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Hypochlorous Acid (HOCl)

5O ml. 5O ml. 1OO ml.

1OO ml. 2OO ml. 4OO ml.

TISSUE-FRIENDLY
DUAL EFFECT
NEW GENERATION
ANTISEPSIS
HUMAN HEALTH

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NATURAL HEALTH PRODUCTS
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MULTIFACTORIAL NATURAL PROTECTION AND TREATMENT IN WOUND CARE

BROAD ANTIMICROBIAL ACTIVITY

-With its High Redox Potential (ORP), it affects all the vital parts from the cell wall to DNA by removing electrons
from the atoms of microorganisms.
-Because of this effect, it kills all microorganisms (Prokaryotic cells) within seconds at the area which
it is applied.1

BACTERIA VIRUSES FUNGI

• Acinetobacter Baumanii** • Adenoviridae species: Adenovirus • Aspergillus Fumigatus
• Actinomyces species • Flaviviridae: Hepatit C Virus • Aspergillus Niger
• Bacilluslar (Spore and asporous Forming) • Herpersviridae: Ebstein-Barr Virus, Herpes • Candida Albicans
• Bacteriodes species Simplex Tip 1,2 and 8, Cytomegalovirus • Epidermophyton Floccosum*
• Bordetella Bronchiseptica Varicella Zoster • Microsporum
• Chlamydia species • Hepadnaviridae: Hepatitis B Virus • Rhizopus Oryzae
• Chryseobacterium Meningosepticum • Hepatitis A Virus • Trichophyton Rubrum*
• Citrobacter Freundii • Orthomyxoviridae: Influenza Virus • Trichophyton Tonsurans*
• Clostridium species (Spore and asporous Forming) • Papovaviridae: Papillomavirus • Trichophyton Verrucosum*
• Corynebacterium Amycolatum • Parainfluenza
• Corynebacterium Kutscheri • Parayxoviridae: Mumps, Measles
• Enterecoccus Feecium* • Picarnoviridae: Coxsackievirus POWER FROM OUR IMMUNE
• Enterobacter Aerogenes • Poliovirus
• Enterobacter Cloacae • Reoviridae: Rota Virus SYSTEM
• Enterococcus Faecalis * • Respiratory Syncytial Virus (HRSV)
• Escherichia Coli • Retroviridae: HIV - The most important difference of Crystalin from
• Haemophilus Influenzae • Rhabdoviridae: Rabies Virus other antiseptics is its active ingredient
• Klebsiella Oxytoca** • Togoviridae: Rubella Virus (Hypochlorous acid (HOCI)) produced by the
• Klebsiella Pneumoniae immune system cells in the mammalian body.
• Listonella Anguillarum
• Micrococcus Luteus - Hypochlorous acid (HOCl) is FDA & CE approved
• Moraxella Catarrhalis and an effective antiseptic in less than
• Mycobacterium species 1 minute against all known microorganisms.
• Mycoplasma species
• Pasteurella Pneumotropica
• Proteus Mirabilis
• Pseudomonas Aeruginosa **
• Rhizobia species
• Salmonella Enteritidis 1. second
• Salmonella Paratyphi A
• Salmonella Typhi
• Serratia Marcescens
• Shigella Flexneri
• Staphylococcus Aureus (MRSA/MSSA)
• Staphylococcus Epidermidis
6. second
• Staphylococcus Haemolyticus
• Staphylococcus Hominis
• Staphylococcus Saprophyticus
• Stenotrophomonas Maltophilia
• Streptococcus Pneumoniae
• Streptococcus Pyogenes
12. second
* Including Vancomycin Resistances
** Including multiple drug resistances (MDR)

“ATCC standard strains were used.” CRYSTALIN: Activity on Pseudomonas Aeruginosa

 BIOFILM ERADICATING ACTIVITY
2
It eradicates the biofilm layer formed by resistant microorganisms.
It also kills microorganisms which in dormant form under biofilm layer. 1
Staphylococcus aureus Pseudomonas aeruginosa Candida albicans

