Drug Name           Route/Dosage        Mechanism of       Indication          Contraindication       Adverse            Nursing
Action                                                        Reaction           Responsibilities
Generic Name:       Intravenous         Intereferes with   Treatment of        Patients with          CNS headache,         Assess CBC
Cefoxitin           infusion            bacterial cell     the following       hypersensitivity       lethargy,              and kidney
                                        wall               infection           drug or other          paresthesia,           and liver
Brand Name:         Adults: 2g in 50-   synthesis and      caused by           cephalosporins;        syncope,               function to tes
Mefoxin             mL. duplex          division by        susceptible         Use cautiously in      seizures CV:           results
                    containers; used    binding to cell    organisms:          patients with          hypotension,          Monitor fluid
Therapeutic         as surgical         wall, causing      Respiratory         hypersersitivity to    palpitations,          intake and
Class: Antibiotic   prophylaxis given   cell               tract infections,   penicillin or has      chest pain,            output.
                    2g IV 30-60         to die. Active     Skin and skin       history of colitis,    vasodilation,         Report
Pharmacologic:      minutes prior to    against gram-      structure           renal insufficiency,   thrombophlebitis       significant
Second              surgery, then 2g    negative and       infections,         or seizures.           EENT: hearing          decrease in
generation          IV every 6 hours    positive           Bone and joint                             loss GI: nausea,       output
cephalosporin       for not more than   bacteria,          infections.                                vomiting.             Monitor for
                    24 hours            with expanded      Urinary tract                              diarrhea,              signs and
                                        activity against   infections,                                abdominal              symptoms of
                                        gram-negative      Intra-                                     cramps, oral           superinfection
                                        bacteria.          abdominal and                              candidiasis            and other
                                        Exhibits           gynecologic                                pseudomembran          serious
minimal            infections.   ous colitis GU:        adverse
immunosuppres                    vaginal                reactions
s                                candidiasis,          Be aware that
ant activity                     nephrotoxicity         cross-
Intereferes with                 HEMATOLOGIC:           sensitivity to
bacterial cell                   lymphocytosis,         penicillins may
wall                             bleeding               occur
synthesis and                    tendency,             Instruct
division by                      hemolytic              patient to
binding to cell                  anemia,                report reduced
wall, causing                    hypoprothrombin        urinary output
cell                             emia,                  persistent
to die. Active                   neutropenia,           diarrhea,
against gram-                    thrombocytopeni        bruising, and
negative and                     a,                     bleeding
positive                         agranulocytosis,      As
bacteria,                        bone marrow            appropriate
with expanded                    depression             review all
activity against                 OTHER: chills,         other
gram-negative                    fever,                 significant and
bacteria.                        superinfection,        life-
Exhibits           pain at IM. site,   threatening
minimal            anaphylaxis,        adverse
immunosuppres      serum sickness,     reactions and
s                  urticarial,         interactions,
ant activity       dyspnea             especially
ntereferes with                        those related
bacterial cell                         to the drugs
wall                                   and tests
synthesis and
division by
binding to cell
wall, causing
cell
to die. Active
against gram-
negative and
positive
bacteria,
with expanded
activity against
gram-negative
bacteria.
Exhibits
minimal
immunosuppres
s
ant activity.
Interferes with
bacterial cell
wall synthesis
and division by
binding to cell
wall, causing
cell to die.
Active against
gram-negative
and positive
bacteria, with
expanded
activity against
gram-negative
bacteria.
Exhibits minimal
immunosuppres
s ant activity.