_® 5 re
Ochi _acknvi ——> Platelets bb} sHekiy El adhee ko collagen fn
‘ fi ; e \ — «
rm leans ADE £1 “Trovernbo: Ay > Vase const rich {> Acwyar-
Place —> Releaat. Platelet thyonobowtheuina atin A nayfosinn
molecules — rourachile protein — 7 casa cenhrathon 1,
chad to _fibrtisa —? Accelerated by Thrromk',,
+ (att fons fe mothn cheadhia,— ER EI Golgi Gppterabua ch Flelelah
4, Dhorde Hemostasin —>
ta) i i :
Uucr Conborylase needs vit (Correratiod jgebme) _—
adds _caxnoxu 4 id vent :
Proterrmenbin , Fath: "eG acd penn -
go, vite b Cnt btou ) y — tleeding Teniney
(b) Hemophisia i=
o No occurs te male,
© 85%) caren comsed by, Aimormatihy ox deppjdiguey ob Codes I
Ly Hemopkivia ‘A’ wre Classe Hemupplitte,
21h sh by deyphciewess oh Bache 8
o X= Linked Recersi tei
+ Pacer Gy —> Gage) = Gera _Comnpoten) UUHe Wemeplatia
by casera tu Borchesic. clothes patos
Deyydeuoy cara Ven WiUlebvard cliecres
+ Vou {oua _No. oh —plaletabs eg Abe
+ Poernal —_bleechiaag fers L2 ventilis El capttarien. —___
+ Skin oh such pecan liplayp enany Smatt _purpulitl atthe.
5 Thresterylopenft pupusa a
+ Normal platelit cous = _/S0,000 fuera
+X t0,000 fy = lethal,
Tape They + anne ap Plateteh -
+ Tt 2 rah wholr blood brasapuaicr oe
a- ; pls fromthe trek oh lange. oaks of beaummatired ar cg
— _pissue thats —body Anas —rekisnta great -Gasati ee of Aisi icbare
i re _aetivetecl tan raicleapread Atos of cPrcastabi
_ . . Oe
4
4 > >
sy, Antizengulocats
ee
sAbouwe = eh body ut. Causts blood ctottinge Bis de New
| feos anormal ch abou € to 30 oy dao minute
— |, 2 i ‘ ¢ _
|| enabole al
stow mol wh. heparisa hour ore preclictibt. sf Creu 'h Lins , &
aK oh droga
+ Actinn of Hiaaxia fark aboup IS-44 Bourse oe we pour _Heparioaae
thy Coumanius
* Nigatinly charged Citrate fon! =
4 Dp BiapalG Fore bone mrewrowe Fo CEpitente :
Reviusloryte -
t \ -
< Corytiorotastes. (Mabuae -
tb fico > Exytnpcetin , Hypoxia, Diehaaty prticha AL evasgy
it, A Vit. C Vit’ & fe 6 Niacin, Riboylovin
_suguiembats of
ta lang —_
drs _Hb {Hypo chvemée ) —
Tt > fe ~ Tabless. a
by folate fh vite By olan — . a
° Bate i ie vo fe
= tag tet Ure oldie nor— epenennttnt— popes +
1» peaulting cols Gre lange , Jownctivve 4 pertay Mhipperiuna bin pec
: g au —_k1a—megatobloats oaanee
ugolotoat : 4 by both Vit. On, & Folic acid rn oe
ta Pownicitus —anoiaic Colasaginois by Vhs Bis chagy.). -
X Thalameufa > Prectie cole deat
# lphero yytosia = REC memb 4 txceaaiutly perauioble be Nat
Na* eulera. RBC bie bfcwnvex ; mace proms to hersunlygria I
% Gre- ft = é 2. Pe.
7 during whit NADPH 4 gesuaped.
7 ° : ; a ;«hue to = “ont tht pt
A myebuaied porhon ob SNPS
Tar Nook oh Ranvier of 3
| if ee
Ihe. nag an an AP is _preducd at noksuapoak df) seectplar juste Ae, Me mp Oy estates,
Pon 4 ;
° fap Pte Sat se
460. thnesild. Su —“guealer. thas Ahasold Straten,
th Rating Stage i. Mawuérane 44 polarincl 4} = 410 mV nega tin
moubtaut poleratial thar ty -+np -
iis _Depelaniiatlon stags i= _Mewsbyasae wueddtelig blma parmecabls
to ~ fons
= Nat I Coates
> foluatial star vai. 5 tx tue olive otion
Git Lepelarization shoge 2 Na —chawaels bogus to clon
K eohaa Spates 40 Leary. hegre
faokt AP acta hat Kkylena Khuot te cmv)
+35 | —- Dueah coh
TX
= 30 fing
»|
e-¢ ug > hy . re
tele ic u -
2, 2,
© Qeenkat
Beige \ © Tyonnrtion ob AP © erove oh OF Ee
Jy i,
Otuenain H
3. Cxpaiuve of 1 Gras Sieg en au
[Reyes Heat tino crt athe i
“Power stroke” ~ muscle shortening.Br Gemsaia aaacl Maiatenaurcr of RMP —> a
situation at which the datuing —xpecece. ee
oh ptneasat tome doum thei. conetabration. PiodisAbs acne ty
——L menabraue fo epual @ goperite 40 diricsiasg fO1ct fio Msg, _
|| teona _dlouna teins —elechnetcasl —gnachiesty 4
KHL Not f 7 Whew Kt channele oper
Cstabushed
Neuen KAD Not - by nla ATPane bet ge our a _
Wh Not channsls open
| Le nat come 4 a
3, = Ble there ve more -
|
I Oper _is+ camels +a: Net channels al Reat
1] Mesbvos Kt pemmrabiig,
T
1 Net Bapleur of Ca das by ths Relaxation or tustoissecl
l| Cowraction din to habe, bvidge 4
| :Se) Bowwgy lowncs ffe a kelotal panicle —
banal eiles—4e— ATE tasks __aigbally chlgline aust. of pros
Cat —dhdss that oh eae ATP.
