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Nanostructured Immunosensor Study

This letter summarizes a research manuscript submitted to the Journal of Material Advances. The manuscript describes an electrochemical immunosensor using a nanostructured lanthanum oxide and reduced graphene oxide composite interface for low detection of ciprofloxacin antibiotic in milk samples. The composite was characterized using various spectroscopic and microscopic techniques. It showed effective and selective determination of ciprofloxacin in a broad linear range with low detection limits. The immunosensor also demonstrated good selectivity and was applied to real milk samples. The composite material has potential for detection of other antibiotic compounds. The author requests peer review and publication of the original research in the journal.

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Navneet Chaudhary
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42 views2 pages

Nanostructured Immunosensor Study

This letter summarizes a research manuscript submitted to the Journal of Material Advances. The manuscript describes an electrochemical immunosensor using a nanostructured lanthanum oxide and reduced graphene oxide composite interface for low detection of ciprofloxacin antibiotic in milk samples. The composite was characterized using various spectroscopic and microscopic techniques. It showed effective and selective determination of ciprofloxacin in a broad linear range with low detection limits. The immunosensor also demonstrated good selectivity and was applied to real milk samples. The composite material has potential for detection of other antibiotic compounds. The author requests peer review and publication of the original research in the journal.

Uploaded by

Navneet Chaudhary
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Jawaharlal Nehru University

Special Centre for Nanoscience


New Delhi -110067, India

Dr. Pratima R. Solanki Dated: 16th August 2023


Assistant Professor

To
The Editor,
Journal of Material Advances

Dear Editor
Please find an attached soft copy of an original research manuscript titled " Electrochemical
Immunosensor based on Nanostructured Lanthanum oxide substituted reduced graphene oxide
Interface for Ultralow Ciprofloxacin Detection in Milk Samples " by Navneet Chaudhary, Amit K.
Yadav, Damini Verma, Jai Gopal Sharma, Pratima R. Solanki to your esteemed journal “ Journal of
Material Advances" for subsequent publication.
This is a transfer manuscript from the Journal of Material Chemistry B. Editor Professor Håkan
Engqvist has suggested us transfer our manuscript to Materials Advances, for which he is also an
editor. He also said that if we transfer this manuscript, the manuscript will be sent for peer review
and will be eligible for a full APC waiver.
Here, we aim to fabricate an electrochemical immunosensor based on nanostructured lanthanum
oxide nanoparticles decorated with reduced graphene oxide nanocomposite (nLa2O3 NPs@rGO) for
sensitive and selective determination of trace amounts of ciprofloxacin (CPX) antibiotic in milk
samples. These, nLa2O3@rGO composites were functionalized by APTES and were deposited
electrophoretically on the surface of the ITO glass substrate followed by immobilizing anti-CPX
antibodies covalently via EDC-NHS chemistry. The morphological, structural, and electrochemical
characterization of nLa2O3 NPs@rGO and other developed immunoelectrodes were done through
spectroscopic (contact angle, FT-IR, Raman, XRD); microscopic (SEM, TEM) and electrochemical
(CV, DPV, and EIS) tools. Here, rGO's large surface area assists in enhancing the nLa 2O3 NPs
dispersibility that provides synergistic effects to the nLa2O3 NPs@rGO nanocomposite which leads
to electron transfer process acceleration. Hence, the developed immunoelectrode
(BSA/anti-CPX/APTES/nLa2O3 NPs@rGO/ITO) effectively determines CPX having a broad linear
detection range from 10-6 to 600 µg mL-1 with a lower detection limit of 0.055 µg mL -1 and good
durability of 25 days. Furthermore, the immunosensor showed good selectivity towards CPX and
was used in real samples of processed milk. Thus, nLa2O3 NPs@rGO composite could rise as
emerging as a potential material for other antibiotics determination also.

I certify that this manuscript, or any part of it, has not been published and will not be submitted
elsewhere for publication while being considered by the “Journal of Material Advances”. We are
looking forward to receiving the referee's reports in the near future.

With Best Regards

Yours Sincerely

Pratima R. Solanki
E-mail: [email protected]; [email protected], Tel:+9111-26704740

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