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Ovarian Cancer Histopathology Report

This histopathology report summarizes the findings from a hysterectomy with bilateral oophorectomy and omentectomy procedure on a 45-year-old female patient. Microscopic examination found high grade serous carcinoma involving both ovaries and the endometrium. Immunostains were positive for WT1 and showed aberrant overexpression of p53, consistent with high grade serous carcinoma. The tumor was classified as pT3b based on macroscopic peritoneal metastasis beyond the pelvis less than 2cm in size.

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0% found this document useful (0 votes)
99 views4 pages

Ovarian Cancer Histopathology Report

This histopathology report summarizes the findings from a hysterectomy with bilateral oophorectomy and omentectomy procedure on a 45-year-old female patient. Microscopic examination found high grade serous carcinoma involving both ovaries and the endometrium. Immunostains were positive for WT1 and showed aberrant overexpression of p53, consistent with high grade serous carcinoma. The tumor was classified as pT3b based on macroscopic peritoneal metastasis beyond the pelvis less than 2cm in size.

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WAQAR YOUNAS
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Shaukat Khanum Memorial Cancer Hospital & Research Centre

Johar Town, Lahore, Pakistan - Phone: +92-42-35905000, 111-155-555, Fax: 042-35945198


Email: [email protected], Website: www.shaukatkhanum.org.pk

Department of Pathology
PDF: 13-Dec-2023 15:51:04 Histopathology Report Page 1

Dept Ref# : 001HIS23097778 Ordered By :


MRNO : 001-80004861735 In-house Consultant :
Name : NIGHAT BIBI Report Destination : Collection Centre - 45

Age/Sex : 45 Year(s)/Female Requested : 04-DEC-2023 10:48:41


Phone : 92 0335 5680422,92 0331 5876848 Specimen Received : 05-DEC-2023 18:21:24
Address : BEER, HARIPUR - PAKISTAN : 13-DEC-2023 15:35:05
Reported

Specimen Nature: HYSTERECTOMY WITH BILATERAL OOPHORECTOMY, OMENTECTOMY


Specimen Site: OVARIES AND UTERUS, OMENTUM
History: Case of carcinoma ovary, bilateral cystic ovaries and small pedunculated nodules, ascites fluid, adhesion
gut wall and urinary bladder.
Gross: SPECIMEN #1 (OVARIES AND UTERUS):
Specimen container is labeled with the patient's name and medical record number and labeled as 1.
Received in formalin is a hysterectomy specimen with both ovaries and a cystic tissue piece separately
present in container.
- Procedure: Hysterectomy with bilateral oophorectomy
- Summary Of Gross (on serial slicing):
- Ectocervix: Smooth and shiny
- There is a polyp in endometrium cavity attached with endometrium measures 30 mm. Cut surface shows
no fibroid
- Measurement:
- Uterus: 69 x 40 x 19 mm
- Thickness of endometrium: 1 mm
- Smaller ovarian cyst measures 51 x 40 x 29 mm. Capsule is intact. No surface deposit and growth is
seen. Serial slicing reveals solid and cystic components 50% cystic and 50% solid components. Inner
surface of the cystic component shows papillary projections and solid area is grey brown in color.
- Larger ovarian cyst measures 67 x 50 x 30 mm. Capsule is intact. No surface deposit and growth is
seen. On opening shows uniloculated cyst filled with brownish fluid and inner lining shows papillary
growth measures 40 x 30 mm. Cystic fragment measures 50 x 30 x 2 mm. Cut surface is grossly
unremarkable.
Representative sections are taken and submitted as follows:-
A&B) Anterior and posterior cervix; C) Section of endomyometrium with polyp; D) Section from the full
thickness of endomyometrium; E) A polyp entirely submitted; F-J) Section from the smaller ovarian cyst;
K-N) Section from the larger ovarian cyst; P) Section from the cystic tissue fragment separately present in
container.

SPECIMEN #2 (OMENTUM):
Specimen container is labeled with the patient's name and medical record number and labeled as 2.
Received in formalin is an omentum tissue fragment measures 19 x 16 x 9 mm. Cut surface shows
nodules, largest measuring 1.9 cm. The entire specimen is submitted in two blocks (A&B).
(Gross assisted by: Kalsoom Majeed).

KHAWAJA SAJID MUSHTAQ DR. MUHAMMAD FAHAD FAIZ DR.


Consultant Pathologist
Electronically verified by,no signature(s) required.
Dr. Asif Loya Dr. Asad Hayat Ahmad Dr. M. Tariq Mahmood Dr. Mudassar Hussain Dr. Maryam Hameed
MBBS, DABP (AP and MBBS, DABP (AP, CP and MBBS, DABP (AP/CP and MBBS, FCPS (Histopathology), MBBS, FRCPath
Cytopathology), FIAC Hematopathology) Hematopathology) Fellowship in Renal Pathology
(Canada)
Dr. Sajid Mushtaq Dr. Usman Hassan Dr. Umer Nisar Sheikh
MBBS, FCPS, FRCPath MBBS, FCPS, FRCPath MBBS, DABP (AP, CP,
Cytopathology)
Shaukat Khanum Memorial Cancer Hospital & Research Centre
Johar Town, Lahore, Pakistan - Phone: +92-42-35905000, 111-155-555, Fax: 042-35945198
Email: [email protected], Website: www.shaukatkhanum.org.pk