© 2nd &
Ac i Lrg, -
lon. Ait ¢ pps eg, Mah At te toteare a
ey lh Conduction —Y
AP _ocerina a tou Node
| ods to Noda, adbia ts
telecine ctumverat. flours —cthrord ugh. Ade
| attr rig clin healta, Afuola through —the
axon —_frtna—_Al0de_to_ Nods «This Neruae
Yer , the APs are eondichtde—fttheen,
cfd Nattatory —condluction«
ECE Outils
Auucrro chin
axoplasm liaakds — thy
Lonpislas panna chins hip,
is Dt of, vole _ for 2 4taatras
inched pbbrta, — —
Re te —elocdty of —Nerun trasnaraaiion dan trey
— finn nent pa
Agile Ore of the Gt
Se ae nat
a tote chaliagie stecypbons ane, meee eo
— ee a gh ng
at
T cope tie Getiutty,
1lame
Gira ocular rmeacten | ; . :
agpectect. Rapti stinasslOdiorn of aokoe nirsien
|b Geveratiteol shel thal pocititidler accusulation of Co ft,
rmerncts Weetenrens
neue Atreurel @l tier Ach thecran
'
to aan Me ain rnc throng,
ay aad A Wontins cxgcscation Both Atyia @ Ventyicles = Reta: ed
. Pexiod ob Rapic bittins
—} ___ - Blood _4rem _Abria ——> Veningce = ely Versbectes
i AS tee ees
_ Aro tystole > Atyia_conhrach — Remaio oe ~ 20). blood {on _
fake _vershaclen by Opening ao AV value ___ —___—
e.
—Abriot fal Vinhiblay spe —= aici ea eaceseeenneael oh
a ——Aoveluinie / | Closing “of AV value
oe J & JS Heavk S0uad
Ao Aiestele<— Blood flow inte _<— _Operstag of, Seri Lear __
‘
wee | Palsy arteg A Avie, Mire —
oe
ng Sodio Peston. ob of, Rapid eon. fer EY Va" bleed 8
2
©. efee ter 24 2S Sloat,
gr Le a Heart sonal, __ PRR a ob low fee br anJa C
7 Lavclice —.Gycle “eadings greatly tees the
vagal nese
+ Aon elraneal ot vagal ee tne ales
Thus.
pexenctithy of —piber_ttembsant
o _ of, conductive —fflaae—
spicl leakage oh -
thd ly Tne tue oe— SE A
process Cebit.
ypc, sn matin ts—saitale AAS let,
via. i
oe
«Gn SA Node. sans oh, _ypevpdderization sca BS Stn a
eye is i 4 A
Sf nod F © its _@ato foitiol naeeda. pots —a qui,
a dp _veach the pote deer _excitkation »
auch Long: Eat ;
* This _cegut a
of Ni
+ 2),_the vagal stimulation %x_shong_eusugh > fac
dn sip suttvely ta Seah —sehhe
Node. . .
+ hi 4—te Junibiti
This ta bates Maa When feck _qerarsbitive of Glove
ous —_fako 0 ete .
Ob Heat chawhers » As a siesistt of tne _Sirefel , the
carding muscle cenkvatks w/- ted force __§ this _actfon
eemphes the —_exea ~—Hood Hak has esterred frmanitne
lo _cieeusharti —
by Stostine tow stating thar forte of cochraction of Heat —
dy__dliueolty i the festol vi eee
Prerure), kin _phyaidlegical bisG% g
Fences % Coarraction Xx P Mesgh of, thu Covelte eounetus]classmate
AP i
Verabriceator gpg ta, >
vpyow 200 (dtastasiratine’). fase fash Nas channel pee. Lone.
7 | tania i Nitlmuutertil A _clipolarizes —_ : :
: by memb. potentiate —blmen move +ve,
_Noltagt = gated la — channels —> 1—? Open — > _Na- = kop tates
Mernb: poke = +20 Caf 7"
| —> Keieny ted —»
_— : ce
“1 Plane 3 ( Rapid vepolarization) Co-channils close 2 Slow Kechenetls
——}
pe |
> Kt ions leave cell —> ends the platecy —> Reburm cell membs
pokeutiat £0 4h esting, Newel.
+ fare u CAMP) > gi OOur =40 Ve
> diay Can't Condes omuinclen orto Tetons “Pe
(0) Cardiac _eowscte naa tong Rewactnsy —pervod
Ij) —» —————_ for blood supply ( Capittary dency
: 7 ° eral fan 3 Ne ynutar
— of lace adie.
—~ ty Careline enusete ts ach tn _wfitochendvia«
~—% Donte baste of Cowling Acton pobeetfal “Pe
~~ Br Seu AP of SA Node,
> Fea HP cf SSA tein, Coreen rruatta
S Mode
ree ree
(a Don J
Medas Flere
€ce = sna — anna a
ase rn tear an
__— = ma ot - ———
- slow sie tn Rp
canes.
Blo Heaxtlocals ayer of Nat
die Hoo, ————~
fn _4+ve—
=ve_dlue cash a._Heantotal,
wh
(Qe RMP seis grockeciy—
> bofenss leo
ochgate = _Activals
yoheu _pok-—=— wom => ange conn. AE
(ne 9) tn ie
100 = 18? mex,
b]m
+ L-type Ca ch L
Lp rere CRE TER Of
calf _ppewiog ar
. ge ak apens————
+ kts channels ia low
[exet
ue ho xeaklag
Qokcntetbsloy pct b|me
ln temminats the AP. (Phas. 3)
Ly channels purine Vnaaic—
.
; 1st a
al af \e — seomnols —> move =i
_\wv)
oid / fosiote.
30 —| teeneids f
lo eo L Hyper polarization,
<< Gunes inward Leck of, Ne
By channely = =~
Crier! chan
& Dorie boss of, fare AP fin _Cavalfae smntucce, t=
AS Fosk @Volrags gaked Na _channtla—epen Chan 0)
(
2) Le type Ca chonnela _opess Phar 2)
PP pemain cpt soe several 10s of secuncls «
ba lage quantity of both ‘Na! €1 ‘Cs’ [tore inside
> This, Achivily —nnainkalas _prclunged erased a
Aepolars ts An
CPhare wo)
13) _ Fast olkage Gated Nia _chenasta — elm
a
| 6) ame SS :
ca
tw) Car ch onde eid Repolawzahtin, | _h*
oS ) k= Chowe 3) e 3clascmate.