Dilution Dilution Dilution

Dilution Dilution Dilution

ACTIVITY IN WOUND HEALING PROCESS

3
According to comparative studies with povidone iodine;
It was shown that povidone iodine inhibits proliferation of fibroblasts and keratinocytes, whereas
hypochlorous acid does not have such an effect and in contrast it increases proliferation as
compared to the control group. 1

ACTIVITY ON FIBROBLASTS ACTIVITY ON KERATINOCYTES

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Hypochlorous acid was included as an ideal agent

to be applied in the 2015 diabetic foot
infections treatment guidelines by IWGDF
(The International Working Group on the Diabetic Foot).15
DIABETIC FOOT ULCERS:

Old dressings on the wound are removed according to the procedure.

All foreign objects in the wound are irrigated by Crystalin using a syringe.

• This method enables debridement of the wound.

• After the wound is subjected to debridement thoroughly,
it can be left to dry for approximately 2 minutes.

Then the gauze dressing should saturated with Crystalin

prior to applied on the wound. BEFORE TREATMENT & AFTER TREATMENT
Applied gauze dressing stays on the wound until the next
dressing without requiring drying.
• If deemed necessary, the dressing on the wound can be
kept moist by applying Crystalin on the wound by an injector.

5 In V.A.C. assisted instillation treatments, it provides antisepsis

to the wound and faster wound healing, if used as an instillation
liquid.
Dressing can be performed 2-3 times a day depending on the
severity of the wound and physician’s opinion. The dressing
may be performed once a day, if the following conditions are met.

• No purulent secretions in the wound

• Appearance of the granulation of the wound
• Fibrin structures on granulation tissue

The treatment is continued until the wound is healed.

Not all antiseptics have wound healing activity.

According to comparative HOCI Povidone Iodine

studies with povidone iodine; Antibiotic Usage Time 20 *

Povidone iodine (PI) delays wound healing due 150

* 15

to its harmful activity on keratinocytes

and fibroblasts. 100 10 *
%
day

PI extends the antibiotic using period. 15,22 50 5

PI increases complications such as reinfection

0 0
and amputation.15,22 HOCI Povidone Iodine Reinfection Minor Amputation
 CHEMICAL AND PHARMACOLOGICAL PROPERTIES
It does not contain alcohol, iodine, antibiotic, steroid and any herbal oil.
Its pH is compatible with skin and body. Hypochlorous Acid (HOCl)
Non toxic and no irritation on open wound (with these properties it is very
safe to apply to open wounds).
No residues on application area
Does not require washing.
It provides antisepsis in the wound area, at the same time it supports wound healing and
tissue regeneration.

pH 7.1

17O-2OO ppm
ORP (OXIDATION REDUCTION POTENTIAL): 871 mV

HOW SHOULD AN IDEAL

WOUND ANTISEPTIC BE?

PROPERTY Good Medium Bad Properties of an ideal

antiseptic/disinfectant
Broad Spectrum
according to CDC
Not affected by environmental conditions
(Center of Disease
Non toxic
Control) Guidelines 24
Surface compatible
Not leaving residue
Affordable In the light of scientific
Soluble studies and guidelines,
Stability Crystalin is an
Cleaning Activity ideal antiseptic,
Environment Friendly wound healing and
Harmless activity on tissue disinfectant agent.
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INDICATIONS
As a result of the clinical and laboratory studies, it has been proven to have a strong activity in
wound healing and eradication of microorganisms. Due to this activity, it can be used in;

OPEN WOUNDS:
Cleaning, irrigation, moistening, debridement,
prevention and treatment of infections.

IN CHRONIC WOUNDS:
• Pressure ulcers stage I-V
• Stasis ulcers
• Diabetic foot ulcers 15,22

VENOUS ULCERS:
In the first 4-5 days it is applied twice a day,
then once a day in the form of wet dressing
until the symptoms have passed.

