Filling and Closing Machines

Vials and Infusion Bottles for Liquid and Powder

OPTIMA
EXCELLENCE IN PHARMA

Member of
 OPTIMA pharma –
Leading in Quality and Diversity

Optima Pharma excels in meeting the pharma- supplying lyophilization and isolation technology.
ceutical industry’s highest expectations with
the four brands Inova, Kugler, Klee and Optima Pharma is internationally recognized by
Metall + Plastic. Optima Pharma offers a diversi- the pharmaceutical industry for machine effi-
fied and innovative portfolio of filling and pack- ciency and precise realization of complex turn-
aging machines for sterile and non-sterile phar- key projects.
maceutical liquids and powders in addition to

Contents

04 Washer

06 Sterilization Tunnel

08 Filling and Closing Machines

16 Loading and Freeze Drying

18 Closing Machines

20 Tray Loader

22 Clean Production

24 Line Concept Integration

30 Service

31 Contact us

2 3
Washer Washer
The Perfect Solution for Wet Cleaning

Optima Pharma washers are completeley made Tunnel Washer

of stainless steel, non-corrosive, pharma-con-
form plastics. The washers are designed in ac-
cordance with cGMP standards and have a wide
Technical Data:
variety of usage. Product contact parts are easy Type 12 17 18
to clean and designed to facilitate accessibility.
Machine type Fully-automatic
For the cleaning and treatment of containers, all
cleaning media customary to the pharmaceuti- Containers Vials and infusion bottles
cal industry can be used.
Container size range:
Neck opening > 7 mm > 7 mm > 13 mm
Two different designs are available:
f Tunnel Washers
Outer diameter 20 – 52 mm 14 – 32 mm 22–86 mm

f Rotary Washers
Max. height up to 104 mm up to 75 mm up to 180 mm

Spray positions 9 – 20 10 – 25 10

Tunnel Washer Rotary Washer Output up to 24,000 up to 30,000 up to 12,000

(depending on container shape size) containers/h containers/h containers/h
Fully-automatic tunnel washers are designed Fully-automatic rotary washers for the treat-
Cleaning sequences 10
for automatic and continuous cleaning of vials ment of vials and infusion bottles. Washers are
and infusion bottles. Washers are available with available with or without ultra-sonic pre-treat- Spray duration per station 1.9“ – 7.5“ 1.8“ – 7.2“ 1.9“ – 12“
or without ultra-sonic pre-treatment and the ment and the connection to a sterilization tun-
Max. number of recirculation pumps 2
connection to a sterilization tunnel can be per- nel can be performed with ease. Output up to
formed with ease. Output up to 30,000 contain- 24,000 containers/hour. The transport can be ei- Infeed of containers Carrier pockets
ers/hour with extremely gentle treatment of ther cycled or continuous by means of one or
your containers. several laned transport grippers.

Rotary Washer

Technical Data:
Type VWM 218 WMR 600 WMR 1800 WMR 2400

Fully automatic
Machine type Fully automatic continuous
intermittent

Containers Vials and infusion bottles

Container size range:

Neck opening
> 7 mm > 5 mm > 5 mm > 5 mm
Outer diameter
16-80 mm 7-52 mm 7-52 mm 7-42 mm
Max. height (depending on
up to 180 mm up to 105 mm up to 105 mm up to 105 mm
container shape)

Spray position 1– 3 1-4 1-6 1-8

Output (depending on container up to 7,200 up to 12,000 up to 18,000 up to 24,000

shape and size) containers/h containers/h containers/h containers/h

Processing sequences 8 7 6

Ultrasonic infeed/Siliconization - optional

Max. number of recirculation stations 1

Infeed of containers Transport grippers

4 5
Sterilization Tunnel Sterilization Tunnel
For all Purposes

Optima Pharma sterilization tunnels are part of a

complete aseptic filling line designed to sterilize
and to depyrogenate glass containers such as
injection and infusion bottles and syringes –
from cleaning to aseptic filling a continuous op-
eration mode in a clean room environment. The
tunnel program consists of Laminar-Flow (LF)
hot air tunnels, and infrared/hot air combina-
tion tunnels. Depending on your application,
Optima Pharma has the right tunnel for you.

