallstone with shadowing. Note the hyperechoic (white) gallstone
with shadowing. At times, the hyperechoic stone and shadowing can obscure the gall-
bladder, and only the wall is visible. This is known as the Wall Echo Shadow (WES) sign.
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516 Lin-Martore & Kornblith
system, and more. However, the use of a POCUS in the evaluation of pelvic pathol-
ogies is less well understood. Although there have been case reports of POCUS being
used to identify ovarian torsion in the pediatric emergency department,53 based on
ovarian size of greater than 4 cm, asymmetry compared with the other ovary, periph-
eralization of ovarian follicles, or lack of flow in the ovaries, additional studies are
needed to understand its usefulness for this application fully. Similar to the technique
for obstetric complaints, POCUS for gynecologic complaints can be performed by
transabdominal or transvaginal approaches. However, transvaginal approaches are
avoided in patients who are younger, premenarchal, and not sexually active.
Fig. 10. POCUS image of uterus with an intrauterine pregnancy including a fetal pole. The
crown–rump length is measured and the fetus is an estimated gestational age of 7 weeks
and 6 days.
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Diagnostic Applications of Pediatric Emergency POCUS 517
Typically, a wide footprint, linear transducer is used with the patient a supine or de-
cubitus position. The subxiphoid area is first viewed, and the gastric wall is traced to-
ward the right until the pylorus is identified in the long axis. A muscle width of greater
than 3 mm or a channel length of greater than 17 mm is considered positive56 (Fig. 11).
Fig. 11. POCUS image of hypertrophic pyloric stenosis with muscle width measured at
greater than 3 mm.
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518 Lin-Martore & Kornblith
Fig. 12. POCUS of a “target sign” lesion measuring 2.63 cm. This is an intussusception in the
transverse view. Not the hyperechoic (white) center of mesenteric fat with a hypoechoic
(dark) lymph node in the center.
Lung
Lung POCUS has been described as a promising tool in the diagnosis of pediatric
pneumonia and other lung pathology.78 In one recent systematic review and meta-
analysis for diagnostic accuracy for pneumonia in children, POCUS had high sensi-
tivity and specificity 0.94 (interquartile range, 0.89–0.97), 0.93 (interquartile range,
0.86–0.98), although the authors note limitations in reference standard and variability
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Diagnostic Applications of Pediatric Emergency POCUS 519
Fig. 13. POCUS of a “sandwich” or “pseudokidney” sign. This is the intussusception viewed
longitudinally with alternating layers of the intussuscipiens and intussusceptum. This had
been noted to look like a kidney given the hyperechoic (bright) center.
Ocular
The role of POCUS in evaluation of pediatric patients with ocular complaints is still un-
der investigation. Optic nerve swelling can be used to help identify children with
increased intracranial pressure and there have been pediatric studies of emergency
medicine physician-performed POCUS evaluating for optic nerve swelling that have
Fig. 14. POCUS of appendicitis, transverse view, with tubular structure measuring 0.84 cm.
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520 Lin-Martore & Kornblith
Fig. 15. POCUS of appendicitis, longitudinal view, with blind ending tube measuring
0.88 cm.
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Diagnostic Applications of Pediatric Emergency POCUS 521
Fig. 17. Ocular POCUS with measurement of optic nerve sheath diameter 3 mm behind
retina.
the optic nerve sheath diameter (measured 3 mm behind the retina) (Fig. 17), with
4.5 mm being the cutoff for normal in children 1 year old and older and 4.0 mm being
the cutoff for children less than 1 year,83,90,91 and 5 mm being the cutoff in adults
(sonoguide.com). Optic disc elevation (>1 mm) and the crescent sign (fluid around
the optic nerve) can also be evaluated with a POCUS.91
Testicular
The evaluation of acute testicular pain is time sensitive and its diagnostic differential in-
cludes emergency diagnoses such as testicular torsion and incarcerated/strangulated
hernia. The literature in adult and pediatric patients for testicular POCUS is limited and,
therefore, these examinations are not considered a core study application, although there
are retrospective data that show that POCUS for pediatric testicular torsion can be accu-
rate.92 Furthermore, these studies require a level of expertise in flow imaging modes. A
high-frequency transducer with color and spectral Doppler can be used to evaluate
and compare blood flow to each testis. However, the physiologic low blood flow velocity
of the prepubertal testis may make this study uniquely challenging. A hernia appears as
fluid-filled bowel within the inguinal canal or scrotum.
SUMMARY
POCUS has a variety of diagnostic applications in PEM and has become an essential part of
PEM practice.
Promising diagnostic POCUS applications according to expert consensus are FAST, E-FAST,
cardiac, IVC, bladder, renal, gallbladder/biliary, pelvis–obstetrics and gynecology, pediatric
abdomen–intussusception, appendicitis, and pyloric stenosis, pulmonary, ocular and
testicular complaints.
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522 Lin-Martore & Kornblith
Evidence for each POCUS application varies and many applications lack randomized,
controlled trials.
Understanding the evidence for each POCUS application can assist providers in deciding
how to best use POCUS in clinical care.
Benefits of POCUS include decreased patient lengths of stay for a variety of pediatric
diagnostic applications, as well as lack of ionizing radiation and improved patient
satisfaction.
DISCLOSURE
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Diagnostic Applications of Pediatric Emergency POCUS 523
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