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EVIDENCE MULTISTAT
Fully Automated Drug Testing
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Evidence MultiSTAT
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MultiSTAT Process

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Benefits
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Test Menu

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Matrices
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Software Overview

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Applications
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Technical Specification
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Randox Toxicology are world leaders in drug testing

solutions with the capability of detecting over 500
drug and drug metabolites using innovative
Biochip Array Technology.
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Evidence MultiSTAT

Using our revolutionary Biochip Array Technology (BAT), the Evidence MultiSTAT is an
automated analyser that enables on-site simultaneous detection of up to 21 classical,
prescription and synthetic drugs from a single sample. Designed to work across a variety
of matrices, our patented multi-analyte testing platform provides a complete toxicology
profile within minutes, changing the landscape of drug detection forever.

Multiplex Explained

BAT is an immunoassay testing platform for the simultaneous multi-analyte testing

of a panel of related tests. The technology works by combining a panel of up to 44
related tests on a single Biochip with a single set of reagents, controls and calibrators.
Competitive chemiluminescent immunoassays are employed for the Biochip Arrays.
The light signal generated from each of the test regions on the Biochip is simultaneously
detected using digital imaging technology and compared to that from a calibration curve.

Key

Discrete test region

Quality control spot

7x7 Biochip surface 44 discrete test regions on each
Biochip for individual analytes
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Benefits

 Rapid Screening
With minimal sample preparation required, qualitative results can be provided in
under 20 minutes, offering an efficient and accurate toxicology screen.

Multiple Matrices
Testing is available across multiple matrices including; blood, urine, and oral fluid
to accommodate any testing requirements.

Simple Process
With prefilled reagent cartridges and a simple interface, non-laboratory trained
staff can operate the analyser in any environment and achieve results in minutes.

Reliable Results
Using chemiluminescence as a measurement principle, the Evidence MultiSTAT
consistently delivers accurate results and offers a highly sensitive way to detect
drugs of abuse.

Extensive Test Menu

The Evidence MultiSTAT facilitates on-site simultaneous screening of multiple
drug classes, including classical, prescription and synthetic drugs of abuse.
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Matrices

Blood

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• Matrix dedicated kit for blood ensures optimum performance
• Sample collection should be carried out in accordance with the
collection tube manufacturer’s recommendations
• Whole blood samples should be centrifuged and diluted 4-fold
prior to analysis
• 200 μl sample volume required

Urine

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Dedicated kit for urine with the most appropriate cut off
Detection of both parent and metabolite drug
200 μl sample volume required
No Sample Preparation

Oral Fluid

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• Matrix dedicated kit for oral fluid ensures optimal assay performance
• Compatible for use with multiple oral fluid collection devices
• Applications for point of collection testing
• 200 μl sample volume required
• Sample preparation should be carried out in accordance with the
collection device manufacturer’s recommendations
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Cartridge & Analyser Overview

Reference Chamber
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Cut off material is added here.

Sample Chamber
2
200μl of sample is added here. 4

Foil Cover & Fluid Reservoirs 3

3
All additional fluids required are stored underneath
a sealed foil cover and pierced by the analyser 1

during testing. 2

Biochip Wells
4
Two Biochips are placed here, one to test the patient
sample and one for the cut off materials, 21 discrete
testing regions are placed on each biochip.

Touch Screen
1
A large touch screen interface allows the user to easily
navigate through the testing screens of the analyser and
view test results.
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Tip Cartridge Drawer
2
The user will insert the prefilled tip cartridge here
prior to testing.
2

Reagent Cartridge Drawer

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3 4 The user will insert the reagent cartridge here
prior to testing.

2 x USB Ports
4
USB Ports allow the user to add accessories e.g barcode
scanner, printer and export test results via USB.
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Applications

Emergency/Hospitals

Emergency room’s typically screen for many routine drugs of abuse, as patients may be
incoherent when providing information.

Workplace Drug Testing

With far-reaching implications, up to 20 percent of work-related fatalities test positive

for drugs or alcohol. The drugs at the root of this issue include cocaine, heroin,
methamphetamine and prescription drugs.

Rehabilitation Centres

It is important to have a clear understanding of the drugs in the patient’s system before
facilitating detox and to monitor abstinence.

Mining Industry

The priority for any mine is preventing accidents, reducing costs associated with high
false rates from current testing methods and keeping workers who are under the influ-
ence of drugs and alcohol off site.