| | gp. st —alfuioled tno _4_plnaaea += —
on Phase 2 — Pertiod of pitas. —— L_peav
bs pegina ab —veuhicistar—wotunne Ga coE) fH diastote preva
| of, 2 ening —
“Veuows Hood fows + Fre cahtun ko Lb vetyicte.—> vor. Aiea to
N aout 4 cfd EBV. El diastolic prea kd, ae
, “oy Piene 2 =f Mtovaleinni ! =
J | [Sven of ventric dosa ak change ble values are closecl,
Prermsure of, vewbritte ‘Trea to Abou 0 _rnnn Hy. ;
: lo Phare @ — Period of, ejecre
! eobractinn
| L Val ob
i o
tc Phare £2 - Period of leovoluumic selaxats
b poke we Close 6) vesabricatay _prenaure Jodta back to
F
dlfastolic euel, & No Chaser i Vole .
a
eo
_—_____|__ __ loo F do
Bo + ye
| ue
—_ vestricuy| —|2@ sv -
prenune a
——_ (enmity) | — SSS
— a ea
a os + >
oo Sen wunicwtay 12°
- 7 ot emo)locked bf it
| Yeast Alo cb» +> : /
| __Sonpualaefirern Slo? Nook ta
a) Sino abiat block t
cuter abot enisa chee —
Sudd eee er “ia sea uibkevak ssklosacl id oh atria,
° en
+ Tenpulse ta cviatnots in AsV Node. ———
fase oy Wesbutne GRE T cempen stets ——
yoylarmciion
+ Tnis block can be due _to neygecantfah eee ™
finder. fowolaiing —Heanst
+ Compreasion oh AV Qunclte by Seas facie or by caleibied Mame
+ Babar aban st, ep yslonle me Bivedllegs
+ Cxhrouse SKmulalen of Hear bby vogal ser ssye
+ Deguvercation th Bal cendutiien syplee,
1
(ey Theoenplobe AV Heoxk BloeR 2°
do _ st deg cc_block — _Prolunged PR interval
ee ee ee ¢ tsa co} —
+ Normat PR iakerval = 0.16 sec
j—+ ben t+ Moen to _grreaker than 0.20 sec. 3S dees eat at
Kulay af, ererlucttirn from abria jlo vewhicle bur ner achat blocks. -
Lio degree block == Wnts tencluer. through AN Bundlte th
tough to the PR fakesval 400.25 9.ur :
+ frat Pwo @ be QR-~T wae © oe
“i a0 = Heart blacks= - - ~
—— TI a “~
2 ike {--- u Type BE mosite =
+, Beoggtatiu_pralinstion. of — yt Red nto ey mirnmtenduched -ocses
eo 3 Liaw a Forever QRS cornplee .
| rewhnrastay beak 2 dbo pect tee twee
| . U i a)
7 4 \ rel\ * P-R inkerucl do er Changs ol
T dropped bear
eh AV Node. og ot ix Artoo iecusl = Constricked
yep. skimnulaticn > Poipherat Resiviaace
1 etd
ewer Heavt appecred > Hatt)
tee 1 sar Como free
Bloc to Hearr 4) —> HR(F) — (ap 4) en -a gees coe eeeel ar aniRenaeag acer
| + Soikated bby Parovecepios | pressoveceptors tmmm Obie ctoud
“tall of each Tat» Causeticl_anteny Blais coath of Aortic uch»
+ slgneats —-fstian— “Comotid Barnrecepion” asce travamitiecd on
_Hewiug Menus 10 Glemoplharyngtal nerues A then _
See ie ogee bhai
+ shyeala—peoen." arti ic barove' pros” > Vagtes Rene —> Sve aches. |
LW > Fintag of tawnrtcephont —¥ Senseny Nero, ;
+
()) Smpathere. Olp + _Carotfovaseutay Cental tga:
| __i SS |
l coe Vesabricul _ Panasynap. ourpur. (1)
| a mycearetitin (4) !
|} Vo sod? bok =
i d fat ef, SA Nod
. cenrract C4) J
oe Pelipherat Reabat 4)
HRY)
|. (ere) Wd
ib kang = heron aigation Bh BB 2
____* Rewha- Angiolemains = Aldosterone lyatewss » —__
it Ase Premere f -
1 > Dut to 2 Headens!~
he Prema
oat wecest ee barrorecephors via Fer cetty weapored
Bitty 5 celts) 0 Hed aerial prercire wt theol release of reeicn, |
| 1 CTD fact Nact detinewy to macula clwre eekly Te tee
-——— = | aly clithal Mebiiles ahimuslaber
Baa —_* __ Pt Sr ety itn Pi aoe
(rr
> Angiokusin L => i ® —> ven of
i : Yasctonrichin“lid : “
"i pu erable pe rads
. ke Bure —_efecteol
ee “ 25 Shr. ein
4 cid Caroline — output + mormo.L
» A Ladi Corre
¢ Tr can te —atan ly Diver Ati la menor dias a
dlitutien —metwedl» = 7 a
by —olnanages— aia Canbiog
X Whew Cauatine — “oulpub 2d. guts Yy
muaclt —_pibe —Ltugl, _, ais 0 fa pupvrracl boas Jteccoweatoc,
7 “cna ins cin wb ob
rT Sucted. ol Cah , on, Dt
about 65
At dhe gtorlen practi i ovale deals of, vesseslonr isin
% Tr aw be meanuvedk + . ae a
disaging the _coeclfat Horol paolo the —euact of, —cldaabole ass ths —
tuk of Wyse Ceguilibdues sadlonuchidt aursicearcdiograliy ),0r by —
Computecl “Terogra
Ye ution a .
lula ether reant — .
arden olieaae| a -
———
| pal tow —Yection opratlon., A _penstn might draue “Foti, dtarnen |
| of —beeals_,Rapiol Heart biat—, Mivollen feet Lega or belly |
[A tow efeetion fraction opctal also be. a MGs of a con _
Li a —— a6] Qusrat Ciucutation ——— a
IS of C0, fe. #80 m£/enbaute “blowal 4 sreciemol.
