eecererve ~ sre were SEMESTER IT GENERIC ELECTIVE 1Paper ‘otal 100 x 1 Marks I. GENERIC ELECTIVE (GE 2) (Credits: Theory-04, Practicals-02) Marks : 75 (ESU: 31trs) + 28 (Pe 3tLrs)=100 Pass Marks: Th ESE = 30+ PrESE =10 Instruction 10 Question Setter for End Semester Examination (ESE): There will be two group of questions. Group A is compulsory and will contain two questions. Question No.t will be very short answer typeconsisting of ten questions of | mark each. Question No.2 will be short answer type of 5 ‘marks: Group B will contain descriptive tspesix questions of fifteen marks each, out of which any four are to Note: There may be subdivisions in each question asked in Theory Examinations. CHEMICAL ENERGETICS, EQUILIBRIA & FUNCTIONAL GROUP; ORGANIC CHEMISTRY-1 Theory: 60 Lectures Section A: Physical Chemistry-1(30 Lectures) Chemical Energetics Review of thermodynamics and the Laws of Thermodynamics. Important principles and definitions of thermochemistry. Concept of standard state andstandard enthalpies of formations, integral and differential enthalpies of solution and dilution. Variation of enthalpy of a reaction with temperature ~ Kirchhoff's equation. (10 Lectures) Chemical Equilibrium: Free energy change in a chemical reaction. Thermodynamic derivation of the law of chemicalequilibrium. Distinction betweenAGandAG”, Le Chatelier’s principle. Relationships between Kp, Ke and Kx for reactions involving ideal gases. (8 Lectures) Tonic Equilibria: Strong, moderate and weak electrolytes, degree of ionization, factors affecting degree ofionization, ionization constant and ionic product of water. lonization of weak acids and basespH scale, common ion effect. Buffer solutions. Solubility and solubility product ofsparingly soluble salts — applications of solubility product principle. SA Den 4,902) (12 Lectures) ‘Scanned with CamScanner 2 «y~VV VO VUUOUUVYUUUYHECUUCCCC CCC eC Cee ee eer e kd CHEMISTRY PRACTICAL-GE2 LAB 60 Lectures Section Az Physical Chemistry Thermochemistry 1. Determination of heat capacity of calorimeter for different volumes 2. Determination of enthalpy of neutralization of hydrochloric acid with sodium hydroxide. 3. Determination of enthalpy of ionization of acetic acid 4. Determination of integral enthalpy of solution of salts (KNO3, NHiCD). 5. Determination of enthalpy of hydration of capper sulphate. 6. Study of the solubility of benzoic acid in water and determination of AH. Tonic equilibria pH measurements 4) Measurement of pH of different solut ns like aerated drinks, fruit juices, shampoos and soaps (use dilute solutions of soaps and shampoos to prevent damage to the glass electrode) using pH-meter, b) Preparation of buffer solutions: M Section B: Organic Chemiste i. Sodium acetate-acetic acid ii, Ammonium chloride-ammonium hydroxide leasurement of the pH of buffer solutions and comparison of the values with theoretical values. Purification of organie compounds by erystallization (from water and aleohol) anddistillation. Criteria of Purity: Determinati Preps n of mel ing points. rations: Mechanism of various reactions involved to be discussed, Recrystallisation, determination of melting point and calculation of quantitative yields to be done, (@) Bromination of Phenol/Aniline (b) Benzoylation of amines/phenols (c) Oxime and 2,4 dinitrophenythydrazone of aldehyde/ketone Reference Books ALL. Vogel: Textbook of Practical Organic Chemistry, Sth edition, Prentice-Hall. F. G, Mann & B. C. Saunders, Practical Organie Chemistry, Orient Longman (1960) B.D. Khosla, Senior Practical Physical Chemistry, R. Chand & Co. ‘Scanned with CamScannerSEMESTER IV 1Paper Total 100 x 1 = 100 Marks. IV. GENERIC ELECTIVE (GE 4) ) (Credits: Theory-04 Practicals-0: ace Marke: Th ESE = 49 PHESE 10 hs: TS (USI: Mrs) + 28 (Pe SMry)=100 Instruction to Questi End Semester Examination (ESE): toms Question No.F will be There will be two group of questions. Group A is compulsory an will cont ners short answer ypeconsisting of en questions of | mark each Question Na.2 will be short answer 6 p marks. Group B will contain descriptive typests questions of fificen marks each, out of which ans} Notes There may be s 'divisions in cach question asked in Theory Examinations CHEMISTRY OF D-BLOCK ELEMENTS, MOLECULES OF LIFE 60 Lectures Theo Section A: Inorganic Chemistry-3(30 Lectures) Transition Elements (3d series) General group trends with special reference to electronic cont magnetic and catalytic properties, ability to form complexes and stability of vs states (Latimer diagrams) for