SURGICAL WOUNDS:
• It can be used in superficial and deep
surgical wounds and
MOUTH, NOSE AND THROAT: • Organ infections.
• Canker sores and ulcers of the lips
and mouth. INTRAABDOMINAL INFECTIONS:
• Herpes labialis
•It can be applied in intraabdominal perforations and
• Periodontitis 3,7,9
•Intraabdominal flushing in cases such as peritonitis.
• Nasal and Throat Infections 2,1O,11

BURNS:
Burns (1.-2. degree)
The wound should be cleaned with
Crystalin at least once a day.
Its use as a spray is the most practical
way for such patients.

VAGINAL DISCHARGE:
• Genital area cleaning

EYES:
• Blepharitis
• Eyelid cleaning
 5O ml. 5O ml. 1OO ml.

1OO ml. 2OO ml. 4OO ml.

USAGE IN WOUNDS USAGE EXCLUDING WOUNDS

· Crystalin should be applied twice a day by spraying or pouring directly
· Directly apply after the debridement of necrotic tissue and cleaning of previously
into the area where the problem is experienced until the symptoms have passed.
applied creams or medications. · It can be applied as mouthwash twice a day in such upper respiratory infections
· Should use twice a day on the wound by pouring, spraying, wet gauze pad or as tonsillitis, pharyngitis and in any kind of bacterial, viral or fungal oral and
injecting into the cavity. dental infections such as dental abscess and gingivitis.
· Crystalin should apply enough to all the parts of the wound. · Nasal irrigation may be done in sinusitis by diluting in the ratio of 1/1O.
· The treatment is continued until the wound is healed. · It can be applied in any kind of oral aptha, ulceration and infection by directly
spraying or pouring onto problematic area twice a day until the symptoms
disappeared.
Do not mix with anything other than water. Do not mix with anything other than water.
STORAGE CONDITIONS
Should keep its original pack under the room temperature without the direct exposure to sunlight.
The lid should be closed properly right after use.
Dilutions should prepare just before use with tap water.
Should keep place out of the reach of children.
REFERENCES:
1-SERHAN SAKARYA, M. D., et al. Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency. WOUNDS, 2014, 26.12: 342-350.
2-KIM, Hyun Jik, et al. Effects of a low concentration hypochlorous acid nasal irrigation solution on bacteria, fungi, and virus. The Laryngoscope, 2008, 118.10: 1862-1867.
3-CASTILLO, Diana Marcela, et al. Viability and Effects on Bacterial Proteins by Oral Rinses with Hypochlorous Acid as Active Ingredient. Brazilian dental journal, 2015, 26.5: 519-524.
4-FUKUYAMA, Tomoki, et al. Hypochlorous acid is antipruritic and anti‐inflammatory in a mouse model of atopic dermatitis. Clinical & Experimental Allergy, 2017.
5-SHAJAHAN, Irfana Fathima, et al. Substantivity of hypochlorous acid-based disinfectant against biofilm formation in the dental unit waterlines. Journal of conservative dentistry: JCD, 2017, 20.1: 2.
6-CHEN, Chun-Ju; CHEN, Chun-Cheng; DING, Shinn-Jyh. Effectiveness of Hypochlorous Acid to Reduce the Biofilms on Titanium Alloy Surfaces in Vitro. International journal of molecular sciences, 2016, 17.7: 1161.
7-Lafaurie G. I. et al. Hypochlorous Acid: New Alternative as Antimicrobial Agent and For Cell Proliferation for Use in Dentistry. Int. J. Odontostomat. 2015; 9(3):475-481.
8- RAHIMI, Saeed, et al. Antibacterial Agents in Dental Treatments. In: Antimicrobial Agents. InTech, 2012.
9- SAM, Chong-Hou; LU, Hsein-Kun. The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. Journal of Dental Sciences, 2009, 4.2: 45-54.
