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Ceftriaxone Med Card

Ceftriaxone is a 3rd generation cephalosporin antibiotic administered intravenously or intramuscularly. It works bactericidally by weakening the bacterial cell wall. Onset of action is within 5 minutes via IV or 1 hour via IM. Common side effects include pain or tenderness at the injection site, diarrhea, and allergic reactions. The nurse should assess for drug allergies and underlying medical conditions prior to administration. After administering, the nurse monitors for signs of allergic reaction and assesses the effectiveness based on urine output and symptom resolution. Ceftriaxone should not be mixed or administered with calcium-containing solutions.

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Anja de Vries
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56 views2 pages

Ceftriaxone Med Card

Ceftriaxone is a 3rd generation cephalosporin antibiotic administered intravenously or intramuscularly. It works bactericidally by weakening the bacterial cell wall. Onset of action is within 5 minutes via IV or 1 hour via IM. Common side effects include pain or tenderness at the injection site, diarrhea, and allergic reactions. The nurse should assess for drug allergies and underlying medical conditions prior to administration. After administering, the nurse monitors for signs of allergic reaction and assesses the effectiveness based on urine output and symptom resolution. Ceftriaxone should not be mixed or administered with calcium-containing solutions.

Uploaded by

Anja de Vries
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Generic Name: Ceftriaxone Trade name: Rocephin

Pharmacologic Class: Antibiotic, 3rd generation Usual dose: 1-2g/50mL IV (or IM) or divided q12hrs, max: 4g
Cephalosporin

Action (What does it do? How long does it take to work?): Uses for this medication:
Bactericidal - weakens bacterial cell wall, causing cell death. - Infections  gonorrhea, pelvic inflammatory disease,
Active against many gram-positive pathogens. meningitis, pneumonia, septicemia, otitis media
- Perioperative prophylaxis
Onset: 5 minutes (IV), 1 hour (IM) Duration: 5-8 hrs
Common side effects:
- pain/tenderness/hardness/warmth @ injection site
- pale skin, weakness, SOB when exercising
- diarrhea (incl. C-diff associated diarrhea)

Serious complications
- rash, bloody/watery stools, cramps, N/V
- chest pain, heartburn, painful urination, decreased urination, foul smelling urine, edema in legs and feet,
peeling/blistering/shedding skin
- seizures

Clinical Judgment
Pre-administration assessment: What should the nurse assess before administering the medication?
- Hx of hypersensitivity reactions to cephalosporins/penicillin (beta-lactam Abx) or other drug allergies
- Bowel functions – N/V/D
- Hx of colitis, hyperbilirubinemia, gallbladder disease, pancreatitis, renal/liver disease, seizure disorders
- Dx of anemia or coagulation disorders – PTT alterations
- Lab tests: CBC, renal and hepatic function, electrolytes
- Culture & sensitivity
- Vitals (RR, pulse, BP, temp)
- IV site – redness, edema, pain, temperature, infection, leakage, embolism

How will the nurse know if it is appropriate to administer?


- No N/V/D, no Hx of hypersensitivity to cephalosporins/penicillin, no complications at IV site, no GI disease, anemia,
coagulation disorders

Post- administration assessment: What should the nurse assess after administering the medication? How will you know if the
medication is effective?
- Monitor S&S of allergic reactions and anaphylaxis: pulmonary symptoms (tightness in throat and chest, wheezing, cough,
dyspnea) or skin reactions (rash, pruritis, urticaria)
- Monitor for hypersensitivity reaction, urine output

Nursing considerations:
- Precipitation of ceftriaxone-calcium can also occur when Rocephin is mixed with calcium-containing solutions in the
same IV administration line  DO NOT admin Ca-containing IV solutions simultaneously (e.g. parenteral nutrition)
- Drug-drug interactions: aminoglycosides – increased risk for nephrotoxicity, oral anticoagulants – increased bleeding
- Avoid alcohol for 72 hours after discontinuation of the drug to prevent disulfiram-like reaction (e.g. flushing, throbbing
headache, N/V, chest pain, palpitations, dyspnea, syncope, vertigo, convulsions)

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