Mn, Fe and Cu. (8 Lectures) Coordination Chemistry Valence Bond Theory (VBT): Inner and outer orbi Cr, Fe, Co, Ni and Culcoordination numbers 4 and 6). Structural and stercoisomerism in complexes Withcoordination numbers 4 and 6, Drawbacks of VBT. IUPAC system of nomenclature, complexes of (8 Lectures) Crystal Field Th Crystal field eff effects for weak and strong fields. Tetrahedral symmetry. Factors attectin Spectrochemical series. Comparison of CFSE ford, and Ty compleres, Tete octahedral geomet € planar coordination. Ce MALL ory . octahedral sy pmetty. Crystal field stabilization energy (CESE), Crystal field themagnitude of D, nal distor ry. Jahn-Teller distortion, Sus (8 Lectures) ‘Scanned with CamScannera écecceec e Section B: Organic Chemistry Unit 1: Carbohydrates Classification ofearbohyd es, reducing and non-reducing sugars. General Properties of Fructose, their open chain structure. Epimers, mutarotation and Funes Determination ofconfiguration of Glucose (Fischer proof). Cyclic structure of glicose {aweuth projections. Cyclic structure of fructose. Linkage between monosachharides, sinnctorc OF disachatrides (sucrose, maltose, lactose) andpolysacharrides (starch and cellulose) excludi their structure elucidation (10 Periods) Unit 2: Amino Acids, Peptides and Prot Classi ns tion of Amino Acids, Zwitterion structure and Isoelectric point Overviewor Primary, Secondary, Tertiary and Quaternary structure of proteins. Determination of primary structure of peptides, determination of N-terminal amino acid (byDNFB and Edman method) and C-terminal amino acid (by thiohydantoin and withcarboxypeptidase enzyme) Synthesis of simple peptides (upto dipeptides) by N-protection (t-butyloxycarbonyl_ and Phthaloyl) & C-activating groups and Merrifield solid phase synthesis, (10 Pe ds) Unit 3: Enzymes and correlation with drug action Mechanism of enzyme a n, factors affecting enzyme action, Coenzymes and cofactors andtheir role in biological reactions, Specificity of enzyme action(Including stereospecifity). ‘ymeinhibitors and their importance, phenomenon of inhibition(Competitive and Non- competitive inhibition including allosteric inhibtion). Drug action-receptor theory. Structure-activity relationships of drug molecules, binding role of — OH group,-NH2 group, double bond and aromatic ring, (8 Periods) Unit 5: Lipids Introduction to lipids, classification. Oils and fats: Common fatty acids Present in oils and fats, Omega fatty acids, Trans fats, Hydrogenation, Saponification value, lodine » aber. Biological importance of triglycerides, phospholipids, glycolipids, and steroids (cholesterol) (8 Periods) Reference Books: + J.C. Kotz, P.M. Treichel & J. R. Townsend: Ger neral Chemistry, Cengage Leninglndia Put, Ltd,, New Delhi (2009). ‘Scanned with CamScannervvuvuvvwuvvuvvwwerr err CHEMISTRY PRACTICAL-GE4 LAB 60 Lectures Section A: Inorganic Chemistry 1. Estimation of the amount of nickel present in hickel(II) or aluminium as oxinate in Estimation of (i) M a given solution asbis(dimethylglyoximato) given solutiongravimetrically oF (ii) Zn” by complexomettic titrations using EDTA. stimation of total hardness of a given sample of water by complexomettic titration. To draw calibration curve {absorbance at Amax vs. concentration) for variousconcentrations of a given coloured compound and estimate the concentrationof the same in a given solution. Determination of the composition of the Fe’ salicylic acid complex/ Fe” phenanthroline complex in solution by Job's method. Determination of concentration of Na+ and K+ using Flame Photometry. 4, Section B: Organic Chemistry J. Separation of amino acids by paper chromatography 2. To determine the concentration of glycine solution by formylation method. 3. Study of titration curve of glycine 4, To determine the saponification value of an oil/fat. 5. To determine the iodine value of an oil/fat 6. Differentiate between a reducing/ nonreducing sugar. 7. To synthesise aspirin by acetylation of salicylic acid and compare aspirin tablet by TLC. with the ingredient of an Reference Books: 1) A.L Vogel, Qualitative Inorganic Analysis, Prentice Hall, 7th Edn, (1 AJL Vogel, Quantitative Chemical Analysis, Prentice Hall, 6th Edn. 1 B.D. Khosla, Senior Practical Physical Chemistry, R. Chand & Co, O) Fumiss, B.S; Hannaford, AJ; Rogers, V.; Smith, P.W.G.; Tatchell, AR. Vogel's Textbook of Practical Organic Chemistry, ELBS. 5. Ahluwalia, V.K.& Aggarwal, R. Comprehensive Practical Organic Chemistry, Universities Press, L Pra pte 7.4, Bay ‘Scanned with CamScanner