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Coagulant and Anticoagulant Med Chem

Vitamin K is a fat soluble vitamin that acts as a cofactor for blood clotting factors like prothrombin. It exists in different forms, with phylloquinone (K1) being the major dietary form and menaquinones (K2) being produced by bacteria. Vitamin K antagonists like warfarin work by interfering with the vitamin K cycle and inhibiting the regeneration of vitamin K from its oxidized form, leading to reduced clotting factor production.

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Rushikesh Dhage
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293 views5 pages

Coagulant and Anticoagulant Med Chem

Vitamin K is a fat soluble vitamin that acts as a cofactor for blood clotting factors like prothrombin. It exists in different forms, with phylloquinone (K1) being the major dietary form and menaquinones (K2) being produced by bacteria. Vitamin K antagonists like warfarin work by interfering with the vitamin K cycle and inhibiting the regeneration of vitamin K from its oxidized form, leading to reduced clotting factor production.

Uploaded by

Rushikesh Dhage
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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COAGU(ANTS

Cogqulan
that causy coagutaton og blol
ac indicaten h ae mooohoyt
Condition
ClasiFicaion:
Nitamin k
h : phyBona dinc

fat Soluble s menadiou ,Acota


menadne
b) waR SOwbe enaiore
Sodiur) btspte

MOA
" víBomi n k isis GOqurotd
eoqutd Foo Syes
a cloting.factoo T,

Car bo|ohon 0chn


Facts Decatbofyteic r-Cagboxyloted fctoy
(I, YI, , )
ut4 K
scucocd
Foon) (oRicdisecl Forsm)
liSe
" Dbstouctive Jaundio

Poolonged fntimicroobtal terscapy


Ovesdoag op orsa Aste Arti coagudot
mlobsophon Syrdoone
Anisindi
ne EX.
Devahve 3-1ndanedi
Coe )
CHa-0-CHg CH-
Warsfa
ni E
Dervoive! Coumamn
Closnticaton
Clot
te fnot
but Form
Clot tedusole do They
not
oocl. o
bl ability
techoose ceaqulan co
Anti
ANTICOAGU
(ANIS
2)Miscteeey Clopidol
Kas MOA

anticocgulcns proluce
Coith Cyele
hey inteact coth koeocuch
enyme
ho+
SO that Vit ko doe
eQcyo back to Vit IC
These coill Iedel to deehy
Hy evet Fosmot
poothrombin (factor D)

WasFain
Syntheis

AG0 o-t-cng
coOCHs
Acicicotion

Ben 2aacotoe
(cH= CH COCh, )

CH,cOCH3

wasfaoin depleb n kHa by


in hibthny
eniyne
Thu i4 leaco to t Fos mohey

Ue9 bsed f poophylan!


~ahon cu fo h embol's
tera Absi

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