Department of Pathology
PDF: 13-Dec-2023 15:51:04 Histopathology Report Page 2

Dept Ref# : 001HIS23097778 Ordered By :


MRNO : 001-80004861735 In-house Consultant :
Name : NIGHAT BIBI Report Destination : Collection Centre - 45

Age/Sex : 45 Year(s)/Female Requested : 04-DEC-2023 10:48:41


Phone : 92 0335 5680422,92 0331 5876848 Specimen Received : 05-DEC-2023 18:21:24
Address : BEER, HARIPUR - PAKISTAN : 13-DEC-2023 15:35:05
Reported

Micro: Procedure: HYSTERECTOMY WITH BILATERAL OOPHORECTOMY, OMENTECTOMY


Specimen Integrity
Specimen Integrity of Right Ovary: Intact
Specimen Integrity of Left Ovary: Intact
Specimen Integrity of Right Fallopian Tube: Intact
Specimen Integrity of Left Fallopian Tube: Intact

Tumor Site: Bilateral ovaries


Ovarian Surface Involvement: Not seen
Fallopian Tube Surface Involvement: Not seen
Tumor Size: 67 mm (largest)
Histologic Type: High grade serous carcinoma
Histologic Grade: High grade serous carcinoma
Implants: Not seen
Other Tissue/ Organ Involvement: Tumor involves endometrium
Peritoneal Ascitic Fluid: Not applicable
Treatment Effect: Not applicable
Regional Lymph Nodes: Not applicable

Pathologic Stage Classification (pTNM, AJCC 8th Edition)


TNM Descriptors
Primary Tumor (pT): pT
___ pT3b: Macroscopic peritoneal metastasis beyond pelvis cm or less in greatest dimension with or
without metastasis to the retroperitoneal lymph nodes

Regional Lymph Nodes (pN): pN


___ pN not assigned (no nodes submitted or found)

Distant Metastasis (pM) pM


___ Not applicable - pM cannot be determined from the submitted specimen(s)
Screened By: Hira Yaqub Dr.
IMMUNO/HISTOCHEMICAL STAIN(S):
WT1: Positive
p53: Aberrant over expression

KHAWAJA SAJID MUSHTAQ DR. MUHAMMAD FAHAD FAIZ DR.


Consultant Pathologist
Electronically verified by,no signature(s) required.
Dr. Asif Loya Dr. Asad Hayat Ahmad Dr. M. Tariq Mahmood Dr. Mudassar Hussain Dr. Maryam Hameed
MBBS, DABP (AP and MBBS, DABP (AP, CP and MBBS, DABP (AP/CP and MBBS, FCPS (Histopathology), MBBS, FRCPath
Cytopathology), FIAC Hematopathology) Hematopathology) Fellowship in Renal Pathology
(Canada)
Dr. Sajid Mushtaq Dr. Usman Hassan Dr. Umer Nisar Sheikh
MBBS, FCPS, FRCPath MBBS, FCPS, FRCPath MBBS, DABP (AP, CP,
Cytopathology)
Shaukat Khanum Memorial Cancer Hospital & Research Centre
Johar Town, Lahore, Pakistan - Phone: +92-42-35905000, 111-155-555, Fax: 042-35945198
Email: [email protected], Website: www.shaukatkhanum.org.pk

Department of Pathology
PDF: 13-Dec-2023 15:51:04 Histopathology Report Page 3

Dept Ref# : 001HIS23097778 Ordered By :


MRNO : 001-80004861735 In-house Consultant :
Name : NIGHAT BIBI Report Destination : Collection Centre - 45

Age/Sex : 45 Year(s)/Female Requested : 04-DEC-2023 10:48:41


Phone : 92 0335 5680422,92 0331 5876848 Specimen Received : 05-DEC-2023 18:21:24
Address : BEER, HARIPUR - PAKISTAN : 13-DEC-2023 15:35:05
Reported

Diagnosis: SPECIMEN #1 (OVARIES AND UTERUS):


High grade serous carcinoma, bilateral ovaries involving endometrium.

SPECIMEN #2 (OMENTUM):
Omentum involved by tumor, size of largest deposit 1.9 cm.

For any query regarding diagnosis, treating physician can contact at 03000453078 between 8:00 AM to
5:00 PM (working days only).
SNOMED: T-82000 M-80103

KHAWAJA SAJID MUSHTAQ DR. MUHAMMAD FAHAD FAIZ DR.


Consultant Pathologist
Electronically verified by,no signature(s) required.
Dr. Asif Loya Dr. Asad Hayat Ahmad Dr. M. Tariq Mahmood Dr. Mudassar Hussain Dr. Maryam Hameed
MBBS, DABP (AP and MBBS, DABP (AP, CP and MBBS, DABP (AP/CP and MBBS, FCPS (Histopathology), MBBS, FRCPath
Cytopathology), FIAC Hematopathology) Hematopathology) Fellowship in Renal Pathology
(Canada)
Dr. Sajid Mushtaq Dr. Usman Hassan Dr. Umer Nisar Sheikh
MBBS, FCPS, FRCPath MBBS, FCPS, FRCPath MBBS, DABP (AP, CP,
Cytopathology)

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