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Analysis I Worksheet Ss Edited PDF

This document contains an assignment on pharmaceutical analysis from the Department of Pharmacy at Seven Star Health Science and Business College. It includes 16 questions covering topics like: - Classification methods of analysis and distinguishing analytical terms - Calculating mean, standard deviation, and percent relative standard deviation of a data set - Classifying sources of error as determinant or indeterminate - Explaining the difference between precision and accuracy - Calculating molarity, normality, and other concentration units for various solutions - Factors that affect drug stability - Calculating pH, pOH, and percent ionization for weak acids and bases

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Binyam Asfaw
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275 views

Analysis I Worksheet Ss Edited PDF

This document contains an assignment on pharmaceutical analysis from the Department of Pharmacy at Seven Star Health Science and Business College. It includes 16 questions covering topics like: - Classification methods of analysis and distinguishing analytical terms - Calculating mean, standard deviation, and percent relative standard deviation of a data set - Classifying sources of error as determinant or indeterminate - Explaining the difference between precision and accuracy - Calculating molarity, normality, and other concentration units for various solutions - Factors that affect drug stability - Calculating pH, pOH, and percent ionization for weak acids and bases

Uploaded by

Binyam Asfaw
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 5

Seven Star Health Science and Business collage

Department of pharmacy
Pharmaceutical Analysis I By: D. A
Assignment I
1. Aster classify method of analysis as macro, micro, semi-micro and micro. What do you think her
bases of classification
2. Distinguish sensitivity, selectivity and specificity
3. Explain the difference between Repeatability , reproducibility, Robustness and Ruggedness
4. Compare systematic analysis and portion analysis in terms of sequence of detection, type of
reagent used and time required for analysis
5. Explain the major steps of chemical analysis

6. Consider the following set of replicate measurements: 2.3, 2.6, 2.2, 2.4 and 2.9

a) Calculate mean, standard deviation and %RSD

b) The accepted value for the data is 2.5: calculate

i) absolute error and ii) relative error in percent

c. what you conclude about precision and accuracy of the data


7. Classify the following as determinant and Indeterminate error

If it is Determinant error, tell whether it is personal, method or Instrumental error and suggest
how to reduce or eliminate

a. Slight solubility of the precipitate leading to the lose of the precipitate


b. Change in concentration of the solution with change in temperature
c. Co –precipitation (Adsorbition) of impurities
d. Mathematical error in calculation
e. Allowing hygroscopic substance to absorb water during or before weighing
f. Instability of the reagents
g. Incorrect sampling

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8. Explain the difference between precision and accuracy?

9. What is the Molarity of 0.9% sodium chloride (Mwt NaCl = 58.5 g/mol)

10. A concentrated HCl has a density is 1.19g/ml and contains 37% HCl(W/W)

a. Determine the Molarity and the normality of the acid solution

b. How many milliliter of the solution are needed to prepare 200ml of 0.1 M solution by dilution
Ans. 1.6ml or 1.6*10-3 liter

11. A 250ml solution contains 45.1mg of Aspirin. Express the Aspirins’ concentration in weight %
and ppm

Ans . 18.04% and 180.4 ppm


12. What is the normality of the 0.0521 M H3PO4 ? Ans. 0.156N

13. How many grams of NaCl are required to prepare 100 mL of a solution of 1 M NaCl? (
Molecular weight of NaCl=58.44 gm/mol ? Ans: 5.844

14. What is the volume of a 0.1 M HCl solution containing 1.46 grams of HCl? Ans: A. O.4L

15. What is the molarity of a solution containing 11.522 grams of KOH in enough water to make

350 mL of solution?(Molecular wt. of KOH=56.1056gm/mol) Ans: A. 0.5867M

16. Write the Factors affecting drug stability

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Seven Star Health Science and Business collage
Department of pharmacy
Pharmaceutical Analysis I By: D. A
Assignment II

1. dentify the Brønsted acids and bases in the following equation

a.

b.

2. What is the pH of pure water at 25 °C [H+] = 1.0 x 10-7 M ?

3. What is the pH and pOH of

a. 0.010 M HCl? Ans pH=2, pOH=12


b. 0.001 NaOH ans. pH=11, pOH= 3

4 .Hypochlorous acid is a weak acid formed in laundry bleach. What is the [H+] and pH of a
0.125 M HClO solution? Ka = 3.5 x 10-8 ans. 4.18

5. The pH of a solution that is 0.295 M in sodium formate (NaHCO2) and 0.205 M


in formic acid (HCO2H) is (The Ka of formic acid is 1.77 × 10-4). Ans pH= 3.8

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6. Ephedrine is a naturally occurring Basic drug useful in the treatment of asthma

A What is the pH of the 5.25 x 10 -5 M Ephedrine solution? [OH-]=5.20 x 10-5 M? Ans PH=9.7

B. What percent of the base ionized at the given pH answer 99%

7. Weak acids and bases are often formulated as their salts to make them more water soluble.
The ionized salts, however, do not cross biological membranes very well.

This resonance-stabilized anion allows barbiturates to function as weak acids, and sodium
salts may be formed to increase the water solubility of the drug and allow parenteral
administration

Calculate the percentage of a dose of pentobarbital that will be ionized at plasma pH (7.4).
The structure and ionization of pentobarbital is shown below.

Ans =20.1%

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8. Asprin is a weekly acidic drug, 1.031622 x 10-5M asprin dissociates in water and produce
1*10-5M H+ ,

a. what is pH of aspirin ? ans: pH=5

b. If Pka of asprin is 3.5 What is % ionization of asprin ans”: 96.9%

9. Calculate the concentration of acetic acid to be added to a 0.1 M solution of sodium acetate to
give a buffer of pH 5 (pKa of acetic acid 4.66). ans. 0.046 M

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