Non
Hodgkin
Lymphoma
Lymphoma
It Is a type of cancer
Hodgkin
that originates from
Lymphoma
lymphocytes in the
lymph nodes and other Non Hodgkin
tissues in the lymphatic
Lymphoma
system .The main
subtypes are :
The Lymphatic System
• It is a circulatory system made up o
spidery network of thin tubes called
lymph vessels or lymphatic vessels
like blood vessels, lymphatic vessels
branch out into all tissues o the
body.
• Lymphatic vessels carry lymph fluid, a
liquid that contains lymphocytes and
other WBCS , antibodies and nutrients.
Lymph nodes sit along with lymph
vessels and filter lymph fluid . The
lymphatic organs include the spleen,
thymus, adenoids, tonsils, and bone
Non Hodgkin Lymphoma
It is a type of blood cancer that
affects specialized white blood cells
called lymphocytes .
Lymphocytes are one type of B Lymphocytes
white blood cell . there are
three main type of T Lymphocytes
lymphocytes; Naturel Killer
Etiology Of NHI
The cause of non Patient at increased risk
Hodgkin lymphoma is include those with;
unknown, although • Primary immunodeficiency
suggests a viral cause • Secondary immunodeficiency
like (Epstein_ Barr virus • Exposure to certain
/ Hepatitis B and C chemicals
virus / HIV / Human • Chronic inflammation and
Herpesvirus8) reactive lymph node
hyperplasia
Non Hodgkin lymphoma is Genetic factors
the 2nd most common appear to play a role.
cancer in HIV_ infected Recent evidence
patients, and some AIDS shows that certain
patients present with single nucleotide
lymphoma. Patient with polymorphisms
non Hodgkin lymphoma increase the risk of
should generally screened lymphoma.
for HIV and hepatitis
viruses.
Classification Of NHI
According to According
cell of origin to WHO
B- Cell T- Cell Indolent Aggressive
NHI NHI NHI NHI
According to cell of origin
B- Cell NHI T- Cell NHI
It develop from abnormal It develop from abnormal
B - lymphocytes T- lymphocytes
Most common Less common
92%of cases of NHI 7% of cases of NHI
According to WHO
Indolent NHI Aggressive NHI
Grow slowly and initially
Grow and spread more
tend to exhibit few
quickly than indolent
symptoms
Follicular Indolent Diffuse Aggressive NHI
NHI Diffuse Large B Cell
Lymphoma
NHI Staging
Stage I Stage II
This mean that you have one of This mean that you have one of
the following : the following :
• Lymphoma in a single • Your lymphoma is
lymph node or one in two or more
group of lymph nodes groups of lymph
or organ of the nodes
lymphatic system • Your lymphoma is in an
• Lymphoma is an extra nodal site and one
or more groups of
extra nodal site (1E)
lymph nodes (2E)
Stage III Stage IV
This mean that you have one of
• This mean that the following :
you have • Your lymphoma is
Lymphoma on an extra nodal site
both sides of the and lymph nodes
are affected
diaphragm
• Your lymphoma is
in more than one
extra nodal site
Symptoms Swollen lymph nodes in
your neck , armpits or groin
of NHI Abdominal pain or
swelling
Chest pain , coughing
or trouble breathing
Persistent fatigue
Night sweats
Unexplained
weight loss
Fever
Treatment Of NHI
Radiation Therapy
Biological Or Target Therapy
Chemotherapy
Case
Study
