NAME : Mrs. KAMAL REG/LAB NO.
: 24031468 / 169036
AGE/SEX : 26 Yrs / Female DATE OF RECEIVED : 17-03-2024 at 11:17 AM
REFERRED BY : DATE OF REPORT : 17-03-2024 at 12:02 PM
REF CENTER : CHAITANYA MEDICAL CENTRE
TEST PARAMETER RESULT REFERENCE RANGE
VITAMIN B12( COBALAMIN)
VITAMIN B-12 263.0 pg/mL 211 - 946 pg/mL
CLIA
Note: To differentiate vitamin B12 & folate deficiency, measurement of Methyl malonic acid & serum
Homocysteine level is suggested.
Comments: Vitamin B12 performs many important functions in the body, but the most significant function is to
act as coenzyme for reducing ribonucleotides to deoxyribonucleotides, a step in the formation of genes.
Inadequate dietary intake is not the commonest cause for cobalamine deficiency. The most common cause is
malabsorption either due to atrophy of gastric mucosa or diseases of terminal ileum. Cobalamine deficiency leads
to Megaloblastic anemia and demyelination of large nerve fibres of spinal cord. Normal body stores are
sufficient to last for 3-6 years. Sources of Vitamin B12 are liver, shellfish, fish, meat, eggs, milk, cheese &
yogurt.
Decreased Levels :
1 ) Lack of Intrinsic factor: Total or partial gastrectomy, Atrophic gastritis, Intrinsic factor
antibodies,2) Malabsorption: Regional ileitis, resected bowel, Tropical Sprue, Celiac disease, pancreatic
insufficiency, bacterial overgrowth & achlorhydria, 3) Loss of ingested vitamin B12: fish tapeworm,4) Dietary
deficiency: Vegetarians, 5) Congenital disorders: Orotic aciduria & transcobalamine deficiency and 6) Increased
demand: Pregnancy specially last trimester.
Increased Levels: Chronic renal failure, Congestive heart failure, Acute & Chronic Myeloid Leukemia,
Polycythemia vera, Carcinomas with liver metastasis, Liver disease, Drug induced cholestasis & Protein
malnutrition.
Page 1 of 4
NAME : Mrs. KAMAL REG/LAB NO. : 24031468 / 169036
AGE/SEX : 26 Yrs / Female DATE OF RECEIVED : 17-03-2024 at 11:17 AM
REFERRED BY : DATE OF REPORT : 17-03-2024 at 12:02 PM
REF CENTER : CHAITANYA MEDICAL CENTRE
TEST PARAMETER RESULT REFERENCE RANGE
VITAMIN D 25 HYDROXY (CHOLECALCIFEROL/VITAMIN D3)
VITAMIN D 25 HYDROXY 21.6 ng/mL (L) 30 - 100 ng/mL
(CHOLECALCIFEROL/VITAMIN D3)
CMIA
Deficiency < 20 ng/mL (High risk
for developing bone disease)
Insufficiency 20 - 29 ng/mL
(Vitamin D concentration which
normalizes Parathyroid hormone
concentration)
Optimum level: 30-100 ng/mL
(Optimal concentration for
maximal health benefit)
Potential intoxication:>100 (High
risk for toxic effects)
Page 2 of 4
NAME : Mrs. KAMAL REG/LAB NO. : 24031468 / 169036
AGE/SEX : 26 Yrs / Female DATE OF RECEIVED : 17-03-2024 at 11:17 AM
REFERRED BY : DATE OF REPORT : 17-03-2024 at 12:02 PM
REF CENTER : CHAITANYA MEDICAL CENTRE
TEST PARAMETER RESULT REFERENCE RANGE
NOTE:
1) The assay measures both D2 (Ergocalciferol) and D3 (Cholecalciferol) metabolites of vitamin D.
2) 25 (OH)D is influenced by sunlight, latitude, skin pigmentation, sunscreen use and hepatic function.
3) Optimal calcium absorption requires vitamin D 25 (OH) levels exceeding 30 ng/mL.
4) It shows seasonal variation, with values being 40-50% lower in winter than in summer.
5) Levels vary with age and are increased in pregnancy.
6) This is the recommended test for evaluation of vitamin D intoxication.
Comment: Vitamin D (Cholecalciferol) promotes absorption of calcium and phosphorus and mineralization of
bones and teeth. Deficiency in children causes Rickets and in adults leads to Osteomalacia. It can also lead to
Hypocalcemia and Tetany. Vitamin D status is best determined by measurement of 25 hydroxy vitamin D, as it is
the major circulating form and has longer half life (2-3 weeks) than 1,25 Dihydroxy vitamin D (5-8 hrs).
Decreased levels:
1) Inadequate exposure to sunlight. 2) Dietary deficiency. 3) Vitamin D malabsorption. 4) Severe Hepatocellular
disease.
5) Drugs like Anticonvulsants & 6) Nephrotic syndrome.
Increased levels: 1) Vitamin D intoxication.
L- Low, H- High
Dispatched by: Lokesh S **** End of Report **** Printed by: CHAITHANYA MEDICAL CENTRE on 17-03-2024 at
12:36 PM
Page 3 of 4
NAME : Mrs. KAMAL REG/LAB NO. : 24031468 / 169036
AGE/SEX : 26 Yrs / Female DATE OF RECEIVED : 17-03-2024 at 11:17 AM
REFERRED BY : DATE OF REPORT : 17-03-2024 at 12:02 PM
REF CENTER : CHAITANYA MEDICAL CENTRE
TEST PARAMETER RESULT REFERENCE RANGE
Dr. MURALI WOODI HEAD OF LABORATORY Dr. SRINIVAS.V
Ph.D Msc ,Mphil ,PGDNBT (KMC No:19863)
CONSULTANT BIOCHEMIST CONSULTANT PATHOLOGIST, MD
Page 4 of 4