Medical Examiners

 It is essential Medical Examiners are able to screen for a wide range of drugs and drug
metabolites in order to successfully investigate deaths that occur under unusual or
suspicious circumstances.
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Racing/Anti-Doping

Most commonly performed on racehorses, drug tests are also performed on horses in
endurance riding and for competitions such as the Olympics. Many competition horses are
regulated by various international and national organisations.

Prisons

Drug testing in prisons is key to ensuring offenders have a better chance of leading a
drug free lifestyle after custody, as the links between drug use and crime is increasing.

Doctor’s Surgery

Drug testing patients who are being treated for pain can be tested for opioid misuse and
abuse, offering wider options and the ability for doctors caring for pain patients to make
informed decisions.

Airports

Testing employees for drugs is extremely important. Random tests and tests after an
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accident or serious incident involving an employee is crucial to passenger safety and

airport security.
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Evidence MultiSTAT Process

User Steps

Step 1 Step 2

Prepare sample and Load reagent

add to cartridge cartridge and
tip cartridge to
MultiSTAT
Analyser Steps

Step 1 Step 2 Step 3

Assay diluent, Biochip incubated Biochip washed

sample & conjugate
dispensed into
Biochip well

Step 6 Step 5 Step 4

Test results reported Biochip loaded Signal reagent

in under 20 minutes into image box and dispensed into
Biochip well
chemiluminescence
measured
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Test Menu

Assay Cut-Off Assay Cut-Off

6-MAM 10 ng/ml Methadone 10 ng/ml

Blood AB-CHMINACA 5 ng/ml Methamphetamine 50 ng/ml

AB-PINACA 2 ng/ml Opiates 80 ng/ml

Cat. No. EV4195
Amphetamine 50 ng/ml Oxycodone 10 ng/ml
Time to Result: 23 minutes
BZG (Cocaine Metabolite) 25 ng/ml PCP (Phencyclidine) 5 ng/ml

Barbiturates 50 ng/ml Pregabalin 1000 ng/ml

Benzodiazepines 20 ng/ml TCA (Tricyclic Anti-depressants) 60 ng/ml

Buprenorphine 2 ng/ml THC (Cannabinoids) 10 ng/ml

EtG (Ethyl Glucuronide) 500 ng/ml Tramadol 5 ng/ml

Fentanyl 1 ng/ml α-PVP 5 ng/ml

Assay Cut-Off Assay Cut-Off

6-MAM 10 ng/ml JWH-018 (Synthetic Cannabinoids) 20 ng/ml

Urine 1 AB-PINACA 2.5ng/ml Methadone 300 ng/ml

Amphetamine 200 ng/ml Methamphetamine 200 ng/ml

Cat. No. EV4193
BZG (Cocaine Metabolite) 150 ng/ml Opiates 200 ng/ml
Time to Result: 19 minutes
Barbiturates 200 ng/ml Oxycodone 50 ng/ml

Benzodiazepines I 150ng/ml TCA (Tricyclic Anti-depressants) 150ng/ml

Benzodiazepines II 150ng/ml THC (Cannabinoids) 20 ng/ml

Buprenorphine 1 ng/ml Tramadol 5 ng/ml

Creatinine 20mg/dl UR-144 (Synthetic Cannabinoids) 10 ng/ml

EtG (Ethyl Glucuronide) 750 ng/ml α-PVP 5 ng/ml

Fentanyl 2 ng/ml -

Assay Cut-Off Assay Cut-Off

6-MAM 10ng/ml Methadone 300ng/ml

Urine II AB-CHMINACA 10ng/ml Methamphetamine 500ng/ml

AB-PINACA 3ng/ml Opiates 300ng/ml

Cat. No. EV4292
Amphetamine 500ng/ml PCP (Phencyclidine) 25ng/ml
Time to Result: 19 minutes
BZG (Cocaine Metabolite) 300ng/ml Pregabalin 300ng/ml

