03/04/24, 11:18 Weight loss in animals and humans treated with "weighlevel", a combination of four medicinal plants used
plants used in traditional arabic a…
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Evid Based Complement Alternat Med. 2011:2011:874538. doi: 10.1093/ecam/nen067.
Epub 2011 Jun 16.
Weight loss in animals and humans treated with
"weighlevel", a combination of four medicinal plants
used in traditional arabic and islamic medicine
Omar Said 1 , Bashar Saad, Stephen Fulder, Khaled Khalil, Eli Kassis
Affiliations
PMID: 18952688 PMCID: PMC3137768 DOI: 10.1093/ecam/nen067
Abstract
Weighlevel, a mixture of extract of four plants used in traditional Arabic and Islamic medicine as well
as in European herbal medicine, was prepared and assessed for its safety and efficacy in weight loss.
Leaves of Alchemilla vulgaris, Olea europaea and Mentha longifolia L., as well as seeds of Cuminum
cyminum, were used. Cultured human fibroblasts treated with Weighlevel did not exhibit any sign of
toxicity as evidenced by lactate dehydrogenase release. These results were confirmed in experimental
studies on rats where an LD(50) of 15.3 g kg(-1) was observed. Significant antioxidant properties were
seen at very low concentrations of Weighlevel (10 μg ml(-1)) as measured by the lipid peroxidation
method. Progressive and significant weight loss was observed in chickens given this mixture weekly
for 4 weeks compared with controls. Furthermore, a 3-fold increase in the thermogenesis was seen in
rat interscapular brown adipose tissue following exposure to different concentrations of Weighlevel
extract as determined by measurement of increased oxygen consumption. In addition, a clinical study
was carried out among 80 human volunteers with a body mass index (BMI) of 30.67 ± 2.14 kg m(-2).
All 80 subjects were asked to continue their usual diet but to eat only three main meals daily and to
take one Weighlevel tablet 30 min before each meal. Fourteen subjects were excluded for not
following the protocol, and 66 subjects were all evaluated for efficacy and tolerability of Weighlevel
monthly for 3 months. Weighlevel was well tolerated by all subjects, and no side effects were
reported. A progressive and significant weight loss was seen in these subjects during the whole study
period. Higher levels of weight loss were seen in people with BMI of 25-30 kg m(-2) (overweight)
compared to people with BMI >30 kg m(-2) (obese). The BMI was reduced after 3 months from 28.5 ±
1.2 and 32.1 ± 1.8 kg m(-2) to 24.5 ± 1.4 and 27.5 ± 2.2 kg m(-2) in overweight and obese group,
respectively. Results indicate safety, tolerability and efficacy of Weighlevel.
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https://pubmed.ncbi.nlm.nih.gov/18952688/ 1/2
03/04/24, 11:18 Weight loss in animals and humans treated with "weighlevel", a combination of four medicinal plants used in traditional arabic a…
Figure 2 Effects of
Figure 1 LDH release Figure 3 Efficacy of
Weighlevel extract
from cultured human… feeding 20 chickens…
different…
Figure 4 Thermogenesis
Figure 5 Clinical efficacy
effects of Weighlevel
studies of Weighlevel…
were…
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