ALNALGESICS Th 2 dug which relieves pawn Withouk the lees a Consuousnens - » Bate only symplermahie reléf (B s_ ———, Opfofa analgesics Non oboe analy oe 08 = (Nshi0€, reodbhurie ty pe binin type Oprotdl Analgesiis Oldist vere for wlif gf pawn: Eadur calli as nancotic analgeats. - lanetfteac on (0 Barrel on_stieblov _cecupahire phil analyx -— ie oly TH 0. See [A” ol Gen fala is pttulic| Nalexene Rentagpune 5 J Natsexone Naloaphere Mofhide Metadlone Nalbuphine Codainn Pelle Caotnaey@ Chemicak clasfftakor (oats U - re Precaac ind ; Pecglioys . se FO 1 Meaplure Naseng Codutie Nescaping ® Bavecd on source Fen Mefha. Pothier pholcodlune Teamadel MORHINE . Mechanism | of Achon Mosbhine ¢ otfier opiordls 4 Ads on crete seceblon fs am Ho receptors YFD achilylyl cyclase “Sener v of \okacellulae CAMP Pamahon L Fadltak obenimg of kt channels te o rt agohon aig & oly 4 caluum tato all J oO opensrig of Ga channds + JY 16 bkacellilase Cat? L release of neuro bsanarnt Hex Phasmacdlagécal achéns a) CNS > a > Emo mer > Sedahdn > Hypnosts @ Resbtaahén, > Respa Aibresion recuchon 9 Senef act of Milly “nk ee Ce @ Deboers tte cough, roflooc Nausea and vomthrig() CVS yw "=> Hypotension > Vawoolblation © qi 5 Decsoares tha mottlily of clnuqulk @) ANS > Mile hypergbycernia, @® Vagus > Mospluie stimulates vagah antes Cau beady casclin. (a) Senaotlis erosscles > haom of ephtocks ¢ odd? > Tohebrh” wwfhany vous rfl > Broncho conshithon + Phasmacohuivhis a0 Oral aderinShoahor — glow and Beomplde absab > Undlesgoes aenaive fast pars mebabelisia = > Broavalabrtity — 2040 HoT. - Ako gwen by subcutaneously. * Dosage. | 10-15 mg IM ‘Vee. childeatn > O-1-O°2 mg ky aa » Vos _ 1c > Pre -anesttch? mediiiadion 5 Co 5 Diardrea » Advesse ec > Sdabion > Constpahon > Respirocooy Aefsoersion + Apnoea . > Blumig J visor. Auili_rorbhine pofooing . Maw be actidlntal euirdal ox homtck - htel dose # non addich —> 2ovng © Addi can tolrati grams J mocbhure - . Sans and Syrotomns ? Resbacrko 3eKION > pin woot as °> Hypotension > shock > Cyonosm > Hypotiuamuc > FlacctolPhy > > Stupod wbee Ot dual.fe Axealment - “a > Posthyve pressure vespaahon > Madtenane Y 4P > Specfhé anttdole : Naloxone > Carta? lavoge wtf, potassium pesanganale ig wemove. J nabeosbel doug : rot . Cotbvaindbahons > Arotcl opfotdls 13 pocherls whtte respial hsuffiiernyy — coPD a > Advanud : > Head “at > Hypovolaemee Shock, ES Unolagnosecl acti abdomen . PENTANYL « Advan > 100 times move potot- than mow punt ak an analgesic > egy ped goluble ancl fast ackog => Mild peck, on cvs > Slight yeduchod 16 BP and HR“Uses > Newaolephanallgessé : Wed A ou chook «i ree Wats, anch pase = Eptlusal ferlange # Used fow posto of obetek gic. pe _» Fea cheonfe pau . Adverse feta > Muscle ot zl? > Nenaea’ 4 =a Vornthiag = Resbiotozy duprersion NaALOXxONS + pare antagout . . Gtver \W > enees all He acho of morfhuc e RespiRadony ese101N) and sedahon > Pat wittiidnaual § 2 ladles le pias of en yc optete Pes - 4 Back Ae analy roca oy AGPeerw orally > urdugoes Past par mlabolord : +> Quahoo > 27 Hbws > Bq sage = 0-4 rg |V Uses > > > moaphute overdose. Dfagnose of opfofd dependence Reverse neonatal asphyouce clue 40 obtotcls wed in labour: Reverse hypotension due +b cnclepiius dl