Barbiturates 200ng/ml TCA (Tricyclic Anti-depressants) 150ng/ml

Benzodiazepine 200ng/ml THC (Cannabinoids) 50ng/ml

Creatinine 20mg/dl Tramadol 20ng/ml

EtG (Ethyl Glucuronide) 750ng/ml UR-144 (Synthetic Cannabinoids) 10ng/ml

Fentanyl 2ng/ml α-PVP 5ng/ml

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Assay Cut-Off Assay Cut-Off

6-MAM 2 ng/ml LSD 1 ng/ml

Oral Fluid Amphetamine 50 ng/ml Methadone 4 ng/ml

Cat. No. EV4117 BZG (Cocaine Metabolite) 20 ng/ml Methamphetamine 50 ng/ml

Barbiturates 50 ng/ml Opiates 10 ng/ml

Time to Result: 17 minutes
Benzodiazepines I 10 ng/ml Oxycodone 8 ng/ml
3-fold dilution applied by the collection
device has been accounted for in the Benzodiazepines II 10 ng/ml PCP (Phencyclidine) 5 ng/ml
cut-off material provided Buprenorphine 1 ng/ml THC (Cannabinoids) 2 ng/ml

Fentanyl 1 ng/ml Tramadol 4 ng/ml

JWH-018 (Synthetic Cannabinoids) 5 ng/ml UR-144 (Synthetic Cannabinoids) 10 ng/ml

Ketamine 50 ng/ml α-PVP 2 ng/ml

Cat. No. EV4279 Assay Cut-Off Assay Cut-Off

Time to Result: 17 minutes 6-MAM 3 ng/ml LSD 1.5 ng/ml

4-fold dilution applied by the collection Amphetamine 60 ng/ml Methadone 5 ng/ml

device has been accounted for in the BZG (Cocaine Metabolite) 30 ng/ml Methamphetamine 70 ng/ml
cut-off material provided
Barbiturates 60 ng/ml Opiates 15 ng/ml

Benzodiazepines I 15 ng/ml Oxycodone 10 ng/ml

Benzodiazepines II 15 ng/ml PCP (Phencyclidine) 7 ng/ml

Buprenorphine 1.5 ng/ml THC (Cannabinoids) 5 ng/ml

Fentanyl 1.5 ng/ml Tramadol 5 ng/ml

JWH-018 (Synthetic Cannabinoids) 20 ng/ml UR-144 (Synthetic Cannabinoids) 25 ng/ml

Ketamine 65 ng/ml α-PVP 2.5 ng/ml

Kits For Forensic Use

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Easy to Use Software

Complete Patient
1
Profiling
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Multiplex testing with Biochip
Array Technology allows clinicians
and investigators to consider the
complete picture allowing for well
informed decisions and accurate
diagnosis.

2 Extensive Test Menu

Our 21 drugs of abuse panels form

part of our unrivalled toxicology test
menu, capable to detecting over 500
drugs and drug metabolites.

3 Data Integrity

Users are able to log in to access data

and lock the MultiSTAT to ensure data
integrity. Search options are available
to retrieve previous results.

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4 4 Result Traceability

Chain of custody features enable

better management, accountability
and responsibility of those using
sample/data.

5 Quality Results

Highly reproducible qualitative

results. Sample classification
displayed in relation to established
5 cut off limits.

6 Connectivity

LIMS integrated for convenient

reporting, and fully printable reports.
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Evidence MultiSTAT Specifications

Analyser Description Fully automated Biochip Array analyser

Dimensions 585 (H) x 535 (D) x 570 (W) mm

Weight 48kg (106lbs)

Biochip Format Cartridge based system – assay reagents sealed in a cartridge

Connectivity LIMS uni-directional interface

Data Back-up Methods Data export functionality

Environment Operating temperature 18˚C-32˚C, <80% Relative humidity, <2000m Altitude, Pollution: Degree 2 (IEC 664)
Stable workbench required

Measurement Principal Competitive techniques with chemiluminescent reaction

Operator Interface 15.6" touch screen

Peripherals Barcode scanner

Printer can be connected (not included)

Power Requirements Input Voltage 110-240v

Sample Loading Single cartridge loading bay

Sample Volume 200μl

Time to Result 17 minutes - 23 minutes

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Randox Toxicology, 55 Diamond Road, Crumlin, Co Antrim, United Kingdom, BT29 4QY
LT650TOX JAN19

T +44 (0) 28 9442 2413 E [email protected] I randoxtoxicology.com

Randox Toxicology is a company registered within Northern Ireland with Company Number NI 069074. VAT Registered Number: GB 151 6827 08. Product availability may vary from country to country. Information correct at time of print.