The cleaned containers are transported through nation of hot air and infrared quartz glass heat-
the infeed, which is equipped with Laminar ers. Both of the sterile systems are designed for Sterilization Tunnel Heat sterilization of the cooling zone
Flow, into the sterilization area – the heating defined applications. The tunnels are equipped
zone. The containers are heated to a defined with state-of-the-art automation and commu- Technical Data: f Automatically lockable and heated
temperature in order to ensure secure steriliza- nication systems. This ensures detailed data re- Type SHT/SHT IR gas-tight tunnel door with sealing at the
tion and depyrogenization. Sterilization can be cording and tracing of temperatures. outfeed ot the tunnel
f
Conveyor belt width 300, 450, 600, 800, 1250, 1600
performed by means of LF-hot air, or a combi- Isolation of the cooling zone
f
Transport height 900 mm +/- 25 mm
Special fans
Filter system HEPA filters - H13/H14 f Separate closed cooling circuit with
Output up to 44,000/h. bei 10H (depending on container) recirculation pump and mixing valve for
Heating temperature output 20 – 200 KW (depending on output) the sterilizable cooling zone
Cooling power 0.3 – 15 m /h
3 f Sterilization program for sterilization
implementing
Sterilizable cooling zone Optional

6 7
Filling and Closing Machines Filling and Closing Machines
Stand Alone and Complete Turn-Key Lines Compact Line VFVM 221/231

Modular and compact designed machines ac- In laboratories and R&D the demands on tech-
cording to cGMP standards with minimum nical equipment for the manufacture of sterile
space requirement – the fully-automatic Optima and aseptic products are continuously increas-
Pharma filling and closing machines are used ing.
for a wide range of applications, are designed
for your individual needs and can be easily ret- Optima Pharma has a leading position in the
rofitted. field of sterile filling technology. To meet the
market challenges a custom-made integral so-
lution for the processing steps of:

f Washing
f Sterilizing
f Filling
f Stopper insertion
f Crimping (optional)

has been developed.

This state-of-the art compact concept meets all

known requirements regarding technological
design and the ever increasing cGMP regula-
tions. The filling machine is also available as a
stand-alone model.

8 9
Filling and Closing Machines Filling and Closing Machines
Large Range, Compact Design

Type VFVM 3000/4000

A fully-automatic filling and closing machine for

vials and infusion bottles. Compact designed
machines according to cGMP standards – ma-
chines are used for a wide range of applications
and designed for your individual needs and can
be easily retrofitted.

10 11
Filling and Closing Machines Filling and Closing Machines
Flexibility by Means of a Modular Design Our Dosing Systems At a Glance

f The diverse product characteristics

Type VFVM
In order to decide on the most suitable filling
f Environmental conditions of the filling
7000 / 10000 / 18000 / 2400
system for sterile pharmaceutical liquids and
powders, different factors must be taken into process
f Given format diversities
A fully automatic filling and closing machine to
consideration:
f The specified output
process vials and infusion bottles from 0.1 ml to

f The specified dosing accuracy

500 ml. Output 500 - 27,000 objects/h. depen-
ding on product viscosity and fill volume.

The following systems are considered:

Advantages of the rake transport system versus
the alternative system for machines with a me-
dium output: The vials and infusion bottles are
not processed or filled in a star wheel or on a
Time Pressure Peristaltic Pumps Disposable Systems
conveyor belt. Easy access to the individual sta-
tion due to the narrow design of the machine.
The vials/infusion bottles are continuously se-
cured and centered during transport ensuring
that the vials or infusion bottles will not topple
over or interchange. The linear transport system
permits better accessibility for cleaning and
monitoring of processes. The absence of a trans-
port star wheel allows for faster and safer
change of size parts.

Time pressure dosing system is the most fre- Peristaltic pumps enjoy a high preference in Disposable systems mark the future trend in the
quently installed in pharmaceutical applica- biotechnological applications. world of drug manufacturing and play a huge
tions. role in the development of new processes and
products.

Rotary Piston Pumps Mass Flow Meter Powder dosing

Self-sucking rotary piston pumps are applied Mass flow meter is usually installed in applica- Auger filling for sterile filling of powders.
for a wide range of products. tions where product viscosity is temperature-
sensitive.