1 Tnkermch Caxptid ¢
____|l* Theva axe 2 separate chica. tion
Vetuebrobaritar.,tahich “anashomnose ab circle.
de There fs a -ctose —_capilany — neuron pron innit» -
of woul
it Cerebral flows of blood! ti_cfostlyy —coupleat to rnebabollimn.
de cecal blond! —floun—sho.os —icele r¢glimal. voulations —
|| dependewk ta tre antag % tre brain habia mntbabeliicaly
oe tha a
t+ feesslatit . ree — -
|e Curing BB fietrerate. —~ve.n :
o ie ° °
a
= abi
ronskinat blond flow desplte changus fu BP ola tina _apecipied$ Cirowlatin {- Coronary arteres
Gertiverenary avkevies
el Aceotes _—————>
TT
Arkioles
| Zo y
- iosiausoidar tapittaries Arnker‘0 launch
l Verety 1 i tou
i Vet Thebaian ]
i velng
SE ee rn a ee
Ht ves Soa a
" = > Hoot an : -
ars a eeerreas -
senawet r T ; Abour 80h of coremary bloal fs
Lf pose wo I
trees deine deithole ab basal He
_piteoure, a
| ' i Za
7 : aa
| Spiele Ditahle -I coeenmny lat ae a
|x Anashsenic bleed _veaseta tao uupply Heol to ucbate aasan_ of 4
| Ineaxt —rowat alao—t SHULL supply the areas of, tu bear tua shay
4 y ive_the veratls of, the rennet —
[mui cesta bus bohm. Qreaty cilaked
4 Thi 2. ‘ e
hn
th ie P
Ksdrewie cond’ wor
Twi At fs gid “Covmary steat”
Sexe} Dieynalamole
= ea, las
Re || Ab
|
+
7S }
7X alty, Lg Hb uuu 4 fairs appfotig tt 0, topo
ob the s+ ahapeat | sigmoicl eure “bho Loge Hb saberating
| aret —_preaatirne of, oxygers ta _blomel, —____—
te sak :
—— a ‘ (~o% : ah leeway Her ag
ae Th cece bloc hor —_
E ea /
tp ae
rf Not |
arene!
= f Weed a
lI we uo (eo - S J
fea babs a
Ain peoportional to Ue _parhial presume +
_ +s A :
1 P24 about (00_t1m Ha,
n fs ¢ MOE 0. ob daw :
(42 af 0,) ; Ih. bac
At towel of bunga, pO 2 atuccti AF & po, ur blood +
| 0, —————_ 2
| Bn Blood, euteng RBG FL __ forma —_ MBO,
| He +0, <= _ a0, _
a di 4 ms 4 jaa of Hé, Sct molecun —
| of Hb cari 8- Ory or 4 _muleculs of, 0... —
AR 4G a 7
0, GH tay,co, _dimeciation— Curve, =
“neue depicts Ler hypidinee of
: ppat boo 0, fo oh of Hs forms on
| pla o Aly
— pormat bioed —PL0, = HO- 4S rm Hees ‘© f
: _yndus blood,
400 Prenitareah
Oy Commits
Dd
Tcl cont OO, ths thy Blood natty tia ;
& ie Sovol but only 4 vol sp of thin 3 betas aie,
yr be Co . Oe hg ee,
7 | ransapo berate Asst be Lasegs “That by a
. ola ths bleed pasate Liye oe
_ ‘hoa: MOH ag
ee
TP pt tre Lowel of Thysuos
ee io Hssucs 4
qo te CD, in blocd cents Pees
———————> _ ¢o,
I Poridle RACs. 2= -
10 + co = Hy tO, SF tk eo
fake oh Ht @- ~ 2
: ot Hr Heo,”
ba
Het forcrn Hewanglobinic acicl (HH)
1 Hen difpere Our fe Lhe Coll ivy the plan Et Conabsing wo)
Nat ov jot fo foem Nanos | eno,
7 ba inkouin ele ch a - o.
RBC. thie 45 calleat — Chloriole high El ib 4a _mmade possible
—| by the tyce of a speciol Bicarbonate chlovidt Crvier_prolefn fa
~divechina ab vapicl velocities
High cone of Cl" catiats Oimohi Gradius hich Causes oul of HO
Ty inelecestts fc pleas inka Ala CGtidas —cthaiewaektdag a
Ial +
# bose oh Lung = hos smalior size of aliscoll
| The Bosal segiona of the Lungs hae Lom
| presoume aa Compared 40 upper-—regiona ob
| tunsga,
A Adu _useighl of the
et Soa they sugion ‘atucolt Arauisng Mier gper.
tha basal &f mice
| elses a Compared to —_atoae he.
lepiaoltoa 2g dna +
-ve_intrapleuoah
Me usga Ase to
a , “ eee
Sr coleutating —obe foccedl_teplcatony vial capacity A Platoon
is thes enhalta taakn boy —
Lt Singles marion ltey fo the TEE rm
Max, -
: Fev, 7
| =~ Fev fevey.Pve a
' =
oe 1 tay _
|
a“
- ah ga é
ein se el pan
ap ge il pang pagar
“suxectant apopraktis” and — “Caletum fons”, Lceopensiblt for reclcig
9
or € - SUarbo
a ithe 1 - Obey
fhe alusoli thus _premeuting they OMG ice Bee
en hag
Prersure ROSS SPACE che ig 2
‘ wo ure te di
ip tare * fewsie a a
+] pies tte venat qo fewsion in taal 2) 3, 5
pre WES eto theec
r bh spurt
a a
sy
aol Surface -
—[ vile snl Ttsame ik ig is sue
jp Ts sme: tnak ta ies -
(Pe opie
Pale $6, S722 —_____Otnwot} stretl Saine,
_ fo Pa 7 Py 7
__ Pa Ts \
atl dluccliy kuds top ewphy fn larger So, Helios, Gh dali aloe
a Fo cwply in levee Wea
| : - —
x, Cuan a
F Aysparcte Peclucicl atest pO, on
+ Alacoler hypoveek a
. ne
nt hgh mage y pana —
ESE oem temas
0, 15 embrace fron
— fst ata tt tage a
a ewe bailar Ciewtahion Len 0, as
+ fell lett vac ospaien ______ plac
ia Gahloi then of the oxidY
2 me sa
a + Cyanide poiseni fag
ome ane
oo OcHuihy,Pasaciple of, enanageanent :
0, therapy at ip ———€,
ty Kypoxic— xa -
janie “Tt of Uadedying, Camas fer “te eet
of the Come -
2 2 Th 49
” Ante at Lb Ameria Hemerchags 5 a
rn Ss
fo _TIt of cow
_— ie hypoxia —> Tt of Canoe, Oe therapy -
ig e —
a tind 08 mc din A th
Bluish_distol “
| trce_f ab at ee -
de ea =
oll utes ible _!- —
LW Mucus mes: tuacunateyace of —Tengties >
uy tps Un €or Coben Liv) nit tals Tipe a
| -
| / _ |}
= — — ¥ _
J] R osuiiph eva t.
enbtol 5 KAW Kaches corti ting L ~
bo cetral cyano ~.