10-CHO, Hyung‐Ju, et al. Improved outcomes after low‐concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis. The Laryngoscope, 2016, 126.4: 791-795.
11-YU, Myeong Sang, et al. The effect of a low concentration of hypochlorous acid on rhinovirus infection of nasal epithelial cells. American journal of rhinology & allergy, 2011, 25.1: 40-44.
12- ARMSTRONG, David G., et al. Expert Recommendations for the Use of Hypochlorous Solution: Science and Clinical Application. Ostomy/wound management, 2015, 61.5: S2-S19.
13- WANG, L., et al. Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. Journal of burns and wounds, 2007, 6.
14-Sakarya S, Gunay N, Özturk ŞB, Ertuğrul MB. Dermatofitozların tedavisinde yeni bir güçlü ajan: Hipokloröz asit (Crystalin®). KLİMİK 2013 XVI TURK KLİNİK MİKROBİYOLOJİ VE İNFEKSİYON HASTALIKLARI KONGRESİ. Antalya- TURKEY; 2013:11-08.
15-LIPSKY, Benjamin A., et al. IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes. Diabetes/metabolism research and reviews, 2016, 32.S1: 45-74.
16-SELKON, J. B., et al. Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers. Journal of wound care, 2006, 15.1: 33.
17-GOTO, Kazuo, et al. Effect of hypochlorous acid solution on the eradication and prevention of Pseudomonas aeruginosa infection, serum biochemical variables, and cecum microbiota in rats. Experimental animals, 2015, 64.2: 191-197.
18-GOTO, Kazuo. Use of Hypochlorous Acid Solution as a Disinfectant in Laboratory Animal Facilites. Ann Clin Med Microbio 1(1): 1005 (2015).
19-L. S. Kavruk, Ye. А. Ziborova. BUZAĞILARDA ÖLÜMCÜL İSHALE KARŞI “HİPOKLORÖZ”. VeterinarnyiKonsultant, Issue 23, 2002, P. 6.
20-KUBOTA, Akio, et al. Effect of electrolyzed strong acid water on peritoneal irrigation of experimental perforated peritonitis. Surgery today, 2009, 39.6: 514-517.
21-TAHARAGUCHI, Motoko, et al. Effect of weak acid hypochlorous solution on selected viruses and bacteria of laboratory rodents. Experimental animals, 2014, 63.2: 141-147.
22- GORETTI, Chiara, et al. Clinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communication.
The international journal of lower extremity wounds, 2007, 6.1: 22-27.
23-ELSASS, Ferne. ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING. In: JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING. TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA:
LIPPINCOTT WILLIAMS & WILKINS, 2016. p. S14-S14.
24-CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC). Guideline for disinfection and sterilization in healthcare facilities, 2008.
25-ODORCIC, Silvia, et al. Fungal Infections After Boston Type 1 Keratoprosthesis Implantation: Literature Review and In Vitro Antifungal Activity of Hypochlorous Acid. Cornea, 2015, 34.12: 1599-1605.
NHP İlaç San. Tic. A.Ş. nhptr.com

MULTIFACTORIAL · BROAD ANTIMICROBIAL EFFECT

· ANTIBIOFILM EFFECT

NATURAL TREATMENT · ACCELERATE WOUND HEALING

· NEUTRAL PH, TISSUE - FRIENDLY AND NON - TOXIC.

IN WOUND HEALING · STABLE FOR 24 MONTHS

CRYSTALIN IS AN IDEAL WOUND CARE

ANTISEPTIC AGENT THANKS
Approved by Republic of
TO ITS SUPERIOR PROPERTIES. Turkey Ministry of Health
with the permission date
11/04/2012 and the
number 2012/68
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1OO ml. 2OO ml. 4OO ml.

+90 232 436 2647 +90 232 436 2648 [email protected] - [email protected]
Egemenlik Neighborhood, Aydınlar Street No: 49 35070 Bornova - İZMİR / TURKEY
NHP PHARMA INC.
NATURAL HEALTH PRODUCTS
“we are improving.” www.nhp.com.tr