MEDICAL TPU

SOLVENT EFFECTS
& CHEMICAL
RESISTANCE
OVERVIEW
Table of Contents
Content Page
Study Introduction 2
Aliphatic Carbothane TPU
™
3–4
Aromatic Carbothane™ TPU 5
Isoplast TPU
®
6
Pellethane TPU
®
7
Tecoflex MG TPU
™
8
Tecoflex™ TPU 9
Tecophilic TPU
™
10
Tecoplast TPU
™
11
Tecothane Soft TPU
™
12
Tecothane™ TPU 13

1
Solvent Effects
Overview
Solvent effects are an important area of interest in the development and use of polymers.

Solvents are used to:

• Dissolve polymer to create device components

• Coat devices to give them desired properties

• Clean and disinfect components in manufacturing and through use of device

Solvent interactions also determine material transportation through

the polymer. An understanding of the effects of solvents on polymers
allows for the optimization of design and processing conditions,
as well as selection of a suitable solvent.

In this study, the effect of solvent absorption was studied by placing

small cut pieces of injection molded bars into 20ml scintillation vials
and filled with solvent. The samples were stored at room temperature
(approximately 23˚C) for 24 hours. Samples were then removed,
wiped gently and weighed immediately. The results note the weight
percentage of solvent the resin absorbed in 24 hours.

2
Solvent Absorption
Aliphatic Carbothane TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU PC-3575A PC-3585A PC-3595A PC-3555D PC-3572D

% wt Increase
Acetonitrile 65 50 35 30 18

Acetone 175 100 80 60 45

Caster Oil 0 0 0 0 0

Chloroform D D D D PD

Cyclohexane 2 1 1 1 0

Cyclohexanone PD PD 100 70 60

Cyclopentanone PD PD PD 125 95

Diethylether 25 20 16 16 9

Dimethylacetamide D D PD PD PD

Dimethylformamide PD PD PD PD PD

Dimethylsulfoxide 40 45 45 45 65

Dioxane PD PD PD 200 125

Ethanol 6 6 6 5 6

Ethylacetate 200 125 80 60 40

Hexane 1 1 1 1 1

Isopropyl alcohol 3 3 3 3 3

Methanol 8 9 9 7 9

Methylene Chloride D PD 775 1150 600

Methyl Ethyl Ketone 300 150 100 80 55

Tetrahydrofuran D PD PD PD 275

Toluene 450 175 100 80 55

Trichloroethane D PD PD PD PD
Normal Saline
(0.9% Sodium Chloride) 0 0 0 0 0

1N HCI (Hydrochloric Acid) 0 0 0 0 0

1N NaOH (Sodium Hydroxide) 0 0 0 0 0

PEG 300 0 0 0 0 0

PolyPropylene Glycol 0 0 0 0 0

Polysorbate - 80 0 0 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

3
Solvent Absorption
Aliphatic Carbothane TPU (continued) ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU PC-3575A-B20 PC-3585A-B20 PC-3595A-B20 PC-3555D-B20 PC-3572D-B20

% wt Increase
Acetonitrile 55 40 30 25 16

Acetone 175 90 65 55 35

Caster Oil 0 0 0 0 0

Chloroform D D D D PD

Cyclohexane 1 1 1 1 0

Cyclohexanone PD PD 95 60 55

Cyclopentanone PD PD PD 125 85

Diethylether 19 16 12 11 8

Dimethylacetamide D D PD PD PD

Dimethylformamide PD PD PD PD PD

Dimethylsulfoxide 30 35 40 40 45

Dioxane PD PD PD 175 125

Ethanol 4 5 5 5 5

Ethylacetate 175 85 60 60 35

Hexane 1 1 1 0 0

Isopropyl alcohol 2 3 2 2 2

Methanol 7 7 7 9 7

Methylene Chloride D PD 700 1175 600

Methyl Ethyl Ketone 300 125 90 80 60

Tetrahydrofuran D PD PD PD 275

Toluene 300 125 90 85 50

Trichloroethane D PD PD PD PD
Normal Saline
0 0 0 0 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 0 0 0 0 0

