Scribd
Upload
1K views6 pages

General Principles of Chemotherapy

The document discusses key concepts in chemotherapy including the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) that determine whether microorganisms are sensitive or resistant to antibiotics. It notes the importance of antibiotic presence at wound closure, broad spectrum antibiotics, and preserving normal flora. Combination chemotherapy is described as using multiple antimicrobial agents to treat mixed, severe, or unknown infections as well as enhancing effect and preventing resistance.

Uploaded by

Inoxcent Moon
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
1K views6 pages

General Principles of Chemotherapy

The document discusses key concepts in chemotherapy including the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) that determine whether microorganisms are sensitive or resistant to antibiotics. It notes the importance of antibiotic presence at wound closure, broad spectrum antibiotics, and preserving normal flora. Combination chemotherapy is described as using multiple antimicrobial agents to treat mixed, severe, or unknown infections as well as enhancing effect and preventing resistance.

Uploaded by

Inoxcent Moon
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 6

General Principles of

Chemotherapy
Dr. Hafiz Muhammad Irfan
• Antibiotics are drugs that are used to inhibit or kill the growth of
microorganisms.
• “MIC” means the lowest concentration of drug that inhibit visible
growth after an overnight incubation.
• “MBC” It is the lowest concentration of the drug that kills at least
99.9% of total bacterial inoculums.
• Post antibiotic effect (PAE) refers to persistant suppression of
bacterial growth after limited exposure to an antimicrobial agent.
• Salient features for rational effective use of antibiotics in PAE:
• 1. Antibiotic should be present at the time of wound closure
• 2. It must be effective or active against most infected
microorganisms(broad spectrum).
• 3. Prevent occurrance of resistance and loss of normal Flora.
• Normal flora has following advantages:
• 1. Make host defense mechanism strong
• 2. Produce vitamin B and K
• 3. Produce antibacterial substance known as bacteriocins
• Sensitivity means “if the dose or concentration of drug produces the
desired pharmacological effects on microorganisms without being
toxic to human cells, the microorganisms are said to be sensative to
the drug.
• Resistance means If the dose or concentration of drug does not
inhibit the growth or kill the microorganisms, the microorganisms are
said to be resistant to that particular drug.
• “Super infection” It refers to the occurrance of new infection during
the treatment of primary infection.
• Super infection may occur due to Following:
• Non selective antibiotic
• Narrow spectrum
• Use of inappropriate drug
• Wrong dose
• Use of inappropriate therapy
• “Combination Chemotherapy” means the use of more than one
antimicrobial agents for the treatment of particular infection.
• Following are some clinical indications where combination
chemotherapy is used.
• 1. Treatment of mixed bacterial infection
• 2. Treatment of severe infection having unknown cause
• 3. To enhance antimicrobial effect
• 4. To prevent resistance

You might also like