“Bue te Grolae ov Can Glee (atk ptriprent But te Pradeguatr
Cpmpionns be_cpfesre, ____Chreuatetien, —_______
tat leadi’to poor Mood
Lokygemation lata
| _ x ia 3
| 40_colel ae
Nusrat Reputation of espluation + - —
Respiratory centre Lowaked bilaterally ta MO ¢l_ pena lp
(la ta ti iva te oe
| major collec : —
22 VRG_P Veubro lateral pant of MO 4 wrcdnly Cour eopirahens —_
t DRG > Dorsal powian ef, MO; mainly cauoe~ tetpi fr
{h2) theumnoktxic ceubre —> D0vsaltey Hs Sup” porbin of pont ; mainly,
Covola Hate A depth of breathing,‘ tracks Solitarius ua _sernso
Aermination
a glossopharyngeal. joe bhi ae
rn tain Heapixahony Combet. _fyorn
7 hh 1p Pesipberal chtsneOreceplon ___p_Rarvoveeeghos -
np Lag Lt pes Cenultiple pars of GOT. -
—~Frainy Kony Spal Aesvna sigacts Monmana magn
Se int c
a ; —____
Ee a tin te hath
ato
é tea dap hh Poe fe vol.
in inspiv” 12 i oY
{Phase Phx | oO
r mt
The tahibits ny nu
Loot susttrot |
oe ce Grice froma prem bute
Bospre, | Sepia ogee
\ cewer
|
trae OF peripherat
| \
_
[ignee centre 0 d24) TO)
t ; ot t ——————
[Rect pg} — Sten |
jo :
jernah'e
oo “are (eer a temp
} | aes | eae
a Abdominal musts
;—| Cothrachin ch Diaphrag..,
\ a tum 4 expivavion_ [a a omypme _cebrael wale flan _
Respiratory Cowre
Stops Pospiration.
| . _
_ + : -
th Head's paradorical Replay _
|| F . ’ .
= 1 2, Hesing
~ saplat Pe
vps —merue_— Lung _byperiaglation —cauaea 0 —furrthee—Pacal 2 Rapidly —aclaphing receplors Ldhich top. HN preety
Typ avo change atti. yo.
__
aa ta atin large “tv Aucneg exctncise,
ae fo sinelatieg— a breaths ch Newborn,
pe ie tot pt ha Al whetrat saga,
ae SHmutation ef T= _wecaptors. (Terapuel mena CapiLlagy
apn atoms Shane ee ne
a ¢ rt e
epecialtay
Counts gruthing stu empivt Lu Lujerces
Us
EF Babies —Spiaal_nencosymaphie scepluse aeapecse,
° ing Pd Iriat Bet ine :
sige —stnsngy sess gen
* foaled Athan or _mechonical actors.
| stinataro
Dovkenk -veceplors
| couse ~reptex
———Britechocenshrichion coughing ,sneeatog , tathypat,
°, > ota eb
. ‘, - inkl.
ph.
shy, + ic
[-——~ i rewasn' = ss+ Pimavy Hime y + ad on
+ Prussiclngical SHnoulus = pco, _
+ Oe depts 4
| \ Ged “
— 008
LO Co, + HO = When
ose
tne
thn
| eit oecepln
[serrutate Medutla
Respivahmny contro)
Cexnhres
|
(veutitation tse) a
By Pe img ¢ plots : Y ‘
HL cfkeaae
| ° .
Also kJa Atoxic teatabing” -
. Chawackezed ory Unpredickeble icregulovalyqui bowls of shaltow *eopivatten Ao\ouwed bay Un precti=
fiocts_ob Apnoea
patil o|- _diiakehe _kermacidosts.
ARK LAKAL
INVVVVVVY
10 Cheyne =a Sects =
erode [\ eta Hypones
ia 4 \ __Apneca— Co, buldup
+ Regulation = 5 —
Fe (4) Angiobas > ‘npetiate 2
: ui
ae Sy var pars
Caan Mees.Abdlosterome ———> tes Nat 6 HO reap? at BOT
ise) eee
H bP MN) ——
J
GER (GD)
RP) > ora ay
—_| w
L
| Seg ht
* move. Jno vascular
u by vaising oe ~renisrauee
BELL), Renal Blood ftovs WL)
H Le Grew
“mM. ty :
meee urine cone ob Sede,
Wee Pose
= UX
Ob fetes serene
Tha _subt a freely fittered 61 is mob _areebs cx secreted lay —
stuol tubules tin var ab elateh thy suse vin em oveleal din fu —
(Und us
tu kidruys. CGPR XB),__ re 2 ae | Ch Paulin, Radfoaerie
fotnalauare yf Crearnicc)
cmc ar macula hewa wl- erates)
FRY —> How Hak i Heatels woop ¥ ==> Neal @ reas of Nace
Pein ——— a est J
, 7 fron ta cella, “—— tse Nace to Macile deusa
Angorwusin B —> Crarrrcs eh oN suatifoues 4° bleed glove ts
GFRt toes : ,
Z
GROG
® Toh > A Stenebea
Rewrin.
Oe Rewian s2 Shored to grate:
+ Dacliuoles cella — TG Celts —> tb ia oat of app. Adreviolr
Macute deusa —> -m in coalt of inihial park of DCT.
ERD Nace FS Maula clorg relecne adenosine ob Bidoy.
ered
* Type ch ue feuctback e/ol ar ‘Tubuloglernerulay tian CE.
—4) Bans hu BP Managemen af Hemorenag, —_
——}—Hemorvhage -—> Btood loss ——> PW —> Grad)
— i RAMS entch. 45 ach\vated
boaki RAas otha oe
| : : Pura:
|| abun \ Blood Wher brewer acres a
I =“ 2 pafnucttgs = 5 _
io Emly 2 Tromacetutay _
2 Pacace bie cos
_
Lt Bevo A0op 4 Hels —
\ * 16 a i _
via AQP 4A water channeta.