1N NaOH (Sodium Hydroxide) 0 0 0 0 0

PEG 300 0 0 0 0 0

PolyPropylene Glycol 0 0 0 0 0

Polysorbate - 80 0 0 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

4
Solvent Absorption
Aromatic Carbothane TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU AC-4075A AC-4085A AC-4095A AC-4055D AC- AC- AC- AC-
4075A-B20 4085A-B20 4095A-B20 4055D-B20
% wt Increase
Acetonitrile 55 35 20 16 45 25 17 14

Acetone 200 125 55 40 175 80 50 40

Caster Oil 0 0 0 0 0 0 0 0

Chloroform PD 525 350 275 PD 725 325 250

Cyclohexane 1 1 0 0 1 0 0 0

Cyclohexanone PD 130 85 50 PD 75 80 55

Cyclopentanone PD PD 250 150 PD PD PD PD

Diethylether 17 12 7 4 13 8 5 4

Dimethylacetamide D D D D D D D D

Dimethylformamide D D D D D D D D

Dimethylsulfoxide 75 125 PD PD 65 PD PD PD

Dioxane PD PD 150 100 PD PD 150 100

Ethanol 3 2 2 1 3 2 1 1

Ethylacetate 160 75 40 25 150 50 30 20

Hexane 1 1 0 0 1 0 0 0

Isopropyl alcohol 2 1 1 0 1 1 1 0

Methanol 5 4 3 2 4 3 2 2

Methylene Chloride 800 650 250 175 825 450 250 200

Methyl Ethyl Ketone 300 175 75 55 PD 125 45 45

Tetrahydrofuran D D PD 375 D D PD PD

Toluene 100 60 30 16 95 40 20 15

Trichloroethane PD PD 175 125 650 325 150 125

Normal Saline
8 0 0 0 0 0 0 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 0 0 0 0 0 0 0 0

1N NaOH (Sodium Hydroxide) 0 0 0 0 0 0 0 0

PEG 300 0 0 0 0 0 0 0 0

PolyPropylene Glycol 0 0 0 0 0 0 0 0

Polysorbate - 80 0 0 0 0 0 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

5
Solvent Absorption
Isoplast TPU ®

24 hours @ 23°C, ASTM-D 570

Solvent, TPU 2510 2530 R1 2531

% wt Increase
Acetonitrile 1 1 1

Acetone 16 10 25

Caster Oil 0 0 0

Chloroform 35 17 60

Cyclohexane 125 0 0

Cyclohexanone 20 20 PD

Cyclopentanone 45 30 PD

Diethylether 1 0 0

Dimethylacetamide D D D

Dimethylformamide D PD D

Dimethylsulfoxide PD PD PD

Dioxane 30 20 PD

Ethanol 1 0 1

Ethylacetate 3 4 10

Hexane 0 0 0

Isopropyl alcohol 0 0 0

Methanol 2 1 2

Methylene Chloride 50 25 60

Methyl Ethyl Ketone 25 13 40

Tetrahydrofuran 125 95 PD

Toluene 0 0 0

Trichloroethane 16 8 40
Normal Saline
0 0 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 0 0 0