12 13
Filling and Closing Filling and Closing
Sterile Liquid and Powder

Optima Pharma is one of the world‘s leading or-

ganization for pharmaceutical filling, packaging
Technical Data:
and freeze drying technologies but also houses VFVM 7000
Type VFVM 2000 VFVM 3000 VFVM 4000 VFVM 18000 VFVM 24000
a team of skilled integrators ranging from de- VFVM 10000
signers, project engineers to the most qualified Machine Compact laboratory Fully automatic illing and closing machine
technicians and programmers. description machine
This in-house expertise and know-how allows (Stand alone
Optima Pharma to act as a one-stop-shop model or in line
where customers benefit from sourcing a wide integration)
range of solutions from a single provider.
Containers Vials Vials and Vials and infusion bottles
infusion bottles
Why OPTIMA pharma?

f Leading position in sterile, aseptic filling, Infeed Manual onto Conveyor belt, Conveyor belt Conveyor belt Conveyor belt Conveyor belt
freeze drying and clean room technology turn table Transport scroll, Turn table Turn table Turn table Turn table
f Custom-tailored solutions for even the most From sterilization Turn table
complex projects tunnel onto
f One-stop-shop turn table
f State-of-the-art GMP compliant machines
f Reliable, goal-orientied, efficient, innovative Filling volume 0.1–100 ml 0.1–250 ml 0.2–250 ml 0.1–15 ml 0.1–500 ml 0.1– 100 ml
and flexible (4-lane)
f Comprehensive service packages 0.1 - 100 ml
(2-lane)
0.1 - 500 ml
(1-lane)

Container size 1-lane: 1-lane: Round Transport star 2R–500 IL Ø 14.5–52 mm

range Ø 14 –52 mm Ø 16 –66 mm containers: wheel, Height:
(36 mm 2-lane) up to Ø 100 mm Ø max. 24 mm 30–105 mm
Height: with infeed scroll: (4-lane)
max. 110 mm Ø max. 30 mm Height: Ø max. 52 mm
max. 220 mm (2-lane)
Height: Ø max. 86 mm
max. 75 mm (1-lane)

Output up to 45 up to 4,200 up to 4,200 up to 7,200 up to 24,000 up to 30,000

(Containers/h.) containers/min. (up to 7,000 (up to 7,000 2-lane
2-lane) 2-lane) up to 12,000
4-lane

Operators 1

IPC 100 % statistical statistical 100 % 100 % statistical

14 15
Loading and Freeze Drying Loading and Freeze Drying
Sophisticated Perfect Solutions Greater benefits for the user

The manufacturing as well as the handling of

pharmaceutical products not only requires a
high degree of competence by all parties, but
also meticulous handling of the products.

In 2005, Klee GmbH joined Optima. Thanks to Highlights Highlights Loading and
many years of specialization, as a brand of Op- Freeze Drying Unloading Systems
tima Pharma, Klee offers a comprehensive and
technically leading product range: f Flexible and customer focused layout f Innovative solutions tailored to the
concepts customer’s requirements, e.g. a loading cart
f Sterilizable freeze drying plants for the phar- f Shelves which display an extremely even freely mobile in a room
maceutical industry – from high-tech pilot temperature distribution f Loading row by row, shelf by shelf,
plants to highly efficient production plants. f Fully automatic filter test units (WIT) frame by frame
A seamless scaled version of the pilot plant f Steam sterilization at 1.5 bar f Fully automatic handling of vials, ampoules,
to a full size production plant is guaranteed. f H2O2 sterilization syringes and magazines
f Fully automatic loading and unloading sys- f Clean In Place (CIP) with a cleaning process f Isolator or RABS technology
tems for vials, ampoules, syringes or bulk that can be validated
loading; also in connection with RABS or iso- f Visualization with Klee Lyomatic and
lator technology. standard applications
f Upgrades of machines not fulfilling state-of- f Modem support /remote control
the-art technology or those who are no lon- f Processing of solvents in compliance with
ger up to date with the current regulations. ATEX directive
f Consulting, training, service, and mainte-
nance.

