What is pharmacogenomics?

Pharmacogenomics (sometimes called pharmacogenetics) is a field of research that studies how a person’s genes affect
how he or she responds to medications. Its long-term goal is to help doctors select the drugs and doses best suited for
each person. It is part of the field of precision medicine, which aims to treat each patient individually.

What role do genes play in how medicines work?

Just as our genes determine our hair and eye color, they partly affect how our bodies respond to medicine.
Genes are instructions, written in DNA, for building protein molecules. Different people can have different versions of
the same gene. Each version has a slightly different DNA sequence. Some of these variants are common, and some are
rare. And some affect health, such as those gene variants linked to certain diseases.

Scientists know that certain proteins affect how drugs

work. Pharmacogenomics looks at variations in genes for
these proteins. Such proteins include liver enzymes that
chemically change drugs. Sometimes chemical changes can
make the drugs more—or less—active in the body. Even
small differences in the genes for these liver enzymes can
have a big impact on a drug’s safety or effectiveness.
One liver enzyme, known as CYP2D6, acts on a quarter of
all prescription drugs. For example, it converts the
painkiller codeine into its active form, morphine. There are
more than 160 versions of the CYP2D6 gene. Many vary by
only a single difference in their DNA sequence. Others
Your genes determine a lot about how you look. They also play a have larger changes. Most of these variants don’t affect
keyrole in how medications work in your body. Credit: NIH. how people respond to the drug.

Typically, people have two copies of each gene. However, some people have hundreds or even thousands of copies of
the CYP2D6 gene. Those with extra copies produce too much of the CYP2D6 enzyme and process the drug very fast. As
a result, their bodies may convert codeine to morphine so quickly and completely that a standard dose can be an
overdose. In contrast, some variants of CYP2D6 create an enzyme that doesn’t work. People with these variants process
codeine slowly, if at all, leading to little, if any, pain relief. For them, doctors can prescribe a different drug.

How is pharmacogenomics affecting drug design, development, and prescribing

guidelines?
The Food and Drug Administration (FDA) monitors drug safety in the United States. It now includes pharmacogenomic
information on the labels of around 200 medications . This information can help doctors tailor drug prescriptions for
individual patients by providing guidance on dose, possible side effects, or differences in effectiveness for people with
certain gene variants.

Pharmacogenomics ● March 2020 ● Page 1

Drug companies are also using pharmacogenomics to develop and market Learn More
medicines for people with specific genetic profiles. By studying a drug only in people
likely to benefit from it, drug companies might be able to speed up the drug’s NIGMS Resources
development and maximize its therapeutic benefit.
Using Genes to Guide
In addition, if scientists can identify genes that cause serious side effects, doctors Prescriptions Article
could prescribe those drugs only to people who do not have those genes. This would from Inside Life Science
allow some individuals to receive potentially lifesaving medicines that otherwise
Medicines By Design Booklet
might be banned because they pose a risk for other people.

How is pharmacogenomics affecting medical treatment? Other Resources

NIH Precision Medicine Inside
Currently, doctors prescribe drugs based mostly on factors such as a patient’s age,
Life Science Initiative (All of Us
weight, sex, and liver and kidney function. For a few drugs, researchers have
Research Program, NIH)
identified gene variants that affect how people respond. In these cases, doctors can
select the best medication and dose for each patient. Genetic Testing Registry (NCBI,
Additionally, learning how patients respond to medications helps to discern the NLM)
different forms of their diseases. Precision Medicine Initiative
(FDA)
What role does the National Institutes of Health (NIH) play in
pharmacogenomics research?
For many years, NIH-funded scientists , through the Pharmacogenomics Research
Network (PGRN), have studied the effect of genes on medications relevant to a
wide range of conditions, including asthma, depression, cancer, and heart disease.
The research findings are collected in an online resource called PharmGKB . In
addition, the Clinical Pharmacogenetics Implementation Consortium (CPIC) was
started as a shared partnership between the PGRN and PharmGKB to help lower
the barrier to clinical use of pharmacogenetic tests. CPIC creates, curates, and
posts freely available, peer-reviewed, evidence-based, updatable, and detailed
gene/drug clinical practice guidelines. Another NIH-funded project, the Clinical
Pharmacogenomics can help doctors pick Genome Resource , aims to define the clinical relevance of genes and variants for
the right treatment option and dose for
use in precision medicine and research.
each patient. Credit: iStock.

NIH takes seriously the ethical and legal implications of pharmacogenomic research. It works closely with researchers,
clinicians, and patient advocates to ensure research participants’ privacy. And it strives to maximize the benefits of
pharmacogenomics research for individuals and society. An NIH initiative where people can participate and learn more
is called All of Us.
Important goals for NIH are to further pharmacogenomics research and ensure that doctors implement the findings.
This represents part of a major initiative on precision medicine that aims to tailor treatments based on each person's
genes, environment, lifestyle, and other characteristics.
NIGMS is a part of the National Institutes of Health that supports basic research to increase our understanding of
biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention. For more
information on the Institute's research and training programs, visit https://www.nigms.nih.gov.

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