1N NaOH (Sodium Hydroxide) 0 0 0

PEG 300 1 1 5

PolyPropylene Glycol 0 0 0

Polysorbate - 80 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

6
Solvent Absorption
Pellethane TPU ®

24 hours @ 23°C, ASTM-D 570

Solvent, TPU 2363-80AE 2363-90AE 2363-55DE

% wt Increase
Acetonitrile 13 10 7

Acetone 70 50 35

Caster Oil 0 0 0

Chloroform 625 375 250

Cyclohexane 4 2 1

Cyclohexanone PD 125 95

Cyclopentanone PD PD PD

Diethylether 25 16 9

Dimethylacetamide D D PD

Dimethylformamide D D D

Dimethylsulfoxide PD PD PD

Dioxane PD 250 125

Ethanol 12 7 5

Ethylacetate 65 35 25

Hexane 3 1 0

Isopropyl alcohol 7 4 3

Methanol 16 12 9

Methylene Chloride 450 250 175

Methyl Ethyl Ketone 70 90 60

Tetrahydrofuran D D D

Toluene 55 30 16

Trichloroethane 375 200 125

Normal Saline
1 1 1
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 1 1 0

1N NaOH (Sodium Hydroxide) 1 0 0

PEG 300 1 1 1

PolyPropylene Glycol 0 0 0

Polysorbate - 80 1 0 0

PD = Partially Dissolved
D = Completely Dissolved

7
Solvent Absorption
Tecoflex MG TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU MG-8020 MG-8812

% wt Increase
Acetonitrile 5 2

Acetone 30 17

Caster Oil 0 0

Chloroform D D

Cyclohexane 0 0

Cyclohexanone 60 55

Cyclopentanone 125 65

Diethylether 10 2

Dimethylacetamide PD PD

Dimethylformamide PD PD

Dimethylsulfoxide 75 75

Dioxane 150 100

Ethanol 20 14

Ethylacetate 35 19

Hexane 0 0

Isopropyl alcohol 11 7

Methanol 30 20

Methylene Chloride - 375

Methyl Ethyl Ketone 50 35

Tetrahydrofuran PD PD

Toluene 50 20

Trichloroethane PD PD
Normal Saline
(0.9% Sodium Chloride) 0 0

1N HCI (Hydrochloric Acid) 0 0

1N NaOH (Sodium Hydroxide) 0 0

PEG 300 0 0

PolyPropylene Glycol 0 0

Polysorbate - 80 0 0

PD = Partially Dissolved
D = Completely Dissolved

8
Solvent Absorption
Tecoflex TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU EG-80A EG-85A EG-93A EG-100A EG-60D EG-65D EG-68D EG-72D

% wt Increase
Acetonitrile 25 19 12 11 9 8 7 6

Acetone 95 65 45 45 40 40 35 30

Caster Oil 3 2 0 0 0 0 0 0

Chloroform D D D D PD D D PD

Cyclohexane 35 20 5 3 2 1 1 1

Cyclohexanone 230 150 80 80 60 60 60 45

Cyclopentanone 425 250 175 175 100 135 125 85

Diethylether 80 55 30 30 20 25 25 15

Dimethylacetamide PD PD PD PD PD PD PD PD

Dimethylformamide D PD PD PD PD PD PD PD

Dimethylsulfoxide 14 16 20 35 25 35 35 45

Dioxane 350 250 175 225 125 175 150 95

Ethanol 50 35 25 30 20 25 20 17

Ethylacetate 175 100 55 65 40 55 45 35

Hexane 17 13 3 2 2 1 1 0

Isopropyl alcohol 35 25 13 17 10 14 12 9

Methanol 55 40 30 40 30 35 30 20

Methylene Chloride D 1050 950 1300 975 850 525 500

Methyl Ethyl Ketone 275 125 80 75 60 65 60 50

Tetrahydrofuran D PD PD PD PD PD PD PD

Toluene 350 175 90 100 65 80 70 55

Trichloroethane PD PD PD PD PD PD PD PD
Normal Saline
1 1 1 1 1 1 1 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 1 1 1 1 0 1 1 0

1N NaOH (Sodium Hydroxide) 1 1 1 1 0 1 1 0

PEG 300 1 0 0 0 0 0 0 0

PolyPropylene Glycol 0 0 0 0 0 0 0 0

Polysorbate - 80 1 0 0 0 0 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

9
Solvent Absorption
Tecophilic TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU HP-93A-100 HP-60D-20 HP-60D-60

% wt Increase
Acetonitrile 100 35 60

Acetone 100 55 60

Caster Oil 0 0 0

Chloroform D D D

Cyclohexane 1 1 0

Cyclohexanone PD 60 45

Cyclopentanone PD 175 125

Diethylether 14 20 7

Dimethylacetamide D PD PD

Dimethylformamide PD PD PD

Dimethylsulfoxide 350 85 PD

Dioxane PD 250 225

Ethanol 60 35 30

Ethylacetate 100 70 55

Hexane 1 1 0

Isopropyl alcohol 25 17 13

Methanol 150 60 75

Methylene Chloride D 1500 1350

Methyl Ethyl Ketone 125 80 70

Tetrahydrofuran PD 575 400

Toluene 80 80 45

Trichloroethane PD PD PD
Normal Saline
80 9 40
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 95 11 45