16 17
Closing Machines Closing Machines
Fine Tuned for your Product and Containers

Machines designed to close a wide variety of

containers for the pharmaceutical industry.
Even in the basic machine, several design de-
tails are utilized, which sets us apart from the
standard:

f Electronic and central height adjustment

f Selectable torque function
f PLC guided size part change

The following process steps

are possible:

f Stopper insertion
f Crimping
f Screwing
f Insertion of droppers, spray pumps
and pipettes
f Placing of press-on caps

Technical Data:
Type VVM 211 VVM 3000 VVM 4000 VVM 7000 VVM 2400

Machine description Fully automatic closing machine

Containers Vials and infusion bottles

Infeed Turn table with Conveyor belt, Conveyor belt, Table rotative Table rotative
feeding plate Transport scroll, Turn table
Turn table

Container size range Ø 15 – 52 mm Ø 15 – 66 mm Ø 15 – 100 mm Ø 40 – 86 mm Ø 15 –52 mm

Height: Height:
Height: Height: Height: 68 – 147 mm 35 up to 105 mm
30 up to 105 mm 30 up to 140 mm 30 up to 200 mm 1-lane (10-lane)
1-lane
Ø 15 – 52 mm Ø 40 – 86 mm
Height: Height:
35 – 105 mm 68 up to 147 mm
2-lane (8-lane)
Output 45/min up to 4,200 up to 4,200 up to 3,600 up to 14,000
(containers/h) 1-lane 1-lane 1-lane 1-lane 8-lane
(up to 7,000 up to 7,000 up to 7,200 up to 27,000
2-lane) 2-lane 2-lane 10-lane

Operators 1
Space requirements 0,7 m2 0,8 m2 (without 1,4 m2 (without 1,4 m2 (without 1,6 m2 (without
convey or belt, sorting convey or belt, sorting convey or belt, sorting convey or belt) sorting
and feeding devices) and feeding devices) and feeding devices) and feeding devices
are integrated

18 19
Tray Loader Tray Loader
Supplementary Machines to Handle Vials

An exact number of steady vials or bottles can

be loaded with our fully automatic, high speed
tray loader. Two/four trays are filled alternately,
ensuring tray swapping without machine stop.
By means of a conveyor belt equipped with a
minimum accumulation sensor, the vials/bott-
les are fed into the infeed. Reciprocal interlocks
at the infeed create an accumulation with the
exact number of vials/bottles. The accumulated
vials/bottles are transported in front of the pu-
sher, with a stopping finger ensuring the cor-
rect placement of the vials/bottles. To prevent
the vials/bottles from tipping over, a mechani-
cally driven pusher with a counter guide main-
tains their placement. The number of cross
pushers are counted, to ensure the exact equal
amount of vials/bottles in each tray. The trays
are secured against overload.

Advantages

The machine works according to the FIFO prin-

ciple (First in – First out). During the process no
vials remain on the conveyor belt.

Technical Data:
Type M 2412 M 2424

Machine Description Fully-automatic Tray Loader

Number of trays 2 4

Steady vials and bottles

Containers Diameter: 14.5 up to 78 mm
Height: 30 bis 240 mm

Width: 250 up to 500 mm Width: 250 up to 400 mm

Traying possibilities of vials/bottles
Length: 300 up to 600 mm Length: 300 up to 600 mm

No nesting
Traying possibilities Semi nesting
Full nesting

Output
(depending on container diameter Max. 12,000 pcs./h Max. 24,000 pcs/h
and tray coniguration)

20 21
Clean Production Clean Production
Triple Protection

Clean room technology provides the basis to

At first glance, all three systems work as a clean
ensure a safe production environment for filling
room micro plant. But as far as technology and
sterile drugs.
regulation are concerned, the differences are
quite considerable and have to be assessed for
The filling technology provides for the precise
each individual project. We would be happy to
dosing of drug products under the aspect of
recommend the correct protection system suit-
sterile product handling. Optima Pharma unites
able for your application.
the required clean room technology with the
state-of-the-art filling technology to help you
market a high-value pharmaceutical product.
The portfolio of Optima Pharma and the brands
Inova and Metall + Plastic offer three different
Restricted Access Barrier Closed Restricted Access
technical air protection systems:
System ( RABS ) Barrier System ( C-RABS ) Isolator
f Restricted Access Barrier System ( RABS )
f Closed Restricted Access
Barrier System ( C-RABS )
f Isolator

