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Clinical Trial Am J Clin Nutr. 1997 Apr;65(4):908-15. doi: 10.1093/ajcn/65.4.908.

Metabolic and behavioral effects of a high-sucrose

diet during weight loss
R S Surwit 1 , M N Feinglos, C C McCaskill, S L Clay, M A Babyak, B S Brownlow, C S Plaisted, P H Lin

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PMID: 9094871 DOI: 10.1093/ajcn/65.4.908

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Abstract
In response to evidence linking obesity and high amounts of dietary fat, the food industry has
developed numerous reduced-fat and nonfat food items. These items frequently derive a relatively
large percentage of their energy from sugars and the effect of these sugars on weight regulation is
not well known. We studied the comparative effects of high- and low-sucrose, low-fat, hypoenergetic
diets on a variety of metabolic and behavioral indexes in a 6-wk weight-loss program. Both diets
contained approximately 4606 kJ energy/d with 11% of energy as fat, 19% as protein, and 71% as
carbohydrate. The high-sucrose diet contained 43% of the total daily energy intake as sucrose; the
low-sucrose diet contained 4% of the total daily energy intake as sucrose. Twenty women aged 40.6
+/- 8.2 y (mean +/- SD) with a body mass index (in kg/m2) of 35.93 +/- 4.8 consumed the high-
sucrose diet; 22 women aged 40.3 +/- 7.3 y with a body mass index of 34.93 +/- 4.4 consumed the
low-sucrose diet. Mixed-design analysis of variance showed a main effect of time (P < 0.01), with both
diet groups showing decreases in weight, blood pressure, resting energy expenditure, percentage
body fat, free triiodothyronine (FT3), urinary norepinephrine, and plasma lipids. Small but significant
interactions were found between group and time in total cholesterol (P = 0.009) and low-density
lipoprotein (LDL) (P = 0.01). Both groups showed decreases in depression, hunger, and negative
mood, and increases in vigilance and positive mood with time (P < 0.01). Results showed that a high
sucrose content in a hypoenergetic, low-fat diet did not adversely affect weight loss, metabolism,
plasma lipids, or emotional affect.

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Comment in
Sucrose in weight-loss regimens.
Baschetti R.
Am J Clin Nutr. 1998 Jan;67(1):150-1. doi: 10.1093/ajcn/67.1.150.
PMID: 9440391 No abstract available.

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Publication types
Clinical Trial
Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms
Adult
Analysis of Variance
Behavior / drug effects
Behavior / physiology*
Blood Glucose / analysis
Blood Pressure / physiology
Body Composition / physiology
Body Mass Index
Body Weight / physiology
Cholesterol / blood
Diet, Fat-Restricted
Dietary Sucrose / pharmacology*
Energy Metabolism / drug effects
Energy Metabolism / physiology*
Epinephrine / blood
Female
Humans
Lipids / blood
Middle Aged
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Weight Loss / drug effects
Weight Loss / physiology*

Substances
Blood Glucose
Dietary Sucrose
Lipids
Triiodothyronine
Thyrotropin
Cholesterol
Thyroxine
Epinephrine

Related information
PubChem Compound (MeSH Keyword)

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