1N NaOH (Sodium Hydroxide) 60 6 30

PEG 300 8 1 2

PolyPropylene Glycol 2 0 0

Polysorbate - 80 1 0 0

PD = Partially Dissolved
D = Completely Dissolved

10
Solvent Absorption
Tecoplast TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU OP 770 -000

% wt Increase
Acetonitrile 4

Acetone 40

Caster Oil 0

Chloroform 350

Cyclohexane 0

Cyclohexanone D

Cyclopentanone D

Diethylether 14

Dimethylacetamide D

Dimethylformamide D

Dimethylsulfoxide PD

Dioxane PD

Ethanol 5

Ethylacetate 45

Hexane 0

Isopropyl alcohol 2

Methanol 7

Methylene Chloride 200

Methyl Ethyl Ketone 75

Tetrahydrofuran D

Toluene 25

Trichloroethane 175

Normal Saline (0.9% Sodium Chloride) 0

1N HCI (Hydrochloric Acid) 0

1N NaOH (Sodium Hydroxide) 0

PEG 300 11

PolyPropylene Glycol 0

Polysorbate - 80 3

PD = Partially Dissolved
D = Completely Dissolved

11
Solvent Absorption
Tecothane Soft TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU AR-75A AR-85A AR-95A

% wt Increase
Acetonitrile 4 3 3

Acetone 30 25 25

Caster Oil 0 0 0

Chloroform 825 375 525

Cyclohexane 40 25 13

Cyclohexanone 200 175 175

Cyclopentanone 325 225 275

Diethylether 95 60 45

Dimethylacetamide PD PD D

Dimethylformamide 75 100 200

Dimethylsulfoxide 16 30 40

Dioxane 200 150 150

Ethanol 3 3 3

Ethylacetate 75 55 45

Hexane 25 20 10

Isopropyl alcohol 3 3 2

Methanol 2 2 2

Methylene Chloride 525 470 325

Methyl Ethyl Ketone 125 45 200

Tetrahydrofuran 600 575 575

Toluene 200 125 80

Trichloroethane 450 275 200

Normal Saline
0 0 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 0 0 0

1N NaOH (Sodium Hydroxide) 2 0 0

PEG 300 0 0 0

PolyPropylene Glycol 0 0 0

Polysorbate - 80 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

12
Solvent Absorption
Tecothane TPU ™

24 hours @ 23°C, ASTM-D 570

Solvent, TPU TT-1074A TT-1085A TT-1095A TT-1055D TT-1065D TT-1069D TT-1072D TT-1075D-M

% wt Increase
Acetonitrile 18 14 10 7 4 5 4 3

Acetone 125 85 45 30 30 20 25 30

Caster Oil 0 0 0 0 0 0 0 0

Chloroform 2000 725 325 225 200 150 175 150

Cyclohexane 6 4 2 1 0 0 0 0

Cyclohexanone PD PD 125 60 50 45 55 75

Cyclopentanone PD PD PD 225 175 125 175 150

Diethylether 40 30 16 10 5 4 4 3

Dimethylacetamide D D D D D D D D

Dimethylformamide D D D D D D D D

Dimethylsulfoxide 60 80 PD PD PD PD PD PD

Dioxane PD PD 175 85 95 60 85 100

Ethanol 17 12 7 5 4 3 4 3

Ethylacetate 125 70 35 20 19 12 18 16

Hexane 3 3 1 1 0 0 0 0

Isopropyl alcohol 10 7 4 3 2 1 1 1

Methanol 20 17 12 9 7 6 7 6

Methylene Chloride 1150 625 225 150 125 100 125 100

Methyl Ethyl Ketone 425 275 70 45 65 30 45 50

Tetrahydrofuran D D D PD PD PD PD PD

Toluene 95 75 50 15 9 7 7 4

Trichloroethane 775 500 175 100 125 70 100 85

Normal Saline
1 1 1 1 0 0 0 0
(0.9% Sodium Chloride)
1N HCI (Hydrochloric Acid) 1 1 1 1 0 0 0 0

1N NaOH (Sodium Hydroxide) 1 1 1 1 1 0 0 0

PEG 300 2 1 1 1 1 1 1 2

PolyPropylene Glycol 0 0 0 0 0 0 0 0

Polysorbate - 80 1 1 0 0 0 0 0 0

PD = Partially Dissolved
D = Completely Dissolved

13
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