To restrict the operator access to the process System description / technical module Possible operation parameters
area, our filling machines can be provided with The technical module consists of high-quality f Air speed
RABS equipment as an option. The restricted ac- stainless steel materials and is located above f Pressure regulation (option)
cess is in this case achieved by glove systems, the protection module. It contains the comple- f Air temperature (option)
and mock-up studies are used to determine in te technical air equipment, such as ventilators, f Humidity
advance the gloves‘ positions. filters, cleanroom illumination and air distributi-
on diaphragm.
Ventilation concept
The required process air is taken from the ma- Protection module
chine environment and filtered by means of a The protection module consists of high-quality
HEPA filter. Variable speed-controlled ventila- stainless steel materials. Doors, windows and
tors supply constant air volume to the unit. Air other functional elements are integrated into
distribution is achieved by means of a plastic the modular sectional framework, as required
diaphragm, which ensures uniform air distribu- for the individual machine. Intervention in the
tion in the protected area with little turbulence. protection module is achieved by means of
glove accesses that are integrated into the glass
doors (tempered safety glass (ESG)).

22 23
Turnkey Line Solutions
INOVA WM 12, SHT 12, VFVM 18000, VVM 2428 with outside washer,
KLEE Freeze dryer, M+P Isolator

Vial Ø Output
15
M+P Isolator
up to
24 mm 24.000/h 14
16

12 13

Features 13
9 11
- Cold loading via nitrogen curtain
- Empty vial inspection 7 14
- 5 double stacked peristaltic pumps
15
- Oxygen less than 1% 6 8
- Processing of toxic products 16

10

Production process
4 1 Product infeed, Vials 9 IPC
2 Washer 10 Sorting bowl for stopper
3 3 Sterilizing tunnel 11 Stopper insertion
4 Infeed turn table 12 Reject
5 Transport 13 Freeze Dryer
6 Product infeed 14 Crimp module
7 Dosing system (peristaltic pumps) 15 Outside washer
2 1 8 Filling station 16 Traying

24 25
Turnkey Line Solutions
INOVA WMR 2400, SHT 13, VFVM 18000, VVM 2428, 2 x RALUT, 2 x Klee Freeze Dryer D-30

Container size range Active open

(up to 10–lane)
2R–25R 8
RABS
9

Features
- Two Dosing systems:
- Peristaltic pumps (CIP / SIP)
- Time pressure (CIP / SIP)) 4

- Fully automatic row by row loading

and unloading
- Glass particle monitoring system
- Cap quality monitoring system

10

10

7 Prozessablauf

1 Rotary washer
2 Sterilizing tunnel
3 In-Process Control
6 4 CIP/SIP Cabinet
5 Dosing module: Time pressure
6 Dosing module: Peristaltic pumps
5
(optional)
3 7 Stoppering module
8 Capping machine
9 RABS
1
10 Freeze dryer, RALUT
2

26 27
Processing Line for Vials under Isolator
INOVA WMR 600, SHT 19 S, VFVVM 7042, EVK 7000

Output Vial Minimized 100 %

up to
5,400/h 10–500 ml product loss In-Process Control
7
6
Features
5
- Minimal product loss in entire
batch process
- Fast changeover time via 4
fully automatic format change 8

- Disposable product path

- Reduced VHP
decontamination cycles
2

Prozessablauf

1 Rotary washer
2 Sterilizing tunnel
3 In-Process Control
4 Dosing module
5 Stoppering station Filling and Closing Machine
6 Capping module
7 Reject 1 f 4+2-lane peristaltic pump dosing
8 Vial coding unit system
9 Reject f 100% IPC
f Redosing, Restoppering,
3
10 Traying
Recapping, Repressing
3 f Rake transport system
f Disposable product path outside 10
of isolator
f Pump outside of isolator, therefore
9
M+P Isolator
Machines changeover time of product contact
parts is max. 15 minutes f Cleanliness class ISO 5
f Rotary Washer, model WMR 600 f Print verification via camera f Integrated material transfer
f Sterilization tunnel, model SHT 19 f Non-circular cap verification chamber (MTC)
f Filling and closing machine, via camera f Integrated M+P H2O2
model VFVVM 7042 f Stopper height verification generator RG 4
f Vial coding unit, model EVK 7000 via camera f Catalytic aeration process

28 29
Service Contact Us
A Comprehensive Service Program The Safety of a Strong Partner

Process reliability is also a question of service.