I. ne . ; . i
I
OO Aero littal tubule a
+ ATPS_eonty segnntaat _
. Co! wu ae
AL obsovos 7
tail «a __mecloled by AQP 2 located tu cynical plasma
aby AGP 2 @ AQP 4 tocatecl 2. b2r0laserat
os So _—
> a
Tae aet — oe
“Te CERES. isco bf Lite formation —D> :
woo) Urine acceens iu tne Nlepnvom tay 9 Procener »
ae a -fivation , Reatso rp hon
Ard “Wbutay
= ax —yilhcation i= Tk is the
of, _blood —
Secrehion,
Oy plasena
Opie . Mop
Celt, ey PrOktinw Are
ioe 5 Re Are _prenece ob ptey
fy sy
UNbea bi Ureabicn
-feoen, Glemneubua to bo we ania
upsronaces ter Plasena_, ex copk
isu
Frees
ar
¢_prersune — (6cop +
NEES Geert haydrasta Capsule preniun
NEP 2 Go Gs) da omg
—T ee
= it
lin iyo Sade |
sees Nae capi. \
‘ is bi ic
inet a
Hperusk artervtote . -
oh Aprcenate 6h
P= Glty
The _chaxk gtuwvaltol. 4m apna which onedabrres
+, Cenracrir force 61 Adu —dtaolol ve. whee woidiang
Myitantig ts +> oa
The hang
| plots te abacus of Leguiet is tte laced — a :
| dhraucal cal A eaaberet |
js —
©
lL 733 nana
die
- ~
3 a
|
| a
TT ~
! _-
«| No ustae 2 = 5 a ;
‘. 0 = Se rol _of, uiae > prnaues = S-\0 em/ no -
° A - . 7 r 7 7 -
l ;
| dM > th 2 She
pewouce de_wite rapidly ;
_Prerure peaks Cd Mitkenihion Louse fin cuyshmoachrngeains ee caus
bay mnfchunbn Se ¢
yl ype ani :
__Unving, ———>_ Urinary Bladoler ——> Srrechea— -
J aervate. -
CNS ~_Stosory alenieS——_Shroch seece ptr
| hr -
Me ail yacrvake
News > Derupor_muicle —> Contras —7 eB
1 on. ih _blene _poratrfysl Suerte le enece SOM
i Cenbachonw
on\crunsn cn. eple Cousts duller YU fade
|_—wdhldla parca terug, — pecisdat Novus fo ext. splincker to iswibit-
ib. So sephin +
causing Mctushion «Ht
1 polegal basta ©} Rear .
- ay plese” Pessction ui, WOLsbeencrac, os
—T exp ju Real Rabsorprion of, weber
4
cheno —alolosterina (net Gt Water @,
—T apne Varo prtasiaa.
‘
| Active browapmit’ of Not LC” gut of thie Ascexctigg._ Lino.
—? Anya of Tubular fluid promo PCT wie oujois tole SCT
D+ Assume A cond’ fn _wrlan oso abity ts 200 mOm/kg of 140
|| d . : o re a ’
DY wast ot cae — ;—e
WY si Oo _uvine _flricl of, 200 1 O.1m) kg to plowing cana
tole the _deacemrcbing — iomib th wih cauae sniphiog of, ty,
Hare rermovat ob Some 200 rnQsen Lea
—Cnacermhrated ftevicls —
lel — for — tpt — past of, adeerrching Linub Hr Sbigbing ch
of, MaclisLloriy dan bersbibicuas A gencratinig @ graditas fore
her Socrebed Solute Beertted.
“fp ech
I -
t a Vesa vecka ack ar _
Pa A PO
Vaoo CxCh ass g hae
veha :Metabolivm C0,
Moin decuing parce furs Hie sec* bay
Abt _paorierot cele aa a _hydnogera =
Ceci yee, 5m \
petacsinsn pusssp [Ht &* ATPaas |
Q@_Ht Kt ATPaae pn
wNtot et ATP aae Coie cone oy
sto _Net xe2otplon prem [tenn s
@ Htos ia endrarye of CL
@ ct chownelo comee Seen of C87 Seat
(iinJ pytode—glsaada = _
et——T
et a Le
I
Cottawued by —pepaisaa)
Beans
—
4 a erode
tu Phystal - as
| Mkts of pase. :
| Ps Cig machieutt ‘ ,
—__+—_—_— Ss“) Se
| stent r
c e |
4)
_1¢0. Weigh ceboe Ujuscle
Yat
- - — Souicle
a - 4
\ = Gp : ;
Thbegtioat Replones.
2» eo too
Cine ald meat OAD _ sfent tan 2 Shear Cobre ction Ou maknal fom partin
\|
fh, clon 40 _ auethene Shy aloo encus material Ashe —Alas vb theses
| 2 : o aye
rs : =
4b Men ae a propagating Com brackibnn 7
Se Segeneabation
.
fue —orsol fre exposure 40 the mucoral Aurpac
2 2 a
° > Cr M —_N _—_
- Not movement = 7
+ Mixing of luminal combats W]- GP seorehing 7
«|| the “exposure to as bou oe
* Tn sma 4 infeshine Sa St 7
dg v _
; Sess ~
5 —, Weotiwal Howekeeper 3 during —lokerclfgeatin. peviod - Neos vtemacn A
+ Gastro
Phas. eu panes cr
| [sald latte Antiseptic ~slloughedt.
= 1/0 mir,
oh,
ab) OrcUyy
oe
igo P =P Moher guiercersce {at= set j—tlal— date)
7 _olipase allows
__| Colipare —_bieols
| Uipcne tp bind 8 ack.tien Bsns evn diosa tat ———___
Tig lucerictua © Deriol ts Ailestisacel Aig
Gite] Upcr .
et tipo Curmenr) lh + —
__FA MG > Re-uskrafttalsan —> TOs
2 TEs cumibine —ual-— cholestrol Et
soluble vi hous na
> Gicly apalipoprroteina ptr Gols
Chylenaitaran — wla stealer vtec “
to lepnaplrabica a
8 Legulatisn of i dates Hf ta fos E
i fan
O Ole Gta Fa _
- blood sKmelar. © Sone .
Pavinchigenal Ihe wloh’cn Cotsoea ocak —
a “ cembrac? of, Galt Blacldey.
