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This Is An Electronic Report & Not: To Be Used For Any Legal Purposes

A 38-year-old female presented with left-sided foot weakness. An MRI showed a right thalamic lesion. Tissue samples from the lesion were analyzed. Microscopic examination found multiple fragments with increased cellularity, atypia, and mitoses. Immunostains were positive for GFAP and ATRX but negative for IDH-1. The diagnosis was diffuse astrocytoma, IDH wild-type, WHO grade 3. A second pathologist concurred with this opinion.

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Khalid Rind
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0% found this document useful (0 votes)
58 views2 pages

This Is An Electronic Report & Not: To Be Used For Any Legal Purposes

A 38-year-old female presented with left-sided foot weakness. An MRI showed a right thalamic lesion. Tissue samples from the lesion were analyzed. Microscopic examination found multiple fragments with increased cellularity, atypia, and mitoses. Immunostains were positive for GFAP and ATRX but negative for IDH-1. The diagnosis was diffuse astrocytoma, IDH wild-type, WHO grade 3. A second pathologist concurred with this opinion.

Uploaded by

Khalid Rind
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Stadium Road, P.O.

Box 3500 ,
Karachi - 74800, Pakistan
Telephone (92-21) - 34861569 / 89
Fax: (92-21) - 34934249 , 34932059
Email: [email protected]

SURGICAL PATHOLOGY REPORT ( Discharged )


Medical Record # : 446-13-18
Patient Name : FAROOQ,SANA Age / Gender : 38Y / Female
Specimen ID : 2023:PS20010R Requested Date/Time : 13/03/2023 - 13:0
Location : D1 Collected Date/Time : 13/03/2023 - 13:0
Attending Physician : NAIA Reported Date/Time : 21/03/2023 - 16:02

Clinical Information: Left-sided foot weakness.


MRI shows right thalamic lesion.

GROSS DESCRIPTION:

The specimen is received in 2 containers in formalin.

Container 1 coded as "Posterio-superior aspect of lesion". It


consists of multiple tan-white to light brown irregular tissue
pieces measuring 2 x 1 cm in aggregate. Entirely submitted in

This is an electronic report & not


cassette 1.

Container 2 coded as "Contrast enhancing part of cystic wall".


to be used for any legal purposes
It consists of single tan-white irregular tissue piece measuring
0.4 x 0.3 cm. Entirely submitted in cassette 2. (HK)

MICROSCOPIC DESCRIPTION:

Sections examined from specimens 1 and 2 reveal multiple


fragments of a neoplastic lesion exhibiting increased
cellularity. The individual neoplastic cells show moderate to
severe atypia, and show increased mitotic activity (16 mitoses/
10 HPF). Multinucleated tumour giant cells are identified.
Necrosis and microvascular proliferation are not identified.

Immunohistochemical stains were performed which show the


following reactivity pattern:

GFAP Positive.
Ki-67 Increased (30%).
p53 Negative.
Printed on/by : 28/03/2023 12:05 PM / Page 1 (Contd. on Page 2) {Dup}

Dr. Arsalan Ahmed Dr. Naila Kayani Dr. Shahid Pervez Dr. Rashida Ahmed Dr. Zubair Ahmad
MD, DABP (Anatomic Pathology and MD, Diplomate American Board of Pathology, MBBS, DCP (Lon), PhD (Histopath, Lon), MBBS, MHPE (MAAS),FCPS (Histopath) MBBS, FCPS (Histopath),FRCPath (UK)
Hematopathology) FCAP (USA), FCPS (Histopath),FRCPath (UK) FCPS(Histopath),FRCPath (UK) Professor & Consultant Professor & Consultant
Associate Professor, Consultant and Section Head Professor & Consultant Professor & Consultant

Dr. Romana Idrees Dr. Saira Fatima Dr. Nasir-Ud-Din Dr. Khurram Minhas Dr. Aisha Memon
MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath)
Associate Professor & Consultant Associate Professor & Consultant Associate Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant

Dr. Zeeshan-Ud-Din Dr. Syeda Samia Fatima Dr. Sidra Arshad Dr. Muhammad Usman Tariq Dr. Muhammad Arif
MBBS, FCPS (Histopath),FRCPath (UK) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath)
Assistant Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant Lecturer & Consultant
Stadium Road, P.O. Box 3500 ,
Karachi - 74800, Pakistan
Telephone (92-21) - 34861569 / 89
Fax: (92-21) - 34934249 , 34932059
Email: [email protected]

SURGICAL PATHOLOGY REPORT ( Discharged )


Medical Record # : 446-13-18
Patient Name : FAROOQ,SANA Age / Gender : 38Y / Female
Specimen ID : 2023:PS20010R Requested Date/Time : 13/03/2023 - 13:0
Location : D1 Collected Date/Time : 13/03/2023 - 13:0
Attending Physician : NAIA Reported Date/Time : 21/03/2023 - 16:02

ATRX Positive (retained).


IDH-1 Negative (wild-type).

DIAGNOSIS: Posterio-superior aspect of lesion, & Contrast


enhancing part of cystic wall (containers 1 and 2):

- Diffuse Astrocytoma, IDH wild-type, CNS WHO Grade 3


in the available material.

Note: Dr. Khurram Minhas has also seen this case and concurs

This is an electronic report & not


with the given opinion.

DR.to beQURESHI
RABIA used for any legal purposes
DR. ARSALAN AHMED
M.B.B.S., M.D.

This is a computer generated report therefore does not require any signature.
Printed on/by : 28/03/2023 12:05 PM / Page 2 {Dup}

Dr. Arsalan Ahmed Dr. Naila Kayani Dr. Shahid Pervez Dr. Rashida Ahmed Dr. Zubair Ahmad
MD, DABP (Anatomic Pathology and MD, Diplomate American Board of Pathology, MBBS, DCP (Lon), PhD (Histopath, Lon), MBBS, MHPE (MAAS),FCPS (Histopath) MBBS, FCPS (Histopath),FRCPath (UK)
Hematopathology) FCAP (USA), FCPS (Histopath),FRCPath (UK) FCPS(Histopath),FRCPath (UK) Professor & Consultant Professor & Consultant
Associate Professor, Consultant and Section Head Professor & Consultant Professor & Consultant

Dr. Romana Idrees Dr. Saira Fatima Dr. Nasir-Ud-Din Dr. Khurram Minhas Dr. Aisha Memon
MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath)
Associate Professor & Consultant Associate Professor & Consultant Associate Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant

Dr. Zeeshan-Ud-Din Dr. Syeda Samia Fatima Dr. Sidra Arshad Dr. Muhammad Usman Tariq Dr. Muhammad Arif
MBBS, FCPS (Histopath),FRCPath (UK) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath) MBBS, FCPS (Histopath)
Assistant Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant Assistant Professor & Consultant Lecturer & Consultant

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