Even the best machines and lines are subject to
a certain extent of wear. With our team of
experts and the worldwide available service
network of the Optima Pharma, you will reduce
the risk of machine downtime to a minimum.
Additionally, a 24-hour hotline as well as an ex-
tensive spare parts supply within a very short
time are at your disposal. Electronic spare parts
catalogs, comprehensive technical documenta-
tion and operating instructions as well as the te-
leservice, facilitate the competent handling of Innovative machine upgrades and individual re-
trouble-shooting. Service already starts when trofitting packages of the Optima Pharma up-
commissioning the machine. The Optima Phar- grade your machines to the state-of-the-art. OPTIMA pharma GmbH OPTIMA Machinery Corporation OPTIMA Japan Co. Ltd.
ma offers you training specifically adapted to Ask us for a service package meeting your re- Otto-Hahn-Str. 1 1330 Contract Drive 362 Shimizu-cho
your requirements. Incidentally, itis not always quirements. It will be our pleasure to assist you. 74523 Schwäbisch Hall Green Bay, WI 54304, USA Kawaramachi-dori
necessary to invest in new machinery. Tel.: +49 791 9495-0 Tel.: +1 920 339-2222 Nijio-agaru, Nakagyo-ku
Fax: +49 791 9495-2610 Fax: +1 920 339-2233 Kyoto 6040911, Japan
[email protected] [email protected] Tel.: +81 75 223-1588
www.optima-pharma.com www.optima-usa.com Fax: +81 75 223-1595
[email protected]
OPTIMA pharma GmbH OPTIMA packaging
Vor dem Langen Loh 8 machines, S.A. de C.V. OPTIMA KOREA CO., LTD
35075 Gladenbach-Mornshausen San Jorge 198 SUITE 1107, 6 WIRyESEONG-DAERO,
Tel.: +49 6462 91576-0 Col. Pedregal Santa Úrsula SONGPA-GU, SEOUL, KOREA, 138-827
Fax: +49 6462 91576-148 Del. Coyoacán Tel.: +82 2 414 7105
[email protected] C.P. 04600 México, D.F. México Fax: +82 2 414 1908
www.optima-pharma.com Tel.: + 52 55 5421-0271 [email protected]
Fax: +52 55 5610-4452 www.optima-kr.com
METALL + PLASTIC GmbH [email protected]
Bodmaner Str. 2 www.optima-mex.com OPTIMA Packaging Machines
78315 Radolfzell-Stahringen (Shanghai) Co., Ltd.
Tel.: +49 7738 9280-0 OPTIMA do Brasil Máquinas de No. 695 Fengmao Road
Fax: +49 7738 9280-10 Embalagem Ltda. Malu Town, Jiading District
[email protected] Rua Joana Foresto Storani, 500 Shanghai 201801, China
www.metall-plastic.de 13280-000 Vinhedo - SP, Brazil Tel.: +86 21 6707 0888
Tel.: +55 19 3886-9800 Fax: +86 21 6707 0889
OPTIMA Packaging Machinery PLC Fax: +55 19 3886-9810 [email protected]
7 Loader Close [email protected] www.optima-cn.com
Kings Worthy www.optima-bra.com
Hampshire SO23 7TF, Great Britain OPTIMA PACKAGING MACHINES
Tel.: +44 1962 620898 OPTIMA India packaging machines (M) SDN. BHD.
Fax: +49 791 506 6500 Pvt. Ltd. 5008 A 1st Floor
[email protected] No. 2, 2nd Floor, Sri Datri Nivas Jalan Lunas, Batu 2.5
www.optima-gb.com Nagawara Circle, Outer Ring Road 09000 Kulim, Kedah
Opp. Manyata Softech Park Malaysia
OPTIMA Packaging France S.A.R.L. Bengaluru – 560045 Tel.: +60 4 495 1619
Zone d´Activités de l´Energie Karnataka, India Fax: +60 4 495 1697
4, rue Ampère B. P. 9 Tel.: +91 80-40854449 [email protected]
59559 Comines Cedex, France [email protected] www.optima-mal.com
Tel.: +33 320 6306-48 www.optima-ind.com
Fax: +33 320 6306-41
[email protected]
www.optima-fra.com

30 31
 Since we are constantly working on finding new ways to optimise our state-of-the-art machines, the texts, illustrations and figures in this prospectus are not binding and exemplar.
More information:
www.optima-pharma.com

10405381/4/EN

OPTIMA pharma GmbH

Otto-Hahn-Str. 1 | 74523 Schwaebisch Hall | Tel.: +49 791 9495-0 | Fax: +49 791 9495-2610 | [email protected] | www.optima-pharma.com