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Mitomycin - Usman

This document provides information on the generic and brand names, classification, dosage, mechanism of action, indications, contraindications, adverse reactions, and nursing responsibilities for mitomycin. Key points include: - Generic name is mitomycin, brand name is Mutamycin. It is an antineoplastic antibiotic. - Recommended dosage is 20mg/m2 as a single IV infusion every 6-8 weeks, with discontinuation if disease progresses after two courses. - Mechanism of action is that it is activated in vivo to a bifunctional and trifunctional alkylating agent, binding to DNA and inhibiting DNA synthesis and function. - Indications include disseminated adenocarcinoma

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Sittie Nashieva A. Usman
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292 views3 pages

Mitomycin - Usman

This document provides information on the generic and brand names, classification, dosage, mechanism of action, indications, contraindications, adverse reactions, and nursing responsibilities for mitomycin. Key points include: - Generic name is mitomycin, brand name is Mutamycin. It is an antineoplastic antibiotic. - Recommended dosage is 20mg/m2 as a single IV infusion every 6-8 weeks, with discontinuation if disease progresses after two courses. - Mechanism of action is that it is activated in vivo to a bifunctional and trifunctional alkylating agent, binding to DNA and inhibiting DNA synthesis and function. - Indications include disseminated adenocarcinoma

Uploaded by

Sittie Nashieva A. Usman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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BRAND NAME Prescribed and Mechanism

GENERIC NAME Recommended Of


Indication Contraindication Adverse Reaction Nursing Responsibilities
CLASSIFICATIO dosage, frequency, Action
N route of
administration

Generic Name: Give by IV infusion. Mitomycin is MUTAMYCIN MUTAMYCIN  Thrombocytopenia  Lab tests: Perform
mitomycin 20mg/m2 as a activated in vivo (mitomycin) is not (mitomycin) is , WBC with differential,
Brand Name: single dose every 6– to a bifunctional recommended as contraindicated in  leukopenia platelet count, PT,
Mutamycin 8 weeks. and trifunctional single-agent, patients who have (cumulative INR, aPTT, Hgb, Hct,
Classes: Discontinue if alkylating agent. primary therapy. It demonstrated a myelosuppression) and serum creatinine
Antineoplastics, disease progresses Binding to DNA has been shown to hypersensitive or ; inj site reactions frequently during and
Antibiotic after two courses. leads to cross- be useful in the idiosyncratic reaction (eg, cellulitis), for at least 7 wk after
Myelosuppression: linking and therapy of to it in the past.  stomatitis, treatment.
see literature for inhibition of disseminated  alopecia,  Do not administer if
dose adjustments. DNA synthesis adenocarcinoma of MUTAMYCIN  renal toxicity, serum creatinine is
and function. the stomach or (mitomycin) is pulmonary toxicity >1.7 mg/dL or if
Mitomycin is cell pancreas in proven contraindicated in (eg, pulmonary platelet count falls
cycle phase- combinations with patients with infiltrates); below 150,000/mm3
nonspecific. other approved thrombocytopenia, discontinue if and WBC is down to
chemotherapeutic coagulation disorder, occurs; 4000/mm3 or if
agents and as or an increase in  hemolytic uremic prothrombin or
palliative treatment bleeding tendency syndrome, bleeding times are
when other due to other causes.  CHF, prolonged.
modalities have  fever,  Monitor I&O ratio and
failed. MUTAMYCIN  anorexia, pattern. Report any
(mitomycin) is not  nausea, sign of impaired
recommended to  vomiting. kidney function:
replace appropriate Change in ratio,
surgery and/or dysuria, hematuria,
radiotherapy. oliguria, frequency,
urgency. Keep patient
well hydrated (at least
2000–2500 mL orally
daily if tolerated).
Drug is nephrotoxic.
 Observe closely for
signs of infection.
Monitor body
temperature
frequently.
 Inspect oral cavity
daily for signs of
stomatitis or
superinfection (see
Appendix F).

 Report respiratory
distress to physician
immediately.
 Report signs of
common cold to
physician
immediately.
 Understand that hair
loss is reversible after
cessation of
treatment.
 Do not breast feed
while taking this drug.

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