© Seen vi i
Uood srresn, =
Stimulates
Cver ducrel SCC |
: ow serra > - _
- conuwrraic
Op hs tre a —
in Get Glaaldew -
CO) GaLt Blaclelir Comrreichion
A) Relax? of Sphincter of, Oddi& Gculotion ~P
al _ppboolupalt. fon
@.sersetess bile sala Consist
987. ou
ytted BIG sain
—aaarepe SI ney
Bile say align. Sere. cnelesrral
= ——* Stored ino _bile Cnnpusabed to
—————glytine_or “Tavnine
Rebeined fo _smats farerice Usetin
heat
Semel Da besing
Bile seen yale K Bite soir quewnhiey 2
euechepilic. Chrculanen
+
| Eh Vogal Newer ——¥ Potro pancreatic ——> Panereatic > Grauere _|
adinay SecreKoy,
Neurons ‘colle |
wma |
or — + —*
renin, at LS of Paueareaht |
- Wr
Lanne se
an Kon /
155 pK- 1
——________|} Roe cebty CS-conte) i
- sebeaoe
= ie cana sun Se res is [a
CK |
—
Fusion of, Grorutia ty,
Wh Apical membrane :
AL dischnowge arakeaua: \7 eV
Wr Conatipatiion andl is pievention <—<—e
Dh vehi bo Pathologic Acard da _bowed nial “Ne
Th occas due to changin ian mohNihy a) ala dm alteration Ba
batlama blo secretin 6! Absorphien du the colon +
_ Dnky ymplrma caused bry cenakipation are _suighh smortxia a
= _mild__aibd: __dfcamdort A _difstasaion .,
& exces absorp of pull or inaupiciens flwiol oabake at ao Cary,
——Piusseration $=
asp 4 “i ite fete dich.
—__* Chatmic mucosal udewcaton ayesing hu linden tae — —_
— — jt htt _tedlcphaitn piled eisspection NSAINs or elgoreste trating — a
Bt Gani acid sect, td aac bla fy
ed disci ens see% ry gaation A cabtigga=> Bleccling , fexporalion. , Obth wotten secendlary bs edeva ce
coming
_fatlacphapiotagy + tyler “Pod
| 1) Abitity tp aeaicle sha .gaamic. acfel eu
f :
2 moriaihy Pr .
1 Preolue Urcaae § Amnmenio fron Urea , alkéloiee ty turroundirg
DD) Toolurce mucesat ee a
tN — vee)
| Hateaplsyaiclegy Smoking duscl PUA
i fol absuree” ah L & Asecd sect of Ce~ £1 Waser
duttohine & colon by small Torotine.wise / Parodie mannen
ee ap , eee
- cat ic 2 ce * -
Etta thong, teas Neutrons dle nok eyes NBR
4. Tae ‘ D ‘att ° - ;
eh Ky neurons 8 tht fe _kefsay onthe
—e is hlsspeptin secveti : .
—_tudnence. 7
— = i L_auclwee wy .>
t ayodsone.
ar Soe
: hen dugagincvion Ch SC% chromed, Caaing KY og, vel
commim SO=SONEMELEME LiLETAN aun, geniba i, . . ns -
Teahnsttevime SECTS A puberty 1s Chea Gurad ore Pe A tne carsehopmeny
of male Charactrahice | ower Slasipercin tubules on, a
gon aaclesace —0f,_mental sebarclation fs Higher thas Nemas
ia KIO Seeubnifere L - -
a . “ Wpageicsain oy Rind ter dpc eres
1» Jpuood=—Teatia anion, +>
tole of Semeiifinoiy tubules ae Urcect iy prdraaiti ae
- ue oe 7 “a
a Surudue
intl by —yeplasonie bec.
ph i Mt Snell ll, nea haat seta foren_a.
tint Alte ey mt pp pe
Stevo
jth march i,
. ila foe wie a
é y Oud vice wrsae
RE Oe ee pre Seattle Aigo al
+> _ - -
— functioas of Susteu’ Colla
tno Sappolding for tne germ cella cluring deuxtopment. .
“ed ypu Bh TSE
reg yor geamn cert _olewts! SCP ELC 2
nn 2 -excers plssicl farm ctolbeenes
a tay pat a ey ap
(Ala 6 secsplon for athim ab FSH On tbe 2.
> es. *Secarekea Dnhibins por Ftd agpulttinn A Actin fee flmn ett
le F f On Of PSH On then. -
eee peat =
: : Stmmmalngmia. psclijeation A Spemnshicyts 22 spexnsbil dems =
F —Stprataiaize Coneloplarvai | Trocsa fp nn: fo Goma Obl heseloper,
: alec ten Pnhibin (Hf Actin () thor foo pPanacine sec Late
7 - hey alt eA uarsohiers » =, Bid fpibatbany glow
7 fe LH 4 FSH - 7
pi Wegatiu jecclback —_eMpech 6} camrogen A pungerierns do die dh 6 ASM tteasnin.. “ “
oll att eee peorehnee i
or coho 4 fi i
2 D oa ast pu
__| auming Suppression ef beth PSH 6 dH seen| |__
1 acai oh Deaton - a
tie tn Aaa — ely tesa. by 05°C or abouk SF -
th teltchame 2 tlk eycte pas anne a -
st feel regia —eicagge Sting
th Panna ae
7 ek ey hapentcopic chsewodtion. rs
ta foe Atak 199 Dtvwmabration of AH peak. a
Ha Lert dleviang 2h A te a
Osi Meal cycle Pudding prt guasacy le Seoretny place,
jr Pecan’, i én ‘
0 _enclomebiives fuerte Nita.
aL ettmutanioa duit pee ss tpecianyy
2s Aloo ts
AC venely Coalug
—bdoratirines Slauighad off, cling whe Bloacl_vernelsattteng Uo mi Bd
G25 ml of serous glecicl
a fusctiee op Plaats, >
st ex > eT
—__|. 2 Pe eee eee
Oo
ee
1 Enolacuiue —_pursctiona > Ethnagens,progeatertiat , hCG.
GoRH Trnibeas
= ng—— EL a —— SS eo —
|| She peta, placenta, asrcl mother aru tinberdspercdent 7
——|_fuactimal dni Cid. thu _peteplacertat writ» — ; bt
1a placenta syntinesi zen pitegmendlons cuad prcyealerore frien choles.
ted. lief, tt png eatenoaa ctabtardetae pital timculation d@
dt peeuidea te —airbibrate por the panmation Of Codigo Fi CorHeose =
Conbrach'ong _—
me Ata Of, Baby /Yelug —> Con m\ Sree ~
d
. a ~
- Ceabrachion Te— Ean <— Baby mire <—_ Cenbrackibly16 RO a : _
~ ached by ues
Y— abe _Netrohypopliggad éc i
Uta wohiich speci’, fea,
~_ Oytasinn alae pcact loans —ofechion Or teh ~chOtim ~proiers in mille 4 cove bie
| . Becrebion +
os ‘ a
A So bee Pian. Oya lsa fa camsied is the book bp the
bent tata thea oniyos lati Celts 8 Ontrack ther
tly Cprensing
pet at ee heen
LS >
+ the _pesinmel—dlewsinsg —wtaicts the cocle C0Gres creel thy piierQle soe a i
(taal 42 Gla ert 43 A heenopacin”, :
ha preodkuithi fb—tahn gene by th evanter us Ga tn 2
h prtaaenrtick
Arm tng Of comical muctes 4 thereby prec
- Ory g the cent — ;
oT,
Maintains : wees
de
SO ctahogem , Aherby sLoaiuing au eudenerinn Unfavornete 1 Iplantetin,,
a14> fot —Po
ENDOCRINE Puys}0104 ———
dea + Sttion :
+ Piapilotigicad sgn. >
—— eceese by passcreatic. B= cetl ha deapraas 20 Tah, bie gluse
fa dig No. of Glucose hrasaporhion. Bak perm,
node af ghacose. a Ao wood. Coner
aha phyatological Mawage
un uch by pina Sill 05 ih dain :Corené lek yobrehem _nfdve. _Cenanns ait, Type - 2 Dm. L
‘ ‘ oon bis — .
Probeinurt D_Niawhora , Erectile cys punch
Vogingl candidiasis, UlCexchre_,amphshe Rent, te ___—© Deal bypaglyctsic agtssla? a
| hese ane some agents whlch aa — una) ante pally to
datas cc by — thing Lenses oh Trawlina.
Sens agus —_—§$ —_ Mechawisen 0h action ———
pa. go) — glucos_ procs / parsopai -_
8 dg se glide giiplite) rsa See i
Wats ate Mii) — t -
Satu gla cebscuoparer-> inka: POY _glassne ccceebion. +
1 Ccamegui pon Dapagtiblozin’
© fuiareridivecines (Rasigtitaene)
Dasulin Hcatteuce + _
4 dele—datertiones tla Seercheel GT
. ; fics Meet meorah
5 ——
[. —10y+ Mek Ca! ig eer
excreted. dea Undine» Normally Revel —_
ileal 28 ok ittewect Ca! ——— -
theese CCl fon emacs in 0 20Gb? hus dase chitbal shubsee
a geuab, El bts
meat Ma! is Leak bent
“Bibtss Ca’ cones fn btooet iy High Deposition of Ca far bores thence sate
‘ he ut
“Cal Ape (Cus)
Abscer” iy Ha
INTESTINE Bones
7 see
Re te eee
#4
alE
Kine ys
Sr. Sterttien auc Regulation of PTH —>
dipewdiag on the Blood ‘Cal concudre.tion
* Aloo Ca Jatt +
= Tt absoxphion
7 decvenia ri PTH “
|
; fecal
PTH ie 4 et a section? t
= * Gene Reasrpon } Sy a datieprin F
ca cpp 7
aeVikmutes D6) sthovt Note ma eitceportais —P ____
+ dt 1h far = soluble vitewuie which haa a. pokeaak—efpeck—tio Ate
| absprptiin —yprem _fiveatimal track 5 tt alao as tisapontiash efper,
| om hme —arporition avol bone seroyahion « 7
* The achinw foro —of vik St. 1,25- déhuyebroxy choke ca.Licepere| tetas
Ae oe td a4 -
> Chole caterferol (vit Da) ——
Il [iver - a
v
tt 22S. = bayer ea ble
{sien
1 Comman ciusats oh Otkeopecsaia >
1d of pagsieal sheen om bomen
| 3. Malnutihion
| 3. kack of, Vit. C
[—4 foikmencpassal lack of earogis sec ;
|__S. Old ge, __ 6. Cushing Sygndherme __4._ Hy perpana tuyprnicliins
a a el raolecutes El - ;
by Osteoblasts
tim fe ly fom es
> —__t Vos stain ti edna aaa 8 ble quiscest + CoeL
Le wwhiss feu clasps aff eileoicl pore Ga cals beg ten to ppt. on luspecen
ee
finaly —-Mybsoryapatinn cystel tou pomnele
—
1]
Va eet et ee
Regulate G=s0ls_gpptana to dips se rata tm ppp,
i
|
ated aetna durivabins of monceyha or mmnctyle Uke colts
ciuida Like Cibéc 61 Jachic. acict
1
TT
| clitsolution of Gone sath.
2 lasbic 08 id, Glaucl
| tay fienetinao 0 Ta Tasch attains © ge,
ic nto tee breasreriphion ob ew -
+ Gece epee — 0 tg hornenta La
b eld Hormones activate —NutCLetor 6C4p EO ——— enn
i is _
| jtommanasa the cebusley — merabolis acti
Oy ne AL cic sity of Mb oo
fac oLukp sk. -
napuoicl hormones tie Respissa tit.» G27 maby. -
‘alcimaisn Hugulates —Blate a’ lett.
Sect) $= :
. pil e fel secre:
a 4 el A
Blooal »
P tien activity of Tadicle pursue El fea Loctissa tion ef, “Trprosiue fo
& i ful f . /
* Ak? _pitut . see 4 i
Horan —fre0a tbs —uypotralosasars
i Gaprseataue bay ave us x ee
Cold exposure > TRH seer t —> TSH seen f —¥ Tuproick omnes b
+ Rtclbatk —efgect oh —Thyprnicl Hormone toe aut” ptheibary ate of T
ft Thypawicd Homes —> fied Metab.
Bahibity
+ 3
- TsH b> prorioe L TRH > TSH — Tryprowioe blib fuuetions of covtial fe
1 Sh atau eates GUcomengerseais.
fies eveymass seg fo Constr AR auto glucctre din Akar celty
Catsaca _mebiledtion of AA. fren exbresrepabie. tases
— a oni2e dvaulin's cppech ee
1 SF cateaes a _moolenate- eee plc utilization by rata le be tay
Sh conser Med cateboldim of ptecketin 61 Wut pluchtin ipsataeals. ”
- , so
Pibsiroxy tp Wie ACTH eco , “
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